Cysteine desulfurase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thiamine biosynthesis-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLM9_LEIBR

TriTrypDb:

LbrM.33.1950 , LBRM2903_330025700

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM9

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0016226	iron-sulfur cluster assembly	4	8
GO:0022607	cellular component assembly	4	8
GO:0031163	metallo-sulfur cluster assembly	5	8
GO:0044237	cellular metabolic process	2	8
GO:0044571	[2Fe-2S] cluster assembly	5	8
GO:0071840	cellular component organization or biogenesis	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	8
GO:0004810	CCA tRNA nucleotidyltransferase activity	8	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0016782	transferase activity, transferring sulphur-containing groups	3	8
GO:0016783	sulfurtransferase activity	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0019842	vitamin binding	3	8
GO:0030170	pyridoxal phosphate binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0031071	cysteine desulfurase activity	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0051536	iron-sulfur cluster binding	3	8
GO:0051540	metal cluster binding	2	8
GO:0070279	vitamin B6 binding	3	8
GO:0070566	adenylyltransferase activity	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:1990817	poly(A) RNA polymerase activity	7	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	614	618	PF00656	0.556
CLV_C14_Caspase3-7	773	777	PF00656	0.537
CLV_NRD_NRD_1	139	141	PF00675	0.532
CLV_NRD_NRD_1	152	154	PF00675	0.373
CLV_NRD_NRD_1	170	172	PF00675	0.388
CLV_NRD_NRD_1	201	203	PF00675	0.694
CLV_NRD_NRD_1	270	272	PF00675	0.319
CLV_NRD_NRD_1	371	373	PF00675	0.358
CLV_NRD_NRD_1	403	405	PF00675	0.551
CLV_NRD_NRD_1	411	413	PF00675	0.498
CLV_NRD_NRD_1	701	703	PF00675	0.317
CLV_NRD_NRD_1	71	73	PF00675	0.669
CLV_PCSK_KEX2_1	104	106	PF00082	0.684
CLV_PCSK_KEX2_1	113	115	PF00082	0.682
CLV_PCSK_KEX2_1	141	143	PF00082	0.488
CLV_PCSK_KEX2_1	152	154	PF00082	0.458
CLV_PCSK_KEX2_1	270	272	PF00082	0.324
CLV_PCSK_KEX2_1	403	405	PF00082	0.551
CLV_PCSK_KEX2_1	411	413	PF00082	0.498
CLV_PCSK_KEX2_1	701	703	PF00082	0.317
CLV_PCSK_KEX2_1	71	73	PF00082	0.634
CLV_PCSK_KEX2_1	85	87	PF00082	0.672
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.631
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.727
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.488
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.627
CLV_PCSK_PC7_1	67	73	PF00082	0.674
CLV_PCSK_SKI1_1	122	126	PF00082	0.341
CLV_PCSK_SKI1_1	152	156	PF00082	0.470
CLV_PCSK_SKI1_1	207	211	PF00082	0.654
CLV_PCSK_SKI1_1	242	246	PF00082	0.356
CLV_PCSK_SKI1_1	411	415	PF00082	0.515
CLV_PCSK_SKI1_1	419	423	PF00082	0.394
CLV_PCSK_SKI1_1	479	483	PF00082	0.226
CLV_PCSK_SKI1_1	585	589	PF00082	0.559
CLV_PCSK_SKI1_1	638	642	PF00082	0.356
CLV_PCSK_SKI1_1	785	789	PF00082	0.462
CLV_PCSK_SKI1_1	9	13	PF00082	0.684
DEG_APCC_DBOX_1	411	419	PF00400	0.609
DEG_APCC_DBOX_1	513	521	PF00400	0.556
DEG_COP1_1	450	460	PF00400	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DEG_ODPH_VHL_1	356	368	PF01847	0.556
DEG_SCF_FBW7_1	754	761	PF00400	0.607
DOC_CDC14_PxL_1	56	64	PF14671	0.625
DOC_CKS1_1	219	224	PF01111	0.522
DOC_MAPK_gen_1	411	420	PF00069	0.530
DOC_MAPK_MEF2A_6	122	129	PF00069	0.411
DOC_MAPK_MEF2A_6	353	362	PF00069	0.556
DOC_MAPK_RevD_3	127	142	PF00069	0.496
DOC_MAPK_RevD_3	57	72	PF00069	0.669
DOC_PP1_RVXF_1	603	609	PF00149	0.556
DOC_PP1_RVXF_1	763	769	PF00149	0.517
DOC_PP2B_LxvP_1	489	492	PF13499	0.433
DOC_PP2B_PxIxI_1	357	363	PF00149	0.607
DOC_USP7_MATH_1	41	45	PF00917	0.649
DOC_USP7_MATH_1	458	462	PF00917	0.679
DOC_USP7_MATH_1	760	764	PF00917	0.556
DOC_USP7_UBL2_3	177	181	PF12436	0.604
DOC_USP7_UBL2_3	199	203	PF12436	0.515
DOC_WW_Pin1_4	19	24	PF00397	0.767
DOC_WW_Pin1_4	218	223	PF00397	0.491
DOC_WW_Pin1_4	233	238	PF00397	0.461
DOC_WW_Pin1_4	451	456	PF00397	0.716
DOC_WW_Pin1_4	754	759	PF00397	0.607
LIG_14-3-3_CanoR_1	275	280	PF00244	0.519
LIG_14-3-3_CanoR_1	372	378	PF00244	0.517
LIG_14-3-3_CanoR_1	403	407	PF00244	0.528
LIG_14-3-3_CanoR_1	412	421	PF00244	0.524
LIG_14-3-3_CanoR_1	72	81	PF00244	0.615
LIG_14-3-3_CanoR_1	726	735	PF00244	0.574
LIG_14-3-3_CanoR_1	765	769	PF00244	0.517
LIG_14-3-3_CanoR_1	779	788	PF00244	0.437
LIG_Actin_WH2_2	119	137	PF00022	0.502
LIG_BRCT_BRCA1_1	432	436	PF00533	0.497
LIG_Clathr_ClatBox_1	603	607	PF01394	0.556
LIG_FHA_1	260	266	PF00498	0.522
LIG_FHA_1	565	571	PF00498	0.482
LIG_FHA_1	578	584	PF00498	0.482
LIG_FHA_1	657	663	PF00498	0.522
LIG_FHA_1	687	693	PF00498	0.556
LIG_FHA_1	719	725	PF00498	0.556
LIG_FHA_1	741	747	PF00498	0.517
LIG_FHA_1	759	765	PF00498	0.517
LIG_FHA_2	164	170	PF00498	0.522
LIG_FHA_2	37	43	PF00498	0.464
LIG_FHA_2	586	592	PF00498	0.462
LIG_FHA_2	747	753	PF00498	0.556
LIG_FHA_2	771	777	PF00498	0.517
LIG_FHA_2	90	96	PF00498	0.686
LIG_GBD_Chelix_1	143	151	PF00786	0.325
LIG_IRF3_LxIS_1	123	128	PF10401	0.527
LIG_LIR_Gen_1	284	293	PF02991	0.496
LIG_LIR_Gen_1	748	759	PF02991	0.519
LIG_LIR_Gen_1	767	774	PF02991	0.556
LIG_LIR_Gen_1	95	103	PF02991	0.599
LIG_LIR_Nem_3	284	290	PF02991	0.496
LIG_LIR_Nem_3	307	313	PF02991	0.517
LIG_LIR_Nem_3	345	351	PF02991	0.517
LIG_LIR_Nem_3	433	439	PF02991	0.536
LIG_LIR_Nem_3	44	50	PF02991	0.600
LIG_LIR_Nem_3	607	611	PF02991	0.556
LIG_LIR_Nem_3	748	754	PF02991	0.519
LIG_LIR_Nem_3	767	771	PF02991	0.556
LIG_LIR_Nem_3	95	100	PF02991	0.600
LIG_LYPXL_S_1	347	351	PF13949	0.356
LIG_LYPXL_yS_3	348	351	PF13949	0.537
LIG_MYND_3	59	63	PF01753	0.698
LIG_NRP_CendR_1	792	795	PF00754	0.542
LIG_PCNA_yPIPBox_3	172	186	PF02747	0.524
LIG_SH2_CRK	545	549	PF00017	0.592
LIG_SH2_CRK	751	755	PF00017	0.556
LIG_SH2_GRB2like	718	721	PF00017	0.607
LIG_SH2_PTP2	287	290	PF00017	0.556
LIG_SH2_PTP2	97	100	PF00017	0.583
LIG_SH2_SRC	287	290	PF00017	0.556
LIG_SH2_STAT3	438	441	PF00017	0.638
LIG_SH2_STAT5	133	136	PF00017	0.594
LIG_SH2_STAT5	287	290	PF00017	0.556
LIG_SH2_STAT5	47	50	PF00017	0.629
LIG_SH2_STAT5	471	474	PF00017	0.556
LIG_SH2_STAT5	636	639	PF00017	0.517
LIG_SH2_STAT5	708	711	PF00017	0.607
LIG_SH2_STAT5	97	100	PF00017	0.583
LIG_SH3_3	216	222	PF00018	0.507
LIG_SH3_3	352	358	PF00018	0.519
LIG_SH3_3	449	455	PF00018	0.723
LIG_SH3_3	54	60	PF00018	0.672
LIG_SH3_3	545	551	PF00018	0.693
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.509
LIG_SUMO_SIM_par_1	125	131	PF11976	0.445
LIG_SUMO_SIM_par_1	225	231	PF11976	0.556
LIG_SUMO_SIM_par_1	55	61	PF11976	0.553
LIG_TRAF2_1	380	383	PF00917	0.556
LIG_TYR_ITSM	344	351	PF00017	0.537
LIG_UBA3_1	147	156	PF00899	0.392
LIG_UBA3_1	182	191	PF00899	0.538
LIG_WRC_WIRS_1	374	379	PF05994	0.517
MOD_CDK_SPxxK_3	218	225	PF00069	0.522
MOD_CK1_1	447	453	PF00069	0.694
MOD_CK1_1	532	538	PF00069	0.556
MOD_CK1_1	553	559	PF00069	0.541
MOD_CK1_1	647	653	PF00069	0.607
MOD_CK1_1	725	731	PF00069	0.556
MOD_CK1_1	767	773	PF00069	0.556
MOD_CK2_1	125	131	PF00069	0.443
MOD_CK2_1	163	169	PF00069	0.509
MOD_CK2_1	261	267	PF00069	0.527
MOD_CK2_1	377	383	PF00069	0.551
MOD_CK2_1	499	505	PF00069	0.556
MOD_CK2_1	585	591	PF00069	0.606
MOD_CK2_1	772	778	PF00069	0.477
MOD_CK2_1	89	95	PF00069	0.681
MOD_Cter_Amidation	111	114	PF01082	0.676
MOD_Cter_Amidation	401	404	PF01082	0.532
MOD_Cter_Amidation	69	72	PF01082	0.686
MOD_GlcNHglycan	135	138	PF01048	0.590
MOD_GlcNHglycan	230	233	PF01048	0.247
MOD_GlcNHglycan	331	334	PF01048	0.356
MOD_GlcNHglycan	394	397	PF01048	0.671
MOD_GlcNHglycan	441	444	PF01048	0.627
MOD_GlcNHglycan	501	504	PF01048	0.317
MOD_GlcNHglycan	531	534	PF01048	0.356
MOD_GlcNHglycan	646	649	PF01048	0.407
MOD_GlcNHglycan	704	708	PF01048	0.319
MOD_GlcNHglycan	738	741	PF01048	0.336
MOD_GlcNHglycan	781	784	PF01048	0.485
MOD_GSK3_1	255	262	PF00069	0.517
MOD_GSK3_1	288	295	PF00069	0.556
MOD_GSK3_1	322	329	PF00069	0.552
MOD_GSK3_1	343	350	PF00069	0.556
MOD_GSK3_1	373	380	PF00069	0.514
MOD_GSK3_1	444	451	PF00069	0.545
MOD_GSK3_1	495	502	PF00069	0.517
MOD_GSK3_1	528	535	PF00069	0.517
MOD_GSK3_1	550	557	PF00069	0.572
MOD_GSK3_1	607	614	PF00069	0.531
MOD_GSK3_1	615	622	PF00069	0.500
MOD_GSK3_1	718	725	PF00069	0.551
MOD_GSK3_1	736	743	PF00069	0.422
MOD_GSK3_1	746	753	PF00069	0.517
MOD_GSK3_1	754	761	PF00069	0.517
MOD_N-GLC_1	256	261	PF02516	0.317
MOD_N-GLC_1	304	309	PF02516	0.298
MOD_N-GLC_1	342	347	PF02516	0.317
MOD_N-GLC_1	447	452	PF02516	0.759
MOD_N-GLC_1	585	590	PF02516	0.598
MOD_N-GLC_1	746	751	PF02516	0.317
MOD_NEK2_1	125	130	PF00069	0.429
MOD_NEK2_1	255	260	PF00069	0.517
MOD_NEK2_1	313	318	PF00069	0.511
MOD_NEK2_1	321	326	PF00069	0.502
MOD_NEK2_1	377	382	PF00069	0.510
MOD_NEK2_1	392	397	PF00069	0.620
MOD_NEK2_1	444	449	PF00069	0.468
MOD_NEK2_1	499	504	PF00069	0.517
MOD_NEK2_1	674	679	PF00069	0.540
MOD_NEK2_2	337	342	PF00069	0.556
MOD_NEK2_2	760	765	PF00069	0.556
MOD_PIKK_1	193	199	PF00454	0.691
MOD_PIKK_1	292	298	PF00454	0.556
MOD_PIKK_1	335	341	PF00454	0.517
MOD_PIKK_1	512	518	PF00454	0.537
MOD_PIKK_1	597	603	PF00454	0.556
MOD_PIKK_1	647	653	PF00454	0.556
MOD_PIKK_1	686	692	PF00454	0.426
MOD_PIKK_1	726	732	PF00454	0.426
MOD_PK_1	275	281	PF00069	0.527
MOD_PK_1	676	682	PF00069	0.454
MOD_PKA_2	274	280	PF00069	0.517
MOD_PKA_2	402	408	PF00069	0.529
MOD_PKA_2	444	450	PF00069	0.623
MOD_PKA_2	725	731	PF00069	0.574
MOD_PKA_2	764	770	PF00069	0.517
MOD_Plk_1	288	294	PF00069	0.529
MOD_Plk_1	304	310	PF00069	0.427
MOD_Plk_1	321	327	PF00069	0.517
MOD_Plk_1	342	348	PF00069	0.517
MOD_Plk_1	377	383	PF00069	0.517
MOD_Plk_1	447	453	PF00069	0.494
MOD_Plk_1	482	488	PF00069	0.426
MOD_Plk_1	746	752	PF00069	0.556
MOD_Plk_2-3	261	267	PF00069	0.556
MOD_Plk_2-3	607	613	PF00069	0.556
MOD_Plk_4	163	169	PF00069	0.497
MOD_Plk_4	261	267	PF00069	0.556
MOD_Plk_4	322	328	PF00069	0.474
MOD_Plk_4	343	349	PF00069	0.517
MOD_Plk_4	565	571	PF00069	0.555
MOD_Plk_4	746	752	PF00069	0.556
MOD_ProDKin_1	19	25	PF00069	0.760
MOD_ProDKin_1	218	224	PF00069	0.495
MOD_ProDKin_1	233	239	PF00069	0.461
MOD_ProDKin_1	451	457	PF00069	0.716
MOD_ProDKin_1	754	760	PF00069	0.607
MOD_SUMO_rev_2	52	57	PF00179	0.663
MOD_SUMO_rev_2	789	793	PF00179	0.411
TRG_DiLeu_BaEn_1	121	126	PF01217	0.532
TRG_DiLeu_BaEn_1	178	183	PF01217	0.579
TRG_DiLeu_BaEn_2	431	437	PF01217	0.351
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.556
TRG_ENDOCYTIC_2	241	244	PF00928	0.517
TRG_ENDOCYTIC_2	287	290	PF00928	0.556
TRG_ENDOCYTIC_2	310	313	PF00928	0.517
TRG_ENDOCYTIC_2	348	351	PF00928	0.517
TRG_ENDOCYTIC_2	545	548	PF00928	0.592
TRG_ENDOCYTIC_2	751	754	PF00928	0.517
TRG_ENDOCYTIC_2	97	100	PF00928	0.583
TRG_ER_diArg_1	140	143	PF00400	0.513
TRG_ER_diArg_1	151	153	PF00400	0.410
TRG_ER_diArg_1	270	272	PF00400	0.524
TRG_ER_diArg_1	410	412	PF00400	0.581
TRG_ER_diArg_1	71	73	PF00400	0.669
TRG_NES_CRM1_1	274	289	PF08389	0.556
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM59	Leptomonas seymouri	82%	100%
A0A0S4JKY0	Bodo saltans	44%	85%
A0A3S7X6Q8	Leishmania donovani	91%	100%
A4I940	Leishmania infantum	91%	100%
E9B405	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q419	Leishmania major	91%	100%