NAD(P)-binding protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-ketoacyl-CoA reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLM0_LEIBR

TriTrypDb:

LbrM.33.1860 , LBRM2903_330024900

Length:

326

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLM0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.264
CLV_NRD_NRD_1	172	174	PF00675	0.274
CLV_NRD_NRD_1	177	179	PF00675	0.267
CLV_PCSK_SKI1_1	119	123	PF00082	0.316
CLV_PCSK_SKI1_1	206	210	PF00082	0.471
CLV_PCSK_SKI1_1	3	7	PF00082	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.402
DOC_CYCLIN_RxL_1	287	299	PF00134	0.360
DOC_MAPK_gen_1	104	110	PF00069	0.436
DOC_MAPK_gen_1	178	186	PF00069	0.450
DOC_MAPK_gen_1	96	103	PF00069	0.480
DOC_MAPK_MEF2A_6	96	103	PF00069	0.499
DOC_PP1_RVXF_1	1	8	PF00149	0.275
DOC_PP1_RVXF_1	289	296	PF00149	0.334
DOC_USP7_MATH_1	177	181	PF00917	0.465
DOC_USP7_MATH_1	246	250	PF00917	0.424
DOC_USP7_UBL2_3	251	255	PF12436	0.396
DOC_WW_Pin1_4	200	205	PF00397	0.267
DOC_WW_Pin1_4	230	235	PF00397	0.243
DOC_WW_Pin1_4	256	261	PF00397	0.364
LIG_14-3-3_CanoR_1	273	277	PF00244	0.303
LIG_14-3-3_CanoR_1	3	8	PF00244	0.266
LIG_APCC_ABBA_1	295	300	PF00400	0.376
LIG_BRCT_BRCA1_1	204	208	PF00533	0.284
LIG_Clathr_ClatBox_1	79	83	PF01394	0.460
LIG_CtBP_PxDLS_1	107	113	PF00389	0.541
LIG_DCNL_PONY_1	1	4	PF03556	0.462
LIG_eIF4E_1	139	145	PF01652	0.471
LIG_FHA_1	123	129	PF00498	0.463
LIG_FHA_1	24	30	PF00498	0.338
LIG_FHA_1	297	303	PF00498	0.333
LIG_FHA_2	146	152	PF00498	0.485
LIG_FHA_2	273	279	PF00498	0.298
LIG_FHA_2	88	94	PF00498	0.451
LIG_LIR_Gen_1	114	121	PF02991	0.541
LIG_LIR_Gen_1	294	302	PF02991	0.327
LIG_LIR_Gen_1	303	311	PF02991	0.341
LIG_LIR_Gen_1	6	15	PF02991	0.268
LIG_LIR_Gen_1	89	99	PF02991	0.453
LIG_LIR_Nem_3	294	298	PF02991	0.322
LIG_LIR_Nem_3	6	12	PF02991	0.339
LIG_LIR_Nem_3	89	94	PF02991	0.453
LIG_LYPXL_yS_3	98	101	PF13949	0.541
LIG_Pex14_1	18	22	PF04695	0.198
LIG_Pex14_2	208	212	PF04695	0.260
LIG_PTB_Apo_2	133	140	PF02174	0.460
LIG_PTB_Phospho_1	133	139	PF10480	0.460
LIG_SH2_GRB2like	307	310	PF00017	0.370
LIG_SH2_SRC	193	196	PF00017	0.331
LIG_SH2_SRC	27	30	PF00017	0.345
LIG_SH2_STAT5	139	142	PF00017	0.453
LIG_SH2_STAT5	14	17	PF00017	0.311
LIG_SH2_STAT5	193	196	PF00017	0.316
LIG_SH2_STAT5	27	30	PF00017	0.291
LIG_SH3_3	226	232	PF00018	0.260
LIG_SUMO_SIM_anti_2	226	231	PF11976	0.284
LIG_SUMO_SIM_par_1	78	84	PF11976	0.460
LIG_WRC_WIRS_1	183	188	PF05994	0.331
MOD_CDC14_SPxK_1	203	206	PF00782	0.284
MOD_CDK_SPxK_1	200	206	PF00069	0.284
MOD_CK1_1	188	194	PF00069	0.256
MOD_CK1_1	23	29	PF00069	0.331
MOD_CK1_1	249	255	PF00069	0.402
MOD_CK1_1	313	319	PF00069	0.259
MOD_CK2_1	145	151	PF00069	0.485
MOD_CK2_1	87	93	PF00069	0.460
MOD_GlcNHglycan	188	191	PF01048	0.269
MOD_GlcNHglycan	59	62	PF01048	0.260
MOD_GSK3_1	182	189	PF00069	0.305
MOD_GSK3_1	207	214	PF00069	0.302
MOD_GSK3_1	230	237	PF00069	0.252
MOD_GSK3_1	296	303	PF00069	0.373
MOD_GSK3_1	316	323	PF00069	0.467
MOD_GSK3_1	53	60	PF00069	0.460
MOD_NEK2_1	186	191	PF00069	0.302
MOD_NEK2_1	212	217	PF00069	0.260
MOD_NEK2_1	87	92	PF00069	0.464
MOD_NEK2_2	197	202	PF00069	0.316
MOD_NEK2_2	246	251	PF00069	0.435
MOD_PIKK_1	120	126	PF00454	0.525
MOD_PIKK_1	69	75	PF00454	0.446
MOD_PKA_2	177	183	PF00069	0.558
MOD_PKA_2	272	278	PF00069	0.303
MOD_PKA_2	313	319	PF00069	0.423
MOD_Plk_1	310	316	PF00069	0.242
MOD_Plk_4	189	195	PF00069	0.328
MOD_Plk_4	197	203	PF00069	0.307
MOD_Plk_4	23	29	PF00069	0.309
MOD_Plk_4	272	278	PF00069	0.321
MOD_ProDKin_1	200	206	PF00069	0.267
MOD_ProDKin_1	230	236	PF00069	0.243
MOD_ProDKin_1	256	262	PF00069	0.363
MOD_SUMO_rev_2	313	321	PF00179	0.412
TRG_ENDOCYTIC_2	115	118	PF00928	0.463
TRG_ENDOCYTIC_2	98	101	PF00928	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS4	Leptomonas seymouri	84%	100%
A0A0N1I1P8	Leptomonas seymouri	27%	95%
A0A0S4IR33	Bodo saltans	29%	96%
A0A0S4JNE8	Bodo saltans	63%	100%
A0A0S4JSF1	Bodo saltans	24%	81%
A0A1X0NKR7	Trypanosomatidae	26%	88%
A0A1X0NWL8	Trypanosomatidae	30%	100%
A0A1X0P1C4	Trypanosomatidae	63%	100%
A0A3Q8IE20	Leishmania donovani	31%	100%
A0A3Q8IHN8	Leishmania donovani	27%	96%
A0A3S7X6T1	Leishmania donovani	90%	100%
A0A422NG64	Trypanosoma rangeli	63%	100%
A0A422NJG3	Trypanosoma rangeli	29%	100%
A3LXZ3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	94%
A4ECA9	Collinsella aerofaciens (strain ATCC 25986 / DSM 3979 / JCM 10188 / KCTC 3647 / NCTC 11838 / VPI 1003)	26%	100%
A4HAC6	Leishmania braziliensis	28%	100%
A4HM71	Leishmania braziliensis	29%	96%
A4I931	Leishmania infantum	90%	100%
A4IAT4	Leishmania infantum	27%	96%
A5E0R1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	25%	93%
A5WWC6	Danio rerio	26%	100%
A6RBW9	Ajellomyces capsulatus (strain NAm1 / WU24)	25%	96%
A6SG70	Botryotinia fuckeliana (strain B05.10)	29%	98%
A7B4V1	Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9)	25%	100%
A7TMJ2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	94%
A8N6B4	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	29%	96%
A8Q1U2	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	23%	100%
B2WMJ3	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	24%	96%
D0A534	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D3U1D9	Klebsiella oxytoca	26%	100%
E9AEL0	Leishmania major	27%	100%
E9B3Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	96%
F4JZN6	Arabidopsis thaliana	25%	98%
G9FRD6	Clostridium sardiniense	23%	100%
M2ZIX7	Pseudocercospora fijiensis (strain CIRAD86)	30%	100%
O16925	Caenorhabditis elegans	25%	100%
O17795	Caenorhabditis elegans	25%	100%
O31642	Bacillus subtilis (strain 168)	25%	100%
O54939	Rattus norvegicus	27%	100%
O57314	Anas platyrhynchos	31%	100%
P0CR34	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	90%
P0CR35	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	90%
P37058	Homo sapiens	26%	100%
P37440	Escherichia coli (strain K12)	24%	100%
P37694	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	24%	100%
P39071	Bacillus subtilis (strain 168)	24%	100%
P70385	Mus musculus	28%	100%
P80869	Bacillus subtilis (strain 168)	27%	100%
Q06136	Homo sapiens	25%	98%
Q0IH28	Xenopus laevis	26%	100%
Q0VFE7	Xenopus tropicalis	24%	100%
Q10130	Caenorhabditis elegans	25%	86%
Q2KIJ5	Bos taurus	26%	98%
Q2UET3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	94%
Q3SXM5	Homo sapiens	30%	99%
Q3T0R4	Bos taurus	25%	100%
Q4JK73	Macaca fascicularis	27%	100%
Q4P622	Ustilago maydis (strain 521 / FGSC 9021)	24%	93%
Q4Q428	Leishmania major	89%	100%
Q556J2	Dictyostelium discoideum	26%	98%
Q566S6	Danio rerio	26%	100%
Q5M875	Rattus norvegicus	26%	100%
Q5R6U1	Pongo abelii	26%	100%
Q5RJY4	Rattus norvegicus	28%	100%
Q5XG41	Xenopus laevis	30%	100%
Q60V51	Caenorhabditis briggsae	28%	100%
Q6BIG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	94%
Q6BQK1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	99%
Q6GV12	Mus musculus	24%	98%
Q6IAN0	Homo sapiens	26%	100%
Q6P3L6	Danio rerio	31%	100%
Q6QA32	Danio rerio	27%	100%
Q75A60	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	93%
Q8L9C4	Arabidopsis thaliana	27%	100%
Q8T197	Dictyostelium discoideum	25%	100%
Q988B7	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	22%	100%
Q99J47	Mus musculus	27%	100%
Q9FYL6	Arabidopsis thaliana	26%	100%
Q9STY7	Arabidopsis thaliana	29%	100%
Q9STY8	Arabidopsis thaliana	28%	100%
Q9Y140	Drosophila melanogaster	23%	100%
R9UAM1	Ruminococcus gnavus	25%	100%
V5B6S6	Trypanosoma cruzi	32%	100%
V5BCN8	Trypanosoma cruzi	62%	100%