A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 15 |
| NetGPI | no | yes: 0, no: 15 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 16 |
| GO:0110165 | cellular anatomical entity | 1 | 16 |
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0005794 | Golgi apparatus | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
Related structures:
AlphaFold database: A4HLL2
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 76 | 80 | PF00656 | 0.444 |
| CLV_NRD_NRD_1 | 13 | 15 | PF00675 | 0.239 |
| CLV_NRD_NRD_1 | 130 | 132 | PF00675 | 0.274 |
| CLV_NRD_NRD_1 | 176 | 178 | PF00675 | 0.378 |
| CLV_NRD_NRD_1 | 182 | 184 | PF00675 | 0.319 |
| CLV_PCSK_KEX2_1 | 176 | 178 | PF00082 | 0.378 |
| CLV_PCSK_KEX2_1 | 184 | 186 | PF00082 | 0.293 |
| CLV_PCSK_KEX2_1 | 192 | 194 | PF00082 | 0.327 |
| CLV_PCSK_PC1ET2_1 | 184 | 186 | PF00082 | 0.336 |
| CLV_PCSK_PC1ET2_1 | 192 | 194 | PF00082 | 0.326 |
| CLV_PCSK_SKI1_1 | 14 | 18 | PF00082 | 0.391 |
| CLV_PCSK_SKI1_1 | 51 | 55 | PF00082 | 0.508 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 88 | 97 | PF00134 | 0.378 |
| DOC_CYCLIN_yCln2_LP_2 | 84 | 90 | PF00134 | 0.378 |
| DOC_MAPK_MEF2A_6 | 111 | 118 | PF00069 | 0.330 |
| DOC_PP1_RVXF_1 | 109 | 116 | PF00149 | 0.239 |
| DOC_PP2B_LxvP_1 | 25 | 28 | PF13499 | 0.457 |
| DOC_USP7_UBL2_3 | 143 | 147 | PF12436 | 0.579 |
| LIG_14-3-3_CanoR_1 | 86 | 91 | PF00244 | 0.414 |
| LIG_DLG_GKlike_1 | 86 | 93 | PF00625 | 0.378 |
| LIG_EH1_1 | 150 | 158 | PF00400 | 0.536 |
| LIG_FHA_1 | 40 | 46 | PF00498 | 0.311 |
| LIG_FHA_1 | 58 | 64 | PF00498 | 0.252 |
| LIG_FHA_2 | 132 | 138 | PF00498 | 0.566 |
| LIG_FHA_2 | 165 | 171 | PF00498 | 0.500 |
| LIG_FHA_2 | 74 | 80 | PF00498 | 0.394 |
| LIG_GBD_Chelix_1 | 97 | 105 | PF00786 | 0.312 |
| LIG_LIR_Gen_1 | 112 | 123 | PF02991 | 0.361 |
| LIG_LIR_Gen_1 | 2 | 10 | PF02991 | 0.439 |
| LIG_LIR_Gen_1 | 31 | 41 | PF02991 | 0.365 |
| LIG_LIR_Gen_1 | 57 | 64 | PF02991 | 0.408 |
| LIG_LIR_Nem_3 | 112 | 118 | PF02991 | 0.364 |
| LIG_LIR_Nem_3 | 2 | 7 | PF02991 | 0.523 |
| LIG_LIR_Nem_3 | 31 | 37 | PF02991 | 0.388 |
| LIG_LIR_Nem_3 | 57 | 61 | PF02991 | 0.362 |
| LIG_LIR_Nem_3 | 89 | 93 | PF02991 | 0.442 |
| LIG_NRBOX | 100 | 106 | PF00104 | 0.330 |
| LIG_NRBOX | 92 | 98 | PF00104 | 0.410 |
| LIG_Pex14_2 | 54 | 58 | PF04695 | 0.318 |
| LIG_PTB_Apo_2 | 47 | 54 | PF02174 | 0.339 |
| LIG_SH2_CRK | 49 | 53 | PF00017 | 0.306 |
| LIG_SH2_CRK | 90 | 94 | PF00017 | 0.458 |
| LIG_SH2_NCK_1 | 49 | 53 | PF00017 | 0.190 |
| LIG_SH2_PTP2 | 34 | 37 | PF00017 | 0.310 |
| LIG_SH2_SRC | 162 | 165 | PF00017 | 0.627 |
| LIG_SH2_SRC | 34 | 37 | PF00017 | 0.270 |
| LIG_SH2_STAP1 | 151 | 155 | PF00017 | 0.539 |
| LIG_SH2_STAP1 | 30 | 34 | PF00017 | 0.484 |
| LIG_SH2_STAP1 | 39 | 43 | PF00017 | 0.300 |
| LIG_SH2_STAT5 | 135 | 138 | PF00017 | 0.589 |
| LIG_SH2_STAT5 | 162 | 165 | PF00017 | 0.604 |
| LIG_SH2_STAT5 | 34 | 37 | PF00017 | 0.318 |
| LIG_SH3_3 | 38 | 44 | PF00018 | 0.347 |
| LIG_SUMO_SIM_anti_2 | 57 | 63 | PF11976 | 0.383 |
| LIG_SUMO_SIM_anti_2 | 79 | 85 | PF11976 | 0.514 |
| LIG_SUMO_SIM_par_1 | 60 | 66 | PF11976 | 0.389 |
| LIG_TYR_ITIM | 88 | 93 | PF00017 | 0.457 |
| LIG_UBA3_1 | 45 | 51 | PF00899 | 0.423 |
| LIG_WRC_WIRS_1 | 55 | 60 | PF05994 | 0.255 |
| MOD_CK2_1 | 165 | 171 | PF00069 | 0.614 |
| MOD_GSK3_1 | 73 | 80 | PF00069 | 0.466 |
| MOD_N-GLC_2 | 120 | 122 | PF02516 | 0.270 |
| MOD_NEK2_1 | 54 | 59 | PF00069 | 0.313 |
| MOD_PKA_1 | 131 | 137 | PF00069 | 0.534 |
| MOD_PKA_1 | 71 | 77 | PF00069 | 0.560 |
| MOD_Plk_4 | 131 | 137 | PF00069 | 0.575 |
| MOD_Plk_4 | 54 | 60 | PF00069 | 0.407 |
| MOD_Plk_4 | 77 | 83 | PF00069 | 0.483 |
| MOD_SUMO_for_1 | 191 | 194 | PF00179 | 0.508 |
| MOD_SUMO_rev_2 | 180 | 186 | PF00179 | 0.538 |
| TRG_DiLeu_BaLyEn_6 | 41 | 46 | PF01217 | 0.279 |
| TRG_ENDOCYTIC_2 | 34 | 37 | PF00928 | 0.304 |
| TRG_ENDOCYTIC_2 | 90 | 93 | PF00928 | 0.472 |
| TRG_ER_diArg_1 | 183 | 186 | PF00400 | 0.543 |
| TRG_NLS_MonoExtN_4 | 68 | 75 | PF00514 | 0.515 |
| TRG_Pf-PMV_PEXEL_1 | 14 | 18 | PF00026 | 0.201 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0S4JEM7 | Bodo saltans | 28% | 94% |
| A0A1X0P0Z7 | Trypanosomatidae | 28% | 93% |
| A0A1X0P100 | Trypanosomatidae | 45% | 74% |
| A0A3Q8IK58 | Leishmania donovani | 82% | 97% |
| A0A3R7ML24 | Trypanosoma rangeli | 25% | 96% |
| A0A3S7X6T0 | Leishmania donovani | 26% | 100% |
| A0A422NG43 | Trypanosoma rangeli | 40% | 66% |
| A4HLL3 | Leishmania braziliensis | 25% | 86% |
| A4I924 | Leishmania infantum | 26% | 100% |
| D0A526 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 87% |
| E9AHN5 | Leishmania infantum | 82% | 97% |
| E9B3Y8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 82% | 95% |
| E9B3Y9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
| Q4Q436 | Leishmania major | 80% | 100% |