Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLL8_LEIBR

TriTrypDb:

LbrM.33.1840 , LBRM2903_330024700

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.473
CLV_NRD_NRD_1	123	125	PF00675	0.750
CLV_NRD_NRD_1	321	323	PF00675	0.474
CLV_NRD_NRD_1	461	463	PF00675	0.633
CLV_NRD_NRD_1	466	468	PF00675	0.641
CLV_NRD_NRD_1	486	488	PF00675	0.539
CLV_NRD_NRD_1	495	497	PF00675	0.487
CLV_PCSK_KEX2_1	15	17	PF00082	0.638
CLV_PCSK_KEX2_1	461	463	PF00082	0.633
CLV_PCSK_KEX2_1	466	468	PF00082	0.641
CLV_PCSK_KEX2_1	495	497	PF00082	0.518
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.585
CLV_PCSK_PC7_1	462	468	PF00082	0.464
CLV_PCSK_SKI1_1	301	305	PF00082	0.480
CLV_PCSK_SKI1_1	355	359	PF00082	0.303
CLV_PCSK_SKI1_1	42	46	PF00082	0.612
CLV_PCSK_SKI1_1	85	89	PF00082	0.408
DEG_MDM2_SWIB_1	156	163	PF02201	0.453
DEG_SPOP_SBC_1	165	169	PF00917	0.626
DEG_SPOP_SBC_1	283	287	PF00917	0.484
DEG_SPOP_SBC_1	44	48	PF00917	0.606
DOC_CKS1_1	206	211	PF01111	0.459
DOC_CYCLIN_RxL_1	438	448	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.382
DOC_MAPK_gen_1	322	330	PF00069	0.446
DOC_MAPK_MEF2A_6	423	431	PF00069	0.576
DOC_PP1_RVXF_1	403	410	PF00149	0.260
DOC_USP7_MATH_1	283	287	PF00917	0.675
DOC_USP7_MATH_1	37	41	PF00917	0.592
DOC_USP7_MATH_1	379	383	PF00917	0.628
DOC_USP7_MATH_1	44	48	PF00917	0.564
DOC_USP7_MATH_1	54	58	PF00917	0.588
DOC_USP7_MATH_1	63	67	PF00917	0.560
DOC_USP7_MATH_1	70	74	PF00917	0.387
DOC_USP7_UBL2_3	125	129	PF12436	0.508
DOC_WW_Pin1_4	169	174	PF00397	0.642
DOC_WW_Pin1_4	198	203	PF00397	0.565
DOC_WW_Pin1_4	205	210	PF00397	0.415
DOC_WW_Pin1_4	287	292	PF00397	0.585
DOC_WW_Pin1_4	33	38	PF00397	0.552
DOC_WW_Pin1_4	337	342	PF00397	0.294
DOC_WW_Pin1_4	363	368	PF00397	0.571
DOC_WW_Pin1_4	380	385	PF00397	0.325
DOC_WW_Pin1_4	422	427	PF00397	0.507
DOC_WW_Pin1_4	430	435	PF00397	0.450
DOC_WW_Pin1_4	79	84	PF00397	0.583
LIG_14-3-3_CanoR_1	158	165	PF00244	0.374
LIG_14-3-3_CanoR_1	183	187	PF00244	0.435
LIG_14-3-3_CanoR_1	230	238	PF00244	0.575
LIG_14-3-3_CanoR_1	385	390	PF00244	0.416
LIG_14-3-3_CanoR_1	42	51	PF00244	0.676
LIG_14-3-3_CanoR_1	442	447	PF00244	0.600
LIG_14-3-3_CanoR_1	487	497	PF00244	0.513
LIG_14-3-3_CanoR_1	505	509	PF00244	0.611
LIG_14-3-3_CanoR_1	74	80	PF00244	0.441
LIG_BRCT_BRCA1_1	152	156	PF00533	0.386
LIG_DLG_GKlike_1	385	392	PF00625	0.404
LIG_DLG_GKlike_1	442	449	PF00625	0.363
LIG_FHA_1	211	217	PF00498	0.384
LIG_FHA_1	233	239	PF00498	0.524
LIG_FHA_1	248	254	PF00498	0.414
LIG_FHA_1	255	261	PF00498	0.348
LIG_FHA_1	290	296	PF00498	0.375
LIG_FHA_1	30	36	PF00498	0.499
LIG_FHA_1	323	329	PF00498	0.610
LIG_FHA_1	395	401	PF00498	0.499
LIG_FHA_1	402	408	PF00498	0.483
LIG_FHA_1	422	428	PF00498	0.541
LIG_FHA_2	292	298	PF00498	0.485
LIG_FHA_2	479	485	PF00498	0.680
LIG_LIR_Apic_2	264	269	PF02991	0.468
LIG_LIR_Gen_1	342	352	PF02991	0.356
LIG_LIR_Gen_1	383	392	PF02991	0.470
LIG_LIR_Nem_3	342	348	PF02991	0.364
LIG_LIR_Nem_3	383	389	PF02991	0.479
LIG_LIR_Nem_3	94	99	PF02991	0.354
LIG_Pex14_1	95	99	PF04695	0.312
LIG_Pex14_2	156	160	PF04695	0.443
LIG_Pex14_2	255	259	PF04695	0.313
LIG_Pex14_2	71	75	PF04695	0.486
LIG_SH2_STAT5	402	405	PF00017	0.374
LIG_SH2_STAT5	99	102	PF00017	0.369
LIG_SH3_3	248	254	PF00018	0.271
LIG_SH3_3	335	341	PF00018	0.340
LIG_SH3_3	378	384	PF00018	0.505
LIG_SH3_3	428	434	PF00018	0.472
LIG_TRAF2_1	294	297	PF00917	0.442
LIG_TRAF2_1	341	344	PF00917	0.431
LIG_TRAF2_2	341	346	PF00917	0.364
LIG_UBA3_1	10	15	PF00899	0.441
MOD_CDC14_SPxK_1	82	85	PF00782	0.441
MOD_CDK_SPK_2	363	368	PF00069	0.442
MOD_CDK_SPK_2	380	385	PF00069	0.304
MOD_CDK_SPxK_1	79	85	PF00069	0.436
MOD_CK1_1	108	114	PF00069	0.456
MOD_CK1_1	166	172	PF00069	0.521
MOD_CK1_1	185	191	PF00069	0.565
MOD_CK1_1	22	28	PF00069	0.521
MOD_CK1_1	232	238	PF00069	0.579
MOD_CK1_1	287	293	PF00069	0.665
MOD_CK1_1	366	372	PF00069	0.617
MOD_CK1_1	373	379	PF00069	0.621
MOD_CK1_1	433	439	PF00069	0.466
MOD_CK1_1	445	451	PF00069	0.553
MOD_CK1_1	47	53	PF00069	0.614
MOD_CK1_1	471	477	PF00069	0.631
MOD_CK1_1	57	63	PF00069	0.460
MOD_CK1_1	73	79	PF00069	0.530
MOD_CK2_1	283	289	PF00069	0.614
MOD_CK2_1	291	297	PF00069	0.427
MOD_CK2_1	445	451	PF00069	0.618
MOD_CK2_1	478	484	PF00069	0.679
MOD_CK2_1	495	501	PF00069	0.360
MOD_DYRK1A_RPxSP_1	363	367	PF00069	0.440
MOD_DYRK1A_RPxSP_1	430	434	PF00069	0.443
MOD_GlcNHglycan	110	113	PF01048	0.526
MOD_GlcNHglycan	117	120	PF01048	0.671
MOD_GlcNHglycan	232	235	PF01048	0.544
MOD_GlcNHglycan	24	27	PF01048	0.607
MOD_GlcNHglycan	240	243	PF01048	0.578
MOD_GlcNHglycan	263	266	PF01048	0.460
MOD_GlcNHglycan	269	272	PF01048	0.559
MOD_GlcNHglycan	279	283	PF01048	0.626
MOD_GlcNHglycan	325	328	PF01048	0.581
MOD_GlcNHglycan	374	378	PF01048	0.501
MOD_GlcNHglycan	39	42	PF01048	0.474
MOD_GlcNHglycan	470	473	PF01048	0.733
MOD_GlcNHglycan	508	511	PF01048	0.519
MOD_GlcNHglycan	56	59	PF01048	0.670
MOD_GlcNHglycan	75	78	PF01048	0.523
MOD_GSK3_1	110	117	PF00069	0.558
MOD_GSK3_1	163	170	PF00069	0.564
MOD_GSK3_1	229	236	PF00069	0.525
MOD_GSK3_1	278	285	PF00069	0.770
MOD_GSK3_1	287	294	PF00069	0.597
MOD_GSK3_1	29	36	PF00069	0.669
MOD_GSK3_1	363	370	PF00069	0.679
MOD_GSK3_1	414	421	PF00069	0.438
MOD_GSK3_1	43	50	PF00069	0.600
MOD_GSK3_1	467	474	PF00069	0.594
MOD_GSK3_1	54	61	PF00069	0.445
MOD_LATS_1	321	327	PF00433	0.405
MOD_LATS_1	440	446	PF00433	0.459
MOD_NEK2_1	150	155	PF00069	0.349
MOD_NEK2_1	19	24	PF00069	0.612
MOD_NEK2_1	387	392	PF00069	0.365
MOD_NEK2_1	413	418	PF00069	0.520
MOD_NEK2_1	455	460	PF00069	0.539
MOD_NEK2_1	478	483	PF00069	0.428
MOD_NEK2_2	63	68	PF00069	0.361
MOD_OFUCOSY	7	13	PF10250	0.439
MOD_PIKK_1	339	345	PF00454	0.431
MOD_PKA_1	322	328	PF00069	0.514
MOD_PKA_1	466	472	PF00069	0.579
MOD_PKA_1	495	501	PF00069	0.510
MOD_PKA_2	182	188	PF00069	0.546
MOD_PKA_2	229	235	PF00069	0.582
MOD_PKA_2	267	273	PF00069	0.544
MOD_PKA_2	315	321	PF00069	0.346
MOD_PKA_2	466	472	PF00069	0.599
MOD_PKA_2	495	501	PF00069	0.515
MOD_PKA_2	504	510	PF00069	0.614
MOD_PKA_2	73	79	PF00069	0.416
MOD_Plk_1	29	35	PF00069	0.472
MOD_Plk_1	450	456	PF00069	0.621
MOD_Plk_1	85	91	PF00069	0.421
MOD_Plk_4	151	157	PF00069	0.347
MOD_Plk_4	182	188	PF00069	0.591
MOD_Plk_4	247	253	PF00069	0.406
MOD_Plk_4	254	260	PF00069	0.346
MOD_Plk_4	367	373	PF00069	0.447
MOD_Plk_4	442	448	PF00069	0.490
MOD_ProDKin_1	169	175	PF00069	0.628
MOD_ProDKin_1	198	204	PF00069	0.547
MOD_ProDKin_1	205	211	PF00069	0.411
MOD_ProDKin_1	287	293	PF00069	0.569
MOD_ProDKin_1	33	39	PF00069	0.552
MOD_ProDKin_1	337	343	PF00069	0.295
MOD_ProDKin_1	363	369	PF00069	0.572
MOD_ProDKin_1	380	386	PF00069	0.315
MOD_ProDKin_1	422	428	PF00069	0.504
MOD_ProDKin_1	430	436	PF00069	0.451
MOD_ProDKin_1	79	85	PF00069	0.581
MOD_SUMO_rev_2	122	130	PF00179	0.699
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.370
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.559
TRG_ER_diArg_1	495	497	PF00400	0.502
TRG_NES_CRM1_1	302	317	PF08389	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U7	Leptomonas seymouri	48%	100%
A0A1X0P266	Trypanosomatidae	24%	100%
A0A3Q8IHT9	Leishmania donovani	75%	100%
A0A3R7LW25	Trypanosoma rangeli	30%	100%
A4I929	Leishmania infantum	75%	100%
D0A532	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B3Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q430	Leishmania major	77%	100%
V5DDH0	Trypanosoma cruzi	31%	100%