ATPase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLJ8_LEIBR

TriTrypDb:

LbrM.33.1640 , LBRM2903_330022000

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.450
CLV_C14_Caspase3-7	149	153	PF00656	0.732
CLV_C14_Caspase3-7	365	369	PF00656	0.472
CLV_MEL_PAP_1	98	104	PF00089	0.360
CLV_NRD_NRD_1	100	102	PF00675	0.451
CLV_NRD_NRD_1	108	110	PF00675	0.409
CLV_NRD_NRD_1	135	137	PF00675	0.470
CLV_NRD_NRD_1	529	531	PF00675	0.530
CLV_PCSK_KEX2_1	100	102	PF00082	0.451
CLV_PCSK_KEX2_1	108	110	PF00082	0.409
CLV_PCSK_KEX2_1	126	128	PF00082	0.426
CLV_PCSK_KEX2_1	529	531	PF00082	0.530
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.433
CLV_PCSK_SKI1_1	108	112	PF00082	0.422
CLV_PCSK_SKI1_1	143	147	PF00082	0.496
CLV_PCSK_SKI1_1	302	306	PF00082	0.714
CLV_PCSK_SKI1_1	360	364	PF00082	0.372
CLV_PCSK_SKI1_1	397	401	PF00082	0.402
CLV_PCSK_SKI1_1	449	453	PF00082	0.609
CLV_PCSK_SKI1_1	529	533	PF00082	0.601
DEG_APCC_DBOX_1	209	217	PF00400	0.357
DEG_APCC_DBOX_1	357	365	PF00400	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.528
DEG_SCF_FBW7_1	504	510	PF00400	0.625
DEG_SPOP_SBC_1	282	286	PF00917	0.495
DEG_SPOP_SBC_1	416	420	PF00917	0.523
DOC_ANK_TNKS_1	562	569	PF00023	0.505
DOC_CKS1_1	504	509	PF01111	0.567
DOC_CYCLIN_RxL_1	16	26	PF00134	0.454
DOC_CYCLIN_RxL_1	355	368	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	493	499	PF00134	0.554
DOC_MAPK_gen_1	355	364	PF00069	0.472
DOC_PP2B_LxvP_1	216	219	PF13499	0.492
DOC_PP2B_LxvP_1	414	417	PF13499	0.542
DOC_USP7_MATH_1	200	204	PF00917	0.559
DOC_USP7_MATH_1	219	223	PF00917	0.407
DOC_USP7_MATH_1	283	287	PF00917	0.563
DOC_USP7_MATH_1	315	319	PF00917	0.550
DOC_USP7_MATH_1	345	349	PF00917	0.502
DOC_USP7_MATH_1	408	412	PF00917	0.578
DOC_USP7_MATH_1	476	480	PF00917	0.603
DOC_USP7_MATH_1	518	522	PF00917	0.566
DOC_WW_Pin1_4	165	170	PF00397	0.585
DOC_WW_Pin1_4	195	200	PF00397	0.654
DOC_WW_Pin1_4	203	208	PF00397	0.525
DOC_WW_Pin1_4	25	30	PF00397	0.501
DOC_WW_Pin1_4	261	266	PF00397	0.398
DOC_WW_Pin1_4	328	333	PF00397	0.842
DOC_WW_Pin1_4	336	341	PF00397	0.527
DOC_WW_Pin1_4	35	40	PF00397	0.436
DOC_WW_Pin1_4	424	429	PF00397	0.698
DOC_WW_Pin1_4	503	508	PF00397	0.564
LIG_14-3-3_CanoR_1	108	117	PF00244	0.397
LIG_14-3-3_CanoR_1	22	30	PF00244	0.467
LIG_14-3-3_CanoR_1	394	400	PF00244	0.412
LIG_14-3-3_CanoR_1	449	457	PF00244	0.686
LIG_14-3-3_CanoR_1	536	543	PF00244	0.515
LIG_14-3-3_CanoR_1	555	561	PF00244	0.717
LIG_BRCT_BRCA1_1	285	289	PF00533	0.511
LIG_BRCT_BRCA1_1	338	342	PF00533	0.534
LIG_BRCT_BRCA1_1	447	451	PF00533	0.479
LIG_Clathr_ClatBox_1	361	365	PF01394	0.370
LIG_FHA_1	190	196	PF00498	0.672
LIG_FHA_1	233	239	PF00498	0.519
LIG_FHA_1	283	289	PF00498	0.508
LIG_FHA_1	351	357	PF00498	0.566
LIG_FHA_1	396	402	PF00498	0.371
LIG_FHA_1	488	494	PF00498	0.515
LIG_FHA_1	557	563	PF00498	0.566
LIG_FHA_2	136	142	PF00498	0.555
LIG_FHA_2	169	175	PF00498	0.478
LIG_FHA_2	8	14	PF00498	0.453
LIG_HP1_1	301	305	PF01393	0.529
LIG_Integrin_isoDGR_2	527	529	PF01839	0.534
LIG_LIR_Apic_2	368	374	PF02991	0.439
LIG_LIR_Apic_2	508	514	PF02991	0.613
LIG_LIR_Apic_2	86	91	PF02991	0.410
LIG_LIR_Gen_1	177	186	PF02991	0.398
LIG_LIR_Gen_1	38	48	PF02991	0.444
LIG_LIR_Gen_1	5	16	PF02991	0.452
LIG_LIR_Gen_1	506	517	PF02991	0.504
LIG_LIR_Nem_3	174	179	PF02991	0.399
LIG_LIR_Nem_3	32	37	PF02991	0.472
LIG_LIR_Nem_3	38	43	PF02991	0.434
LIG_LIR_Nem_3	506	512	PF02991	0.496
LIG_NRBOX	49	55	PF00104	0.425
LIG_PTB_Apo_2	288	295	PF02174	0.682
LIG_PTB_Phospho_1	288	294	PF10480	0.681
LIG_SH2_CRK	435	439	PF00017	0.479
LIG_SH2_CRK	88	92	PF00017	0.431
LIG_SH2_GRB2like	525	528	PF00017	0.529
LIG_SH2_NCK_1	294	298	PF00017	0.531
LIG_SH2_PTP2	179	182	PF00017	0.366
LIG_SH2_PTP2	511	514	PF00017	0.594
LIG_SH2_SRC	525	528	PF00017	0.530
LIG_SH2_SRC	542	545	PF00017	0.496
LIG_SH2_STAP1	435	439	PF00017	0.380
LIG_SH2_STAT3	252	255	PF00017	0.510
LIG_SH2_STAT5	106	109	PF00017	0.429
LIG_SH2_STAT5	179	182	PF00017	0.366
LIG_SH2_STAT5	511	514	PF00017	0.648
LIG_SH2_STAT5	542	545	PF00017	0.496
LIG_SH3_3	196	202	PF00018	0.668
LIG_SH3_3	231	237	PF00018	0.674
LIG_SH3_3	259	265	PF00018	0.467
LIG_SH3_3	295	301	PF00018	0.685
LIG_SH3_3	334	340	PF00018	0.555
LIG_SH3_3	396	402	PF00018	0.490
LIG_SH3_3	422	428	PF00018	0.710
LIG_SUMO_SIM_anti_2	544	551	PF11976	0.632
LIG_SUMO_SIM_par_1	360	365	PF11976	0.374
LIG_SUMO_SIM_par_1	500	506	PF11976	0.618
LIG_TRAF2_1	172	175	PF00917	0.530
LIG_TYR_ITIM	433	438	PF00017	0.370
MOD_CDK_SPxxK_3	203	210	PF00069	0.558
MOD_CK1_1	168	174	PF00069	0.698
MOD_CK1_1	198	204	PF00069	0.624
MOD_CK1_1	222	228	PF00069	0.489
MOD_CK1_1	232	238	PF00069	0.558
MOD_CK1_1	281	287	PF00069	0.599
MOD_CK1_1	318	324	PF00069	0.604
MOD_CK1_1	331	337	PF00069	0.586
MOD_CK1_1	338	344	PF00069	0.626
MOD_CK1_1	409	415	PF00069	0.619
MOD_CK1_1	503	509	PF00069	0.576
MOD_CK1_1	52	58	PF00069	0.450
MOD_CK1_1	545	551	PF00069	0.610
MOD_CK1_1	7	13	PF00069	0.472
MOD_CK1_1	93	99	PF00069	0.366
MOD_CK2_1	135	141	PF00069	0.493
MOD_CK2_1	150	156	PF00069	0.592
MOD_CK2_1	168	174	PF00069	0.418
MOD_CK2_1	261	267	PF00069	0.399
MOD_CK2_1	67	73	PF00069	0.540
MOD_Cter_Amidation	527	530	PF01082	0.534
MOD_GlcNHglycan	13	16	PF01048	0.520
MOD_GlcNHglycan	163	166	PF01048	0.626
MOD_GlcNHglycan	25	28	PF01048	0.544
MOD_GlcNHglycan	294	297	PF01048	0.549
MOD_GlcNHglycan	379	382	PF01048	0.453
MOD_GlcNHglycan	478	481	PF01048	0.576
MOD_GlcNHglycan	520	524	PF01048	0.549
MOD_GlcNHglycan	63	66	PF01048	0.522
MOD_GlcNHglycan	67	72	PF01048	0.544
MOD_GlcNHglycan	92	95	PF01048	0.389
MOD_GSK3_1	161	168	PF00069	0.604
MOD_GSK3_1	189	196	PF00069	0.629
MOD_GSK3_1	278	285	PF00069	0.545
MOD_GSK3_1	328	335	PF00069	0.689
MOD_GSK3_1	377	384	PF00069	0.450
MOD_GSK3_1	408	415	PF00069	0.603
MOD_GSK3_1	434	441	PF00069	0.380
MOD_GSK3_1	503	510	PF00069	0.572
MOD_GSK3_1	531	538	PF00069	0.631
MOD_GSK3_1	63	70	PF00069	0.527
MOD_GSK3_1	7	14	PF00069	0.548
MOD_N-GLC_1	290	295	PF02516	0.536
MOD_N-GLC_1	377	382	PF02516	0.432
MOD_N-GLC_2	442	444	PF02516	0.490
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	11	16	PF00069	0.466
MOD_NEK2_1	220	225	PF00069	0.581
MOD_NEK2_1	23	28	PF00069	0.449
MOD_NEK2_1	289	294	PF00069	0.571
MOD_NEK2_1	43	48	PF00069	0.390
MOD_NEK2_1	434	439	PF00069	0.499
MOD_NEK2_1	535	540	PF00069	0.538
MOD_PIKK_1	309	315	PF00454	0.622
MOD_PKA_1	108	114	PF00069	0.370
MOD_PKA_1	529	535	PF00069	0.522
MOD_PKA_2	108	114	PF00069	0.381
MOD_PKA_2	122	128	PF00069	0.551
MOD_PKA_2	135	141	PF00069	0.516
MOD_PKA_2	23	29	PF00069	0.466
MOD_PKA_2	315	321	PF00069	0.563
MOD_PKA_2	476	482	PF00069	0.598
MOD_PKA_2	529	535	PF00069	0.596
MOD_Plk_1	129	135	PF00069	0.464
MOD_Plk_1	290	296	PF00069	0.550
MOD_Plk_1	409	415	PF00069	0.532
MOD_Plk_1	519	525	PF00069	0.529
MOD_Plk_1	72	78	PF00069	0.529
MOD_Plk_2-3	150	156	PF00069	0.523
MOD_Plk_4	129	135	PF00069	0.464
MOD_Plk_4	200	206	PF00069	0.613
MOD_Plk_4	229	235	PF00069	0.511
MOD_Plk_4	284	290	PF00069	0.712
MOD_Plk_4	409	415	PF00069	0.532
MOD_Plk_4	434	440	PF00069	0.421
MOD_Plk_4	49	55	PF00069	0.432
MOD_Plk_4	500	506	PF00069	0.571
MOD_Plk_4	542	548	PF00069	0.578
MOD_Plk_4	556	562	PF00069	0.544
MOD_Plk_4	93	99	PF00069	0.366
MOD_ProDKin_1	165	171	PF00069	0.576
MOD_ProDKin_1	195	201	PF00069	0.650
MOD_ProDKin_1	203	209	PF00069	0.513
MOD_ProDKin_1	25	31	PF00069	0.505
MOD_ProDKin_1	261	267	PF00069	0.399
MOD_ProDKin_1	328	334	PF00069	0.842
MOD_ProDKin_1	336	342	PF00069	0.524
MOD_ProDKin_1	35	41	PF00069	0.436
MOD_ProDKin_1	424	430	PF00069	0.690
MOD_ProDKin_1	503	509	PF00069	0.566
TRG_DiLeu_BaEn_2	266	272	PF01217	0.391
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.396
TRG_ENDOCYTIC_2	179	182	PF00928	0.366
TRG_ENDOCYTIC_2	34	37	PF00928	0.458
TRG_ENDOCYTIC_2	435	438	PF00928	0.484
TRG_ER_diArg_1	107	109	PF00400	0.410
TRG_ER_diArg_1	17	20	PF00400	0.446
TRG_ER_diArg_1	21	24	PF00400	0.446
TRG_ER_diArg_1	358	361	PF00400	0.465
TRG_ER_diArg_1	529	531	PF00400	0.530
TRG_ER_diArg_1	99	101	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	360	365	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L8	Leptomonas seymouri	40%	100%
A0A3S7X6N2	Leishmania donovani	68%	100%
A4I908	Leishmania infantum	67%	100%
E9B3X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q451	Leishmania major	70%	100%