Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLL0_LEIBR

TriTrypDb:

LbrM.33.1760 , LBRM2903_330023900

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.452
CLV_C14_Caspase3-7	514	518	PF00656	0.498
CLV_MEL_PAP_1	375	381	PF00089	0.523
CLV_NRD_NRD_1	131	133	PF00675	0.739
CLV_NRD_NRD_1	446	448	PF00675	0.428
CLV_NRD_NRD_1	527	529	PF00675	0.442
CLV_NRD_NRD_1	558	560	PF00675	0.431
CLV_NRD_NRD_1	814	816	PF00675	0.549
CLV_PCSK_KEX2_1	131	133	PF00082	0.762
CLV_PCSK_KEX2_1	448	450	PF00082	0.423
CLV_PCSK_KEX2_1	527	529	PF00082	0.442
CLV_PCSK_KEX2_1	560	562	PF00082	0.421
CLV_PCSK_KEX2_1	829	831	PF00082	0.500
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.483
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.495
CLV_PCSK_PC1ET2_1	829	831	PF00082	0.429
CLV_PCSK_SKI1_1	189	193	PF00082	0.415
CLV_PCSK_SKI1_1	293	297	PF00082	0.413
CLV_PCSK_SKI1_1	318	322	PF00082	0.419
CLV_PCSK_SKI1_1	463	467	PF00082	0.292
CLV_PCSK_SKI1_1	561	565	PF00082	0.385
CLV_PCSK_SKI1_1	580	584	PF00082	0.445
CLV_PCSK_SKI1_1	74	78	PF00082	0.473
CLV_PCSK_SKI1_1	805	809	PF00082	0.399
DEG_APCC_DBOX_1	814	822	PF00400	0.528
DEG_SPOP_SBC_1	725	729	PF00917	0.466
DEG_SPOP_SBC_1	740	744	PF00917	0.496
DOC_ANK_TNKS_1	131	138	PF00023	0.515
DOC_CKS1_1	191	196	PF01111	0.383
DOC_CKS1_1	613	618	PF01111	0.457
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.582
DOC_MAPK_gen_1	815	821	PF00069	0.525
DOC_MAPK_MEF2A_6	12	21	PF00069	0.508
DOC_MAPK_MEF2A_6	333	341	PF00069	0.567
DOC_MAPK_MEF2A_6	363	372	PF00069	0.469
DOC_PP1_RVXF_1	352	359	PF00149	0.426
DOC_PP2B_LxvP_1	113	116	PF13499	0.680
DOC_PP2B_LxvP_1	341	344	PF13499	0.456
DOC_PP2B_LxvP_1	592	595	PF13499	0.553
DOC_PP2B_LxvP_1	628	631	PF13499	0.467
DOC_PP2B_LxvP_1	745	748	PF13499	0.563
DOC_PP4_FxxP_1	296	299	PF00568	0.580
DOC_SPAK_OSR1_1	783	787	PF12202	0.520
DOC_USP7_MATH_1	105	109	PF00917	0.580
DOC_USP7_MATH_1	331	335	PF00917	0.570
DOC_USP7_MATH_1	345	349	PF00917	0.382
DOC_USP7_MATH_1	432	436	PF00917	0.636
DOC_USP7_MATH_1	571	575	PF00917	0.372
DOC_USP7_MATH_1	662	666	PF00917	0.616
DOC_USP7_MATH_1	730	734	PF00917	0.599
DOC_USP7_UBL2_3	80	84	PF12436	0.468
DOC_WW_Pin1_4	172	177	PF00397	0.557
DOC_WW_Pin1_4	183	188	PF00397	0.614
DOC_WW_Pin1_4	190	195	PF00397	0.598
DOC_WW_Pin1_4	249	254	PF00397	0.610
DOC_WW_Pin1_4	612	617	PF00397	0.515
DOC_WW_Pin1_4	675	680	PF00397	0.439
LIG_14-3-3_CanoR_1	266	270	PF00244	0.428
LIG_14-3-3_CanoR_1	357	361	PF00244	0.343
LIG_14-3-3_CanoR_1	378	384	PF00244	0.557
LIG_14-3-3_CanoR_1	472	476	PF00244	0.507
LIG_14-3-3_CanoR_1	481	487	PF00244	0.439
LIG_14-3-3_CanoR_1	561	570	PF00244	0.446
LIG_14-3-3_CanoR_1	692	700	PF00244	0.598
LIG_14-3-3_CanoR_1	815	819	PF00244	0.556
LIG_14-3-3_CanoR_1	823	829	PF00244	0.535
LIG_14-3-3_CanoR_1	841	845	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	284	288	PF00533	0.362
LIG_EVH1_1	341	345	PF00568	0.463
LIG_FHA_1	105	111	PF00498	0.550
LIG_FHA_1	177	183	PF00498	0.406
LIG_FHA_1	26	32	PF00498	0.418
LIG_FHA_1	281	287	PF00498	0.449
LIG_FHA_1	357	363	PF00498	0.401
LIG_FHA_1	374	380	PF00498	0.472
LIG_FHA_1	589	595	PF00498	0.452
LIG_FHA_1	668	674	PF00498	0.496
LIG_FHA_1	742	748	PF00498	0.516
LIG_FHA_1	777	783	PF00498	0.417
LIG_FHA_1	823	829	PF00498	0.403
LIG_FHA_2	101	107	PF00498	0.558
LIG_FHA_2	282	288	PF00498	0.379
LIG_FHA_2	493	499	PF00498	0.511
LIG_FHA_2	595	601	PF00498	0.546
LIG_FHA_2	765	771	PF00498	0.581
LIG_LIR_Apic_2	355	361	PF02991	0.504
LIG_LIR_Gen_1	152	161	PF02991	0.484
LIG_LIR_Gen_1	219	230	PF02991	0.360
LIG_LIR_Gen_1	406	414	PF02991	0.719
LIG_LIR_Gen_1	564	575	PF02991	0.410
LIG_LIR_Nem_3	152	156	PF02991	0.501
LIG_LIR_Nem_3	169	174	PF02991	0.576
LIG_LIR_Nem_3	218	223	PF02991	0.367
LIG_LIR_Nem_3	406	411	PF02991	0.664
LIG_LIR_Nem_3	564	570	PF02991	0.424
LIG_LIR_Nem_3	572	578	PF02991	0.379
LIG_LIR_Nem_3	665	671	PF02991	0.452
LIG_LIR_Nem_3	712	716	PF02991	0.465
LIG_NRBOX	369	375	PF00104	0.469
LIG_Pex14_2	96	100	PF04695	0.501
LIG_SH2_CRK	428	432	PF00017	0.542
LIG_SH2_PTP2	153	156	PF00017	0.479
LIG_SH2_SRC	408	411	PF00017	0.568
LIG_SH2_SRC	428	431	PF00017	0.394
LIG_SH2_STAP1	282	286	PF00017	0.384
LIG_SH2_STAP1	586	590	PF00017	0.398
LIG_SH2_STAT5	153	156	PF00017	0.479
LIG_SH2_STAT5	276	279	PF00017	0.466
LIG_SH2_STAT5	282	285	PF00017	0.371
LIG_SH2_STAT5	541	544	PF00017	0.474
LIG_SH3_3	170	176	PF00018	0.534
LIG_SH3_3	296	302	PF00018	0.587
LIG_SH3_3	325	331	PF00018	0.502
LIG_SH3_3	334	340	PF00018	0.389
LIG_SH3_3	386	392	PF00018	0.560
LIG_SH3_3	396	402	PF00018	0.604
LIG_SH3_3	418	424	PF00018	0.564
LIG_SH3_3	51	57	PF00018	0.480
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.552
LIG_SUMO_SIM_par_1	154	160	PF11976	0.336
LIG_SUMO_SIM_par_1	371	376	PF11976	0.526
LIG_SUMO_SIM_par_1	41	47	PF11976	0.393
LIG_SUMO_SIM_par_1	594	601	PF11976	0.536
LIG_SUMO_SIM_par_1	621	627	PF11976	0.504
LIG_SUMO_SIM_par_1	853	858	PF11976	0.431
LIG_SxIP_EBH_1	175	189	PF03271	0.375
LIG_SxIP_EBH_1	812	823	PF03271	0.391
LIG_TRAF2_1	535	538	PF00917	0.510
LIG_TRAF2_1	767	770	PF00917	0.584
LIG_TYR_ITIM	151	156	PF00017	0.498
LIG_UBA3_1	373	382	PF00899	0.477
LIG_WW_3	387	391	PF00397	0.446
MOD_CDK_SPK_2	190	195	PF00069	0.345
MOD_CDK_SPxK_1	183	189	PF00069	0.568
MOD_CDK_SPxK_1	675	681	PF00069	0.446
MOD_CK1_1	108	114	PF00069	0.653
MOD_CK1_1	144	150	PF00069	0.630
MOD_CK1_1	15	21	PF00069	0.559
MOD_CK1_1	247	253	PF00069	0.644
MOD_CK1_1	324	330	PF00069	0.513
MOD_CK1_1	632	638	PF00069	0.593
MOD_CK1_1	726	732	PF00069	0.559
MOD_CK1_1	760	766	PF00069	0.661
MOD_CK1_1	822	828	PF00069	0.522
MOD_CK2_1	100	106	PF00069	0.515
MOD_CK2_1	281	287	PF00069	0.391
MOD_CK2_1	594	600	PF00069	0.532
MOD_CK2_1	764	770	PF00069	0.520
MOD_CK2_1	92	98	PF00069	0.444
MOD_Cter_Amidation	129	132	PF01082	0.629
MOD_GlcNHglycan	106	110	PF01048	0.479
MOD_GlcNHglycan	143	146	PF01048	0.703
MOD_GlcNHglycan	159	162	PF01048	0.374
MOD_GlcNHglycan	179	182	PF01048	0.433
MOD_GlcNHglycan	254	257	PF01048	0.576
MOD_GlcNHglycan	310	313	PF01048	0.557
MOD_GlcNHglycan	347	350	PF01048	0.644
MOD_GlcNHglycan	599	603	PF01048	0.488
MOD_GlcNHglycan	650	653	PF01048	0.676
MOD_GlcNHglycan	664	667	PF01048	0.377
MOD_GlcNHglycan	716	719	PF01048	0.635
MOD_GlcNHglycan	748	751	PF01048	0.624
MOD_GlcNHglycan	762	765	PF01048	0.722
MOD_GlcNHglycan	850	853	PF01048	0.585
MOD_GSK3_1	104	111	PF00069	0.550
MOD_GSK3_1	139	146	PF00069	0.673
MOD_GSK3_1	157	164	PF00069	0.506
MOD_GSK3_1	172	179	PF00069	0.512
MOD_GSK3_1	243	250	PF00069	0.642
MOD_GSK3_1	261	268	PF00069	0.375
MOD_GSK3_1	373	380	PF00069	0.472
MOD_GSK3_1	52	59	PF00069	0.627
MOD_GSK3_1	594	601	PF00069	0.538
MOD_GSK3_1	726	733	PF00069	0.539
MOD_GSK3_1	735	742	PF00069	0.554
MOD_GSK3_1	756	763	PF00069	0.673
MOD_GSK3_1	824	831	PF00069	0.548
MOD_GSK3_1	88	95	PF00069	0.507
MOD_GSK3_1	96	103	PF00069	0.519
MOD_N-GLC_1	15	20	PF02516	0.435
MOD_N-GLC_1	96	101	PF02516	0.434
MOD_N-GLC_2	62	64	PF02516	0.500
MOD_NEK2_1	244	249	PF00069	0.636
MOD_NEK2_1	25	30	PF00069	0.500
MOD_NEK2_1	265	270	PF00069	0.367
MOD_NEK2_1	294	299	PF00069	0.452
MOD_NEK2_1	303	308	PF00069	0.426
MOD_NEK2_1	321	326	PF00069	0.307
MOD_NEK2_1	373	378	PF00069	0.404
MOD_NEK2_1	588	593	PF00069	0.548
MOD_NEK2_1	683	688	PF00069	0.403
MOD_NEK2_1	723	728	PF00069	0.476
MOD_NEK2_1	739	744	PF00069	0.595
MOD_NEK2_1	758	763	PF00069	0.584
MOD_NEK2_1	828	833	PF00069	0.356
MOD_NEK2_1	89	94	PF00069	0.466
MOD_NEK2_1	96	101	PF00069	0.470
MOD_NEK2_2	824	829	PF00069	0.490
MOD_PIKK_1	415	421	PF00454	0.735
MOD_PIKK_1	432	438	PF00454	0.463
MOD_PIKK_1	629	635	PF00454	0.681
MOD_PIKK_1	645	651	PF00454	0.669
MOD_PK_1	681	687	PF00069	0.418
MOD_PKA_2	139	145	PF00069	0.493
MOD_PKA_2	265	271	PF00069	0.398
MOD_PKA_2	356	362	PF00069	0.480
MOD_PKA_2	377	383	PF00069	0.513
MOD_PKA_2	471	477	PF00069	0.511
MOD_PKA_2	691	697	PF00069	0.582
MOD_PKA_2	814	820	PF00069	0.581
MOD_PKA_2	822	828	PF00069	0.536
MOD_PKA_2	840	846	PF00069	0.572
MOD_PKB_1	559	567	PF00069	0.443
MOD_Plk_1	105	111	PF00069	0.517
MOD_Plk_1	15	21	PF00069	0.381
MOD_Plk_1	548	554	PF00069	0.541
MOD_Plk_1	776	782	PF00069	0.398
MOD_Plk_1	96	102	PF00069	0.428
MOD_Plk_4	146	152	PF00069	0.597
MOD_Plk_4	265	271	PF00069	0.398
MOD_Plk_4	324	330	PF00069	0.553
MOD_Plk_4	735	741	PF00069	0.498
MOD_Plk_4	814	820	PF00069	0.305
MOD_ProDKin_1	172	178	PF00069	0.567
MOD_ProDKin_1	183	189	PF00069	0.613
MOD_ProDKin_1	190	196	PF00069	0.601
MOD_ProDKin_1	249	255	PF00069	0.610
MOD_ProDKin_1	612	618	PF00069	0.517
MOD_ProDKin_1	675	681	PF00069	0.446
MOD_SUMO_for_1	706	709	PF00179	0.499
MOD_SUMO_rev_2	208	217	PF00179	0.515
MOD_SUMO_rev_2	553	562	PF00179	0.506
TRG_DiLeu_BaEn_1	558	563	PF01217	0.484
TRG_DiLeu_BaEn_3	537	543	PF01217	0.481
TRG_ENDOCYTIC_2	153	156	PF00928	0.480
TRG_ENDOCYTIC_2	171	174	PF00928	0.565
TRG_ENDOCYTIC_2	408	411	PF00928	0.600
TRG_ENDOCYTIC_2	428	431	PF00928	0.394
TRG_ENDOCYTIC_2	575	578	PF00928	0.499
TRG_ER_diArg_1	526	528	PF00400	0.399
TRG_ER_diArg_1	559	562	PF00400	0.453
TRG_NLS_MonoExtN_4	445	451	PF00514	0.326
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW62	Leptomonas seymouri	63%	100%
A0A1X0P2J7	Trypanosomatidae	41%	100%
A0A3S7X6N7	Leishmania donovani	84%	100%
A0A422NG65	Trypanosoma rangeli	42%	100%
A4I922	Leishmania infantum	84%	100%
D0A522	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q438	Leishmania major	84%	99%
V5AXC5	Trypanosoma cruzi	40%	100%