Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLM1_LEIBR

TriTrypDb:

LbrM.33.1870 , LBRM2903_330028000

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM1

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	655	659	PF00656	0.674
CLV_C14_Caspase3-7	894	898	PF00656	0.587
CLV_NRD_NRD_1	217	219	PF00675	0.524
CLV_NRD_NRD_1	277	279	PF00675	0.678
CLV_NRD_NRD_1	340	342	PF00675	0.610
CLV_NRD_NRD_1	547	549	PF00675	0.505
CLV_NRD_NRD_1	606	608	PF00675	0.561
CLV_NRD_NRD_1	635	637	PF00675	0.404
CLV_NRD_NRD_1	730	732	PF00675	0.748
CLV_PCSK_FUR_1	275	279	PF00082	0.674
CLV_PCSK_KEX2_1	103	105	PF00082	0.542
CLV_PCSK_KEX2_1	217	219	PF00082	0.524
CLV_PCSK_KEX2_1	275	277	PF00082	0.686
CLV_PCSK_KEX2_1	340	342	PF00082	0.722
CLV_PCSK_KEX2_1	546	548	PF00082	0.566
CLV_PCSK_KEX2_1	605	607	PF00082	0.537
CLV_PCSK_KEX2_1	635	637	PF00082	0.551
CLV_PCSK_KEX2_1	730	732	PF00082	0.746
CLV_PCSK_KEX2_1	831	833	PF00082	0.755
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.542
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.566
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.781
CLV_PCSK_PC7_1	271	277	PF00082	0.508
CLV_PCSK_SKI1_1	282	286	PF00082	0.557
CLV_PCSK_SKI1_1	421	425	PF00082	0.560
CLV_PCSK_SKI1_1	445	449	PF00082	0.291
CLV_PCSK_SKI1_1	458	462	PF00082	0.537
CLV_PCSK_SKI1_1	636	640	PF00082	0.621
CLV_PCSK_SKI1_1	662	666	PF00082	0.761
CLV_PCSK_SKI1_1	754	758	PF00082	0.413
CLV_PCSK_SKI1_1	787	791	PF00082	0.686
CLV_PCSK_SKI1_1	834	838	PF00082	0.708
CLV_PCSK_SKI1_1	99	103	PF00082	0.601
DEG_APCC_DBOX_1	457	465	PF00400	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.715
DEG_SIAH_1	821	829	PF03145	0.713
DOC_ANK_TNKS_1	31	38	PF00023	0.509
DOC_ANK_TNKS_1	325	332	PF00023	0.507
DOC_CKS1_1	81	86	PF01111	0.707
DOC_CYCLIN_RxL_1	751	761	PF00134	0.545
DOC_MAPK_MEF2A_6	445	452	PF00069	0.410
DOC_MAPK_NFAT4_5	445	453	PF00069	0.281
DOC_PP4_FxxP_1	774	777	PF00568	0.593
DOC_USP7_MATH_1	113	117	PF00917	0.689
DOC_USP7_MATH_1	119	123	PF00917	0.700
DOC_USP7_MATH_1	247	251	PF00917	0.623
DOC_USP7_MATH_1	252	256	PF00917	0.469
DOC_USP7_MATH_1	348	352	PF00917	0.631
DOC_USP7_MATH_1	79	83	PF00917	0.684
DOC_USP7_MATH_1	816	820	PF00917	0.612
DOC_USP7_MATH_1	846	850	PF00917	0.604
DOC_USP7_UBL2_3	99	103	PF12436	0.639
DOC_WW_Pin1_4	239	244	PF00397	0.710
DOC_WW_Pin1_4	481	486	PF00397	0.667
DOC_WW_Pin1_4	520	525	PF00397	0.426
DOC_WW_Pin1_4	662	667	PF00397	0.738
DOC_WW_Pin1_4	724	729	PF00397	0.622
DOC_WW_Pin1_4	738	743	PF00397	0.720
DOC_WW_Pin1_4	80	85	PF00397	0.759
LIG_14-3-3_CanoR_1	104	110	PF00244	0.457
LIG_14-3-3_CanoR_1	286	293	PF00244	0.420
LIG_14-3-3_CanoR_1	375	381	PF00244	0.450
LIG_14-3-3_CanoR_1	671	676	PF00244	0.644
LIG_14-3-3_CanoR_1	734	742	PF00244	0.765
LIG_14-3-3_CanoR_1	834	841	PF00244	0.585
LIG_14-3-3_CanoR_1	879	883	PF00244	0.536
LIG_Actin_WH2_2	163	179	PF00022	0.454
LIG_Actin_WH2_2	882	898	PF00022	0.549
LIG_BRCT_BRCA1_1	348	352	PF00533	0.364
LIG_BRCT_BRCA1_1	530	534	PF00533	0.423
LIG_CSL_BTD_1	129	132	PF09270	0.493
LIG_deltaCOP1_diTrp_1	589	596	PF00928	0.486
LIG_deltaCOP1_diTrp_1	614	623	PF00928	0.233
LIG_EVH1_1	774	778	PF00568	0.375
LIG_EVH1_2	280	284	PF00568	0.331
LIG_FHA_1	286	292	PF00498	0.494
LIG_FHA_1	415	421	PF00498	0.304
LIG_FHA_1	441	447	PF00498	0.273
LIG_FHA_1	535	541	PF00498	0.478
LIG_FHA_1	8	14	PF00498	0.668
LIG_FHA_1	81	87	PF00498	0.475
LIG_FHA_1	835	841	PF00498	0.656
LIG_FHA_2	307	313	PF00498	0.506
LIG_FHA_2	565	571	PF00498	0.574
LIG_FHA_2	698	704	PF00498	0.580
LIG_FHA_2	786	792	PF00498	0.632
LIG_FHA_2	799	805	PF00498	0.420
LIG_HCF-1_HBM_1	722	725	PF13415	0.464
LIG_HP1_1	457	461	PF01393	0.535
LIG_LIR_Apic_2	722	728	PF02991	0.471
LIG_LIR_Apic_2	773	777	PF02991	0.588
LIG_LIR_Gen_1	157	168	PF02991	0.464
LIG_LIR_Gen_1	614	625	PF02991	0.404
LIG_LIR_Nem_3	157	163	PF02991	0.464
LIG_LIR_Nem_3	614	620	PF02991	0.404
LIG_LIR_Nem_3	750	756	PF02991	0.512
LIG_PCNA_yPIPBox_3	474	487	PF02747	0.427
LIG_PDZ_Class_1	895	900	PF00595	0.644
LIG_PDZ_Wminus1_1	898	900	PF00595	0.430
LIG_Pex14_1	770	774	PF04695	0.561
LIG_REV1ctd_RIR_1	532	540	PF16727	0.489
LIG_SH2_CRK	490	494	PF00017	0.390
LIG_SH2_CRK	725	729	PF00017	0.487
LIG_SH2_NCK_1	264	268	PF00017	0.414
LIG_SH2_NCK_1	549	553	PF00017	0.480
LIG_SH2_SRC	202	205	PF00017	0.457
LIG_SH2_SRC	47	50	PF00017	0.710
LIG_SH2_SRC	549	552	PF00017	0.466
LIG_SH2_STAP1	287	291	PF00017	0.495
LIG_SH2_STAP1	490	494	PF00017	0.390
LIG_SH2_STAP1	549	553	PF00017	0.463
LIG_SH2_STAT3	93	96	PF00017	0.406
LIG_SH2_STAT5	185	188	PF00017	0.556
LIG_SH2_STAT5	227	230	PF00017	0.666
LIG_SH2_STAT5	23	26	PF00017	0.488
LIG_SH2_STAT5	287	290	PF00017	0.473
LIG_SH2_STAT5	345	348	PF00017	0.470
LIG_SH2_STAT5	47	50	PF00017	0.700
LIG_SH2_STAT5	521	524	PF00017	0.518
LIG_SH2_STAT5	93	96	PF00017	0.406
LIG_SH3_1	772	778	PF00018	0.362
LIG_SH3_3	237	243	PF00018	0.728
LIG_SH3_3	39	45	PF00018	0.611
LIG_SH3_3	647	653	PF00018	0.565
LIG_SH3_3	772	778	PF00018	0.362
LIG_SH3_3	780	786	PF00018	0.459
LIG_Sin3_3	212	219	PF02671	0.443
LIG_SUMO_SIM_anti_2	674	679	PF11976	0.323
LIG_SUMO_SIM_anti_2	887	894	PF11976	0.270
LIG_SUMO_SIM_par_1	429	435	PF11976	0.369
LIG_SUMO_SIM_par_1	694	704	PF11976	0.640
LIG_TRFH_1	649	653	PF08558	0.339
LIG_TYR_ITIM	488	493	PF00017	0.501
LIG_WRC_WIRS_1	106	111	PF05994	0.642
LIG_WRC_WIRS_1	302	307	PF05994	0.468
LIG_WRC_WIRS_1	620	625	PF05994	0.236
LIG_WW_3	279	283	PF00397	0.355
MOD_CDC14_SPxK_1	484	487	PF00782	0.617
MOD_CDC14_SPxK_1	727	730	PF00782	0.489
MOD_CDK_SPxK_1	481	487	PF00069	0.651
MOD_CDK_SPxK_1	724	730	PF00069	0.487
MOD_CDK_SPxxK_3	664	671	PF00069	0.500
MOD_CDK_SPxxK_3	724	731	PF00069	0.490
MOD_CK1_1	105	111	PF00069	0.651
MOD_CK1_1	122	128	PF00069	0.736
MOD_CK1_1	265	271	PF00069	0.685
MOD_CK1_1	355	361	PF00069	0.529
MOD_CK1_1	362	368	PF00069	0.548
MOD_CK1_1	701	707	PF00069	0.460
MOD_CK1_1	732	738	PF00069	0.792
MOD_CK1_1	743	749	PF00069	0.662
MOD_CK1_1	82	88	PF00069	0.689
MOD_CK1_1	854	860	PF00069	0.522
MOD_CK2_1	140	146	PF00069	0.602
MOD_CK2_1	306	312	PF00069	0.597
MOD_CK2_1	348	354	PF00069	0.613
MOD_CK2_1	564	570	PF00069	0.578
MOD_CK2_1	697	703	PF00069	0.605
MOD_CK2_1	770	776	PF00069	0.535
MOD_CK2_1	785	791	PF00069	0.591
MOD_CMANNOS	592	595	PF00535	0.505
MOD_Cter_Amidation	633	636	PF01082	0.401
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.680
MOD_DYRK1A_RPxSP_1	662	666	PF00069	0.520
MOD_GlcNHglycan	121	124	PF01048	0.761
MOD_GlcNHglycan	188	191	PF01048	0.582
MOD_GlcNHglycan	230	233	PF01048	0.663
MOD_GlcNHglycan	249	252	PF01048	0.275
MOD_GlcNHglycan	254	257	PF01048	0.496
MOD_GlcNHglycan	265	268	PF01048	0.613
MOD_GlcNHglycan	346	349	PF01048	0.519
MOD_GlcNHglycan	395	398	PF01048	0.515
MOD_GlcNHglycan	426	429	PF01048	0.655
MOD_GlcNHglycan	662	665	PF01048	0.764
MOD_GlcNHglycan	671	674	PF01048	0.700
MOD_GlcNHglycan	742	745	PF01048	0.635
MOD_GlcNHglycan	848	851	PF01048	0.598
MOD_GlcNHglycan	857	860	PF01048	0.649
MOD_GlcNHglycan	87	90	PF01048	0.437
MOD_GSK3_1	113	120	PF00069	0.739
MOD_GSK3_1	122	129	PF00069	0.644
MOD_GSK3_1	136	143	PF00069	0.639
MOD_GSK3_1	235	242	PF00069	0.663
MOD_GSK3_1	262	269	PF00069	0.568
MOD_GSK3_1	344	351	PF00069	0.674
MOD_GSK3_1	355	362	PF00069	0.515
MOD_GSK3_1	534	541	PF00069	0.423
MOD_GSK3_1	660	667	PF00069	0.775
MOD_GSK3_1	669	676	PF00069	0.681
MOD_GSK3_1	697	704	PF00069	0.548
MOD_GSK3_1	846	853	PF00069	0.539
MOD_N-GLC_1	197	202	PF02516	0.460
MOD_N-GLC_1	748	753	PF02516	0.649
MOD_N-GLC_1	792	797	PF02516	0.650
MOD_NEK2_1	1	6	PF00069	0.746
MOD_NEK2_1	102	107	PF00069	0.597
MOD_NEK2_1	186	191	PF00069	0.579
MOD_NEK2_1	234	239	PF00069	0.620
MOD_NEK2_1	262	267	PF00069	0.589
MOD_NEK2_1	346	351	PF00069	0.413
MOD_NEK2_1	534	539	PF00069	0.393
MOD_NEK2_1	669	674	PF00069	0.571
MOD_NEK2_1	729	734	PF00069	0.638
MOD_NEK2_1	855	860	PF00069	0.534
MOD_NEK2_1	895	900	PF00069	0.567
MOD_NEK2_1	94	99	PF00069	0.629
MOD_NEK2_2	348	353	PF00069	0.470
MOD_NEK2_2	685	690	PF00069	0.496
MOD_NEK2_2	792	797	PF00069	0.377
MOD_PIKK_1	113	119	PF00454	0.749
MOD_PIKK_1	729	735	PF00454	0.743
MOD_PIKK_1	743	749	PF00454	0.729
MOD_PIKK_1	804	810	PF00454	0.515
MOD_PK_1	671	677	PF00069	0.379
MOD_PKA_2	252	258	PF00069	0.471
MOD_PKA_2	285	291	PF00069	0.516
MOD_PKA_2	352	358	PF00069	0.522
MOD_PKA_2	729	735	PF00069	0.673
MOD_PKA_2	878	884	PF00069	0.536
MOD_PKB_1	832	840	PF00069	0.683
MOD_Plk_1	748	754	PF00069	0.637
MOD_Plk_1	792	798	PF00069	0.642
MOD_Plk_4	126	132	PF00069	0.496
MOD_Plk_4	241	247	PF00069	0.605
MOD_Plk_4	25	31	PF00069	0.607
MOD_Plk_4	673	679	PF00069	0.337
MOD_Plk_4	792	798	PF00069	0.604
MOD_Plk_4	851	857	PF00069	0.636
MOD_ProDKin_1	239	245	PF00069	0.701
MOD_ProDKin_1	481	487	PF00069	0.656
MOD_ProDKin_1	520	526	PF00069	0.432
MOD_ProDKin_1	662	668	PF00069	0.735
MOD_ProDKin_1	724	730	PF00069	0.624
MOD_ProDKin_1	738	744	PF00069	0.718
MOD_ProDKin_1	80	86	PF00069	0.757
MOD_SUMO_rev_2	189	199	PF00179	0.383
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.532
TRG_ENDOCYTIC_2	490	493	PF00928	0.391
TRG_ER_diArg_1	216	218	PF00400	0.521
TRG_ER_diArg_1	224	227	PF00400	0.535
TRG_ER_diArg_1	275	278	PF00400	0.678
TRG_ER_diArg_1	547	549	PF00400	0.505
TRG_ER_diArg_1	604	607	PF00400	0.533
TRG_ER_diArg_1	623	626	PF00400	0.491
TRG_ER_diArg_1	729	731	PF00400	0.736
TRG_ER_diArg_1	822	825	PF00400	0.612
TRG_NES_CRM1_1	614	627	PF08389	0.407
TRG_NLS_MonoExtC_3	545	551	PF00514	0.508
TRG_NLS_MonoExtN_4	828	835	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E0	Leptomonas seymouri	45%	99%
A0A1X0P134	Trypanosomatidae	25%	100%
A0A3Q8IEW6	Leishmania donovani	78%	100%
A0A3R7KAP3	Trypanosoma rangeli	29%	100%
A4I932	Leishmania infantum	78%	100%
D0A535	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B3Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q427	Leishmania major	78%	100%
V5BLS1	Trypanosoma cruzi	29%	100%