Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron-sulfur cluster assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLJ7_LEIBR

TriTrypDb:

LbrM.33.1630 , LBRM2903_330021700

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990221	L-cysteine desulfurase complex	3	1

Expansion

Sequence features

A4HLJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016226	iron-sulfur cluster assembly	4	5
GO:0022607	cellular component assembly	4	5
GO:0031163	metallo-sulfur cluster assembly	5	5
GO:0044237	cellular metabolic process	2	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034227	tRNA thio-modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.377
CLV_PCSK_KEX2_1	81	83	PF00082	0.608
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.608
CLV_PCSK_SKI1_1	55	59	PF00082	0.401
CLV_PCSK_SKI1_1	6	10	PF00082	0.527
DEG_APCC_DBOX_1	62	70	PF00400	0.431
DOC_MAPK_gen_1	65	74	PF00069	0.527
DOC_PP1_RVXF_1	80	87	PF00149	0.610
DOC_USP7_UBL2_3	103	107	PF12436	0.527
DOC_USP7_UBL2_3	6	10	PF12436	0.496
LIG_APCC_ABBAyCdc20_2	81	87	PF00400	0.578
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_LIR_Gen_1	41	50	PF02991	0.331
LIG_LIR_Nem_3	28	34	PF02991	0.331
LIG_LIR_Nem_3	41	46	PF02991	0.238
LIG_Pex14_2	31	35	PF04695	0.331
LIG_PTB_Apo_2	73	80	PF02174	0.454
LIG_PTB_Phospho_1	73	79	PF10480	0.487
LIG_SH2_STAT3	34	37	PF00017	0.356
LIG_SH2_STAT5	34	37	PF00017	0.331
LIG_SH2_STAT5	85	88	PF00017	0.576
LIG_TRAF2_1	50	53	PF00917	0.337
MOD_GlcNHglycan	1	4	PF01048	0.652
MOD_GSK3_1	4	11	PF00069	0.528
MOD_NEK2_1	1	6	PF00069	0.502
MOD_NEK2_1	19	24	PF00069	0.364
TRG_DiLeu_BaEn_3	52	58	PF01217	0.387
TRG_NES_CRM1_1	64	77	PF08389	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG9	Leptomonas seymouri	67%	100%
A0A0S4JDV2	Bodo saltans	37%	79%
A0A3S5IQY6	Trypanosoma rangeli	47%	100%
D0A503	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q452	Leishmania major	80%	66%