QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4HLJ5_LEIBR

TriTrypDb:

LbrM.33.1610 , LBRM2903_330021000

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	14
GO:0032991	protein-containing complex	1	14
GO:0098796	membrane protein complex	2	14
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HLJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006886	intracellular protein transport	4	14
GO:0008104	protein localization	4	14
GO:0009987	cellular process	1	14
GO:0015031	protein transport	4	14
GO:0016192	vesicle-mediated transport	4	13
GO:0033036	macromolecule localization	2	14
GO:0045184	establishment of protein localization	3	14
GO:0046907	intracellular transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051641	cellular localization	2	14
GO:0051649	establishment of localization in cell	3	14
GO:0070727	cellular macromolecule localization	3	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	3
GO:0060090	molecular adaptor activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.387
CLV_NRD_NRD_1	15	17	PF00675	0.424
CLV_NRD_NRD_1	157	159	PF00675	0.274
CLV_NRD_NRD_1	78	80	PF00675	0.174
CLV_PCSK_KEX2_1	15	17	PF00082	0.412
CLV_PCSK_KEX2_1	156	158	PF00082	0.276
CLV_PCSK_KEX2_1	78	80	PF00082	0.404
CLV_PCSK_SKI1_1	124	128	PF00082	0.390
CLV_PCSK_SKI1_1	211	215	PF00082	0.398
DEG_Nend_UBRbox_2	1	3	PF02207	0.576
DOC_CKS1_1	31	36	PF01111	0.586
DOC_CYCLIN_RxL_1	135	146	PF00134	0.395
DOC_MAPK_gen_1	136	144	PF00069	0.372
DOC_MAPK_MEF2A_6	136	144	PF00069	0.393
DOC_PP1_RVXF_1	6	13	PF00149	0.307
DOC_PP4_FxxP_1	39	42	PF00568	0.477
DOC_PP4_FxxP_1	72	75	PF00568	0.441
DOC_USP7_MATH_1	251	255	PF00917	0.564
DOC_USP7_UBL2_3	76	80	PF12436	0.417
DOC_WW_Pin1_4	30	35	PF00397	0.521
LIG_14-3-3_CanoR_1	15	23	PF00244	0.600
LIG_Actin_WH2_2	101	117	PF00022	0.312
LIG_Clathr_ClatBox_1	70	74	PF01394	0.256
LIG_FHA_1	105	111	PF00498	0.449
LIG_FHA_1	230	236	PF00498	0.420
LIG_FHA_1	33	39	PF00498	0.690
LIG_FHA_1	92	98	PF00498	0.383
LIG_FHA_2	115	121	PF00498	0.297
LIG_FHA_2	190	196	PF00498	0.316
LIG_FHA_2	207	213	PF00498	0.398
LIG_FHA_2	31	37	PF00498	0.420
LIG_FHA_2	86	92	PF00498	0.174
LIG_GBD_Chelix_1	125	133	PF00786	0.301
LIG_LIR_Apic_2	36	42	PF02991	0.503
LIG_LIR_Gen_1	162	173	PF02991	0.356
LIG_LIR_Gen_1	7	13	PF02991	0.308
LIG_LIR_Nem_3	134	140	PF02991	0.404
LIG_LIR_Nem_3	162	168	PF02991	0.360
LIG_LIR_Nem_3	171	177	PF02991	0.365
LIG_LIR_Nem_3	7	12	PF02991	0.304
LIG_SH2_CRK	165	169	PF00017	0.272
LIG_SH2_NCK_1	165	169	PF00017	0.243
LIG_SH2_NCK_1	174	178	PF00017	0.451
LIG_SH2_STAT5	165	168	PF00017	0.398
LIG_SH3_3	28	34	PF00018	0.608
LIG_SUMO_SIM_par_1	251	256	PF11976	0.432
LIG_TRAF2_1	119	122	PF00917	0.398
LIG_TRAF2_1	219	222	PF00917	0.398
LIG_UBA3_1	70	76	PF00899	0.419
MOD_CAAXbox	272	275	PF01239	0.507
MOD_CDK_SPxxK_3	30	37	PF00069	0.534
MOD_CK1_1	128	134	PF00069	0.307
MOD_CK1_1	26	32	PF00069	0.500
MOD_CK2_1	114	120	PF00069	0.323
MOD_CK2_1	206	212	PF00069	0.398
MOD_CK2_1	216	222	PF00069	0.272
MOD_CK2_1	30	36	PF00069	0.582
MOD_GSK3_1	128	135	PF00069	0.279
MOD_GSK3_1	14	21	PF00069	0.505
MOD_GSK3_1	159	166	PF00069	0.250
MOD_GSK3_1	26	33	PF00069	0.447
MOD_NEK2_1	104	109	PF00069	0.345
MOD_NEK2_1	114	119	PF00069	0.263
MOD_NEK2_1	56	61	PF00069	0.379
MOD_PIKK_1	128	134	PF00454	0.418
MOD_PKA_2	14	20	PF00069	0.545
MOD_Plk_1	104	110	PF00069	0.312
MOD_Plk_1	26	32	PF00069	0.640
MOD_Plk_2-3	236	242	PF00069	0.457
MOD_Plk_4	104	110	PF00069	0.387
MOD_Plk_4	229	235	PF00069	0.263
MOD_Plk_4	236	242	PF00069	0.439
MOD_Plk_4	85	91	PF00069	0.174
MOD_ProDKin_1	30	36	PF00069	0.520
MOD_SUMO_rev_2	207	216	PF00179	0.398
TRG_AP2beta_CARGO_1	7	16	PF09066	0.363
TRG_DiLeu_BaEn_1	96	101	PF01217	0.301
TRG_DiLeu_BaEn_3	120	126	PF01217	0.398
TRG_DiLeu_BaEn_4	81	87	PF01217	0.242
TRG_ENDOCYTIC_2	165	168	PF00928	0.279
TRG_ENDOCYTIC_2	174	177	PF00928	0.320
TRG_ER_diArg_1	155	158	PF00400	0.190
TRG_ER_diArg_1	77	79	PF00400	0.195
TRG_NES_CRM1_1	61	74	PF08389	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I246	Leptomonas seymouri	59%	99%
A0A0N1IMN0	Leptomonas seymouri	26%	91%
A0A0S4J7F1	Bodo saltans	33%	93%
A0A0S4JKJ1	Bodo saltans	29%	92%
A0A1X0P0Y0	Trypanosomatidae	38%	93%
A0A1X0P5S4	Trypanosomatidae	26%	91%
A0A3Q8IK46	Leishmania donovani	78%	100%
A0A3R7MIN3	Trypanosoma rangeli	34%	92%
A0A3S7X9G5	Leishmania donovani	25%	91%
A0A422P2Q8	Trypanosoma rangeli	26%	91%
A4HMT8	Leishmania braziliensis	24%	91%
A4HN16	Leishmania braziliensis	97%	88%
A4I905	Leishmania infantum	78%	100%
A4IBD9	Leishmania infantum	25%	91%
A8WVD0	Caenorhabditis briggsae	26%	94%
C9ZZ78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	90%
D0A501	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
E9AF95	Leishmania major	24%	100%
E9B3X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9B6F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
O14662	Homo sapiens	26%	85%
O16000	Caenorhabditis elegans	27%	95%
O65359	Arabidopsis thaliana	25%	85%
P32850	Bos taurus	26%	95%
P61264	Mus musculus	26%	95%
P61265	Rattus norvegicus	26%	95%
P61266	Homo sapiens	26%	95%
P61267	Bos taurus	26%	95%
P61268	Ovis aries	26%	95%
Q08849	Rattus norvegicus	27%	95%
Q13277	Homo sapiens	28%	95%
Q16932	Aplysia californica	26%	95%
Q4Q454	Leishmania major	77%	100%
Q64704	Mus musculus	27%	95%
Q8BVI5	Mus musculus	26%	84%
Q9P6P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	91%
Q9SUJ1	Arabidopsis thaliana	26%	83%
Q9SWH4	Arabidopsis thaliana	24%	85%
V5BLU5	Trypanosoma cruzi	35%	93%
V5C306	Trypanosoma cruzi	24%	91%