TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HLN3_LEIBR

TriTrypDb:

LbrM.33.1990 , LBRM2903_330026300

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.538
CLV_PCSK_KEX2_1	117	119	PF00082	0.538
CLV_PCSK_KEX2_1	40	42	PF00082	0.680
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.680
CLV_PCSK_PC7_1	36	42	PF00082	0.669
CLV_PCSK_SKI1_1	192	196	PF00082	0.378
CLV_PCSK_SKI1_1	23	27	PF00082	0.695
CLV_PCSK_SKI1_1	5	9	PF00082	0.684
CLV_PCSK_SKI1_1	73	77	PF00082	0.489
DEG_APCC_DBOX_1	27	35	PF00400	0.648
DEG_APCC_DBOX_1	72	80	PF00400	0.488
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.541
DOC_MAPK_gen_1	192	200	PF00069	0.320
DOC_MAPK_MEF2A_6	323	332	PF00069	0.315
DOC_PP1_RVXF_1	206	213	PF00149	0.462
DOC_PP2B_LxvP_1	89	92	PF13499	0.549
DOC_PP4_FxxP_1	95	98	PF00568	0.581
DOC_USP7_MATH_1	129	133	PF00917	0.741
DOC_USP7_MATH_1	158	162	PF00917	0.549
DOC_USP7_MATH_1	369	373	PF00917	0.455
DOC_USP7_MATH_2	63	69	PF00917	0.744
DOC_WW_Pin1_4	133	138	PF00397	0.746
LIG_Actin_WH2_2	283	301	PF00022	0.455
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BRCT_BRCA1_1	176	180	PF00533	0.536
LIG_FHA_1	285	291	PF00498	0.328
LIG_FHA_1	394	400	PF00498	0.641
LIG_FHA_2	142	148	PF00498	0.671
LIG_GBD_Chelix_1	115	123	PF00786	0.572
LIG_LIR_Apic_2	99	104	PF02991	0.637
LIG_LIR_Gen_1	256	265	PF02991	0.447
LIG_LIR_Gen_1	335	342	PF02991	0.328
LIG_LIR_Gen_1	61	69	PF02991	0.587
LIG_LIR_Nem_3	256	260	PF02991	0.440
LIG_LIR_Nem_3	335	340	PF02991	0.328
LIG_LIR_Nem_3	61	67	PF02991	0.601
LIG_NBox_RRM_1	194	204	PF00076	0.538
LIG_NRBOX	327	333	PF00104	0.449
LIG_SH2_CRK	101	105	PF00017	0.705
LIG_SH2_CRK	15	19	PF00017	0.596
LIG_SH2_CRK	257	261	PF00017	0.435
LIG_SH2_CRK	337	341	PF00017	0.344
LIG_SH2_GRB2like	47	50	PF00017	0.769
LIG_SH2_NCK_1	15	19	PF00017	0.701
LIG_SH2_SRC	47	50	PF00017	0.769
LIG_SH2_STAP1	244	248	PF00017	0.434
LIG_SH3_3	57	63	PF00018	0.634
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.725
LIG_SUMO_SIM_par_1	329	335	PF11976	0.328
LIG_SUMO_SIM_par_1	72	78	PF11976	0.739
LIG_TRAF2_1	105	108	PF00917	0.628
LIG_TRAF2_1	97	100	PF00917	0.632
LIG_TYR_ITIM	255	260	PF00017	0.405
MOD_CK1_1	324	330	PF00069	0.413
MOD_CK1_1	398	404	PF00069	0.635
MOD_CK2_1	141	147	PF00069	0.684
MOD_Cter_Amidation	164	167	PF01082	0.473
MOD_GlcNHglycan	127	130	PF01048	0.483
MOD_GlcNHglycan	176	179	PF01048	0.442
MOD_GlcNHglycan	322	326	PF01048	0.347
MOD_GlcNHglycan	43	46	PF01048	0.628
MOD_GlcNHglycan	79	82	PF01048	0.619
MOD_GlcNHglycan	86	89	PF01048	0.490
MOD_GSK3_1	125	132	PF00069	0.687
MOD_GSK3_1	17	24	PF00069	0.636
MOD_GSK3_1	280	287	PF00069	0.437
MOD_N-GLC_1	48	53	PF02516	0.739
MOD_NEK2_1	157	162	PF00069	0.490
MOD_NEK2_1	174	179	PF00069	0.386
MOD_NEK2_1	240	245	PF00069	0.523
MOD_NEK2_1	253	258	PF00069	0.324
MOD_NEK2_1	284	289	PF00069	0.407
MOD_NEK2_1	393	398	PF00069	0.616
MOD_NEK2_1	6	11	PF00069	0.672
MOD_NEK2_1	75	80	PF00069	0.714
MOD_NEK2_2	158	163	PF00069	0.564
MOD_NEK2_2	294	299	PF00069	0.449
MOD_PIKK_1	401	407	PF00454	0.652
MOD_PIKK_1	48	54	PF00454	0.760
MOD_PK_1	395	401	PF00069	0.673
MOD_PKA_2	277	283	PF00069	0.560
MOD_PKA_2	369	375	PF00069	0.426
MOD_PKA_2	382	388	PF00069	0.438
MOD_Plk_1	141	147	PF00069	0.599
MOD_Plk_1	280	286	PF00069	0.441
MOD_Plk_4	21	27	PF00069	0.654
MOD_Plk_4	227	233	PF00069	0.432
MOD_Plk_4	280	286	PF00069	0.437
MOD_Plk_4	335	341	PF00069	0.328
MOD_Plk_4	382	388	PF00069	0.600
MOD_Plk_4	398	404	PF00069	0.433
MOD_ProDKin_1	133	139	PF00069	0.745
MOD_SUMO_rev_2	20	25	PF00179	0.741
MOD_SUMO_rev_2	225	230	PF00179	0.308
TRG_DiLeu_BaEn_1	335	340	PF01217	0.344
TRG_ENDOCYTIC_2	15	18	PF00928	0.594
TRG_ENDOCYTIC_2	184	187	PF00928	0.564
TRG_ENDOCYTIC_2	257	260	PF00928	0.413
TRG_ENDOCYTIC_2	337	340	PF00928	0.328
TRG_ER_diArg_1	117	119	PF00400	0.538
TRG_NLS_MonoExtN_4	163	170	PF00514	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P843	Leptomonas seymouri	79%	100%
A0A0S4JIY4	Bodo saltans	46%	85%
A0A1X0P137	Trypanosomatidae	55%	94%
A0A3Q8IDU0	Leishmania donovani	91%	100%
A0A422MV93	Trypanosoma rangeli	55%	88%
A4I968	Leishmania infantum	91%	100%
C9ZIW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	87%
E9B409	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q415	Leishmania major	89%	100%
V5BLY0	Trypanosoma cruzi	54%	93%