LeishMANIAdb
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Calmodulin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calmodulin
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HLN2_LEIBR
TriTrypDb:
LbrM.33.1980 , LBRM2903_330026100
Length:
644

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLN2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLN2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005509 calcium ion binding 5 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.464
CLV_C14_Caspase3-7 242 246 PF00656 0.274
CLV_C14_Caspase3-7 369 373 PF00656 0.255
CLV_C14_Caspase3-7 449 453 PF00656 0.468
CLV_C14_Caspase3-7 472 476 PF00656 0.305
CLV_NRD_NRD_1 248 250 PF00675 0.278
CLV_NRD_NRD_1 518 520 PF00675 0.320
CLV_NRD_NRD_1 621 623 PF00675 0.342
CLV_NRD_NRD_1 88 90 PF00675 0.241
CLV_PCSK_FUR_1 516 520 PF00082 0.349
CLV_PCSK_KEX2_1 250 252 PF00082 0.270
CLV_PCSK_KEX2_1 518 520 PF00082 0.320
CLV_PCSK_KEX2_1 621 623 PF00082 0.476
CLV_PCSK_PC1ET2_1 250 252 PF00082 0.258
CLV_PCSK_SKI1_1 158 162 PF00082 0.257
CLV_PCSK_SKI1_1 22 26 PF00082 0.674
CLV_PCSK_SKI1_1 250 254 PF00082 0.179
CLV_PCSK_SKI1_1 325 329 PF00082 0.620
CLV_PCSK_SKI1_1 371 375 PF00082 0.240
CLV_PCSK_SKI1_1 438 442 PF00082 0.429
CLV_PCSK_SKI1_1 445 449 PF00082 0.325
CLV_PCSK_SKI1_1 550 554 PF00082 0.416
CLV_PCSK_SKI1_1 582 586 PF00082 0.424
CLV_PCSK_SKI1_1 615 619 PF00082 0.358
CLV_PCSK_SKI1_1 622 626 PF00082 0.291
CLV_PCSK_SKI1_1 89 93 PF00082 0.299
CLV_Separin_Metazoa 627 631 PF03568 0.344
CLV_Separin_Metazoa 86 90 PF03568 0.225
DEG_APCC_DBOX_1 370 378 PF00400 0.240
DOC_CYCLIN_RxL_1 461 473 PF00134 0.305
DOC_CYCLIN_RxL_1 546 558 PF00134 0.468
DOC_CYCLIN_yClb5_NLxxxL_5 107 115 PF00134 0.334
DOC_MAPK_gen_1 158 167 PF00069 0.240
DOC_MAPK_gen_1 461 469 PF00069 0.399
DOC_MAPK_gen_1 57 64 PF00069 0.240
DOC_MAPK_gen_1 582 589 PF00069 0.410
DOC_MAPK_gen_1 89 99 PF00069 0.240
DOC_MAPK_MEF2A_6 463 471 PF00069 0.305
DOC_MAPK_MEF2A_6 509 517 PF00069 0.452
DOC_MAPK_MEF2A_6 57 66 PF00069 0.239
DOC_MAPK_MEF2A_6 582 591 PF00069 0.379
DOC_USP7_MATH_1 342 346 PF00917 0.468
DOC_USP7_MATH_1 353 357 PF00917 0.250
DOC_USP7_MATH_1 453 457 PF00917 0.212
DOC_USP7_UBL2_3 18 22 PF12436 0.441
DOC_USP7_UBL2_3 25 29 PF12436 0.470
DOC_USP7_UBL2_3 3 7 PF12436 0.596
DOC_USP7_UBL2_3 461 465 PF12436 0.385
DOC_USP7_UBL2_3 65 69 PF12436 0.246
DOC_WW_Pin1_4 309 314 PF00397 0.540
DOC_WW_Pin1_4 325 330 PF00397 0.640
DOC_WW_Pin1_4 338 343 PF00397 0.633
LIG_14-3-3_CanoR_1 283 293 PF00244 0.255
LIG_14-3-3_CanoR_1 402 410 PF00244 0.280
LIG_14-3-3_CanoR_1 533 537 PF00244 0.463
LIG_BIR_II_1 1 5 PF00653 0.596
LIG_BRCT_BRCA1_1 127 131 PF00533 0.245
LIG_BRCT_BRCA1_1 491 495 PF00533 0.305
LIG_BRCT_BRCA1_1 560 564 PF00533 0.320
LIG_deltaCOP1_diTrp_1 222 231 PF00928 0.288
LIG_FHA_1 284 290 PF00498 0.274
LIG_FHA_1 326 332 PF00498 0.602
LIG_FHA_1 597 603 PF00498 0.363
LIG_FHA_2 283 289 PF00498 0.362
LIG_FHA_2 382 388 PF00498 0.385
LIG_FHA_2 402 408 PF00498 0.332
LIG_FHA_2 470 476 PF00498 0.323
LIG_FHA_2 560 566 PF00498 0.377
LIG_LIR_Apic_2 202 208 PF02991 0.240
LIG_LIR_Gen_1 106 117 PF02991 0.251
LIG_LIR_Gen_1 120 126 PF02991 0.280
LIG_LIR_Gen_1 193 203 PF02991 0.385
LIG_LIR_Gen_1 437 448 PF02991 0.471
LIG_LIR_Gen_1 477 486 PF02991 0.258
LIG_LIR_Nem_3 106 112 PF02991 0.251
LIG_LIR_Nem_3 120 125 PF02991 0.280
LIG_LIR_Nem_3 193 199 PF02991 0.385
LIG_LIR_Nem_3 437 443 PF02991 0.490
LIG_LIR_Nem_3 446 451 PF02991 0.457
LIG_LIR_Nem_3 492 498 PF02991 0.263
LIG_PALB2_WD40_1 612 620 PF16756 0.342
LIG_Pex14_2 391 395 PF04695 0.240
LIG_Pex14_2 408 412 PF04695 0.334
LIG_Pex14_2 613 617 PF04695 0.326
LIG_PTB_Apo_2 316 323 PF02174 0.580
LIG_Rb_LxCxE_1 626 644 PF01857 0.417
LIG_REV1ctd_RIR_1 505 511 PF16727 0.511
LIG_SH2_CRK 109 113 PF00017 0.240
LIG_SH2_CRK 598 602 PF00017 0.294
LIG_SH2_NCK_1 540 544 PF00017 0.436
LIG_SH2_STAP1 598 602 PF00017 0.328
LIG_SH2_STAT3 139 142 PF00017 0.240
LIG_SH2_STAT3 149 152 PF00017 0.269
LIG_SH2_STAT5 139 142 PF00017 0.288
LIG_SH2_STAT5 149 152 PF00017 0.240
LIG_SH2_STAT5 183 186 PF00017 0.282
LIG_SH2_STAT5 237 240 PF00017 0.249
LIG_SH2_STAT5 263 266 PF00017 0.280
LIG_SH2_STAT5 284 287 PF00017 0.404
LIG_SH2_STAT5 540 543 PF00017 0.364
LIG_SH2_STAT5 577 580 PF00017 0.392
LIG_SH2_STAT5 598 601 PF00017 0.297
LIG_SH2_STAT5 80 83 PF00017 0.240
LIG_SH3_3 274 280 PF00018 0.305
LIG_SH3_3 310 316 PF00018 0.573
LIG_SUMO_SIM_par_1 275 281 PF11976 0.193
LIG_TRAF2_1 384 387 PF00917 0.274
LIG_TRAF2_1 404 407 PF00917 0.119
LIG_TRAF2_1 555 558 PF00917 0.522
LIG_TRAF2_1 563 566 PF00917 0.461
LIG_TRAF2_2 265 270 PF00917 0.305
LIG_UBA3_1 87 92 PF00899 0.322
LIG_UBA3_1 99 107 PF00899 0.334
MOD_CDK_SPK_2 325 330 PF00069 0.681
MOD_CK1_1 181 187 PF00069 0.255
MOD_CK1_1 278 284 PF00069 0.463
MOD_CK1_1 315 321 PF00069 0.470
MOD_CK1_1 341 347 PF00069 0.577
MOD_CK1_1 478 484 PF00069 0.340
MOD_CK1_1 491 497 PF00069 0.333
MOD_CK1_1 535 541 PF00069 0.516
MOD_CK2_1 342 348 PF00069 0.481
MOD_CK2_1 381 387 PF00069 0.271
MOD_CK2_1 401 407 PF00069 0.298
MOD_CK2_1 552 558 PF00069 0.382
MOD_CK2_1 559 565 PF00069 0.294
MOD_CK2_1 76 82 PF00069 0.299
MOD_DYRK1A_RPxSP_1 325 329 PF00069 0.583
MOD_GlcNHglycan 280 283 PF01048 0.343
MOD_GlcNHglycan 454 458 PF01048 0.334
MOD_GlcNHglycan 74 77 PF01048 0.385
MOD_GSK3_1 195 202 PF00069 0.301
MOD_GSK3_1 241 248 PF00069 0.278
MOD_GSK3_1 278 285 PF00069 0.308
MOD_GSK3_1 338 345 PF00069 0.620
MOD_GSK3_1 353 360 PF00069 0.170
MOD_GSK3_1 453 460 PF00069 0.323
MOD_GSK3_1 475 482 PF00069 0.367
MOD_GSK3_1 552 559 PF00069 0.400
MOD_GSK3_1 72 79 PF00069 0.382
MOD_N-GLC_1 257 262 PF02516 0.385
MOD_N-GLC_1 357 362 PF02516 0.343
MOD_N-GLC_2 378 380 PF02516 0.269
MOD_NEK2_1 178 183 PF00069 0.322
MOD_NEK2_1 195 200 PF00069 0.244
MOD_NEK2_1 275 280 PF00069 0.163
MOD_NEK2_1 410 415 PF00069 0.414
MOD_NEK2_1 532 537 PF00069 0.535
MOD_NEK2_1 552 557 PF00069 0.194
MOD_NEK2_1 573 578 PF00069 0.358
MOD_NEK2_1 71 76 PF00069 0.385
MOD_OFUCOSY 221 226 PF10250 0.240
MOD_PIKK_1 125 131 PF00454 0.214
MOD_PIKK_1 575 581 PF00454 0.518
MOD_PKA_2 181 187 PF00069 0.240
MOD_PKA_2 282 288 PF00069 0.299
MOD_PKA_2 401 407 PF00069 0.255
MOD_PKA_2 532 538 PF00069 0.554
MOD_PKA_2 72 78 PF00069 0.370
MOD_PKB_1 249 257 PF00069 0.359
MOD_Plk_1 632 638 PF00069 0.435
MOD_Plk_4 299 305 PF00069 0.410
MOD_Plk_4 475 481 PF00069 0.269
MOD_Plk_4 76 82 PF00069 0.263
MOD_ProDKin_1 309 315 PF00069 0.540
MOD_ProDKin_1 325 331 PF00069 0.632
MOD_ProDKin_1 338 344 PF00069 0.626
MOD_SUMO_for_1 160 163 PF00179 0.240
MOD_SUMO_for_1 624 627 PF00179 0.440
MOD_SUMO_rev_2 385 391 PF00179 0.417
MOD_SUMO_rev_2 481 490 PF00179 0.279
TRG_DiLeu_BaEn_2 386 392 PF01217 0.385
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.331
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.334
TRG_ENDOCYTIC_2 109 112 PF00928 0.240
TRG_ENDOCYTIC_2 237 240 PF00928 0.240
TRG_ENDOCYTIC_2 505 508 PF00928 0.436
TRG_ENDOCYTIC_2 598 601 PF00928 0.297
TRG_ER_diArg_1 249 252 PF00400 0.262
TRG_ER_diArg_1 515 518 PF00400 0.305
TRG_ER_diArg_1 620 622 PF00400 0.354
TRG_NES_CRM1_1 439 454 PF08389 0.459
TRG_Pf-PMV_PEXEL_1 158 163 PF00026 0.255
TRG_Pf-PMV_PEXEL_1 251 256 PF00026 0.220
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.280
TRG_Pf-PMV_PEXEL_1 621 626 PF00026 0.332

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMD1 Leptomonas seymouri 80% 100%
A0A0S4IPB3 Bodo saltans 30% 95%
A0A0S4JIY0 Bodo saltans 54% 100%
A0A1X0NJJ7 Trypanosomatidae 30% 86%
A0A1X0P150 Trypanosomatidae 57% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 28% 100%
A0A3Q8IU22 Leishmania donovani 92% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A0A3S5H5U5 Leishmania donovani 25% 100%
A0A3S5IQS7 Trypanosoma rangeli 30% 87%
A0A422N215 Trypanosoma rangeli 54% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 100%
A0A509AQE6 Plasmodium berghei (strain Anka) 29% 100%
A0A5K1K8H0 Plasmodium falciparum (isolate 3D7) 26% 100%
A0AAR7 Lotus japonicus 26% 100%
A2ZVI7 Oryza sativa subsp. japonica 30% 100%
A4H459 Leishmania braziliensis 25% 100%
A4H4S9 Leishmania braziliensis 25% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4HFF3 Leishmania braziliensis 27% 100%
A4HSE2 Leishmania infantum 25% 100%
A4I967 Leishmania infantum 92% 100%
A5A7I7 Solanum tuberosum 28% 100%
A5A7I8 Solanum tuberosum 28% 100%
B9FKW9 Oryza sativa subsp. japonica 31% 100%
C9ZIW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
E9AET0 Leishmania major 25% 100%
E9AG71 Leishmania infantum 25% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B408 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O49717 Arabidopsis thaliana 30% 100%
P28582 Daucus carota 30% 100%
P28583 Glycine max 29% 100%
P49101 Zea mays 29% 100%
P53681 Daucus carota 29% 100%
P53683 Oryza sativa subsp. japonica 30% 100%
P53684 Oryza sativa subsp. japonica 28% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 28% 100%
P62344 Plasmodium falciparum (isolate 3D7) 28% 100%
P62345 Plasmodium berghei (strain Anka) 28% 100%
P93759 Arabidopsis thaliana 30% 100%
Q06850 Arabidopsis thaliana 28% 100%
Q0D715 Oryza sativa subsp. japonica 30% 100%
Q0DYK7 Oryza sativa subsp. japonica 29% 100%
Q1PE17 Arabidopsis thaliana 29% 100%
Q1PFH8 Arabidopsis thaliana 29% 100%
Q2QQR2 Oryza sativa subsp. japonica 28% 100%
Q2QVG8 Oryza sativa subsp. japonica 31% 100%
Q2QX45 Oryza sativa subsp. japonica 28% 100%
Q2QY37 Oryza sativa subsp. japonica 30% 100%
Q2RAV0 Oryza sativa subsp. japonica 30% 100%
Q38868 Arabidopsis thaliana 31% 100%
Q38869 Arabidopsis thaliana 29% 100%
Q38870 Arabidopsis thaliana 28% 100%
Q38871 Arabidopsis thaliana 29% 100%
Q38872 Arabidopsis thaliana 29% 100%
Q38873 Arabidopsis thaliana 30% 100%
Q39016 Arabidopsis thaliana 28% 100%
Q3E9C0 Arabidopsis thaliana 32% 100%
Q42396 Arabidopsis thaliana 28% 100%
Q42438 Arabidopsis thaliana 28% 100%
Q42479 Arabidopsis thaliana 31% 100%
Q43531 Lilium longiflorum 30% 100%
Q4Q416 Leishmania major 91% 99%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 25% 100%
Q53P85 Oryza sativa subsp. japonica 28% 100%
Q5VQQ5 Oryza sativa subsp. japonica 31% 100%
Q60806 Mus musculus 28% 100%
Q69IM9 Oryza sativa subsp. japonica 30% 100%
Q6AVI8 Oryza sativa subsp. japonica 29% 100%
Q6F3A6 Oryza sativa subsp. japonica 29% 100%
Q6I587 Oryza sativa subsp. japonica 30% 100%
Q6I5I8 Oryza sativa subsp. japonica 29% 100%
Q6K968 Oryza sativa subsp. japonica 29% 100%
Q6NLQ6 Arabidopsis thaliana 30% 100%
Q6RET6 Pisum sativum 26% 100%
Q6Z2M9 Oryza sativa subsp. japonica 30% 100%
Q75GE8 Oryza sativa subsp. japonica 29% 100%
Q7RAH3 Plasmodium yoelii yoelii 28% 100%
Q7RJG2 Plasmodium yoelii yoelii 28% 100%
Q7XIM0 Oryza sativa subsp. japonica 28% 100%
Q7XJR9 Arabidopsis thaliana 31% 100%
Q7XSQ5 Oryza sativa subsp. japonica 29% 100%
Q84SL0 Oryza sativa subsp. japonica 29% 100%
Q852N6 Oryza sativa subsp. japonica 28% 100%
Q8IBS5 Plasmodium falciparum (isolate 3D7) 27% 100%
Q8LPZ7 Oryza sativa subsp. japonica 30% 100%
Q8RWL2 Arabidopsis thaliana 31% 100%
Q8W4I7 Arabidopsis thaliana 29% 100%
Q9C6P3 Arabidopsis thaliana 31% 100%
Q9FJ54 Arabidopsis thaliana 32% 100%
Q9FKW4 Arabidopsis thaliana 30% 100%
Q9FMP5 Arabidopsis thaliana 32% 100%
Q9FXQ3 Oryza sativa subsp. japonica 30% 100%
Q9LJL9 Arabidopsis thaliana 28% 100%
Q9M101 Arabidopsis thaliana 29% 100%
Q9S9V0 Arabidopsis thaliana 27% 100%
Q9SCS2 Arabidopsis thaliana 27% 100%
Q9SSF8 Arabidopsis thaliana 29% 100%
Q9SZM3 Arabidopsis thaliana 28% 100%
Q9XF67 Arabidopsis thaliana 27% 100%
Q9ZSA2 Arabidopsis thaliana 30% 100%
Q9ZSA3 Arabidopsis thaliana 29% 100%
Q9ZSA4 Arabidopsis thaliana 28% 100%
Q9ZV15 Arabidopsis thaliana 27% 100%
V5BCN4 Trypanosoma cruzi 60% 100%
V5BN97 Trypanosoma cruzi 30% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS