LeishMANIAdb
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Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial RNA binding complex 1 subunit
Gene product:
mitochondrial RNA binding complex 1 subunit, putative
Species:
Leishmania braziliensis
UniProt:
A4HLN4_LEIBR
TriTrypDb:
LbrM.33.2000 , LBRM2903_330026400
Length:
898

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLN4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLN4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009451 RNA modification 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016553 base conversion or substitution editing 6 1
GO:0016554 cytidine to uridine editing 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 323 327 PF00656 0.399
CLV_C14_Caspase3-7 504 508 PF00656 0.458
CLV_C14_Caspase3-7 646 650 PF00656 0.483
CLV_NRD_NRD_1 13 15 PF00675 0.516
CLV_NRD_NRD_1 206 208 PF00675 0.276
CLV_NRD_NRD_1 517 519 PF00675 0.469
CLV_NRD_NRD_1 766 768 PF00675 0.402
CLV_NRD_NRD_1 79 81 PF00675 0.391
CLV_NRD_NRD_1 814 816 PF00675 0.446
CLV_NRD_NRD_1 865 867 PF00675 0.399
CLV_NRD_NRD_1 879 881 PF00675 0.420
CLV_PCSK_KEX2_1 395 397 PF00082 0.488
CLV_PCSK_KEX2_1 558 560 PF00082 0.507
CLV_PCSK_KEX2_1 728 730 PF00082 0.345
CLV_PCSK_KEX2_1 766 768 PF00082 0.402
CLV_PCSK_KEX2_1 79 81 PF00082 0.372
CLV_PCSK_KEX2_1 814 816 PF00082 0.386
CLV_PCSK_KEX2_1 865 867 PF00082 0.384
CLV_PCSK_KEX2_1 879 881 PF00082 0.417
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.407
CLV_PCSK_PC1ET2_1 558 560 PF00082 0.507
CLV_PCSK_PC1ET2_1 728 730 PF00082 0.345
CLV_PCSK_SKI1_1 15 19 PF00082 0.520
CLV_PCSK_SKI1_1 246 250 PF00082 0.435
CLV_PCSK_SKI1_1 287 291 PF00082 0.424
CLV_PCSK_SKI1_1 306 310 PF00082 0.214
CLV_PCSK_SKI1_1 419 423 PF00082 0.332
CLV_PCSK_SKI1_1 528 532 PF00082 0.363
CLV_PCSK_SKI1_1 600 604 PF00082 0.462
CLV_PCSK_SKI1_1 671 675 PF00082 0.380
CLV_PCSK_SKI1_1 680 684 PF00082 0.339
CLV_PCSK_SKI1_1 686 690 PF00082 0.334
CLV_PCSK_SKI1_1 777 781 PF00082 0.462
CLV_PCSK_SKI1_1 804 808 PF00082 0.390
CLV_Separin_Metazoa 639 643 PF03568 0.518
DEG_APCC_DBOX_1 305 313 PF00400 0.530
DEG_APCC_DBOX_1 395 403 PF00400 0.400
DEG_APCC_DBOX_1 43 51 PF00400 0.496
DEG_Nend_UBRbox_2 1 3 PF02207 0.416
DEG_SCF_FBW7_1 779 784 PF00400 0.452
DEG_SCF_FBW7_2 623 628 PF00400 0.546
DEG_SPOP_SBC_1 103 107 PF00917 0.379
DOC_CDC14_PxL_1 342 350 PF14671 0.522
DOC_CKS1_1 778 783 PF01111 0.520
DOC_CKS1_1 825 830 PF01111 0.428
DOC_CKS1_1 834 839 PF01111 0.366
DOC_CYCLIN_RxL_1 416 426 PF00134 0.337
DOC_CYCLIN_yCln2_LP_2 759 765 PF00134 0.441
DOC_MAPK_DCC_7 444 454 PF00069 0.386
DOC_MAPK_gen_1 41 50 PF00069 0.536
DOC_MAPK_gen_1 503 512 PF00069 0.505
DOC_PP2B_LxvP_1 387 390 PF13499 0.394
DOC_PP2B_LxvP_1 759 762 PF13499 0.259
DOC_PP4_FxxP_1 664 667 PF00568 0.406
DOC_PP4_FxxP_1 778 781 PF00568 0.309
DOC_PP4_FxxP_1 825 828 PF00568 0.494
DOC_USP7_MATH_1 151 155 PF00917 0.390
DOC_USP7_MATH_1 160 164 PF00917 0.341
DOC_USP7_MATH_1 432 436 PF00917 0.299
DOC_USP7_MATH_1 466 470 PF00917 0.621
DOC_USP7_MATH_1 560 564 PF00917 0.323
DOC_USP7_MATH_1 64 68 PF00917 0.518
DOC_USP7_MATH_1 82 86 PF00917 0.253
DOC_USP7_MATH_1 888 892 PF00917 0.574
DOC_USP7_UBL2_3 686 690 PF12436 0.398
DOC_WW_Pin1_4 191 196 PF00397 0.486
DOC_WW_Pin1_4 375 380 PF00397 0.511
DOC_WW_Pin1_4 621 626 PF00397 0.507
DOC_WW_Pin1_4 68 73 PF00397 0.360
DOC_WW_Pin1_4 777 782 PF00397 0.249
DOC_WW_Pin1_4 824 829 PF00397 0.423
DOC_WW_Pin1_4 833 838 PF00397 0.367
DOC_WW_Pin1_4 850 855 PF00397 0.314
LIG_14-3-3_CanoR_1 102 111 PF00244 0.477
LIG_14-3-3_CanoR_1 130 138 PF00244 0.451
LIG_14-3-3_CanoR_1 41 50 PF00244 0.342
LIG_14-3-3_CanoR_1 459 464 PF00244 0.271
LIG_14-3-3_CanoR_1 518 527 PF00244 0.517
LIG_14-3-3_CanoR_1 642 651 PF00244 0.437
LIG_14-3-3_CanoR_1 703 709 PF00244 0.468
LIG_14-3-3_CanoR_1 771 779 PF00244 0.455
LIG_14-3-3_CanoR_1 832 837 PF00244 0.475
LIG_14-3-3_CterR_2 894 898 PF00244 0.618
LIG_Actin_WH2_2 108 124 PF00022 0.452
LIG_Actin_WH2_2 750 768 PF00022 0.466
LIG_APCC_ABBA_1 34 39 PF00400 0.419
LIG_BIR_III_2 887 891 PF00653 0.474
LIG_BIR_III_4 180 184 PF00653 0.405
LIG_BIR_III_4 39 43 PF00653 0.290
LIG_BIR_III_4 490 494 PF00653 0.451
LIG_FHA_1 106 112 PF00498 0.391
LIG_FHA_1 134 140 PF00498 0.304
LIG_FHA_1 174 180 PF00498 0.588
LIG_FHA_1 211 217 PF00498 0.517
LIG_FHA_1 33 39 PF00498 0.481
LIG_FHA_1 43 49 PF00498 0.320
LIG_FHA_1 532 538 PF00498 0.371
LIG_FHA_1 825 831 PF00498 0.445
LIG_FHA_1 834 840 PF00498 0.376
LIG_FHA_1 876 882 PF00498 0.408
LIG_FHA_2 17 23 PF00498 0.519
LIG_FHA_2 261 267 PF00498 0.517
LIG_FHA_2 342 348 PF00498 0.441
LIG_FHA_2 443 449 PF00498 0.491
LIG_FHA_2 641 647 PF00498 0.530
LIG_FHA_2 750 756 PF00498 0.368
LIG_FHA_2 778 784 PF00498 0.452
LIG_HCF-1_HBM_1 669 672 PF13415 0.477
LIG_LIR_Gen_1 231 241 PF02991 0.324
LIG_LIR_Gen_1 296 305 PF02991 0.364
LIG_LIR_Gen_1 417 424 PF02991 0.384
LIG_LIR_Gen_1 507 516 PF02991 0.340
LIG_LIR_Gen_1 545 556 PF02991 0.458
LIG_LIR_Gen_1 611 619 PF02991 0.533
LIG_LIR_Gen_1 656 665 PF02991 0.347
LIG_LIR_Gen_1 722 731 PF02991 0.448
LIG_LIR_Gen_1 736 747 PF02991 0.249
LIG_LIR_Gen_1 97 104 PF02991 0.495
LIG_LIR_Nem_3 231 236 PF02991 0.335
LIG_LIR_Nem_3 296 300 PF02991 0.454
LIG_LIR_Nem_3 344 348 PF02991 0.455
LIG_LIR_Nem_3 411 415 PF02991 0.439
LIG_LIR_Nem_3 417 423 PF02991 0.350
LIG_LIR_Nem_3 507 512 PF02991 0.351
LIG_LIR_Nem_3 545 551 PF02991 0.464
LIG_LIR_Nem_3 611 616 PF02991 0.528
LIG_LIR_Nem_3 656 661 PF02991 0.350
LIG_LIR_Nem_3 722 727 PF02991 0.483
LIG_LIR_Nem_3 97 103 PF02991 0.500
LIG_LYPXL_yS_3 345 348 PF13949 0.532
LIG_PCNA_TLS_4 503 510 PF02747 0.384
LIG_PCNA_yPIPBox_3 3 15 PF02747 0.350
LIG_SH2_NCK_1 134 138 PF00017 0.337
LIG_SH2_SRC 37 40 PF00017 0.445
LIG_SH2_STAP1 134 138 PF00017 0.483
LIG_SH2_STAP1 658 662 PF00017 0.255
LIG_SH2_STAT5 37 40 PF00017 0.440
LIG_SH2_STAT5 437 440 PF00017 0.491
LIG_SH2_STAT5 554 557 PF00017 0.371
LIG_SH2_STAT5 672 675 PF00017 0.428
LIG_SH2_STAT5 723 726 PF00017 0.480
LIG_SH3_3 112 118 PF00018 0.495
LIG_SH3_3 277 283 PF00018 0.479
LIG_SH3_3 836 842 PF00018 0.379
LIG_SUMO_SIM_anti_2 337 342 PF11976 0.384
LIG_SUMO_SIM_par_1 160 167 PF11976 0.397
LIG_SUMO_SIM_par_1 30 35 PF11976 0.363
LIG_SUMO_SIM_par_1 333 339 PF11976 0.455
LIG_SUMO_SIM_par_1 353 359 PF11976 0.243
LIG_TRAF2_1 218 221 PF00917 0.345
LIG_TRAF2_1 263 266 PF00917 0.522
LIG_TRAF2_1 367 370 PF00917 0.499
LIG_UBA3_1 750 756 PF00899 0.448
LIG_WRC_WIRS_1 415 420 PF05994 0.480
MOD_CDK_SPxxK_3 850 857 PF00069 0.312
MOD_CK1_1 105 111 PF00069 0.454
MOD_CK1_1 163 169 PF00069 0.466
MOD_CK1_1 374 380 PF00069 0.525
MOD_CK1_1 411 417 PF00069 0.496
MOD_CK1_1 462 468 PF00069 0.498
MOD_CK1_1 568 574 PF00069 0.384
MOD_CK1_1 702 708 PF00069 0.382
MOD_CK1_1 732 738 PF00069 0.526
MOD_CK1_1 826 832 PF00069 0.517
MOD_CK1_1 90 96 PF00069 0.559
MOD_CK2_1 16 22 PF00069 0.547
MOD_CK2_1 164 170 PF00069 0.408
MOD_CK2_1 260 266 PF00069 0.528
MOD_CK2_1 832 838 PF00069 0.531
MOD_Cter_Amidation 77 80 PF01082 0.366
MOD_GlcNHglycan 131 134 PF01048 0.554
MOD_GlcNHglycan 153 156 PF01048 0.362
MOD_GlcNHglycan 276 279 PF01048 0.434
MOD_GlcNHglycan 319 322 PF01048 0.505
MOD_GlcNHglycan 373 376 PF01048 0.526
MOD_GlcNHglycan 478 481 PF01048 0.727
MOD_GlcNHglycan 562 565 PF01048 0.387
MOD_GlcNHglycan 567 570 PF01048 0.382
MOD_GlcNHglycan 605 608 PF01048 0.493
MOD_GlcNHglycan 66 69 PF01048 0.373
MOD_GlcNHglycan 704 707 PF01048 0.377
MOD_GlcNHglycan 847 850 PF01048 0.586
MOD_GlcNHglycan 860 863 PF01048 0.329
MOD_GlcNHglycan 866 869 PF01048 0.286
MOD_GlcNHglycan 92 95 PF01048 0.539
MOD_GSK3_1 129 136 PF00069 0.376
MOD_GSK3_1 160 167 PF00069 0.385
MOD_GSK3_1 371 378 PF00069 0.477
MOD_GSK3_1 462 469 PF00069 0.519
MOD_GSK3_1 617 624 PF00069 0.600
MOD_GSK3_1 64 71 PF00069 0.553
MOD_GSK3_1 708 715 PF00069 0.398
MOD_GSK3_1 777 784 PF00069 0.312
MOD_GSK3_1 90 97 PF00069 0.540
MOD_GSK3_1 98 105 PF00069 0.472
MOD_N-GLC_2 274 276 PF02516 0.367
MOD_N-GLC_2 407 409 PF02516 0.446
MOD_NEK2_1 111 116 PF00069 0.513
MOD_NEK2_1 189 194 PF00069 0.536
MOD_NEK2_1 32 37 PF00069 0.394
MOD_NEK2_1 336 341 PF00069 0.449
MOD_NEK2_1 442 447 PF00069 0.393
MOD_NEK2_1 640 645 PF00069 0.400
MOD_NEK2_1 730 735 PF00069 0.435
MOD_NEK2_1 845 850 PF00069 0.512
MOD_NEK2_2 723 728 PF00069 0.362
MOD_PIKK_1 519 525 PF00454 0.396
MOD_PIKK_1 608 614 PF00454 0.504
MOD_PK_1 459 465 PF00069 0.318
MOD_PKA_2 129 135 PF00069 0.418
MOD_PKA_2 260 266 PF00069 0.503
MOD_PKA_2 40 46 PF00069 0.462
MOD_PKA_2 542 548 PF00069 0.547
MOD_PKA_2 702 708 PF00069 0.480
MOD_PKA_2 770 776 PF00069 0.472
MOD_PKA_2 864 870 PF00069 0.391
MOD_Plk_1 32 38 PF00069 0.413
MOD_Plk_1 336 342 PF00069 0.419
MOD_Plk_1 817 823 PF00069 0.369
MOD_Plk_2-3 268 274 PF00069 0.473
MOD_Plk_4 111 117 PF00069 0.292
MOD_Plk_4 160 166 PF00069 0.525
MOD_Plk_4 32 38 PF00069 0.480
MOD_Plk_4 336 342 PF00069 0.369
MOD_Plk_4 708 714 PF00069 0.427
MOD_ProDKin_1 191 197 PF00069 0.479
MOD_ProDKin_1 375 381 PF00069 0.512
MOD_ProDKin_1 621 627 PF00069 0.499
MOD_ProDKin_1 68 74 PF00069 0.360
MOD_ProDKin_1 777 783 PF00069 0.246
MOD_ProDKin_1 824 830 PF00069 0.421
MOD_ProDKin_1 833 839 PF00069 0.360
MOD_ProDKin_1 850 856 PF00069 0.313
MOD_SUMO_for_1 602 605 PF00179 0.321
MOD_SUMO_rev_2 388 397 PF00179 0.403
MOD_SUMO_rev_2 668 673 PF00179 0.346
TRG_DiLeu_BaEn_1 737 742 PF01217 0.403
TRG_DiLeu_BaEn_2 292 298 PF01217 0.346
TRG_DiLeu_BaEn_2 588 594 PF01217 0.465
TRG_DiLeu_BaEn_2 773 779 PF01217 0.419
TRG_DiLeu_BaLyEn_6 174 179 PF01217 0.438
TRG_DiLeu_BaLyEn_6 382 387 PF01217 0.467
TRG_DiLeu_BaLyEn_6 839 844 PF01217 0.378
TRG_ENDOCYTIC_2 345 348 PF00928 0.504
TRG_ENDOCYTIC_2 658 661 PF00928 0.338
TRG_ER_diArg_1 641 644 PF00400 0.529
TRG_ER_diArg_1 765 767 PF00400 0.405
TRG_ER_diArg_1 79 81 PF00400 0.421
TRG_ER_diArg_1 814 816 PF00400 0.446
TRG_ER_diArg_1 864 866 PF00400 0.469
TRG_ER_diArg_1 879 881 PF00400 0.436
TRG_ER_diArg_1 893 896 PF00400 0.477
TRG_NES_CRM1_1 292 307 PF08389 0.374
TRG_NES_CRM1_1 504 515 PF08389 0.373
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.405
TRG_Pf-PMV_PEXEL_1 436 440 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 485 489 PF00026 0.687
TRG_Pf-PMV_PEXEL_1 871 875 PF00026 0.398

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAS6 Leptomonas seymouri 60% 99%
A0A0S4JFF4 Bodo saltans 34% 86%
A0A1X0P174 Trypanosomatidae 42% 100%
A0A3Q8IHV0 Leishmania donovani 89% 100%
A0A3R7M0F7 Trypanosoma rangeli 41% 100%
A4I969 Leishmania infantum 89% 100%
C9ZIW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B410 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q414 Leishmania major 90% 99%
V5AXB1 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS