Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLK2_LEIBR

TriTrypDb:

LbrM.33.1680 , LBRM2903_330022500

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000421	autophagosome membrane	6	1
GO:0005774	vacuolar membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HLK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK2

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	11
GO:0006996	organelle organization	4	11
GO:0007033	vacuole organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:1905037	autophagosome organization	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.418
CLV_C14_Caspase3-7	527	531	PF00656	0.618
CLV_C14_Caspase3-7	552	556	PF00656	0.447
CLV_NRD_NRD_1	208	210	PF00675	0.431
CLV_NRD_NRD_1	391	393	PF00675	0.399
CLV_NRD_NRD_1	428	430	PF00675	0.393
CLV_PCSK_KEX2_1	207	209	PF00082	0.432
CLV_PCSK_KEX2_1	390	392	PF00082	0.436
CLV_PCSK_KEX2_1	428	430	PF00082	0.393
CLV_PCSK_SKI1_1	180	184	PF00082	0.421
CLV_PCSK_SKI1_1	293	297	PF00082	0.269
CLV_PCSK_SKI1_1	396	400	PF00082	0.369
CLV_PCSK_SKI1_1	429	433	PF00082	0.525
CLV_PCSK_SKI1_1	442	446	PF00082	0.241
CLV_PCSK_SKI1_1	471	475	PF00082	0.410
CLV_PCSK_SKI1_1	539	543	PF00082	0.518
CLV_PCSK_SKI1_1	99	103	PF00082	0.583
DEG_APCC_DBOX_1	391	399	PF00400	0.467
DEG_COP1_1	4	12	PF00400	0.445
DOC_CYCLIN_RxL_1	471	480	PF00134	0.480
DOC_MAPK_gen_1	127	135	PF00069	0.313
DOC_MAPK_gen_1	468	478	PF00069	0.256
DOC_MAPK_JIP1_4	35	41	PF00069	0.325
DOC_MAPK_MEF2A_6	509	518	PF00069	0.406
DOC_PP1_RVXF_1	473	479	PF00149	0.270
DOC_USP7_MATH_1	198	202	PF00917	0.561
DOC_USP7_MATH_1	257	261	PF00917	0.658
DOC_USP7_MATH_1	265	269	PF00917	0.543
DOC_USP7_MATH_1	326	330	PF00917	0.479
DOC_USP7_MATH_1	431	435	PF00917	0.497
DOC_USP7_MATH_1	504	508	PF00917	0.367
DOC_USP7_MATH_1	528	532	PF00917	0.613
DOC_USP7_MATH_1	575	579	PF00917	0.467
DOC_USP7_MATH_1	83	87	PF00917	0.563
DOC_WW_Pin1_4	237	242	PF00397	0.745
DOC_WW_Pin1_4	531	536	PF00397	0.560
DOC_WW_Pin1_4	545	550	PF00397	0.408
DOC_WW_Pin1_4	8	13	PF00397	0.641
LIG_14-3-3_CanoR_1	167	173	PF00244	0.457
LIG_14-3-3_CanoR_1	246	251	PF00244	0.518
LIG_14-3-3_CanoR_1	269	273	PF00244	0.513
LIG_14-3-3_CanoR_1	309	317	PF00244	0.448
LIG_14-3-3_CanoR_1	442	449	PF00244	0.378
LIG_14-3-3_CanoR_1	509	516	PF00244	0.525
LIG_14-3-3_CanoR_1	70	78	PF00244	0.549
LIG_Actin_WH2_2	165	182	PF00022	0.439
LIG_Actin_WH2_2	19	37	PF00022	0.538
LIG_CaM_IQ_9	148	164	PF13499	0.526
LIG_Clathr_ClatBox_1	515	519	PF01394	0.286
LIG_CtBP_PxDLS_1	2	6	PF00389	0.462
LIG_DLG_GKlike_1	391	398	PF00625	0.464
LIG_FHA_1	146	152	PF00498	0.612
LIG_FHA_1	358	364	PF00498	0.456
LIG_FHA_1	381	387	PF00498	0.424
LIG_FHA_1	472	478	PF00498	0.412
LIG_FHA_1	497	503	PF00498	0.304
LIG_FHA_1	70	76	PF00498	0.487
LIG_FHA_2	108	114	PF00498	0.331
LIG_FHA_2	169	175	PF00498	0.454
LIG_FHA_2	182	188	PF00498	0.336
LIG_FHA_2	401	407	PF00498	0.375
LIG_FHA_2	422	428	PF00498	0.438
LIG_FHA_2	478	484	PF00498	0.265
LIG_FHA_2	87	93	PF00498	0.505
LIG_LIR_Gen_1	157	165	PF02991	0.407
LIG_LIR_Gen_1	42	52	PF02991	0.517
LIG_LIR_Nem_3	114	120	PF02991	0.394
LIG_LIR_Nem_3	157	161	PF02991	0.405
LIG_LIR_Nem_3	163	168	PF02991	0.412
LIG_LIR_Nem_3	42	47	PF02991	0.513
LIG_NRBOX	394	400	PF00104	0.455
LIG_Pex14_2	564	568	PF04695	0.450
LIG_SH2_CRK	117	121	PF00017	0.394
LIG_SH2_CRK	158	162	PF00017	0.454
LIG_SH2_CRK	165	169	PF00017	0.467
LIG_SH2_CRK	194	198	PF00017	0.288
LIG_SH2_CRK	44	48	PF00017	0.514
LIG_SH2_GRB2like	551	554	PF00017	0.440
LIG_SH2_STAT3	551	554	PF00017	0.495
LIG_SH2_STAT5	109	112	PF00017	0.445
LIG_SH2_STAT5	158	161	PF00017	0.519
LIG_SH2_STAT5	178	181	PF00017	0.468
LIG_SH2_STAT5	317	320	PF00017	0.441
LIG_SH2_STAT5	333	336	PF00017	0.360
LIG_SH2_STAT5	44	47	PF00017	0.516
LIG_SH3_3	4	10	PF00018	0.650
LIG_SH3_3	543	549	PF00018	0.378
LIG_SUMO_SIM_anti_2	406	413	PF11976	0.232
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.261
LIG_SUMO_SIM_anti_2	510	517	PF11976	0.401
LIG_SUMO_SIM_par_1	195	202	PF11976	0.337
LIG_SUMO_SIM_par_1	462	469	PF11976	0.427
LIG_SUMO_SIM_par_1	575	582	PF11976	0.460
LIG_TYR_ITIM	192	197	PF00017	0.300
MOD_CDK_SPxxK_3	239	246	PF00069	0.471
MOD_CK1_1	249	255	PF00069	0.571
MOD_CK1_1	259	265	PF00069	0.584
MOD_CK1_1	268	274	PF00069	0.512
MOD_CK1_1	279	285	PF00069	0.388
MOD_CK1_1	319	325	PF00069	0.295
MOD_CK1_1	379	385	PF00069	0.262
MOD_CK1_1	394	400	PF00069	0.310
MOD_CK1_1	43	49	PF00069	0.577
MOD_CK1_1	507	513	PF00069	0.403
MOD_CK1_1	531	537	PF00069	0.620
MOD_CK1_1	69	75	PF00069	0.595
MOD_CK1_1	86	92	PF00069	0.448
MOD_CK2_1	107	113	PF00069	0.434
MOD_CK2_1	135	141	PF00069	0.439
MOD_CK2_1	168	174	PF00069	0.524
MOD_CK2_1	181	187	PF00069	0.360
MOD_CK2_1	477	483	PF00069	0.266
MOD_CK2_1	86	92	PF00069	0.512
MOD_GlcNHglycan	226	229	PF01048	0.635
MOD_GlcNHglycan	278	281	PF01048	0.316
MOD_GlcNHglycan	297	300	PF01048	0.266
MOD_GlcNHglycan	310	313	PF01048	0.387
MOD_GlcNHglycan	370	373	PF01048	0.247
MOD_GlcNHglycan	415	418	PF01048	0.260
MOD_GlcNHglycan	433	436	PF01048	0.361
MOD_GlcNHglycan	449	452	PF01048	0.249
MOD_GlcNHglycan	506	509	PF01048	0.476
MOD_GlcNHglycan	555	558	PF01048	0.638
MOD_GSK3_1	107	114	PF00069	0.297
MOD_GSK3_1	245	252	PF00069	0.600
MOD_GSK3_1	253	260	PF00069	0.527
MOD_GSK3_1	376	383	PF00069	0.246
MOD_GSK3_1	427	434	PF00069	0.473
MOD_GSK3_1	43	50	PF00069	0.513
MOD_GSK3_1	504	511	PF00069	0.400
MOD_GSK3_1	526	533	PF00069	0.742
MOD_GSK3_1	545	552	PF00069	0.403
MOD_GSK3_1	577	584	PF00069	0.351
MOD_GSK3_1	82	89	PF00069	0.609
MOD_LATS_1	440	446	PF00433	0.355
MOD_N-GLC_1	224	229	PF02516	0.570
MOD_N-GLC_1	246	251	PF02516	0.468
MOD_N-GLC_1	83	88	PF02516	0.570
MOD_NEK2_1	135	140	PF00069	0.317
MOD_NEK2_1	295	300	PF00069	0.280
MOD_NEK2_1	3	8	PF00069	0.549
MOD_NEK2_1	327	332	PF00069	0.280
MOD_NEK2_1	354	359	PF00069	0.320
MOD_NEK2_1	368	373	PF00069	0.214
MOD_NEK2_1	399	404	PF00069	0.339
MOD_NEK2_1	455	460	PF00069	0.357
MOD_NEK2_1	47	52	PF00069	0.444
MOD_NEK2_1	477	482	PF00069	0.399
MOD_NEK2_1	66	71	PF00069	0.610
MOD_PIKK_1	107	113	PF00454	0.342
MOD_PIKK_1	34	40	PF00454	0.476
MOD_PKA_1	391	397	PF00069	0.419
MOD_PKA_2	111	117	PF00069	0.448
MOD_PKA_2	135	141	PF00069	0.385
MOD_PKA_2	168	174	PF00069	0.524
MOD_PKA_2	245	251	PF00069	0.491
MOD_PKA_2	268	274	PF00069	0.483
MOD_PKA_2	308	314	PF00069	0.486
MOD_PKA_2	391	397	PF00069	0.421
MOD_PKA_2	427	433	PF00069	0.382
MOD_PKA_2	447	453	PF00069	0.448
MOD_PKA_2	508	514	PF00069	0.366
MOD_PKA_2	69	75	PF00069	0.623
MOD_Plk_1	121	127	PF00069	0.466
MOD_Plk_1	156	162	PF00069	0.489
MOD_Plk_1	163	169	PF00069	0.444
MOD_Plk_1	246	252	PF00069	0.635
MOD_Plk_1	3	9	PF00069	0.456
MOD_Plk_1	380	386	PF00069	0.246
MOD_Plk_1	405	411	PF00069	0.431
MOD_Plk_1	581	587	PF00069	0.400
MOD_Plk_1	66	72	PF00069	0.558
MOD_Plk_1	83	89	PF00069	0.459
MOD_Plk_2-3	157	163	PF00069	0.478
MOD_Plk_4	268	274	PF00069	0.446
MOD_Plk_4	405	411	PF00069	0.308
MOD_Plk_4	47	53	PF00069	0.460
MOD_Plk_4	483	489	PF00069	0.332
MOD_ProDKin_1	237	243	PF00069	0.743
MOD_ProDKin_1	531	537	PF00069	0.549
MOD_ProDKin_1	545	551	PF00069	0.411
MOD_ProDKin_1	8	14	PF00069	0.638
MOD_SUMO_rev_2	176	185	PF00179	0.528
MOD_SUMO_rev_2	290	295	PF00179	0.379
TRG_DiLeu_BaEn_1	23	28	PF01217	0.534
TRG_ENDOCYTIC_2	117	120	PF00928	0.404
TRG_ENDOCYTIC_2	158	161	PF00928	0.434
TRG_ENDOCYTIC_2	165	168	PF00928	0.446
TRG_ENDOCYTIC_2	194	197	PF00928	0.375
TRG_ENDOCYTIC_2	44	47	PF00928	0.497
TRG_ER_diArg_1	167	170	PF00400	0.533
TRG_ER_diArg_1	206	209	PF00400	0.479
TRG_ER_diArg_1	389	392	PF00400	0.419
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK2	Leptomonas seymouri	67%	100%
A0A0S4IUZ3	Bodo saltans	24%	100%
A0A1X0NWL7	Trypanosomatidae	37%	100%
A0A3S7X6T5	Leishmania donovani	81%	100%
A0A422NYX2	Trypanosoma rangeli	35%	100%
A4I913	Leishmania infantum	81%	100%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A7L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B3X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q09406	Caenorhabditis elegans	27%	100%
Q19124	Caenorhabditis elegans	25%	100%
Q4Q446	Leishmania major	81%	100%
Q5RAC9	Pongo abelii	26%	97%
Q676U5	Homo sapiens	26%	97%
Q6NNP0	Arabidopsis thaliana	26%	100%
Q8C0J2	Mus musculus	25%	97%
V5BW76	Trypanosoma cruzi	38%	100%