Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLK8_LEIBR

TriTrypDb:

LbrM.33.1740 , LBRM2903_330023600

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0005488	binding	1	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	97	99	PF00675	0.493
CLV_PCSK_KEX2_1	97	99	PF00082	0.508
CLV_PCSK_SKI1_1	36	40	PF00082	0.256
DOC_USP7_MATH_1	75	79	PF00917	0.496
DOC_USP7_UBL2_3	112	116	PF12436	0.563
LIG_14-3-3_CanoR_1	36	42	PF00244	0.476
LIG_14-3-3_CanoR_1	67	74	PF00244	0.517
LIG_14-3-3_CanoR_1	97	105	PF00244	0.502
LIG_Actin_WH2_2	38	54	PF00022	0.517
LIG_BIR_III_4	53	57	PF00653	0.517
LIG_FHA_1	16	22	PF00498	0.468
LIG_FHA_1	46	52	PF00498	0.517
LIG_FHA_1	63	69	PF00498	0.517
LIG_FHA_2	29	35	PF00498	0.430
LIG_LIR_Gen_1	61	68	PF02991	0.447
LIG_LIR_Gen_1	71	79	PF02991	0.419
LIG_LIR_Nem_3	40	45	PF02991	0.414
LIG_LIR_Nem_3	61	66	PF02991	0.405
LIG_SH2_SRC	107	110	PF00017	0.465
LIG_SH2_STAP1	107	111	PF00017	0.491
LIG_SH2_STAT5	95	98	PF00017	0.401
LIG_SH3_3	118	124	PF00018	0.457
LIG_WRC_WIRS_1	38	43	PF05994	0.517
LIG_WRC_WIRS_1	63	68	PF05994	0.492
MOD_CK1_1	58	64	PF00069	0.417
MOD_GlcNHglycan	102	105	PF01048	0.338
MOD_GlcNHglycan	15	18	PF01048	0.536
MOD_GlcNHglycan	60	63	PF01048	0.211
MOD_GSK3_1	58	65	PF00069	0.453
MOD_GSK3_1	96	103	PF00069	0.334
MOD_N-GLC_1	116	121	PF02516	0.567
MOD_N-GLC_1	4	9	PF02516	0.573
MOD_NEK2_1	91	96	PF00069	0.362
MOD_NEK2_2	62	67	PF00069	0.491
MOD_NEK2_2	75	80	PF00069	0.403
MOD_PKA_2	66	72	PF00069	0.492
MOD_PKA_2	96	102	PF00069	0.508
MOD_SUMO_rev_2	53	59	PF00179	0.517
TRG_ENDOCYTIC_2	42	45	PF00928	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z2	Leptomonas seymouri	29%	96%
A0A0N1I2T7	Leptomonas seymouri	90%	100%
A0A0S4J311	Bodo saltans	59%	100%
A0A0S4JKJ5	Bodo saltans	38%	69%
A0A1X0NTL2	Trypanosomatidae	44%	71%
A0A1X0P0Y7	Trypanosomatidae	59%	100%
A0A1X0P102	Trypanosomatidae	60%	100%
A0A1X0P2H6	Trypanosomatidae	33%	91%
A0A3Q8IMA7	Leishmania donovani	94%	100%
A0A3R7KDP6	Trypanosoma rangeli	59%	100%
A0A422NG57	Trypanosoma rangeli	61%	100%
A4HIQ2	Leishmania braziliensis	30%	91%
A4I919	Leishmania infantum	95%	100%
C9ZRC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	84%
C9ZRQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	72%
D0A516	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A517	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B3Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	74%
E9B3Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q440	Leishmania major	96%	100%
Q9LIS2	Arabidopsis thaliana	34%	95%