Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLK4_LEIBR

TriTrypDb:

LbrM.33.1700 , LBRM2903_330022700

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.508
CLV_C14_Caspase3-7	402	406	PF00656	0.537
CLV_NRD_NRD_1	25	27	PF00675	0.422
CLV_NRD_NRD_1	284	286	PF00675	0.633
CLV_NRD_NRD_1	299	301	PF00675	0.503
CLV_NRD_NRD_1	462	464	PF00675	0.544
CLV_NRD_NRD_1	5	7	PF00675	0.661
CLV_PCSK_FUR_1	3	7	PF00082	0.662
CLV_PCSK_KEX2_1	25	27	PF00082	0.422
CLV_PCSK_KEX2_1	284	286	PF00082	0.596
CLV_PCSK_KEX2_1	298	300	PF00082	0.567
CLV_PCSK_KEX2_1	462	464	PF00082	0.544
CLV_PCSK_KEX2_1	5	7	PF00082	0.661
CLV_PCSK_KEX2_1	530	532	PF00082	0.338
CLV_PCSK_KEX2_1	61	63	PF00082	0.530
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.342
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.530
CLV_PCSK_PC7_1	57	63	PF00082	0.520
CLV_PCSK_SKI1_1	132	136	PF00082	0.619
CLV_PCSK_SKI1_1	203	207	PF00082	0.499
DEG_APCC_DBOX_1	454	462	PF00400	0.494
DEG_APCC_KENBOX_2	242	246	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SCF_FBW7_2	330	336	PF00400	0.636
DEG_SCF_FBW7_2	67	73	PF00400	0.534
DEG_SPOP_SBC_1	150	154	PF00917	0.541
DEG_SPOP_SBC_1	216	220	PF00917	0.607
DOC_CDC14_PxL_1	259	267	PF14671	0.500
DOC_CDC14_PxL_1	553	561	PF14671	0.454
DOC_CKS1_1	330	335	PF01111	0.647
DOC_CKS1_1	67	72	PF01111	0.536
DOC_MAPK_DCC_7	510	518	PF00069	0.486
DOC_MAPK_MEF2A_6	451	460	PF00069	0.576
DOC_PP4_FxxP_1	180	183	PF00568	0.587
DOC_PP4_FxxP_1	357	360	PF00568	0.504
DOC_USP7_MATH_1	121	125	PF00917	0.539
DOC_USP7_MATH_1	216	220	PF00917	0.584
DOC_USP7_MATH_1	289	293	PF00917	0.531
DOC_USP7_MATH_1	338	342	PF00917	0.523
DOC_USP7_MATH_1	82	86	PF00917	0.619
DOC_USP7_UBL2_3	352	356	PF12436	0.507
DOC_WW_Pin1_4	187	192	PF00397	0.547
DOC_WW_Pin1_4	205	210	PF00397	0.535
DOC_WW_Pin1_4	228	233	PF00397	0.511
DOC_WW_Pin1_4	252	257	PF00397	0.476
DOC_WW_Pin1_4	329	334	PF00397	0.636
DOC_WW_Pin1_4	386	391	PF00397	0.595
DOC_WW_Pin1_4	430	435	PF00397	0.676
DOC_WW_Pin1_4	442	447	PF00397	0.624
DOC_WW_Pin1_4	66	71	PF00397	0.568
LIG_14-3-3_CanoR_1	122	126	PF00244	0.636
LIG_14-3-3_CanoR_1	298	308	PF00244	0.517
LIG_14-3-3_CanoR_1	313	319	PF00244	0.465
LIG_14-3-3_CanoR_1	44	49	PF00244	0.680
LIG_14-3-3_CanoR_1	539	544	PF00244	0.495
LIG_BIR_III_4	405	409	PF00653	0.534
LIG_BRCT_BRCA1_1	189	193	PF00533	0.487
LIG_BRCT_BRCA1_1	353	357	PF00533	0.498
LIG_BRCT_BRCA1_1	48	52	PF00533	0.492
LIG_deltaCOP1_diTrp_1	194	202	PF00928	0.481
LIG_eIF4E_1	260	266	PF01652	0.409
LIG_FHA_1	187	193	PF00498	0.645
LIG_FHA_1	26	32	PF00498	0.459
LIG_FHA_1	267	273	PF00498	0.518
LIG_FHA_1	398	404	PF00498	0.587
LIG_FHA_1	455	461	PF00498	0.672
LIG_FHA_1	67	73	PF00498	0.534
LIG_FHA_2	133	139	PF00498	0.646
LIG_FHA_2	151	157	PF00498	0.566
LIG_FHA_2	239	245	PF00498	0.503
LIG_FHA_2	315	321	PF00498	0.562
LIG_FHA_2	353	359	PF00498	0.626
LIG_FHA_2	387	393	PF00498	0.547
LIG_FHA_2	400	406	PF00498	0.535
LIG_FHA_2	409	415	PF00498	0.469
LIG_FHA_2	496	502	PF00498	0.381
LIG_Integrin_RGD_1	486	488	PF01839	0.416
LIG_LIR_Apic_2	179	183	PF02991	0.509
LIG_LIR_Apic_2	258	263	PF02991	0.406
LIG_LIR_Apic_2	354	360	PF02991	0.499
LIG_LIR_Apic_2	377	383	PF02991	0.553
LIG_LIR_Gen_1	361	370	PF02991	0.608
LIG_LIR_Gen_1	415	426	PF02991	0.494
LIG_LIR_Gen_1	472	482	PF02991	0.392
LIG_LIR_Nem_3	194	198	PF02991	0.536
LIG_LIR_Nem_3	258	262	PF02991	0.488
LIG_LIR_Nem_3	361	365	PF02991	0.668
LIG_LIR_Nem_3	415	421	PF02991	0.516
LIG_LIR_Nem_3	472	477	PF02991	0.401
LIG_LIR_Nem_3	478	483	PF02991	0.369
LIG_LIR_Nem_3	555	559	PF02991	0.438
LIG_LYPXL_yS_3	556	559	PF13949	0.439
LIG_SH2_CRK	107	111	PF00017	0.556
LIG_SH2_CRK	480	484	PF00017	0.358
LIG_SH2_CRK	554	558	PF00017	0.521
LIG_SH2_PTP2	418	421	PF00017	0.584
LIG_SH2_SRC	418	421	PF00017	0.648
LIG_SH2_SRC	535	538	PF00017	0.383
LIG_SH2_SRC	554	557	PF00017	0.459
LIG_SH2_STAP1	48	52	PF00017	0.492
LIG_SH2_STAP1	480	484	PF00017	0.358
LIG_SH2_STAT3	198	201	PF00017	0.378
LIG_SH2_STAT5	198	201	PF00017	0.518
LIG_SH2_STAT5	260	263	PF00017	0.417
LIG_SH2_STAT5	418	421	PF00017	0.585
LIG_SH3_1	57	63	PF00018	0.520
LIG_SH3_3	385	391	PF00018	0.636
LIG_SH3_3	453	459	PF00018	0.614
LIG_SH3_3	57	63	PF00018	0.541
LIG_SH3_3	64	70	PF00018	0.518
LIG_SH3_CIN85_PxpxPR_1	446	451	PF14604	0.515
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.523
LIG_TRFH_1	259	263	PF08558	0.483
LIG_TRFH_1	264	268	PF08558	0.482
LIG_TYR_ITIM	416	421	PF00017	0.645
LIG_WRC_WIRS_1	359	364	PF05994	0.665
MOD_CDK_SPK_2	446	451	PF00069	0.515
MOD_CDK_SPxxK_3	444	451	PF00069	0.517
MOD_CK1_1	151	157	PF00069	0.556
MOD_CK1_1	21	27	PF00069	0.538
MOD_CK1_1	219	225	PF00069	0.657
MOD_CK1_1	342	348	PF00069	0.511
MOD_CK1_1	410	416	PF00069	0.575
MOD_CK1_1	424	430	PF00069	0.599
MOD_CK1_1	454	460	PF00069	0.557
MOD_CK1_1	47	53	PF00069	0.765
MOD_CK1_1	55	61	PF00069	0.675
MOD_CK1_1	85	91	PF00069	0.526
MOD_CK2_1	121	127	PF00069	0.667
MOD_CK2_1	132	138	PF00069	0.687
MOD_CK2_1	238	244	PF00069	0.536
MOD_CK2_1	314	320	PF00069	0.572
MOD_CK2_1	352	358	PF00069	0.595
MOD_CK2_1	360	366	PF00069	0.558
MOD_CK2_1	386	392	PF00069	0.549
MOD_CK2_1	85	91	PF00069	0.527
MOD_GlcNHglycan	11	14	PF01048	0.614
MOD_GlcNHglycan	174	177	PF01048	0.707
MOD_GlcNHglycan	20	23	PF01048	0.499
MOD_GlcNHglycan	221	224	PF01048	0.673
MOD_GlcNHglycan	291	294	PF01048	0.546
MOD_GlcNHglycan	309	312	PF01048	0.454
MOD_GlcNHglycan	491	494	PF01048	0.369
MOD_GlcNHglycan	77	80	PF01048	0.771
MOD_GlcNHglycan	87	90	PF01048	0.639
MOD_GSK3_1	132	139	PF00069	0.624
MOD_GSK3_1	150	157	PF00069	0.627
MOD_GSK3_1	172	179	PF00069	0.590
MOD_GSK3_1	21	28	PF00069	0.487
MOD_GSK3_1	215	222	PF00069	0.674
MOD_GSK3_1	230	237	PF00069	0.573
MOD_GSK3_1	309	316	PF00069	0.577
MOD_GSK3_1	338	345	PF00069	0.573
MOD_GSK3_1	382	389	PF00069	0.618
MOD_GSK3_1	408	415	PF00069	0.545
MOD_GSK3_1	421	428	PF00069	0.587
MOD_GSK3_1	442	449	PF00069	0.553
MOD_GSK3_1	495	502	PF00069	0.378
MOD_GSK3_1	535	542	PF00069	0.537
MOD_LATS_1	215	221	PF00433	0.522
MOD_N-GLC_1	539	544	PF02516	0.495
MOD_N-GLC_1	55	60	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	238	243	PF00069	0.580
MOD_NEK2_1	279	284	PF00069	0.738
MOD_NEK2_1	489	494	PF00069	0.419
MOD_NEK2_1	499	504	PF00069	0.458
MOD_NEK2_1	52	57	PF00069	0.600
MOD_NEK2_2	399	404	PF00069	0.537
MOD_OFUCOSY	500	505	PF10250	0.325
MOD_PIKK_1	158	164	PF00454	0.553
MOD_PIKK_1	230	236	PF00454	0.500
MOD_PK_1	83	89	PF00069	0.537
MOD_PKA_1	25	31	PF00069	0.461
MOD_PKA_1	299	305	PF00069	0.458
MOD_PKA_2	121	127	PF00069	0.637
MOD_PKA_2	139	145	PF00069	0.545
MOD_PKA_2	154	160	PF00069	0.511
MOD_PKA_2	25	31	PF00069	0.479
MOD_PKA_2	299	305	PF00069	0.504
MOD_PKA_2	454	460	PF00069	0.497
MOD_PKA_2	82	88	PF00069	0.564
MOD_Plk_1	158	164	PF00069	0.580
MOD_Plk_1	234	240	PF00069	0.595
MOD_Plk_1	487	493	PF00069	0.315
MOD_Plk_1	539	545	PF00069	0.499
MOD_Plk_2-3	392	398	PF00069	0.694
MOD_ProDKin_1	187	193	PF00069	0.541
MOD_ProDKin_1	205	211	PF00069	0.549
MOD_ProDKin_1	228	234	PF00069	0.510
MOD_ProDKin_1	252	258	PF00069	0.469
MOD_ProDKin_1	329	335	PF00069	0.637
MOD_ProDKin_1	386	392	PF00069	0.598
MOD_ProDKin_1	430	436	PF00069	0.679
MOD_ProDKin_1	442	448	PF00069	0.626
MOD_ProDKin_1	66	72	PF00069	0.569
MOD_SUMO_rev_2	124	134	PF00179	0.529
MOD_SUMO_rev_2	316	323	PF00179	0.488
MOD_SUMO_rev_2	55	63	PF00179	0.649
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.460
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.506
TRG_ENDOCYTIC_2	259	262	PF00928	0.517
TRG_ENDOCYTIC_2	418	421	PF00928	0.611
TRG_ENDOCYTIC_2	480	483	PF00928	0.359
TRG_ENDOCYTIC_2	556	559	PF00928	0.439
TRG_ER_diArg_1	2	5	PF00400	0.666
TRG_ER_diArg_1	283	285	PF00400	0.563
TRG_ER_diArg_1	298	300	PF00400	0.562
TRG_ER_diArg_1	461	463	PF00400	0.471
TRG_ER_diArg_1	510	513	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L4	Leptomonas seymouri	40%	100%
A0A3Q8IEV6	Leishmania donovani	68%	97%
A4I915	Leishmania infantum	68%	93%
E9B3Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q444	Leishmania major	66%	100%