LeishMANIAdb
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Amino acid permease-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease-like protein
Gene product:
amino acid permease-like protein
Species:
Leishmania braziliensis
UniProt:
A4HLK3_LEIBR
TriTrypDb:
LbrM.33.1690 , LBRM2903_330022600
Length:
485

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 24
NetGPI no yes: 0, no: 24
Cellular components
Term Name Level Count
GO:0016020 membrane 2 22
GO:0110165 cellular anatomical entity 1 22

Expansion

Sequence features

A4HLK3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK3

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 3
GO:0006810 transport 3 3
GO:0006865 amino acid transport 5 3
GO:0009987 cellular process 1 3
GO:0015849 organic acid transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0015171 amino acid transmembrane transporter activity 5 3
GO:0015179 L-amino acid transmembrane transporter activity 6 3
GO:0022857 transmembrane transporter activity 2 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 236 238 PF00675 0.212
CLV_PCSK_KEX2_1 236 238 PF00082 0.242
CLV_PCSK_SKI1_1 284 288 PF00082 0.353
CLV_PCSK_SKI1_1 332 336 PF00082 0.206
CLV_PCSK_SKI1_1 481 485 PF00082 0.452
CLV_PCSK_SKI1_1 80 84 PF00082 0.257
CLV_PCSK_SKI1_1 92 96 PF00082 0.285
CLV_Separin_Metazoa 89 93 PF03568 0.335
DEG_ODPH_VHL_1 449 461 PF01847 0.528
DEG_SCF_FBW7_1 127 134 PF00400 0.319
DOC_ANK_TNKS_1 175 182 PF00023 0.394
DOC_CDC14_PxL_1 146 154 PF14671 0.394
DOC_CKS1_1 128 133 PF01111 0.406
DOC_CKS1_1 293 298 PF01111 0.160
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.257
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.314
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.282
DOC_MAPK_gen_1 236 243 PF00069 0.432
DOC_MAPK_HePTP_8 391 403 PF00069 0.353
DOC_MAPK_MEF2A_6 206 214 PF00069 0.272
DOC_MAPK_MEF2A_6 236 245 PF00069 0.473
DOC_MAPK_MEF2A_6 394 403 PF00069 0.427
DOC_PP2B_LxvP_1 113 116 PF13499 0.341
DOC_PP2B_LxvP_1 210 213 PF13499 0.314
DOC_PP2B_LxvP_1 31 34 PF13499 0.302
DOC_PP2B_LxvP_1 412 415 PF13499 0.289
DOC_PP4_FxxP_1 434 437 PF00568 0.303
DOC_USP7_MATH_1 131 135 PF00917 0.387
DOC_USP7_UBL2_3 383 387 PF12436 0.462
DOC_WW_Pin1_4 127 132 PF00397 0.312
DOC_WW_Pin1_4 292 297 PF00397 0.160
LIG_14-3-3_CanoR_1 236 240 PF00244 0.522
LIG_14-3-3_CanoR_1 72 76 PF00244 0.518
LIG_APCC_ABBA_1 107 112 PF00400 0.194
LIG_BRCT_BRCA1_1 222 226 PF00533 0.339
LIG_BRCT_BRCA1_1 330 334 PF00533 0.521
LIG_Clathr_ClatBox_1 107 111 PF01394 0.394
LIG_FHA_1 120 126 PF00498 0.339
LIG_FHA_1 164 170 PF00498 0.307
LIG_FHA_1 293 299 PF00498 0.316
LIG_FHA_1 333 339 PF00498 0.562
LIG_FHA_1 403 409 PF00498 0.400
LIG_FHA_1 44 50 PF00498 0.314
LIG_FHA_1 460 466 PF00498 0.249
LIG_FHA_1 77 83 PF00498 0.482
LIG_FHA_2 452 458 PF00498 0.425
LIG_GBD_Chelix_1 224 232 PF00786 0.394
LIG_HCF-1_HBM_1 353 356 PF13415 0.353
LIG_IRF3_LxIS_1 152 158 PF10401 0.542
LIG_LIR_Apic_2 431 437 PF02991 0.338
LIG_LIR_Gen_1 158 168 PF02991 0.300
LIG_LIR_Gen_1 331 338 PF02991 0.509
LIG_LIR_Gen_1 454 464 PF02991 0.441
LIG_LIR_Gen_1 59 70 PF02991 0.292
LIG_LIR_Gen_1 74 83 PF02991 0.479
LIG_LIR_Nem_3 122 127 PF02991 0.207
LIG_LIR_Nem_3 137 141 PF02991 0.356
LIG_LIR_Nem_3 158 163 PF02991 0.300
LIG_LIR_Nem_3 166 171 PF02991 0.279
LIG_LIR_Nem_3 223 229 PF02991 0.293
LIG_LIR_Nem_3 331 337 PF02991 0.509
LIG_LIR_Nem_3 454 459 PF02991 0.437
LIG_LIR_Nem_3 59 65 PF02991 0.292
LIG_LIR_Nem_3 74 78 PF02991 0.494
LIG_PCNA_PIPBox_1 118 127 PF02747 0.296
LIG_PCNA_yPIPBox_3 118 132 PF02747 0.321
LIG_PCNA_yPIPBox_3 365 379 PF02747 0.353
LIG_PDZ_Class_2 480 485 PF00595 0.298
LIG_Pex14_2 463 467 PF04695 0.395
LIG_SH2_CRK 293 297 PF00017 0.331
LIG_SH2_NCK_1 319 323 PF00017 0.428
LIG_SH2_NCK_1 37 41 PF00017 0.318
LIG_SH2_PTP2 62 65 PF00017 0.229
LIG_SH2_SRC 37 40 PF00017 0.306
LIG_SH2_STAT3 440 443 PF00017 0.394
LIG_SH2_STAT5 106 109 PF00017 0.294
LIG_SH2_STAT5 124 127 PF00017 0.305
LIG_SH2_STAT5 177 180 PF00017 0.303
LIG_SH2_STAT5 263 266 PF00017 0.300
LIG_SH2_STAT5 290 293 PF00017 0.299
LIG_SH2_STAT5 358 361 PF00017 0.353
LIG_SH2_STAT5 62 65 PF00017 0.371
LIG_SH3_3 113 119 PF00018 0.274
LIG_SH3_3 176 182 PF00018 0.276
LIG_SUMO_SIM_anti_2 341 349 PF11976 0.521
LIG_SUMO_SIM_anti_2 419 425 PF11976 0.308
LIG_SUMO_SIM_anti_2 457 462 PF11976 0.370
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.390
LIG_SUMO_SIM_par_1 265 272 PF11976 0.378
LIG_SUMO_SIM_par_1 29 35 PF11976 0.325
LIG_SUMO_SIM_par_1 397 402 PF11976 0.260
LIG_SUMO_SIM_par_1 416 422 PF11976 0.321
LIG_SUMO_SIM_par_1 45 51 PF11976 0.279
LIG_SUMO_SIM_par_1 5 11 PF11976 0.605
LIG_SUMO_SIM_par_1 53 59 PF11976 0.307
LIG_SUMO_SIM_par_1 63 68 PF11976 0.463
LIG_TRAF2_1 74 77 PF00917 0.496
LIG_TYR_ITIM 104 109 PF00017 0.319
LIG_TYR_ITIM 60 65 PF00017 0.257
LIG_WRC_WIRS_1 135 140 PF05994 0.238
LIG_WRC_WIRS_1 157 162 PF05994 0.396
LIG_WRC_WIRS_1 216 221 PF05994 0.280
LIG_WRC_WIRS_1 460 465 PF05994 0.294
MOD_CDK_SPK_2 127 132 PF00069 0.321
MOD_CK1_1 134 140 PF00069 0.261
MOD_CK1_1 164 170 PF00069 0.338
MOD_CK1_1 186 192 PF00069 0.245
MOD_CK1_1 320 326 PF00069 0.426
MOD_CK1_1 419 425 PF00069 0.321
MOD_CK1_1 8 14 PF00069 0.594
MOD_CK2_1 451 457 PF00069 0.499
MOD_CK2_1 71 77 PF00069 0.494
MOD_Cter_Amidation 83 86 PF01082 0.318
MOD_GlcNHglycan 10 13 PF01048 0.365
MOD_GlcNHglycan 101 104 PF01048 0.282
MOD_GlcNHglycan 163 166 PF01048 0.312
MOD_GlcNHglycan 190 193 PF01048 0.457
MOD_GlcNHglycan 198 201 PF01048 0.457
MOD_GlcNHglycan 250 253 PF01048 0.212
MOD_GlcNHglycan 320 323 PF01048 0.253
MOD_GlcNHglycan 34 37 PF01048 0.340
MOD_GlcNHglycan 348 351 PF01048 0.318
MOD_GlcNHglycan 369 372 PF01048 0.159
MOD_GSK3_1 127 134 PF00069 0.240
MOD_GSK3_1 144 151 PF00069 0.328
MOD_GSK3_1 17 24 PF00069 0.328
MOD_GSK3_1 180 187 PF00069 0.315
MOD_GSK3_1 244 251 PF00069 0.328
MOD_GSK3_1 328 335 PF00069 0.545
MOD_GSK3_1 397 404 PF00069 0.314
MOD_N-GLC_2 201 203 PF02516 0.353
MOD_NEK2_1 120 125 PF00069 0.318
MOD_NEK2_1 15 20 PF00069 0.313
MOD_NEK2_1 155 160 PF00069 0.494
MOD_NEK2_1 161 166 PF00069 0.328
MOD_NEK2_1 188 193 PF00069 0.326
MOD_NEK2_1 21 26 PF00069 0.276
MOD_NEK2_1 235 240 PF00069 0.452
MOD_NEK2_1 248 253 PF00069 0.320
MOD_NEK2_1 346 351 PF00069 0.353
MOD_NEK2_1 427 432 PF00069 0.312
MOD_NEK2_2 479 484 PF00069 0.272
MOD_NEK2_2 53 58 PF00069 0.320
MOD_PKA_2 235 241 PF00069 0.490
MOD_PKA_2 308 314 PF00069 0.482
MOD_PKA_2 71 77 PF00069 0.518
MOD_Plk_1 332 338 PF00069 0.551
MOD_Plk_4 10 16 PF00069 0.500
MOD_Plk_4 120 126 PF00069 0.278
MOD_Plk_4 131 137 PF00069 0.211
MOD_Plk_4 156 162 PF00069 0.464
MOD_Plk_4 164 170 PF00069 0.344
MOD_Plk_4 220 226 PF00069 0.324
MOD_Plk_4 308 314 PF00069 0.523
MOD_Plk_4 416 422 PF00069 0.263
MOD_Plk_4 43 49 PF00069 0.313
MOD_Plk_4 451 457 PF00069 0.470
MOD_Plk_4 459 465 PF00069 0.271
MOD_Plk_4 479 485 PF00069 0.393
MOD_ProDKin_1 127 133 PF00069 0.312
MOD_ProDKin_1 292 298 PF00069 0.160
TRG_DiLeu_BaEn_1 342 347 PF01217 0.521
TRG_DiLeu_BaEn_3 342 348 PF01217 0.353
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.289
TRG_DiLeu_BaLyEn_6 123 128 PF01217 0.273
TRG_DiLeu_BaLyEn_6 205 210 PF01217 0.239
TRG_ENDOCYTIC_2 106 109 PF00928 0.315
TRG_ENDOCYTIC_2 124 127 PF00928 0.287
TRG_ENDOCYTIC_2 229 232 PF00928 0.446
TRG_ENDOCYTIC_2 62 65 PF00928 0.278
TRG_ENDOCYTIC_2 75 78 PF00928 0.458
TRG_ER_diArg_1 235 237 PF00400 0.521

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P613 Leptomonas seymouri 39% 100%
A0A0N1I3F8 Leptomonas seymouri 26% 91%
A0A0N1I3H4 Leptomonas seymouri 25% 88%
A0A0N1IAJ0 Leptomonas seymouri 28% 100%
A0A0N1IJ81 Leptomonas seymouri 75% 100%
A0A0N1PA98 Leptomonas seymouri 20% 79%
A0A0S4IV32 Bodo saltans 31% 99%
A0A0S4JHM8 Bodo saltans 23% 100%
A0A0S4JQ87 Bodo saltans 26% 100%
A0A1X0NNX9 Trypanosomatidae 27% 100%
A0A1X0P1N2 Trypanosomatidae 47% 100%
A0A1X0P4S1 Trypanosomatidae 39% 100%
A0A3Q8ID74 Leishmania donovani 24% 91%
A0A3Q8IHH7 Leishmania donovani 85% 99%
A0A3R7MQD8 Trypanosoma rangeli 26% 100%
A0A3R7MWF1 Trypanosoma rangeli 49% 100%
A0A3S7X4L2 Leishmania donovani 20% 80%
A0A3S7X4N4 Leishmania donovani 20% 80%
A0A3S7XA86 Leishmania donovani 38% 100%
A0A3S7XCE3 Leishmania donovani 26% 100%
A0A422MW74 Trypanosoma rangeli 24% 95%
A0A422N5W8 Trypanosoma rangeli 38% 100%
A1YG32 Pan paniscus 26% 96%
A4HFT5 Leishmania braziliensis 26% 100%
A4HJ35 Leishmania braziliensis 26% 100%
A4HJF8 Leishmania braziliensis 21% 100%
A4HJF9 Leishmania braziliensis 21% 100%
A4HJG1 Leishmania braziliensis 21% 100%
A4HJG3 Leishmania braziliensis 21% 100%
A4HJG5 Leishmania braziliensis 21% 100%
A4HNJ6 Leishmania braziliensis 37% 100%
A4HNJ7 Leishmania braziliensis 43% 100%
A4I6J8 Leishmania infantum 24% 91%
A4I914 Leishmania infantum 85% 99%
A4IC53 Leishmania infantum 38% 100%
A4IC66 Leishmania infantum 39% 100%
A4ICC3 Leishmania infantum 26% 100%
D0A4B3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 86%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AD45 Leishmania major 24% 91%
E9ADD7 Leishmania major 26% 100%
E9AG08 Leishmania major 38% 87%
E9AG09 Leishmania major 38% 87%
E9AHD9 Leishmania infantum 24% 91%
E9AHL2 Leishmania infantum 21% 100%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B3X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 99%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
F4KBM7 Arabidopsis thaliana 23% 100%
G3UVW3 Mus musculus 25% 100%
P38176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
P40074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
P40501 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 99%
Q28HE5 Xenopus tropicalis 26% 100%
Q4Q072 Leishmania major 27% 100%
Q4Q445 Leishmania major 84% 100%
Q4Q6N1 Leishmania major 23% 91%
Q503G8 Danio rerio 25% 100%
Q5E9S9 Bos taurus 23% 100%
Q5F468 Gallus gallus 24% 97%
Q5R9F5 Pongo abelii 24% 100%
Q5XH90 Xenopus tropicalis 23% 98%
Q6DEL1 Danio rerio 23% 100%
Q6DFE7 Xenopus laevis 22% 100%
Q6JWR2 Rattus norvegicus 23% 100%
Q6WWW3 Rattus norvegicus 27% 100%
Q8BWH0 Mus musculus 24% 100%
Q8R1S9 Mus musculus 23% 89%
Q8WUX1 Homo sapiens 23% 100%
Q96QD8 Homo sapiens 26% 96%
Q99624 Homo sapiens 24% 96%
Q9DCP2 Mus musculus 25% 96%
Q9EQ25 Rattus norvegicus 22% 89%
Q9JHE5 Rattus norvegicus 25% 96%
Q9JHZ9 Rattus norvegicus 25% 96%
Q9LI61 Arabidopsis thaliana 21% 100%
Q9LYM2 Arabidopsis thaliana 23% 100%
Q9M8L9 Arabidopsis thaliana 22% 99%
Q9NVC3 Homo sapiens 24% 100%
V5AXD0 Trypanosoma cruzi 48% 100%
V5BQ72 Trypanosoma cruzi 22% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS