Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLM7_LEIBR

TriTrypDb:

LbrM.33.1930 , LBRM2903_330025500

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.475
CLV_C14_Caspase3-7	169	173	PF00656	0.514
CLV_C14_Caspase3-7	190	194	PF00656	0.516
CLV_NRD_NRD_1	186	188	PF00675	0.478
CLV_PCSK_KEX2_1	186	188	PF00082	0.494
CLV_PCSK_KEX2_1	99	101	PF00082	0.583
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.552
CLV_PCSK_SKI1_1	160	164	PF00082	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.682
DOC_MAPK_MEF2A_6	156	165	PF00069	0.397
DOC_PP4_FxxP_1	58	61	PF00568	0.581
DOC_USP7_MATH_1	109	113	PF00917	0.571
DOC_USP7_MATH_1	116	120	PF00917	0.473
DOC_USP7_MATH_1	144	148	PF00917	0.585
DOC_USP7_MATH_1	173	177	PF00917	0.512
LIG_14-3-3_CanoR_1	186	192	PF00244	0.471
LIG_APCC_ABBA_1	149	154	PF00400	0.577
LIG_DLG_GKlike_1	187	195	PF00625	0.516
LIG_FHA_1	11	17	PF00498	0.447
LIG_FHA_1	193	199	PF00498	0.567
LIG_FHA_1	37	43	PF00498	0.490
LIG_LIR_Gen_1	121	132	PF02991	0.476
LIG_LIR_Gen_1	49	59	PF02991	0.319
LIG_LIR_Gen_1	66	75	PF02991	0.263
LIG_LIR_Nem_3	121	127	PF02991	0.523
LIG_LIR_Nem_3	49	55	PF02991	0.365
LIG_LIR_Nem_3	66	71	PF02991	0.255
LIG_SH2_CRK	52	56	PF00017	0.458
LIG_SH2_CRK	68	72	PF00017	0.540
LIG_SH2_NCK_1	191	195	PF00017	0.525
LIG_SH2_SRC	107	110	PF00017	0.430
LIG_SH2_SRC	191	194	PF00017	0.519
LIG_SH2_STAP1	52	56	PF00017	0.438
LIG_SH2_STAT5	102	105	PF00017	0.435
LIG_SH2_STAT5	124	127	PF00017	0.394
MOD_CK2_1	144	150	PF00069	0.585
MOD_GlcNHglycan	146	149	PF01048	0.580
MOD_GSK3_1	63	70	PF00069	0.457
MOD_NEK2_1	10	15	PF00069	0.496
MOD_NEK2_1	143	148	PF00069	0.527
MOD_NEK2_1	180	185	PF00069	0.515
MOD_PKA_2	185	191	PF00069	0.547
MOD_Plk_4	37	43	PF00069	0.556
MOD_Plk_4	51	57	PF00069	0.316
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.325
TRG_ENDOCYTIC_2	124	127	PF00928	0.464
TRG_ENDOCYTIC_2	52	55	PF00928	0.376
TRG_ENDOCYTIC_2	68	71	PF00928	0.403
TRG_ER_diArg_1	185	187	PF00400	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU1	Leptomonas seymouri	56%	99%
A0A3R7KFM1	Trypanosoma rangeli	26%	94%
A0A3S7X6V4	Leishmania donovani	83%	100%
A4I938	Leishmania infantum	84%	100%
C9ZIV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9B403	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q421	Leishmania major	80%	100%