PRA1 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PRA1 family protein

Gene product:

PRA1 family protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLL3_LEIBR

TriTrypDb:

LbrM.33.1790 , LBRM2903_330024200

Length:

228

Annotations

LeishMANIAdb annotations

A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HLL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.275
CLV_PCSK_KEX2_1	216	218	PF00082	0.298
CLV_PCSK_SKI1_1	170	174	PF00082	0.298
CLV_PCSK_SKI1_1	70	74	PF00082	0.216
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DOC_PP1_RVXF_1	2	8	PF00149	0.537
DOC_PP4_FxxP_1	87	90	PF00568	0.441
DOC_USP7_MATH_1	17	21	PF00917	0.680
DOC_USP7_MATH_1	25	29	PF00917	0.635
DOC_USP7_MATH_1	39	43	PF00917	0.622
DOC_WW_Pin1_4	86	91	PF00397	0.473
LIG_14-3-3_CanoR_1	144	153	PF00244	0.479
LIG_14-3-3_CanoR_1	170	175	PF00244	0.399
LIG_14-3-3_CanoR_1	70	78	PF00244	0.394
LIG_BRCT_BRCA1_1	195	199	PF00533	0.247
LIG_BRCT_BRCA1_1	44	48	PF00533	0.496
LIG_BRCT_BRCA1_1	51	55	PF00533	0.470
LIG_BRCT_BRCA1_1	78	82	PF00533	0.492
LIG_FHA_1	92	98	PF00498	0.499
LIG_LIR_Apic_2	84	90	PF02991	0.476
LIG_LIR_Gen_1	119	129	PF02991	0.336
LIG_LIR_Gen_1	175	186	PF02991	0.445
LIG_LIR_Gen_1	222	228	PF02991	0.644
LIG_LIR_Gen_1	42	48	PF02991	0.597
LIG_LIR_Nem_3	119	124	PF02991	0.361
LIG_LIR_Nem_3	175	181	PF02991	0.445
LIG_LIR_Nem_3	222	228	PF02991	0.625
LIG_LIR_Nem_3	42	46	PF02991	0.575
LIG_MLH1_MIPbox_1	78	82	PF16413	0.492
LIG_PDZ_Class_3	223	228	PF00595	0.663
LIG_Pex14_1	78	82	PF04695	0.456
LIG_Pex14_2	82	86	PF04695	0.534
LIG_PTB_Apo_2	123	130	PF02174	0.310
LIG_PTB_Apo_2	166	173	PF02174	0.479
LIG_SH2_CRK	140	144	PF00017	0.249
LIG_SH2_CRK	43	47	PF00017	0.563
LIG_SH2_GRB2like	108	111	PF00017	0.441
LIG_SH2_PTP2	121	124	PF00017	0.338
LIG_SH2_STAP1	108	112	PF00017	0.505
LIG_SH2_STAP1	132	136	PF00017	0.339
LIG_SH2_STAP1	43	47	PF00017	0.569
LIG_SH2_STAT5	106	109	PF00017	0.478
LIG_SH2_STAT5	111	114	PF00017	0.322
LIG_SH2_STAT5	121	124	PF00017	0.295
LIG_SH2_STAT5	132	135	PF00017	0.268
LIG_SH2_STAT5	166	169	PF00017	0.469
LIG_SH2_STAT5	178	181	PF00017	0.213
LIG_SH2_STAT5	190	193	PF00017	0.290
LIG_SUMO_SIM_anti_2	119	126	PF11976	0.312
LIG_TRAF2_1	158	161	PF00917	0.534
LIG_WRC_WIRS_1	113	118	PF05994	0.193
MOD_CK1_1	202	208	PF00069	0.367
MOD_CK1_1	42	48	PF00069	0.599
MOD_CK1_1	49	55	PF00069	0.586
MOD_CK1_1	91	97	PF00069	0.512
MOD_CK2_1	156	162	PF00069	0.534
MOD_CK2_1	3	9	PF00069	0.555
MOD_GlcNHglycan	146	149	PF01048	0.328
MOD_GlcNHglycan	222	225	PF01048	0.475
MOD_GlcNHglycan	27	30	PF01048	0.406
MOD_GlcNHglycan	48	51	PF01048	0.349
MOD_GlcNHglycan	90	93	PF01048	0.301
MOD_GSK3_1	112	119	PF00069	0.382
MOD_GSK3_1	189	196	PF00069	0.314
MOD_GSK3_1	202	209	PF00069	0.349
MOD_GSK3_1	42	49	PF00069	0.608
MOD_GSK3_1	82	89	PF00069	0.474
MOD_N-GLC_1	144	149	PF02516	0.240
MOD_N-GLC_1	70	75	PF02516	0.175
MOD_NEK2_1	112	117	PF00069	0.339
MOD_NEK2_1	172	177	PF00069	0.481
MOD_NEK2_1	189	194	PF00069	0.181
MOD_NEK2_1	199	204	PF00069	0.268
MOD_NEK2_1	206	211	PF00069	0.203
MOD_NEK2_1	48	53	PF00069	0.491
MOD_NEK2_1	81	86	PF00069	0.488
MOD_NEK2_2	211	216	PF00069	0.414
MOD_PIKK_1	172	178	PF00454	0.473
MOD_Plk_1	144	150	PF00069	0.440
MOD_Plk_1	70	76	PF00069	0.518
MOD_Plk_1	82	88	PF00069	0.488
MOD_Plk_4	112	118	PF00069	0.302
MOD_Plk_4	130	136	PF00069	0.363
MOD_Plk_4	193	199	PF00069	0.272
MOD_Plk_4	42	48	PF00069	0.543
MOD_Plk_4	82	88	PF00069	0.534
MOD_ProDKin_1	86	92	PF00069	0.473
TRG_ENDOCYTIC_2	111	114	PF00928	0.311
TRG_ENDOCYTIC_2	121	124	PF00928	0.311
TRG_ENDOCYTIC_2	132	135	PF00928	0.265
TRG_ENDOCYTIC_2	140	143	PF00928	0.303
TRG_ENDOCYTIC_2	178	181	PF00928	0.323
TRG_ENDOCYTIC_2	43	46	PF00928	0.599
TRG_ER_diArg_1	143	146	PF00400	0.534
TRG_ER_diArg_1	215	217	PF00400	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K1	Leptomonas seymouri	67%	96%
A0A0S4JEM7	Bodo saltans	35%	100%
A0A1X0P0Z7	Trypanosomatidae	38%	100%
A0A3Q8IK58	Leishmania donovani	26%	100%
A0A3R7ML24	Trypanosoma rangeli	39%	100%
A0A3S7X6T0	Leishmania donovani	88%	100%
A4HLL2	Leishmania braziliensis	25%	100%
A4I924	Leishmania infantum	89%	100%
D0A528	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHN5	Leishmania infantum	26%	100%
E9B3Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B3Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O80915	Arabidopsis thaliana	21%	100%
Q4Q435	Leishmania major	89%	100%