Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLM6_LEIBR

TriTrypDb:

LbrM.33.1920 , LBRM2903_330025400

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.508
CLV_NRD_NRD_1	30	32	PF00675	0.513
CLV_PCSK_KEX2_1	171	173	PF00082	0.508
CLV_PCSK_KEX2_1	30	32	PF00082	0.513
CLV_PCSK_SKI1_1	223	227	PF00082	0.458
CLV_PCSK_SKI1_1	35	39	PF00082	0.448
DEG_SPOP_SBC_1	70	74	PF00917	0.309
DOC_MAPK_FxFP_2	3	6	PF00069	0.378
DOC_MAPK_gen_1	253	262	PF00069	0.452
DOC_MAPK_MEF2A_6	230	237	PF00069	0.453
DOC_MAPK_NFAT4_5	230	238	PF00069	0.291
DOC_PP4_FxxP_1	3	6	PF00568	0.342
DOC_USP7_MATH_1	56	60	PF00917	0.506
DOC_USP7_UBL2_3	226	230	PF12436	0.421
DOC_WW_Pin1_4	90	95	PF00397	0.324
LIG_14-3-3_CanoR_1	171	181	PF00244	0.451
LIG_14-3-3_CanoR_1	183	188	PF00244	0.383
LIG_14-3-3_CanoR_1	210	217	PF00244	0.390
LIG_14-3-3_CanoR_1	253	262	PF00244	0.342
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_Clathr_ClatBox_1	244	248	PF01394	0.362
LIG_FHA_1	102	108	PF00498	0.437
LIG_FHA_1	13	19	PF00498	0.424
LIG_FHA_1	182	188	PF00498	0.465
LIG_FHA_1	255	261	PF00498	0.373
LIG_FHA_1	40	46	PF00498	0.446
LIG_FHA_1	81	87	PF00498	0.462
LIG_FHA_2	142	148	PF00498	0.501
LIG_FHA_2	34	40	PF00498	0.471
LIG_GBD_Chelix_1	99	107	PF00786	0.485
LIG_LIR_Gen_1	216	225	PF02991	0.439
LIG_LIR_Gen_1	49	56	PF02991	0.330
LIG_LIR_Nem_3	216	220	PF02991	0.378
LIG_LIR_Nem_3	49	53	PF02991	0.326
LIG_LIR_Nem_3	87	92	PF02991	0.417
LIG_Pex14_2	245	249	PF04695	0.298
LIG_SH2_CRK	217	221	PF00017	0.366
LIG_SH2_CRK	50	54	PF00017	0.249
LIG_SH2_NCK_1	143	147	PF00017	0.409
LIG_SH2_NCK_1	50	54	PF00017	0.460
LIG_SH2_STAP1	50	54	PF00017	0.289
LIG_SH2_STAT3	17	20	PF00017	0.447
LIG_SH2_STAT5	143	146	PF00017	0.456
LIG_SH2_STAT5	17	20	PF00017	0.314
LIG_SH2_STAT5	50	53	PF00017	0.442
LIG_SH3_3	40	46	PF00018	0.422
LIG_SUMO_SIM_par_1	36	42	PF11976	0.454
LIG_SUMO_SIM_par_1	93	98	PF11976	0.408
MOD_CK1_1	185	191	PF00069	0.416
MOD_CK1_1	49	55	PF00069	0.522
MOD_CK2_1	191	197	PF00069	0.461
MOD_CK2_1	33	39	PF00069	0.434
MOD_GlcNHglycan	151	154	PF01048	0.321
MOD_GlcNHglycan	206	210	PF01048	0.434
MOD_GSK3_1	181	188	PF00069	0.385
MOD_GSK3_1	205	212	PF00069	0.538
MOD_GSK3_1	236	243	PF00069	0.393
MOD_GSK3_1	248	255	PF00069	0.363
MOD_GSK3_1	80	87	PF00069	0.467
MOD_N-GLC_1	149	154	PF02516	0.447
MOD_NEK2_1	12	17	PF00069	0.361
MOD_NEK2_1	182	187	PF00069	0.373
MOD_NEK2_1	191	196	PF00069	0.407
MOD_NEK2_1	205	210	PF00069	0.437
MOD_NEK2_1	21	26	PF00069	0.346
MOD_NEK2_1	38	43	PF00069	0.264
MOD_NEK2_1	48	53	PF00069	0.376
MOD_PIKK_1	12	18	PF00454	0.418
MOD_PKA_1	171	177	PF00069	0.514
MOD_PKA_2	171	177	PF00069	0.550
MOD_PKA_2	182	188	PF00069	0.385
MOD_PKA_2	209	215	PF00069	0.440
MOD_PKA_2	252	258	PF00069	0.356
MOD_Plk_1	101	107	PF00069	0.369
MOD_Plk_1	21	27	PF00069	0.401
MOD_Plk_1	228	234	PF00069	0.404
MOD_Plk_1	38	44	PF00069	0.271
MOD_Plk_4	229	235	PF00069	0.388
MOD_ProDKin_1	90	96	PF00069	0.321
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.414
TRG_ENDOCYTIC_2	217	220	PF00928	0.391
TRG_ENDOCYTIC_2	50	53	PF00928	0.362
TRG_ER_diArg_1	170	172	PF00400	0.484
TRG_ER_diArg_1	29	31	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K0	Leptomonas seymouri	58%	100%
A0A1X0P1S9	Trypanosomatidae	29%	100%
A0A3Q8IGM7	Leishmania donovani	85%	100%
A0A3R7MBB6	Trypanosoma rangeli	32%	98%
A4I937	Leishmania infantum	85%	100%
C9ZIV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9B402	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q422	Leishmania major	84%	100%
V5AXA5	Trypanosoma cruzi	30%	98%