Lipase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Lipase-like protein

Gene product:

lipase precursor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLK7_LEIBR

TriTrypDb:

LbrM.33.1730 , LBRM2903_330023500

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 7
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	17
GO:0008152	metabolic process	1	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004806	triglyceride lipase activity	5	7
GO:0016298	lipase activity	4	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0052689	carboxylic ester hydrolase activity	4	8
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	5	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	268	270	PF00675	0.282
CLV_PCSK_KEX2_1	2	4	PF00082	0.429
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.351
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DOC_MAPK_gen_1	2	10	PF00069	0.323
DOC_MAPK_gen_1	250	259	PF00069	0.284
DOC_MAPK_MEF2A_6	124	132	PF00069	0.274
DOC_PP1_RVXF_1	315	321	PF00149	0.403
DOC_PP2B_LxvP_1	197	200	PF13499	0.158
DOC_PP2B_LxvP_1	241	244	PF13499	0.259
DOC_USP7_MATH_1	145	149	PF00917	0.271
DOC_USP7_MATH_1	253	257	PF00917	0.373
DOC_USP7_MATH_1	34	38	PF00917	0.339
DOC_USP7_MATH_1	41	45	PF00917	0.315
DOC_WW_Pin1_4	260	265	PF00397	0.420
LIG_14-3-3_CanoR_1	144	154	PF00244	0.201
LIG_14-3-3_CanoR_1	209	215	PF00244	0.278
LIG_14-3-3_CanoR_1	222	230	PF00244	0.254
LIG_14-3-3_CanoR_1	42	46	PF00244	0.451
LIG_14-3-3_CanoR_1	97	107	PF00244	0.392
LIG_Actin_WH2_2	311	326	PF00022	0.254
LIG_BRCT_BRCA1_1	107	111	PF00533	0.326
LIG_BRCT_BRCA1_1	236	240	PF00533	0.376
LIG_eIF4E_1	107	113	PF01652	0.158
LIG_EVH1_2	234	238	PF00568	0.180
LIG_FHA_1	101	107	PF00498	0.381
LIG_FHA_1	209	215	PF00498	0.291
LIG_FHA_1	330	336	PF00498	0.399
LIG_FHA_1	5	11	PF00498	0.445
LIG_LIR_Gen_1	135	143	PF02991	0.329
LIG_LIR_Gen_1	156	161	PF02991	0.431
LIG_LIR_Gen_1	180	188	PF02991	0.158
LIG_LIR_Gen_1	4	13	PF02991	0.382
LIG_LIR_Gen_1	74	85	PF02991	0.388
LIG_LIR_Nem_3	110	116	PF02991	0.213
LIG_LIR_Nem_3	135	139	PF02991	0.349
LIG_LIR_Nem_3	152	157	PF02991	0.255
LIG_LIR_Nem_3	237	241	PF02991	0.369
LIG_LIR_Nem_3	4	8	PF02991	0.494
LIG_LIR_Nem_3	74	80	PF02991	0.274
LIG_MYND_1	231	235	PF01753	0.160
LIG_Pex14_2	182	186	PF04695	0.158
LIG_PTB_Apo_2	201	208	PF02174	0.274
LIG_SH2_CRK	157	161	PF00017	0.246
LIG_SH2_CRK	315	319	PF00017	0.544
LIG_SH2_NCK_1	31	35	PF00017	0.452
LIG_SH2_NCK_1	40	44	PF00017	0.390
LIG_SH2_SRC	29	32	PF00017	0.421
LIG_SH2_STAP1	107	111	PF00017	0.166
LIG_SH2_STAP1	133	137	PF00017	0.419
LIG_SH2_STAP1	31	35	PF00017	0.257
LIG_SH2_STAP1	315	319	PF00017	0.247
LIG_SH2_STAP1	69	73	PF00017	0.215
LIG_SH2_STAT5	136	139	PF00017	0.309
LIG_SH2_STAT5	195	198	PF00017	0.308
LIG_SH2_STAT5	286	289	PF00017	0.296
LIG_SH2_STAT5	29	32	PF00017	0.340
LIG_SH2_STAT5	45	48	PF00017	0.297
LIG_SH2_STAT5	69	72	PF00017	0.387
LIG_SH3_3	185	191	PF00018	0.367
LIG_SH3_3	199	205	PF00018	0.243
LIG_SH3_3	228	234	PF00018	0.247
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.531
LIG_SUMO_SIM_par_1	190	196	PF11976	0.407
LIG_SUMO_SIM_par_1	276	282	PF11976	0.265
LIG_WRC_WIRS_1	69	74	PF05994	0.401
LIG_WRC_WIRS_1	77	82	PF05994	0.329
LIG_WRPW_2	66	69	PF00400	0.211
MOD_CK1_1	135	141	PF00069	0.211
MOD_CK1_1	294	300	PF00069	0.474
MOD_CK1_1	303	309	PF00069	0.501
MOD_CK1_1	55	61	PF00069	0.277
MOD_GlcNHglycan	100	103	PF01048	0.385
MOD_GlcNHglycan	324	327	PF01048	0.483
MOD_GSK3_1	145	152	PF00069	0.298
MOD_GSK3_1	265	272	PF00069	0.348
MOD_GSK3_1	287	294	PF00069	0.350
MOD_GSK3_1	67	74	PF00069	0.421
MOD_GSK3_1	96	103	PF00069	0.246
MOD_N-GLC_1	116	121	PF02516	0.229
MOD_N-GLC_1	253	258	PF02516	0.376
MOD_N-GLC_1	260	265	PF02516	0.351
MOD_N-GLC_1	52	57	PF02516	0.268
MOD_NEK2_1	132	137	PF00069	0.339
MOD_NEK2_1	248	253	PF00069	0.429
MOD_NEK2_1	287	292	PF00069	0.445
MOD_NEK2_1	329	334	PF00069	0.395
MOD_NEK2_1	52	57	PF00069	0.424
MOD_NEK2_1	72	77	PF00069	0.371
MOD_NEK2_1	96	101	PF00069	0.357
MOD_NEK2_2	68	73	PF00069	0.205
MOD_OFUCOSY	293	298	PF10250	0.352
MOD_PIKK_1	138	144	PF00454	0.198
MOD_PIKK_1	303	309	PF00454	0.346
MOD_PKA_1	269	275	PF00069	0.249
MOD_PKA_2	208	214	PF00069	0.341
MOD_PKA_2	221	227	PF00069	0.237
MOD_PKA_2	41	47	PF00069	0.392
MOD_PKA_2	96	102	PF00069	0.287
MOD_Plk_1	253	259	PF00069	0.342
MOD_Plk_1	3	9	PF00069	0.318
MOD_Plk_4	107	113	PF00069	0.354
MOD_Plk_4	132	138	PF00069	0.278
MOD_Plk_4	181	187	PF00069	0.346
MOD_Plk_4	253	259	PF00069	0.336
MOD_Plk_4	47	53	PF00069	0.296
MOD_Plk_4	68	74	PF00069	0.286
MOD_ProDKin_1	260	266	PF00069	0.418
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.236
TRG_ENDOCYTIC_2	136	139	PF00928	0.313
TRG_ENDOCYTIC_2	157	160	PF00928	0.419
TRG_ENDOCYTIC_2	315	318	PF00928	0.474
TRG_ENDOCYTIC_2	69	72	PF00928	0.416
TRG_ENDOCYTIC_2	77	80	PF00928	0.388
TRG_ER_diArg_1	249	252	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.234

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	39%	93%
A0A0S4IJE8	Bodo saltans	38%	100%
A0A0S4J5D7	Bodo saltans	38%	100%
A0A0S4JTA1	Bodo saltans	39%	100%
A0A1X0NZH3	Trypanosomatidae	41%	79%
A0A1X0P001	Trypanosomatidae	41%	98%
A0A3Q8IFI3	Leishmania donovani	36%	92%
A0A3Q8IG97	Leishmania donovani	40%	100%
A0A3S7X4C1	Leishmania donovani	46%	100%
A0A422NPJ5	Trypanosoma rangeli	42%	68%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A4HJN0	Leishmania braziliensis	35%	100%
A4I6H7	Leishmania infantum	40%	100%
A4I6H8	Leishmania infantum	47%	100%
A4I752	Leishmania infantum	36%	92%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	100%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	93%
O42807	Aspergillus niger	28%	100%
O42815	Aspergillus tubingensis	29%	100%
O59952	Thermomyces lanuginosus	37%	100%
P0CT91	Sodiomyces alcalophilus	27%	81%
P19515	Rhizomucor miehei	38%	93%
P47145	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P61871	Rhizopus niveus	37%	86%
P61872	Rhizopus oryzae	37%	86%
Q0CBM7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	100%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q4Q615	Leishmania major	35%	100%
Q4Q6I0	Leishmania major	39%	100%
Q9BHD5	Leishmania major	46%	100%
Q9P979	Aspergillus awamori	31%	100%
Q9XTR8	Caenorhabditis elegans	28%	95%
V5B761	Trypanosoma cruzi	40%	100%