Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 4, putative

Species:

Leishmania braziliensis

UniProt:

A4HLM4_LEIBR

TriTrypDb:

LbrM.33.1900 , LBRM2903_330025200

Length:

196

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HLM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM4

PDB structure(s): 2hqj_A

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	19
GO:0006457	protein folding	2	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009987	cellular process	1	19
GO:0018193	peptidyl-amino acid modification	5	19
GO:0018208	peptidyl-proline modification	6	19
GO:0019538	protein metabolic process	3	19
GO:0036211	protein modification process	4	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043412	macromolecule modification	4	19
GO:0044238	primary metabolic process	2	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	19
GO:0003824	catalytic activity	1	19
GO:0016853	isomerase activity	2	19
GO:0016859	cis-trans isomerase activity	3	19
GO:0140096	catalytic activity, acting on a protein	2	19
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.348
CLV_NRD_NRD_1	10	12	PF00675	0.467
CLV_PCSK_SKI1_1	4	8	PF00082	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_CYCLIN_yClb1_LxF_4	21	27	PF00134	0.413
DOC_PP1_RVXF_1	152	159	PF00149	0.352
DOC_PP1_RVXF_1	68	75	PF00149	0.423
DOC_USP7_MATH_1	110	114	PF00917	0.332
LIG_14-3-3_CanoR_1	182	188	PF00244	0.489
LIG_APCC_ABBA_1	41	46	PF00400	0.352
LIG_BRCT_BRCA1_1	138	142	PF00533	0.352
LIG_Clathr_ClatBox_1	24	28	PF01394	0.351
LIG_FHA_1	146	152	PF00498	0.352
LIG_FHA_2	167	173	PF00498	0.447
LIG_FHA_2	184	190	PF00498	0.344
LIG_FHA_2	97	103	PF00498	0.352
LIG_LIR_Gen_1	162	171	PF02991	0.332
LIG_LIR_Gen_1	77	87	PF02991	0.373
LIG_LIR_Nem_3	162	168	PF02991	0.332
LIG_LIR_Nem_3	42	47	PF02991	0.348
LIG_LIR_Nem_3	53	58	PF02991	0.352
LIG_LIR_Nem_3	77	82	PF02991	0.373
LIG_MLH1_MIPbox_1	138	142	PF16413	0.352
LIG_SH2_CRK	165	169	PF00017	0.423
LIG_SH2_NCK_1	165	169	PF00017	0.243
LIG_SH2_SRC	165	168	PF00017	0.217
LIG_SH2_STAT3	174	177	PF00017	0.217
LIG_SH3_1	11	17	PF00018	0.434
LIG_SH3_3	11	17	PF00018	0.397
LIG_SUMO_SIM_par_1	183	189	PF11976	0.346
MOD_CK1_1	173	179	PF00069	0.362
MOD_CK1_1	30	36	PF00069	0.391
MOD_CK2_1	166	172	PF00069	0.217
MOD_CK2_1	96	102	PF00069	0.352
MOD_GlcNHglycan	177	180	PF01048	0.362
MOD_GlcNHglycan	67	70	PF01048	0.352
MOD_GSK3_1	166	173	PF00069	0.419
MOD_GSK3_1	96	103	PF00069	0.354
MOD_N-GLC_1	136	141	PF02516	0.352
MOD_N-GLC_1	96	101	PF02516	0.352
MOD_NEK2_1	142	147	PF00069	0.352
MOD_NEK2_1	2	7	PF00069	0.573
MOD_NEK2_1	27	32	PF00069	0.337
MOD_NEK2_1	74	79	PF00069	0.408
MOD_NEK2_2	100	105	PF00069	0.352
MOD_PIKK_1	136	142	PF00454	0.352
MOD_PIKK_1	173	179	PF00454	0.414
MOD_PIKK_1	30	36	PF00454	0.363
MOD_Plk_1	110	116	PF00069	0.347
MOD_Plk_1	27	33	PF00069	0.346
MOD_Plk_4	100	106	PF00069	0.342
MOD_SUMO_for_1	193	196	PF00179	0.601
MOD_SUMO_rev_2	149	156	PF00179	0.354
TRG_ENDOCYTIC_2	165	168	PF00928	0.332
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A075B759	Homo sapiens	57%	100%
A0A075B767	Homo sapiens	57%	100%
A0A0B4J2A2	Homo sapiens	58%	100%
A0A0N0P364	Leptomonas seymouri	49%	86%
A0A0N0P3D1	Leptomonas seymouri	30%	99%
A0A0N0P523	Leptomonas seymouri	73%	71%
A0A0N0P839	Leptomonas seymouri	91%	100%
A0A0N1I0P5	Leptomonas seymouri	71%	100%
A0A0N1I6E6	Leptomonas seymouri	56%	100%
A0A0N1I8P9	Leptomonas seymouri	54%	67%
A0A0N1PC19	Leptomonas seymouri	36%	98%
A0A0N1PDY0	Leptomonas seymouri	33%	80%
A0A0S4IZ55	Bodo saltans	26%	100%
A0A0S4J0W0	Bodo saltans	60%	80%
A0A0S4J378	Bodo saltans	51%	100%
A0A0S4J465	Bodo saltans	24%	81%
A0A0S4J4A4	Bodo saltans	65%	100%
A0A0S4J7K8	Bodo saltans	69%	100%
A0A0S4J8W7	Bodo saltans	49%	85%
A0A0S4J9U9	Bodo saltans	34%	94%
A0A0S4JID7	Bodo saltans	61%	87%
A0A0S4KDV3	Bodo saltans	35%	100%
A0A0S4KGS8	Bodo saltans	38%	79%
A0A0S4KLH0	Bodo saltans	82%	98%
A0A1X0NJS0	Trypanosomatidae	56%	100%
A0A1X0NTQ9	Trypanosomatidae	57%	86%
A0A1X0NTS4	Trypanosomatidae	52%	85%
A0A1X0NXG7	Trypanosomatidae	74%	76%
A0A1X0P184	Trypanosomatidae	89%	100%
A0A1X0P2K2	Trypanosomatidae	35%	75%
A0A1X0P4X3	Trypanosomatidae	38%	100%
A0A1X0P5F9	Trypanosomatidae	69%	100%
A0A1X0P6P3	Trypanosomatidae	36%	100%
A0A3Q8ICB3	Leishmania donovani	47%	86%
A0A3Q8IDR1	Leishmania donovani	39%	69%
A0A3R7MP70	Trypanosoma rangeli	40%	100%
A0A3R7NMR3	Trypanosoma rangeli	70%	100%
A0A3R7RC31	Trypanosoma rangeli	85%	100%
A0A3R7RE54	Trypanosoma rangeli	72%	76%
A0A3R7RI88	Trypanosoma rangeli	53%	100%
A0A3S5H5N2	Leishmania donovani	55%	100%
A0A3S5H7U6	Leishmania donovani	92%	76%
A0A3S5IQL2	Trypanosoma rangeli	36%	75%
A0A3S7WXF4	Leishmania donovani	73%	66%
A0A3S7WYD9	Leishmania donovani	27%	81%
A0A3S7WYY5	Leishmania donovani	71%	100%
A0A3S7X325	Leishmania donovani	34%	80%
A0A3S7X410	Leishmania donovani	56%	86%
A0A3S7XB52	Leishmania donovani	37%	74%
A0A422N1Z9	Trypanosoma rangeli	56%	88%
A0A422N490	Trypanosoma rangeli	50%	85%
A0A422NR67	Trypanosoma rangeli	33%	100%
A4H4H8	Leishmania braziliensis	49%	97%
A4HCI8	Leishmania braziliensis	48%	100%
A4HCL8	Leishmania braziliensis	70%	66%
A4HE26	Leishmania braziliensis	72%	98%
A4HHU7	Leishmania braziliensis	34%	100%
A4HIW9	Leishmania braziliensis	55%	100%
A4HPH9	Leishmania braziliensis	37%	98%
A4HSQ3	Leishmania infantum	55%	100%
A4I004	Leishmania infantum	47%	86%
A4I042	Leishmania infantum	73%	66%
A4I0X0	Leishmania infantum	27%	81%
A4I1D2	Leishmania infantum	71%	100%
A4I4Z7	Leishmania infantum	34%	80%
A4I698	Leishmania infantum	56%	86%
A4I935	Leishmania infantum	92%	76%
A4IDA1	Leishmania infantum	37%	74%
B3A0R0	Lottia gigantea	53%	95%
C9ZIV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
C9ZNS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	83%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	75%
C9ZRQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	87%
C9ZSQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	85%
C9ZT99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	70%
C9ZWH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A5M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
D0A8E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D4AY02	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	58%	87%
E9AKP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	89%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	86%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	68%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	81%
E9AXG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	80%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	86%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	77%
F5H284	Homo sapiens	57%	100%
O00060	Uromyces fabae	59%	100%
O00845	Paramecium primaurelia	54%	100%
O02614	Leishmania major	70%	98%
O25982	Helicobacter pylori (strain ATCC 700392 / 26695)	36%	100%
O43447	Homo sapiens	54%	100%
O49605	Arabidopsis thaliana	50%	88%
O49886	Lupinus luteus	69%	100%
O53021	Dickeya dadantii (strain 3937)	30%	100%
O66105	Treponema pallidum (strain Nichols)	50%	91%
O74729	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
O93826	Arthroderma benhamiae	58%	87%
O94273	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	98%
P0AFL3	Escherichia coli (strain K12)	34%	100%
P0AFL4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	34%	100%
P0AFL5	Escherichia coli O157:H7	34%	100%
P0C1H7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	63%	100%
P0C1H8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	64%	100%
P0C1H9	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	49%	94%
P0C1I0	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	49%	94%
P0C1I3	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	53%	100%
P0C1I4	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	48%	100%
P0C1I5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	49%	100%
P0C1I7	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	63%	100%
P0C1I8	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	62%	100%
P0CP78	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	55%	85%
P0CP79	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	55%	85%
P0CP82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	56%	100%
P0CP83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	56%	100%
P0CP84	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	100%
P0CP85	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	100%
P0CP86	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	100%
P0CP87	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	100%
P0DN26	Homo sapiens	57%	100%
P0DN37	Homo sapiens	57%	100%
P10111	Rattus norvegicus	65%	100%
P10255	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	88%
P14088	Echinococcus granulosus	65%	100%
P14832	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	66%	100%
P14851	Cricetulus griseus	66%	100%
P15425	Drosophila melanogaster	43%	83%
P17742	Mus musculus	65%	100%
P18253	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	67%	100%
P20753	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P21568	Solanum lycopersicum	72%	100%
P21569	Zea mays	69%	100%
P22011	Candida albicans (strain SC5314 / ATCC MYA-2876)	64%	100%
P23284	Homo sapiens	55%	91%
P23285	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	96%
P23869	Escherichia coli (strain K12)	28%	100%
P24367	Gallus gallus	58%	95%
P24368	Rattus norvegicus	56%	91%
P24369	Mus musculus	55%	91%
P24525	Brassica napus	67%	100%
P25007	Drosophila melanogaster	65%	86%
P25719	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P28517	Calliphora vicina	39%	84%
P29117	Rattus norvegicus	61%	95%
P29820	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	40%	100%
P30404	Bos taurus	67%	94%
P30405	Homo sapiens	66%	95%
P30412	Mus musculus	56%	92%
P34790	Arabidopsis thaliana	70%	100%
P34791	Arabidopsis thaliana	54%	75%
P34887	Allium cepa	72%	100%
P35176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	87%
P35627	Unspecified eudicot DB-1992	63%	100%
P42693	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	32%	100%
P44499	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
P45877	Homo sapiens	59%	92%
P52009	Caenorhabditis elegans	70%	100%
P52010	Caenorhabditis elegans	67%	100%
P52011	Caenorhabditis elegans	69%	100%
P52013	Caenorhabditis elegans	52%	96%
P52014	Caenorhabditis elegans	51%	98%
P52015	Caenorhabditis elegans	70%	100%
P52017	Caenorhabditis elegans	43%	100%
P52018	Caenorhabditis elegans	52%	100%
P54985	Blattella germanica	67%	100%
P62935	Bos taurus	66%	100%
P62936	Sus scrofa	66%	100%
P62937	Homo sapiens	65%	100%
P62938	Chlorocebus aethiops	65%	100%
P62940	Macaca mulatta	65%	100%
P62941	Papio anubis	65%	100%
P65763	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	100%
P73789	Synechocystis sp. (strain PCC 6803 / Kazusa)	71%	100%
P77949	Streptomyces anulatus	47%	100%
P80311	Bos taurus	56%	91%
P83221	Streptomyces antibioticus	31%	100%
P84343	Neospora caninum	49%	100%
P87051	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
P91791	Hemicentrotus pulcherrimus	68%	100%
P9WHW2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	100%
P9WHW3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	100%
Q01490	Orpinomyces sp. (strain PC-2)	55%	97%
Q06118	Streptomyces anulatus	58%	100%
Q08E11	Bos taurus	59%	92%
Q0P5D0	Bos taurus	54%	100%
Q0ZQK3	Saguinus oedipus	65%	100%
Q0ZQK6	Symphalangus syndactylus	65%	100%
Q0ZQK7	Nomascus leucogenys	65%	100%
Q0ZQK8	Hylobates lar	65%	100%
Q0ZQL0	Gorilla gorilla gorilla	65%	100%
Q0ZQL1	Pan troglodytes	65%	100%
Q0ZQL2	Pan paniscus	65%	100%
Q26516	Schistosoma japonicum	61%	100%
Q26548	Schistosoma mansoni	62%	72%
Q26551	Schistosoma mansoni	53%	92%
Q26565	Schistosoma mansoni	57%	100%
Q27774	Schistosoma japonicum	52%	92%
Q2FIC1	Staphylococcus aureus (strain USA300)	42%	99%
Q2FZU9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	42%	99%
Q2TZ33	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	52%	100%
Q2U6U0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	49%	100%
Q2UGK2	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	54%	100%
Q2YPY5	Brucella abortus (strain 2308)	33%	100%
Q2YWT2	Staphylococcus aureus (strain bovine RF122 / ET3-1)	42%	99%
Q38867	Arabidopsis thaliana	66%	100%
Q38900	Arabidopsis thaliana	67%	100%
Q39613	Catharanthus roseus	72%	100%
Q41651	Vicia faba	57%	79%
Q42406	Arabidopsis thaliana	70%	100%
Q49W93	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	40%	99%
Q4I1Y1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	51%	100%
Q4I5R9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	57%	79%
Q4IPB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	100%
Q4IPH4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	58%	100%
Q4L4W9	Staphylococcus haemolyticus (strain JCSC1435)	39%	99%
Q4P6X6	Ustilago maydis (strain 521 / FGSC 9021)	52%	100%
Q4PCH8	Ustilago maydis (strain 521 / FGSC 9021)	40%	100%
Q4Q1A6	Leishmania major	37%	100%
Q4Q424	Leishmania major	92%	100%
Q4Q6Q9	Leishmania major	56%	100%
Q4Q7V7	Leishmania major	34%	100%
Q4QAK0	Leishmania major	27%	100%
Q4QBH1	Leishmania major	74%	66%
Q4QBK2	Leishmania major	47%	100%
Q4QJ67	Leishmania major	54%	100%
Q4WCM6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	54%	100%
Q4WCR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	50%	100%
Q4WMB6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	92%
Q4WP12	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	54%	94%
Q54E95	Dictyostelium discoideum	42%	100%
Q54SM3	Dictyostelium discoideum	71%	100%
Q57D43	Brucella abortus biovar 1 (strain 9-941)	33%	100%
Q5AQL0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	54%	100%
Q5ASQ0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	50%	100%
Q5B4R3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	51%	92%
Q5BAH7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	93%
Q5E992	Bos taurus	45%	100%
Q5HHD1	Staphylococcus aureus (strain COL)	42%	99%
Q5HQK8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	40%	99%
Q5R8S7	Pongo pygmaeus	65%	100%
Q5UP71	Acanthamoeba polyphaga mimivirus	28%	84%
Q5ZLV2	Gallus gallus	45%	100%
Q6C4W6	Yarrowia lipolytica (strain CLIB 122 / E 150)	59%	86%
Q6DTV9	Aotus trivirgatus	65%	100%
Q6GAX2	Staphylococcus aureus (strain MSSA476)	42%	99%
Q6GID4	Staphylococcus aureus (strain MRSA252)	42%	99%
Q7A1C0	Staphylococcus aureus (strain MW2)	42%	99%
Q7A6I1	Staphylococcus aureus (strain N315)	42%	99%
Q7S7Z6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	69%
Q7SF72	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	52%	100%
Q7SG06	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	100%
Q812D3	Rattus norvegicus	45%	100%
Q8CT84	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	40%	99%
Q8G0J9	Brucella suis biovar 1 (strain 1330)	34%	100%
Q8HXS3	Felis catus	65%	100%
Q8L8W5	Arabidopsis thaliana	61%	86%
Q8LDP4	Arabidopsis thaliana	63%	98%
Q8SRE1	Encephalitozoon cuniculi (strain GB-M1)	54%	100%
Q8W171	Glycine max	71%	100%
Q8X166	Aspergillus niger	54%	92%
Q8X191	Aspergillus niger	48%	100%
Q8YHB5	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	34%	100%
Q94A16	Arabidopsis thaliana	31%	85%
Q99KR7	Mus musculus	67%	95%
Q99VD4	Staphylococcus aureus (strain Mu50 / ATCC 700699)	42%	99%
Q9ASS6	Arabidopsis thaliana	56%	76%
Q9C835	Arabidopsis thaliana	26%	83%
Q9CDE9	Mycobacterium leprae (strain TN)	42%	100%
Q9D0W5	Mus musculus	46%	100%
Q9D6L8	Mus musculus	44%	100%
Q9D868	Mus musculus	59%	100%
Q9H2H8	Homo sapiens	45%	100%
Q9LIK6	Arabidopsis thaliana	41%	84%
Q9LPC7	Arabidopsis thaliana	46%	100%
Q9NI62	Dictyostelium discoideum	46%	100%
Q9SIH1	Arabidopsis thaliana	47%	100%
Q9SKQ0	Arabidopsis thaliana	72%	100%
Q9SP02	Arabidopsis thaliana	62%	96%
Q9TTC6	Oryctolagus cuniculus	65%	100%
Q9TW32	Dictyostelium discoideum	63%	99%
Q9UA41	Dictyostelium discoideum	61%	100%
Q9Y3C6	Homo sapiens	45%	100%
Q9Y536	Homo sapiens	57%	100%
Q9ZVJ4	Arabidopsis thaliana	56%	98%
V5B2A0	Trypanosoma cruzi	73%	76%
V5BGX2	Trypanosoma cruzi	39%	74%
V5BHF5	Trypanosoma cruzi	86%	100%
V5BM49	Trypanosoma cruzi	38%	79%
V5BTK6	Trypanosoma cruzi	34%	100%
V5D532	Trypanosoma cruzi	52%	100%