HEAT repeat-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLM3_LEIBR

TriTrypDb:

LbrM.33.1890 , LBRM2903_330025000

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.388
CLV_NRD_NRD_1	304	306	PF00675	0.450
CLV_NRD_NRD_1	337	339	PF00675	0.310
CLV_NRD_NRD_1	375	377	PF00675	0.291
CLV_NRD_NRD_1	719	721	PF00675	0.276
CLV_PCSK_KEX2_1	18	20	PF00082	0.332
CLV_PCSK_KEX2_1	304	306	PF00082	0.440
CLV_PCSK_KEX2_1	337	339	PF00082	0.311
CLV_PCSK_KEX2_1	867	869	PF00082	0.340
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.332
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.340
CLV_PCSK_SKI1_1	104	108	PF00082	0.269
CLV_PCSK_SKI1_1	163	167	PF00082	0.360
CLV_PCSK_SKI1_1	174	178	PF00082	0.275
CLV_PCSK_SKI1_1	304	308	PF00082	0.430
CLV_PCSK_SKI1_1	352	356	PF00082	0.364
CLV_PCSK_SKI1_1	563	567	PF00082	0.483
CLV_PCSK_SKI1_1	651	655	PF00082	0.362
CLV_PCSK_SKI1_1	675	679	PF00082	0.361
CLV_PCSK_SKI1_1	843	847	PF00082	0.311
CLV_PCSK_SKI1_1	882	886	PF00082	0.462
CLV_Separin_Metazoa	233	237	PF03568	0.372
CLV_Separin_Metazoa	698	702	PF03568	0.304
DEG_APCC_DBOX_1	103	111	PF00400	0.279
DEG_APCC_DBOX_1	351	359	PF00400	0.385
DEG_Nend_UBRbox_2	1	3	PF02207	0.377
DEG_SCF_FBW7_1	508	513	PF00400	0.366
DEG_SPOP_SBC_1	519	523	PF00917	0.327
DEG_SPOP_SBC_1	749	753	PF00917	0.353
DOC_CKS1_1	324	329	PF01111	0.273
DOC_MAPK_DCC_7	586	595	PF00069	0.405
DOC_MAPK_gen_1	163	172	PF00069	0.277
DOC_MAPK_gen_1	376	383	PF00069	0.265
DOC_MAPK_gen_1	460	468	PF00069	0.452
DOC_MAPK_gen_1	570	579	PF00069	0.383
DOC_MAPK_gen_1	584	592	PF00069	0.346
DOC_MAPK_gen_1	843	849	PF00069	0.326
DOC_MAPK_HePTP_8	583	595	PF00069	0.443
DOC_MAPK_MEF2A_6	163	172	PF00069	0.277
DOC_MAPK_MEF2A_6	259	268	PF00069	0.268
DOC_MAPK_MEF2A_6	376	383	PF00069	0.267
DOC_MAPK_MEF2A_6	586	595	PF00069	0.454
DOC_PP1_RVXF_1	307	314	PF00149	0.421
DOC_PP1_RVXF_1	380	386	PF00149	0.269
DOC_PP1_RVXF_1	680	686	PF00149	0.312
DOC_PP2B_PxIxI_1	873	879	PF00149	0.453
DOC_PP4_FxxP_1	139	142	PF00568	0.434
DOC_PP4_FxxP_1	324	327	PF00568	0.402
DOC_PP4_FxxP_1	431	434	PF00568	0.265
DOC_USP7_MATH_1	510	514	PF00917	0.490
DOC_USP7_MATH_1	97	101	PF00917	0.394
DOC_USP7_UBL2_3	148	152	PF12436	0.420
DOC_WW_Pin1_4	323	328	PF00397	0.360
DOC_WW_Pin1_4	475	480	PF00397	0.354
DOC_WW_Pin1_4	506	511	PF00397	0.422
DOC_WW_Pin1_4	553	558	PF00397	0.335
DOC_WW_Pin1_4	824	829	PF00397	0.414
DOC_WW_Pin1_4	870	875	PF00397	0.361
LIG_14-3-3_CanoR_1	218	227	PF00244	0.292
LIG_14-3-3_CanoR_1	304	309	PF00244	0.488
LIG_14-3-3_CanoR_1	462	467	PF00244	0.351
LIG_14-3-3_CanoR_1	584	593	PF00244	0.326
LIG_14-3-3_CanoR_1	660	668	PF00244	0.391
LIG_14-3-3_CanoR_1	675	680	PF00244	0.234
LIG_14-3-3_CanoR_1	809	817	PF00244	0.424
LIG_Actin_WH2_2	161	179	PF00022	0.353
LIG_Actin_WH2_2	773	789	PF00022	0.211
LIG_AP2alpha_1	139	143	PF02296	0.405
LIG_AP2alpha_2	141	143	PF02296	0.432
LIG_AP2alpha_2	270	272	PF02296	0.225
LIG_APCC_ABBA_1	845	850	PF00400	0.322
LIG_APCC_ABBAyCdc20_2	844	850	PF00400	0.321
LIG_BRCT_BRCA1_1	221	225	PF00533	0.390
LIG_BRCT_BRCA1_1	320	324	PF00533	0.419
LIG_BRCT_BRCA1_1	803	807	PF00533	0.340
LIG_Clathr_ClatBox_1	132	136	PF01394	0.322
LIG_Clathr_ClatBox_1	798	802	PF01394	0.333
LIG_Clathr_ClatBox_1	846	850	PF01394	0.326
LIG_deltaCOP1_diTrp_1	366	371	PF00928	0.318
LIG_deltaCOP1_diTrp_1	822	829	PF00928	0.362
LIG_eIF4E_1	127	133	PF01652	0.334
LIG_eIF4E_1	260	266	PF01652	0.289
LIG_FHA_1	152	158	PF00498	0.305
LIG_FHA_1	171	177	PF00498	0.169
LIG_FHA_1	193	199	PF00498	0.330
LIG_FHA_1	397	403	PF00498	0.388
LIG_FHA_1	420	426	PF00498	0.451
LIG_FHA_1	463	469	PF00498	0.358
LIG_FHA_1	476	482	PF00498	0.419
LIG_FHA_1	512	518	PF00498	0.350
LIG_FHA_1	520	526	PF00498	0.367
LIG_FHA_1	533	539	PF00498	0.493
LIG_FHA_1	607	613	PF00498	0.529
LIG_FHA_1	615	621	PF00498	0.406
LIG_FHA_1	66	72	PF00498	0.355
LIG_FHA_1	669	675	PF00498	0.386
LIG_FHA_1	695	701	PF00498	0.506
LIG_FHA_1	713	719	PF00498	0.248
LIG_FHA_1	750	756	PF00498	0.383
LIG_FHA_1	853	859	PF00498	0.461
LIG_FHA_2	305	311	PF00498	0.416
LIG_FHA_2	361	367	PF00498	0.334
LIG_FHA_2	467	473	PF00498	0.532
LIG_FHA_2	519	525	PF00498	0.315
LIG_FHA_2	676	682	PF00498	0.350
LIG_FHA_2	810	816	PF00498	0.332
LIG_LIR_Apic_2	136	142	PF02991	0.423
LIG_LIR_Apic_2	321	327	PF02991	0.405
LIG_LIR_Apic_2	366	370	PF02991	0.354
LIG_LIR_Apic_2	81	85	PF02991	0.285
LIG_LIR_Gen_1	129	139	PF02991	0.283
LIG_LIR_Gen_1	269	279	PF02991	0.382
LIG_LIR_Gen_1	330	339	PF02991	0.459
LIG_LIR_Gen_1	40	50	PF02991	0.327
LIG_LIR_Gen_1	450	458	PF02991	0.548
LIG_LIR_Gen_1	634	643	PF02991	0.332
LIG_LIR_Nem_3	129	134	PF02991	0.281
LIG_LIR_Nem_3	141	146	PF02991	0.282
LIG_LIR_Nem_3	269	275	PF02991	0.367
LIG_LIR_Nem_3	330	335	PF02991	0.451
LIG_LIR_Nem_3	40	46	PF02991	0.352
LIG_LIR_Nem_3	435	440	PF02991	0.340
LIG_LIR_Nem_3	450	455	PF02991	0.536
LIG_LIR_Nem_3	634	639	PF02991	0.388
LIG_LIR_Nem_3	673	679	PF02991	0.278
LIG_LIR_Nem_3	804	810	PF02991	0.516
LIG_LYPXL_yS_3	319	322	PF13949	0.336
LIG_NRBOX	533	539	PF00104	0.303
LIG_NRBOX	578	584	PF00104	0.355
LIG_NRBOX	679	685	PF00104	0.271
LIG_NRBOX	726	732	PF00104	0.307
LIG_NRBOX	815	821	PF00104	0.346
LIG_PCNA_TLS_4	125	132	PF02747	0.341
LIG_PCNA_yPIPBox_3	570	578	PF02747	0.339
LIG_Pex14_1	367	371	PF04695	0.313
LIG_Pex14_1	385	389	PF04695	0.249
LIG_Pex14_2	139	143	PF04695	0.405
LIG_PTB_Apo_2	401	408	PF02174	0.208
LIG_PTB_Phospho_1	401	407	PF10480	0.200
LIG_SH2_CRK	23	27	PF00017	0.362
LIG_SH2_GRB2like	7	10	PF00017	0.360
LIG_SH2_NCK_1	332	336	PF00017	0.266
LIG_SH2_NCK_1	345	349	PF00017	0.191
LIG_SH2_PTP2	452	455	PF00017	0.381
LIG_SH2_SRC	260	263	PF00017	0.320
LIG_SH2_SRC	332	335	PF00017	0.406
LIG_SH2_SRC	452	455	PF00017	0.511
LIG_SH2_STAT5	117	120	PF00017	0.322
LIG_SH2_STAT5	127	130	PF00017	0.276
LIG_SH2_STAT5	260	263	PF00017	0.320
LIG_SH2_STAT5	390	393	PF00017	0.378
LIG_SH2_STAT5	437	440	PF00017	0.343
LIG_SH2_STAT5	452	455	PF00017	0.562
LIG_SH2_STAT5	499	502	PF00017	0.308
LIG_SH2_STAT5	676	679	PF00017	0.290
LIG_SH2_STAT5	7	10	PF00017	0.356
LIG_SH2_STAT5	735	738	PF00017	0.356
LIG_SH2_STAT5	848	851	PF00017	0.441
LIG_SH2_STAT5	893	896	PF00017	0.331
LIG_SH2_STAT5	900	903	PF00017	0.344
LIG_SH3_3	265	271	PF00018	0.198
LIG_SH3_3	554	560	PF00018	0.364
LIG_SH3_3	700	706	PF00018	0.373
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.412
LIG_SUMO_SIM_anti_2	454	459	PF11976	0.620
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.349
LIG_SUMO_SIM_par_1	131	136	PF11976	0.319
LIG_SUMO_SIM_par_1	238	244	PF11976	0.265
LIG_SUMO_SIM_par_1	246	252	PF11976	0.304
LIG_SUMO_SIM_par_1	263	270	PF11976	0.196
LIG_SUMO_SIM_par_1	464	470	PF11976	0.359
LIG_SUMO_SIM_par_1	876	881	PF11976	0.432
LIG_SxIP_EBH_1	583	596	PF03271	0.272
LIG_TRAF2_1	60	63	PF00917	0.446
LIG_TRAF2_1	738	741	PF00917	0.244
LIG_TYR_ITIM	674	679	PF00017	0.271
LIG_UBA3_1	537	543	PF00899	0.321
LIG_UBA3_1	578	586	PF00899	0.388
LIG_WRC_WIRS_1	707	712	PF05994	0.266
MOD_CDC14_SPxK_1	556	559	PF00782	0.264
MOD_CDK_SPxK_1	553	559	PF00069	0.236
MOD_CK1_1	241	247	PF00069	0.459
MOD_CK1_1	340	346	PF00069	0.400
MOD_CK1_1	57	63	PF00069	0.524
MOD_CK1_1	634	640	PF00069	0.324
MOD_CK1_1	659	665	PF00069	0.426
MOD_CK1_1	694	700	PF00069	0.340
MOD_CK1_1	748	754	PF00069	0.284
MOD_CK1_1	86	92	PF00069	0.398
MOD_CK2_1	453	459	PF00069	0.473
MOD_CK2_1	57	63	PF00069	0.367
MOD_CK2_1	675	681	PF00069	0.316
MOD_CK2_1	809	815	PF00069	0.423
MOD_GlcNHglycan	185	188	PF01048	0.436
MOD_GlcNHglycan	327	330	PF01048	0.561
MOD_GlcNHglycan	633	636	PF01048	0.319
MOD_GlcNHglycan	832	837	PF01048	0.488
MOD_GlcNHglycan	882	885	PF01048	0.445
MOD_GSK3_1	166	173	PF00069	0.324
MOD_GSK3_1	318	325	PF00069	0.397
MOD_GSK3_1	41	48	PF00069	0.511
MOD_GSK3_1	458	465	PF00069	0.375
MOD_GSK3_1	467	474	PF00069	0.399
MOD_GSK3_1	477	484	PF00069	0.438
MOD_GSK3_1	485	492	PF00069	0.394
MOD_GSK3_1	506	513	PF00069	0.475
MOD_GSK3_1	532	539	PF00069	0.315
MOD_GSK3_1	599	606	PF00069	0.341
MOD_GSK3_1	610	617	PF00069	0.445
MOD_GSK3_1	744	751	PF00069	0.388
MOD_N-GLC_1	462	467	PF02516	0.522
MOD_N-GLC_1	745	750	PF02516	0.404
MOD_NEK2_1	11	16	PF00069	0.432
MOD_NEK2_1	176	181	PF00069	0.334
MOD_NEK2_1	29	34	PF00069	0.347
MOD_NEK2_1	322	327	PF00069	0.360
MOD_NEK2_1	383	388	PF00069	0.306
MOD_NEK2_1	471	476	PF00069	0.507
MOD_NEK2_1	481	486	PF00069	0.397
MOD_NEK2_1	537	542	PF00069	0.342
MOD_NEK2_1	603	608	PF00069	0.480
MOD_NEK2_1	750	755	PF00069	0.370
MOD_NEK2_1	880	885	PF00069	0.368
MOD_NEK2_2	485	490	PF00069	0.369
MOD_NEK2_2	614	619	PF00069	0.422
MOD_PIKK_1	29	35	PF00454	0.409
MOD_PK_1	166	172	PF00069	0.227
MOD_PK_1	543	549	PF00069	0.191
MOD_PK_1	745	751	PF00069	0.394
MOD_PKA_1	304	310	PF00069	0.431
MOD_PKA_1	337	343	PF00069	0.291
MOD_PKA_2	304	310	PF00069	0.486
MOD_PKA_2	337	343	PF00069	0.349
MOD_PKA_2	659	665	PF00069	0.394
MOD_PKA_2	810	816	PF00069	0.423
MOD_PKA_2	858	864	PF00069	0.349
MOD_PKB_1	460	468	PF00069	0.433
MOD_Plk_1	360	366	PF00069	0.326
MOD_Plk_1	391	397	PF00069	0.320
MOD_Plk_1	41	47	PF00069	0.409
MOD_Plk_1	419	425	PF00069	0.322
MOD_Plk_1	453	459	PF00069	0.489
MOD_Plk_1	462	468	PF00069	0.426
MOD_Plk_1	745	751	PF00069	0.247
MOD_Plk_1	75	81	PF00069	0.363
MOD_Plk_1	852	858	PF00069	0.394
MOD_Plk_4	113	119	PF00069	0.201
MOD_Plk_4	194	200	PF00069	0.236
MOD_Plk_4	238	244	PF00069	0.472
MOD_Plk_4	384	390	PF00069	0.290
MOD_Plk_4	453	459	PF00069	0.510
MOD_Plk_4	462	468	PF00069	0.281
MOD_Plk_4	477	483	PF00069	0.458
MOD_Plk_4	489	495	PF00069	0.279
MOD_Plk_4	511	517	PF00069	0.293
MOD_Plk_4	573	579	PF00069	0.288
MOD_Plk_4	603	609	PF00069	0.296
MOD_Plk_4	745	751	PF00069	0.486
MOD_Plk_4	75	81	PF00069	0.295
MOD_Plk_4	772	778	PF00069	0.359
MOD_Plk_4	793	799	PF00069	0.327
MOD_Plk_4	83	89	PF00069	0.272
MOD_ProDKin_1	323	329	PF00069	0.359
MOD_ProDKin_1	475	481	PF00069	0.343
MOD_ProDKin_1	506	512	PF00069	0.419
MOD_ProDKin_1	553	559	PF00069	0.343
MOD_ProDKin_1	824	830	PF00069	0.404
MOD_ProDKin_1	870	876	PF00069	0.363
MOD_SUMO_for_1	146	149	PF00179	0.281
MOD_SUMO_for_1	417	420	PF00179	0.410
MOD_SUMO_rev_2	159	165	PF00179	0.452
TRG_DiLeu_BaEn_1	101	106	PF01217	0.291
TRG_DiLeu_BaEn_1	529	534	PF01217	0.457
TRG_DiLeu_BaEn_1	695	700	PF01217	0.375
TRG_DiLeu_BaEn_1	815	820	PF01217	0.341
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.300
TRG_DiLeu_LyEn_5	101	106	PF01217	0.291
TRG_DiLeu_LyEn_5	815	820	PF01217	0.341
TRG_ENDOCYTIC_2	127	130	PF00928	0.286
TRG_ENDOCYTIC_2	23	26	PF00928	0.324
TRG_ENDOCYTIC_2	319	322	PF00928	0.362
TRG_ENDOCYTIC_2	332	335	PF00928	0.436
TRG_ENDOCYTIC_2	407	410	PF00928	0.286
TRG_ENDOCYTIC_2	437	440	PF00928	0.330
TRG_ENDOCYTIC_2	452	455	PF00928	0.671
TRG_ENDOCYTIC_2	676	679	PF00928	0.257
TRG_ER_diArg_1	304	306	PF00400	0.437
TRG_ER_diArg_1	337	339	PF00400	0.313
TRG_ER_diArg_1	808	811	PF00400	0.353
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B9	Leptomonas seymouri	74%	100%
A0A0S4KNI8	Bodo saltans	45%	99%
A0A1X0NM76	Trypanosomatidae	52%	100%
A0A3S7X6Q1	Leishmania donovani	88%	100%
A0A422N6C6	Trypanosoma rangeli	50%	100%
A4I934	Leishmania infantum	88%	100%
B9EJR8	Mus musculus	22%	100%
C9ZQE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q425	Leishmania major	87%	100%
Q86Y56	Homo sapiens	24%	100%
Q8INF7	Drosophila melanogaster	23%	100%
V5BDB2	Trypanosoma cruzi	51%	100%