RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HLK6_LEIBR

TriTrypDb:

LbrM.33.1720 , LBRM2903_330022900

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.522
CLV_NRD_NRD_1	66	68	PF00675	0.643
CLV_PCSK_KEX2_1	110	112	PF00082	0.300
CLV_PCSK_KEX2_1	66	68	PF00082	0.625
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.300
CLV_PCSK_SKI1_1	179	183	PF00082	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_SCF_FBW7_1	194	201	PF00400	0.600
DEG_SCF_FBW7_1	54	61	PF00400	0.614
DOC_MAPK_gen_1	69	78	PF00069	0.564
DOC_USP7_MATH_1	120	124	PF00917	0.501
DOC_USP7_MATH_1	145	149	PF00917	0.493
DOC_USP7_MATH_1	192	196	PF00917	0.623
DOC_USP7_MATH_1	198	202	PF00917	0.584
DOC_USP7_MATH_1	45	49	PF00917	0.485
DOC_WW_Pin1_4	116	121	PF00397	0.670
DOC_WW_Pin1_4	13	18	PF00397	0.490
DOC_WW_Pin1_4	194	199	PF00397	0.597
DOC_WW_Pin1_4	54	59	PF00397	0.609
LIG_APCC_ABBA_1	182	187	PF00400	0.595
LIG_BRCT_BRCA1_1	129	133	PF00533	0.529
LIG_FHA_1	168	174	PF00498	0.588
LIG_FHA_1	197	203	PF00498	0.587
LIG_FHA_2	136	142	PF00498	0.519
LIG_FHA_2	84	90	PF00498	0.499
LIG_LIR_Nem_3	130	136	PF02991	0.497
LIG_LIR_Nem_3	95	100	PF02991	0.501
LIG_PTB_Apo_2	18	25	PF02174	0.506
LIG_PTB_Phospho_1	18	24	PF10480	0.508
LIG_SH2_CRK	97	101	PF00017	0.511
LIG_SH2_NCK_1	60	64	PF00017	0.638
LIG_SH2_PTP2	2	5	PF00017	0.475
LIG_SH2_SRC	2	5	PF00017	0.450
LIG_SH2_STAP1	204	208	PF00017	0.597
LIG_SH2_STAT3	38	41	PF00017	0.606
LIG_SH2_STAT5	153	156	PF00017	0.535
LIG_SH2_STAT5	166	169	PF00017	0.547
LIG_SH2_STAT5	2	5	PF00017	0.499
LIG_SH2_STAT5	38	41	PF00017	0.603
LIG_SH3_3	131	137	PF00018	0.491
LIG_SH3_3	186	192	PF00018	0.624
LIG_SH3_3	59	65	PF00018	0.635
LIG_SUMO_SIM_anti_2	143	148	PF11976	0.520
LIG_SUMO_SIM_par_1	102	109	PF11976	0.507
LIG_WW_3	63	67	PF00397	0.629
MOD_CDC14_SPxK_1	119	122	PF00782	0.514
MOD_CDK_SPxK_1	116	122	PF00069	0.524
MOD_CK1_1	13	19	PF00069	0.500
MOD_CK2_1	135	141	PF00069	0.522
MOD_GlcNHglycan	130	133	PF01048	0.499
MOD_GSK3_1	106	113	PF00069	0.463
MOD_GSK3_1	116	123	PF00069	0.621
MOD_GSK3_1	128	135	PF00069	0.517
MOD_GSK3_1	167	174	PF00069	0.571
MOD_GSK3_1	192	199	PF00069	0.606
MOD_GSK3_1	45	52	PF00069	0.501
MOD_GSK3_1	54	61	PF00069	0.614
MOD_N-GLC_1	111	116	PF02516	0.415
MOD_NEK2_1	10	15	PF00069	0.479
MOD_NEK2_1	106	111	PF00069	0.500
MOD_NEK2_1	36	41	PF00069	0.607
MOD_NEK2_1	43	48	PF00069	0.565
MOD_NEK2_1	49	54	PF00069	0.515
MOD_NEK2_2	145	150	PF00069	0.510
MOD_PIKK_1	37	43	PF00454	0.480
MOD_PIKK_1	8	14	PF00454	0.471
MOD_PKA_1	110	116	PF00069	0.424
MOD_PKA_2	110	116	PF00069	0.459
MOD_Plk_4	15	21	PF00069	0.677
MOD_Plk_4	45	51	PF00069	0.503
MOD_ProDKin_1	116	122	PF00069	0.670
MOD_ProDKin_1	13	19	PF00069	0.488
MOD_ProDKin_1	194	200	PF00069	0.592
MOD_ProDKin_1	54	60	PF00069	0.613
TRG_ENDOCYTIC_2	97	100	PF00928	0.496
TRG_ER_diArg_1	65	67	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P505	Leptomonas seymouri	68%	100%
A0A0N1I1M2	Leptomonas seymouri	32%	67%
A0A3S5H7Q7	Leishmania donovani	30%	67%
A0A3S7X6S0	Leishmania donovani	84%	100%
A4HJR5	Leishmania braziliensis	31%	67%
A4I917	Leishmania infantum	84%	100%
E9B3Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q442	Leishmania major	84%	100%