Putative elongation factor 1-gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor 1-gamma, putative

Species:

Leishmania braziliensis

UniProt:

A4HLL4_LEIBR

TriTrypDb:

LbrM.33.1800 , LBRM2903_330024300

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLL4

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003746	translation elongation factor activity	4	7
GO:0005488	binding	1	7
GO:0008135	translation factor activity, RNA binding	3	7
GO:0045182	translation regulator activity	1	7
GO:0090079	translation regulator activity, nucleic acid binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.452
CLV_NRD_NRD_1	177	179	PF00675	0.452
CLV_NRD_NRD_1	209	211	PF00675	0.651
CLV_PCSK_KEX2_1	209	211	PF00082	0.522
CLV_PCSK_KEX2_1	7	9	PF00082	0.617
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.525
CLV_PCSK_SKI1_1	138	142	PF00082	0.452
CLV_PCSK_SKI1_1	151	155	PF00082	0.452
DOC_WW_Pin1_4	89	94	PF00397	0.667
LIG_14-3-3_CanoR_1	193	199	PF00244	0.452
LIG_deltaCOP1_diTrp_1	100	105	PF00928	0.643
LIG_FHA_1	124	130	PF00498	0.527
LIG_FHA_1	150	156	PF00498	0.399
LIG_FHA_1	68	74	PF00498	0.271
LIG_FHA_2	106	112	PF00498	0.636
LIG_FHA_2	90	96	PF00498	0.660
LIG_LIR_Gen_1	100	110	PF02991	0.639
LIG_LIR_Nem_3	100	105	PF02991	0.611
LIG_LIR_Nem_3	187	191	PF02991	0.444
LIG_LIR_Nem_3	41	47	PF02991	0.433
LIG_LIR_Nem_3	53	57	PF02991	0.332
LIG_LYPXL_yS_3	54	57	PF13949	0.452
LIG_Pex14_2	168	172	PF04695	0.420
LIG_SH2_CRK	188	192	PF00017	0.452
LIG_SH2_CRK	195	199	PF00017	0.452
LIG_SH2_CRK	23	27	PF00017	0.271
LIG_SH2_STAT5	117	120	PF00017	0.452
LIG_SH2_STAT5	47	50	PF00017	0.294
LIG_SH2_STAT5	76	79	PF00017	0.379
LIG_SUMO_SIM_par_1	145	152	PF11976	0.452
LIG_SUMO_SIM_par_1	55	63	PF11976	0.420
LIG_WRC_WIRS_1	150	155	PF05994	0.452
MOD_CK1_1	149	155	PF00069	0.452
MOD_CK2_1	103	109	PF00069	0.641
MOD_CK2_1	89	95	PF00069	0.667
MOD_GlcNHglycan	38	41	PF01048	0.271
MOD_GlcNHglycan	60	65	PF01048	0.511
MOD_N-GLC_2	46	48	PF02516	0.524
MOD_NEK2_1	59	64	PF00069	0.322
MOD_NEK2_1	94	99	PF00069	0.622
MOD_PIKK_1	94	100	PF00454	0.649
MOD_PKA_2	157	163	PF00069	0.452
MOD_Plk_1	94	100	PF00069	0.653
MOD_Plk_2-3	157	163	PF00069	0.452
MOD_Plk_4	194	200	PF00069	0.436
MOD_ProDKin_1	89	95	PF00069	0.667
MOD_SUMO_rev_2	31	39	PF00179	0.463
TRG_ENDOCYTIC_2	117	120	PF00928	0.452
TRG_ENDOCYTIC_2	188	191	PF00928	0.452
TRG_ENDOCYTIC_2	195	198	PF00928	0.452
TRG_ENDOCYTIC_2	23	26	PF00928	0.452
TRG_ENDOCYTIC_2	54	57	PF00928	0.420
TRG_ER_diArg_1	208	210	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUF6	Leptomonas seymouri	78%	100%
A0A0S4INS1	Bodo saltans	40%	100%
A0A3Q8IGW0	Leishmania donovani	87%	100%
A0A6J4B5J2	Fusarium sp.	29%	100%
A4I925	Leishmania infantum	88%	100%
E9B3Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P42769	Arabidopsis thaliana	27%	100%
Q4Q434	Leishmania major	88%	100%
S0EHD0	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	28%	100%
W7MMJ0	Gibberella moniliformis (strain M3125 / FGSC 7600)	28%	100%