LeishMANIAdb
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p53 and DNA damage-regulated protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
p53 and DNA damage-regulated protein 1
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLM5_LEIBR
TriTrypDb:
LbrM.33.1910 , LBRM2903_330025300
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HLM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.514
CLV_NRD_NRD_1 31 33 PF00675 0.391
CLV_NRD_NRD_1 40 42 PF00675 0.424
CLV_PCSK_KEX2_1 31 33 PF00082 0.391
CLV_PCSK_KEX2_1 46 48 PF00082 0.429
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.487
CLV_PCSK_SKI1_1 42 46 PF00082 0.435
DEG_Nend_UBRbox_1 1 4 PF02207 0.424
DOC_MAPK_gen_1 2 12 PF00069 0.354
DOC_MAPK_gen_1 46 54 PF00069 0.452
DOC_MAPK_MEF2A_6 5 14 PF00069 0.406
DOC_MAPK_MEF2A_6 90 97 PF00069 0.519
DOC_MAPK_NFAT4_5 90 98 PF00069 0.545
DOC_USP7_UBL2_3 42 46 PF12436 0.312
LIG_14-3-3_CanoR_1 5 12 PF00244 0.336
LIG_Actin_WH2_2 106 122 PF00022 0.411
LIG_Clathr_ClatBox_1 26 30 PF01394 0.412
LIG_FHA_1 5 11 PF00498 0.430
LIG_SH2_STAT5 25 28 PF00017 0.422
LIG_SH2_STAT5 74 77 PF00017 0.405
LIG_SUMO_SIM_par_1 25 30 PF11976 0.417
LIG_TRAF2_1 15 18 PF00917 0.424
LIG_UBA3_1 26 33 PF00899 0.277
MOD_CK1_1 56 62 PF00069 0.536
MOD_GlcNHglycan 107 110 PF01048 0.573
MOD_GlcNHglycan 55 58 PF01048 0.458
MOD_GSK3_1 53 60 PF00069 0.580
MOD_GSK3_1 64 71 PF00069 0.481
MOD_PKA_2 4 10 PF00069 0.432
MOD_Plk_4 57 63 PF00069 0.509
MOD_SUMO_rev_2 115 122 PF00179 0.625
MOD_SUMO_rev_2 87 95 PF00179 0.487
TRG_DiLeu_BaEn_3 49 55 PF01217 0.528
TRG_ENDOCYTIC_2 114 117 PF00928 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFY8 Leptomonas seymouri 81% 100%
A0A0S4JTC5 Bodo saltans 33% 98%
A0A1X0P149 Trypanosomatidae 53% 100%
A0A3Q8IMC7 Leishmania donovani 89% 100%
A0A3R7N3H7 Trypanosoma rangeli 49% 95%
A4I936 Leishmania infantum 89% 100%
C9ZIV3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B401 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P59048 Mus musculus 29% 92%
Q4Q423 Leishmania major 87% 100%
Q642A0 Rattus norvegicus 31% 92%
V5DDK9 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS