Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLK0_LEIBR

TriTrypDb:

LbrM.33.1660 , LBRM2903_330022300

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLK0

PDB structure(s): 7aih_Y , 7ane_Y

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.511
CLV_NRD_NRD_1	162	164	PF00675	0.564
CLV_NRD_NRD_1	224	226	PF00675	0.543
CLV_NRD_NRD_1	58	60	PF00675	0.513
CLV_PCSK_KEX2_1	129	131	PF00082	0.511
CLV_PCSK_KEX2_1	162	164	PF00082	0.561
CLV_PCSK_KEX2_1	260	262	PF00082	0.533
CLV_PCSK_KEX2_1	60	62	PF00082	0.492
CLV_PCSK_KEX2_1	88	90	PF00082	0.339
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.332
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.492
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.339
CLV_PCSK_SKI1_1	110	114	PF00082	0.498
CLV_PCSK_SKI1_1	225	229	PF00082	0.399
CLV_PCSK_SKI1_1	261	265	PF00082	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_MAPK_DCC_7	260	268	PF00069	0.337
DOC_MAPK_gen_1	162	170	PF00069	0.580
DOC_MAPK_gen_1	260	268	PF00069	0.555
DOC_MAPK_MEF2A_6	230	237	PF00069	0.297
DOC_PP1_RVXF_1	272	279	PF00149	0.393
DOC_PP2B_LxvP_1	133	136	PF13499	0.491
DOC_PP2B_LxvP_1	146	149	PF13499	0.465
DOC_USP7_MATH_1	12	16	PF00917	0.463
DOC_USP7_MATH_1	288	292	PF00917	0.556
DOC_USP7_MATH_1	95	99	PF00917	0.537
DOC_USP7_UBL2_3	106	110	PF12436	0.528
DOC_USP7_UBL2_3	260	264	PF12436	0.324
DOC_WW_Pin1_4	131	136	PF00397	0.483
LIG_14-3-3_CanoR_1	14	18	PF00244	0.600
LIG_14-3-3_CanoR_1	96	104	PF00244	0.437
LIG_Actin_WH2_2	94	112	PF00022	0.341
LIG_APCC_ABBA_1	235	240	PF00400	0.538
LIG_deltaCOP1_diTrp_1	166	170	PF00928	0.599
LIG_FHA_1	132	138	PF00498	0.505
LIG_FHA_1	163	169	PF00498	0.486
LIG_FHA_1	180	186	PF00498	0.264
LIG_FHA_2	208	214	PF00498	0.445
LIG_FHA_2	42	48	PF00498	0.531
LIG_LIR_Gen_1	165	172	PF02991	0.608
LIG_LIR_Gen_1	218	228	PF02991	0.402
LIG_LIR_Gen_1	277	288	PF02991	0.554
LIG_LIR_Gen_1	76	86	PF02991	0.480
LIG_LIR_Nem_3	157	161	PF02991	0.500
LIG_LIR_Nem_3	165	170	PF02991	0.456
LIG_LIR_Nem_3	175	180	PF02991	0.376
LIG_LIR_Nem_3	215	220	PF02991	0.425
LIG_LIR_Nem_3	277	283	PF02991	0.504
LIG_LIR_Nem_3	287	292	PF02991	0.413
LIG_LIR_Nem_3	72	78	PF02991	0.490
LIG_LYPXL_yS_3	158	161	PF13949	0.498
LIG_MYND_1	131	135	PF01753	0.498
LIG_SH2_CRK	128	132	PF00017	0.565
LIG_SH2_CRK	280	284	PF00017	0.575
LIG_SH2_CRK	78	82	PF00017	0.495
LIG_SH2_NCK_1	280	284	PF00017	0.563
LIG_SH2_NCK_1	78	82	PF00017	0.559
LIG_SH2_PTP2	220	223	PF00017	0.427
LIG_SH2_SRC	140	143	PF00017	0.456
LIG_SH2_STAT5	179	182	PF00017	0.589
LIG_SH2_STAT5	220	223	PF00017	0.412
LIG_SH2_STAT5	48	51	PF00017	0.513
LIG_TRAF2_1	100	103	PF00917	0.509
LIG_TRAF2_1	112	115	PF00917	0.402
MOD_CK1_1	79	85	PF00069	0.554
MOD_CK2_1	207	213	PF00069	0.458
MOD_CK2_1	41	47	PF00069	0.530
MOD_GlcNHglycan	23	26	PF01048	0.595
MOD_GlcNHglycan	30	33	PF01048	0.609
MOD_GlcNHglycan	71	74	PF01048	0.577
MOD_GlcNHglycan	78	81	PF01048	0.554
MOD_LATS_1	127	133	PF00433	0.654
MOD_NEK2_2	249	254	PF00069	0.335
MOD_PIKK_1	150	156	PF00454	0.547
MOD_PKA_1	129	135	PF00069	0.503
MOD_PKA_1	162	168	PF00069	0.540
MOD_PKA_1	21	27	PF00069	0.558
MOD_PKA_1	88	94	PF00069	0.339
MOD_PKA_2	129	135	PF00069	0.503
MOD_PKA_2	13	19	PF00069	0.667
MOD_PKA_2	162	168	PF00069	0.457
MOD_PKA_2	76	82	PF00069	0.563
MOD_PKA_2	88	94	PF00069	0.461
MOD_PKA_2	95	101	PF00069	0.416
MOD_Plk_1	249	255	PF00069	0.551
MOD_Plk_1	67	73	PF00069	0.604
MOD_Plk_4	13	19	PF00069	0.608
MOD_ProDKin_1	131	137	PF00069	0.480
MOD_SUMO_for_1	190	193	PF00179	0.573
MOD_SUMO_rev_2	37	42	PF00179	0.389
MOD_SUMO_rev_2	79	86	PF00179	0.554
TRG_DiLeu_BaEn_1	114	119	PF01217	0.513
TRG_DiLeu_BaEn_4	102	108	PF01217	0.536
TRG_DiLeu_BaEn_4	114	120	PF01217	0.417
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.590
TRG_ENDOCYTIC_2	158	161	PF00928	0.497
TRG_ENDOCYTIC_2	220	223	PF00928	0.412
TRG_ENDOCYTIC_2	280	283	PF00928	0.479
TRG_ENDOCYTIC_2	286	289	PF00928	0.388
TRG_ENDOCYTIC_2	78	81	PF00928	0.475
TRG_ER_diArg_1	128	130	PF00400	0.496
TRG_ER_diArg_1	161	163	PF00400	0.557
TRG_NES_CRM1_1	99	111	PF08389	0.484
TRG_NLS_MonoExtC_3	58	64	PF00514	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q5	Leptomonas seymouri	78%	100%
A0A0S4JF52	Bodo saltans	53%	100%
A0A1X0P198	Trypanosomatidae	66%	100%
A0A3Q8IDR8	Leishmania donovani	92%	100%
A0A3R7MCA1	Trypanosoma rangeli	67%	100%
A4I911	Leishmania infantum	92%	100%
D0A511	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B3X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q448	Leishmania major	90%	100%
V5BHC0	Trypanosoma cruzi	68%	100%