Anaphase-promoting complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLL9_LEIBR

TriTrypDb:

LbrM.33.1850 , LBRM2903_330024800

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	486	492	PF00089	0.590
CLV_NRD_NRD_1	125	127	PF00675	0.622
CLV_PCSK_KEX2_1	125	127	PF00082	0.622
CLV_PCSK_KEX2_1	294	296	PF00082	0.602
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.452
CLV_PCSK_SKI1_1	287	291	PF00082	0.387
CLV_PCSK_SKI1_1	299	303	PF00082	0.389
CLV_PCSK_SKI1_1	305	309	PF00082	0.462
CLV_PCSK_SKI1_1	484	488	PF00082	0.576
DEG_APCC_DBOX_1	389	397	PF00400	0.547
DEG_ODPH_VHL_1	19	30	PF01847	0.755
DEG_SCF_FBW7_1	269	276	PF00400	0.637
DEG_SIAH_1	152	160	PF03145	0.640
DEG_SPOP_SBC_1	574	578	PF00917	0.769
DOC_CKS1_1	159	164	PF01111	0.630
DOC_CYCLIN_RxL_1	284	293	PF00134	0.500
DOC_CYCLIN_RxL_1	369	380	PF00134	0.599
DOC_MAPK_gen_1	294	300	PF00069	0.459
DOC_MAPK_MEF2A_6	506	514	PF00069	0.709
DOC_PP1_RVXF_1	297	304	PF00149	0.567
DOC_PP1_RVXF_1	370	377	PF00149	0.589
DOC_PP4_FxxP_1	145	148	PF00568	0.778
DOC_USP7_MATH_1	135	139	PF00917	0.547
DOC_USP7_MATH_1	191	195	PF00917	0.607
DOC_USP7_MATH_1	225	229	PF00917	0.434
DOC_USP7_MATH_1	403	407	PF00917	0.518
DOC_USP7_MATH_1	519	523	PF00917	0.621
DOC_USP7_MATH_1	60	64	PF00917	0.582
DOC_WW_Pin1_4	158	163	PF00397	0.632
DOC_WW_Pin1_4	22	27	PF00397	0.646
DOC_WW_Pin1_4	269	274	PF00397	0.506
LIG_14-3-3_CanoR_1	125	132	PF00244	0.565
LIG_14-3-3_CanoR_1	184	190	PF00244	0.660
LIG_14-3-3_CanoR_1	299	304	PF00244	0.405
LIG_14-3-3_CanoR_1	385	389	PF00244	0.456
LIG_14-3-3_CanoR_1	449	457	PF00244	0.523
LIG_14-3-3_CanoR_1	585	591	PF00244	0.630
LIG_Actin_WH2_2	336	352	PF00022	0.494
LIG_BRCT_BRCA1_1	24	28	PF00533	0.637
LIG_CSL_BTD_1	169	172	PF09270	0.761
LIG_deltaCOP1_diTrp_1	183	190	PF00928	0.558
LIG_eIF4E_1	103	109	PF01652	0.542
LIG_eIF4E_1	112	118	PF01652	0.569
LIG_eIF4E_1	56	62	PF01652	0.568
LIG_EVH1_2	141	145	PF00568	0.592
LIG_EVH1_2	26	30	PF00568	0.580
LIG_FHA_1	159	165	PF00498	0.754
LIG_FHA_1	236	242	PF00498	0.535
LIG_FHA_1	249	255	PF00498	0.398
LIG_FHA_1	270	276	PF00498	0.642
LIG_FHA_1	334	340	PF00498	0.506
LIG_FHA_1	397	403	PF00498	0.479
LIG_FHA_1	449	455	PF00498	0.573
LIG_FHA_1	464	470	PF00498	0.494
LIG_FHA_1	519	525	PF00498	0.721
LIG_FHA_1	545	551	PF00498	0.761
LIG_FHA_1	56	62	PF00498	0.532
LIG_FHA_1	579	585	PF00498	0.614
LIG_FHA_2	3	9	PF00498	0.650
LIG_FHA_2	361	367	PF00498	0.604
LIG_GBD_Chelix_1	282	290	PF00786	0.439
LIG_GBD_Chelix_1	453	461	PF00786	0.472
LIG_LIR_Apic_2	143	148	PF02991	0.769
LIG_LIR_Gen_1	29	36	PF02991	0.540
LIG_LIR_Gen_1	444	454	PF02991	0.599
LIG_LIR_Nem_3	29	33	PF02991	0.557
LIG_LIR_Nem_3	444	450	PF02991	0.621
LIG_LIR_Nem_3	50	56	PF02991	0.520
LIG_LIR_Nem_3	553	557	PF02991	0.717
LIG_PTAP_UEV_1	147	152	PF05743	0.784
LIG_SH2_CRK	103	107	PF00017	0.542
LIG_SH2_CRK	447	451	PF00017	0.556
LIG_SH2_GRB2like	321	324	PF00017	0.639
LIG_SH2_SRC	146	149	PF00017	0.785
LIG_SH2_STAP1	250	254	PF00017	0.453
LIG_SH2_STAP1	494	498	PF00017	0.543
LIG_SH2_STAT5	250	253	PF00017	0.493
LIG_SH2_STAT5	262	265	PF00017	0.516
LIG_SH2_STAT5	321	324	PF00017	0.672
LIG_SH2_STAT5	423	426	PF00017	0.803
LIG_SH2_STAT5	526	529	PF00017	0.630
LIG_SH3_1	166	172	PF00018	0.783
LIG_SH3_3	136	142	PF00018	0.601
LIG_SH3_3	145	151	PF00018	0.648
LIG_SH3_3	15	21	PF00018	0.790
LIG_SH3_3	156	162	PF00018	0.541
LIG_SH3_3	166	172	PF00018	0.675
LIG_SH3_3	204	210	PF00018	0.522
LIG_SH3_3	251	257	PF00018	0.464
LIG_SH3_3	285	291	PF00018	0.403
LIG_SH3_3	402	408	PF00018	0.550
LIG_SH3_3	487	493	PF00018	0.591
LIG_SH3_3	495	501	PF00018	0.550
LIG_SH3_3	86	92	PF00018	0.592
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.530
LIG_SUMO_SIM_par_1	222	228	PF11976	0.435
LIG_TRAF2_1	171	174	PF00917	0.627
LIG_TRAF2_1	312	315	PF00917	0.736
LIG_UBA3_1	108	113	PF00899	0.582
LIG_Vh1_VBS_1	190	208	PF01044	0.542
LIG_WRC_WIRS_1	300	305	PF05994	0.582
MOD_CK1_1	194	200	PF00069	0.725
MOD_CK1_1	306	312	PF00069	0.546
MOD_CK1_1	360	366	PF00069	0.463
MOD_CK1_1	463	469	PF00069	0.502
MOD_CK1_1	482	488	PF00069	0.571
MOD_CK1_1	517	523	PF00069	0.713
MOD_CK1_1	565	571	PF00069	0.687
MOD_CK1_1	578	584	PF00069	0.617
MOD_CK1_1	63	69	PF00069	0.675
MOD_CK1_1	71	77	PF00069	0.732
MOD_CK2_1	2	8	PF00069	0.653
MOD_CK2_1	309	315	PF00069	0.713
MOD_CK2_1	360	366	PF00069	0.594
MOD_Cter_Amidation	9	12	PF01082	0.790
MOD_GlcNHglycan	126	129	PF01048	0.723
MOD_GlcNHglycan	148	151	PF01048	0.680
MOD_GlcNHglycan	153	156	PF01048	0.659
MOD_GlcNHglycan	193	196	PF01048	0.647
MOD_GlcNHglycan	227	230	PF01048	0.446
MOD_GlcNHglycan	305	308	PF01048	0.483
MOD_GlcNHglycan	326	329	PF01048	0.645
MOD_GlcNHglycan	359	362	PF01048	0.497
MOD_GlcNHglycan	38	41	PF01048	0.544
MOD_GlcNHglycan	463	466	PF01048	0.510
MOD_GlcNHglycan	521	524	PF01048	0.595
MOD_GlcNHglycan	544	547	PF01048	0.623
MOD_GlcNHglycan	564	567	PF01048	0.404
MOD_GlcNHglycan	65	68	PF01048	0.692
MOD_GlcNHglycan	76	80	PF01048	0.602
MOD_GSK3_1	185	192	PF00069	0.569
MOD_GSK3_1	196	203	PF00069	0.561
MOD_GSK3_1	269	276	PF00069	0.620
MOD_GSK3_1	299	306	PF00069	0.465
MOD_GSK3_1	34	41	PF00069	0.544
MOD_GSK3_1	433	440	PF00069	0.728
MOD_GSK3_1	459	466	PF00069	0.493
MOD_GSK3_1	514	521	PF00069	0.593
MOD_GSK3_1	540	547	PF00069	0.783
MOD_GSK3_1	561	568	PF00069	0.665
MOD_GSK3_1	574	581	PF00069	0.620
MOD_GSK3_1	63	70	PF00069	0.622
MOD_GSK3_1	71	78	PF00069	0.668
MOD_LATS_1	425	431	PF00433	0.793
MOD_N-GLC_1	433	438	PF02516	0.615
MOD_N-GLC_1	63	68	PF02516	0.606
MOD_N-GLC_2	217	219	PF02516	0.601
MOD_NEK2_1	134	139	PF00069	0.591
MOD_NEK2_1	190	195	PF00069	0.714
MOD_NEK2_1	303	308	PF00069	0.457
MOD_NEK2_1	461	466	PF00069	0.500
MOD_NEK2_1	586	591	PF00069	0.763
MOD_NEK2_1	65	70	PF00069	0.644
MOD_NEK2_2	185	190	PF00069	0.653
MOD_NEK2_2	235	240	PF00069	0.603
MOD_NEK2_2	250	255	PF00069	0.337
MOD_NEK2_2	508	513	PF00069	0.589
MOD_PIKK_1	68	74	PF00454	0.799
MOD_PKA_2	124	130	PF00069	0.595
MOD_PKA_2	185	191	PF00069	0.542
MOD_PKA_2	384	390	PF00069	0.449
MOD_PKA_2	448	454	PF00069	0.549
MOD_PKA_2	584	590	PF00069	0.626
MOD_Plk_1	135	141	PF00069	0.648
MOD_Plk_1	433	439	PF00069	0.580
MOD_Plk_1	482	488	PF00069	0.571
MOD_Plk_4	113	119	PF00069	0.538
MOD_Plk_4	14	20	PF00069	0.752
MOD_Plk_4	185	191	PF00069	0.659
MOD_Plk_4	209	215	PF00069	0.612
MOD_Plk_4	250	256	PF00069	0.448
MOD_Plk_4	482	488	PF00069	0.571
MOD_Plk_4	508	514	PF00069	0.585
MOD_Plk_4	579	585	PF00069	0.650
MOD_ProDKin_1	158	164	PF00069	0.630
MOD_ProDKin_1	22	28	PF00069	0.640
MOD_ProDKin_1	269	275	PF00069	0.516
MOD_SUMO_rev_2	228	234	PF00179	0.547
MOD_SUMO_rev_2	356	360	PF00179	0.645
MOD_SUMO_rev_2	375	383	PF00179	0.268
TRG_DiLeu_BaEn_1	80	85	PF01217	0.786
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.440
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.690
TRG_ENDOCYTIC_2	103	106	PF00928	0.549
TRG_ENDOCYTIC_2	447	450	PF00928	0.614
TRG_ER_diArg_1	285	288	PF00400	0.471
TRG_ER_diArg_1	369	372	PF00400	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA3	Leptomonas seymouri	59%	98%