Cysteine conjugate beta-lyase,aminotransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutamine aminotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLJ4_LEIBR

TriTrypDb:

LbrM.33.1600 , LBRM2903_330020900

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0008483	transaminase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016769	transferase activity, transferring nitrogenous groups	3	10
GO:0016829	lyase activity	2	6
GO:0019842	vitamin binding	3	10
GO:0030170	pyridoxal phosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0070279	vitamin B6 binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0016212	kynurenine-oxoglutarate transaminase activity	6	1
GO:0036137	kynurenine aminotransferase activity	5	1
GO:0047945	L-glutamine:pyruvate aminotransferase activity	6	1
GO:0070548	L-glutamine aminotransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.212
CLV_PCSK_KEX2_1	363	365	PF00082	0.212
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.212
CLV_PCSK_SKI1_1	161	165	PF00082	0.378
CLV_PCSK_SKI1_1	173	177	PF00082	0.233
CLV_PCSK_SKI1_1	234	238	PF00082	0.306
CLV_PCSK_SKI1_1	52	56	PF00082	0.376
DEG_APCC_DBOX_1	160	168	PF00400	0.465
DOC_CKS1_1	177	182	PF01111	0.324
DOC_CYCLIN_RxL_1	3	17	PF00134	0.474
DOC_MAPK_gen_1	158	167	PF00069	0.454
DOC_MAPK_MEF2A_6	220	227	PF00069	0.212
DOC_PP1_RVXF_1	249	255	PF00149	0.324
DOC_PP2B_LxvP_1	261	264	PF13499	0.400
DOC_PP2B_PxIxI_1	220	226	PF00149	0.319
DOC_PP4_FxxP_1	41	44	PF00568	0.324
DOC_USP7_MATH_1	374	378	PF00917	0.266
DOC_USP7_UBL2_3	337	341	PF12436	0.404
DOC_USP7_UBL2_3	349	353	PF12436	0.335
DOC_USP7_UBL2_3	82	86	PF12436	0.465
DOC_WW_Pin1_4	176	181	PF00397	0.348
DOC_WW_Pin1_4	20	25	PF00397	0.384
DOC_WW_Pin1_4	275	280	PF00397	0.324
DOC_WW_Pin1_4	66	71	PF00397	0.283
LIG_14-3-3_CanoR_1	143	148	PF00244	0.319
LIG_14-3-3_CanoR_1	234	239	PF00244	0.324
LIG_14-3-3_CanoR_1	260	264	PF00244	0.212
LIG_APCC_ABBA_1	124	129	PF00400	0.324
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_BRCT_BRCA1_1	276	280	PF00533	0.417
LIG_BRCT_BRCA1_1	84	88	PF00533	0.212
LIG_deltaCOP1_diTrp_1	354	360	PF00928	0.324
LIG_FHA_1	13	19	PF00498	0.541
LIG_FHA_1	136	142	PF00498	0.439
LIG_FHA_1	170	176	PF00498	0.304
LIG_FHA_1	233	239	PF00498	0.380
LIG_FHA_1	260	266	PF00498	0.390
LIG_FHA_1	360	366	PF00498	0.360
LIG_FHA_1	98	104	PF00498	0.252
LIG_FHA_2	399	405	PF00498	0.381
LIG_Integrin_RGD_1	71	73	PF01839	0.212
LIG_LIR_Apic_2	217	221	PF02991	0.384
LIG_LIR_Gen_1	129	137	PF02991	0.481
LIG_LIR_Gen_1	142	149	PF02991	0.250
LIG_LIR_Gen_1	16	26	PF02991	0.410
LIG_LIR_Gen_1	172	180	PF02991	0.380
LIG_LIR_Gen_1	210	221	PF02991	0.343
LIG_LIR_Gen_1	270	279	PF02991	0.422
LIG_LIR_Gen_1	385	395	PF02991	0.324
LIG_LIR_Gen_1	83	92	PF02991	0.465
LIG_LIR_Nem_3	125	131	PF02991	0.347
LIG_LIR_Nem_3	142	147	PF02991	0.358
LIG_LIR_Nem_3	172	177	PF02991	0.380
LIG_LIR_Nem_3	210	216	PF02991	0.343
LIG_LIR_Nem_3	270	274	PF02991	0.422
LIG_LIR_Nem_3	293	299	PF02991	0.354
LIG_LIR_Nem_3	385	390	PF02991	0.324
LIG_LIR_Nem_3	83	87	PF02991	0.465
LIG_PDZ_Class_2	409	414	PF00595	0.489
LIG_SH2_CRK	213	217	PF00017	0.327
LIG_SH2_CRK	218	222	PF00017	0.320
LIG_SH2_CRK	29	33	PF00017	0.251
LIG_SH2_CRK	297	301	PF00017	0.465
LIG_SH2_CRK	67	71	PF00017	0.423
LIG_SH2_CRK	84	88	PF00017	0.423
LIG_SH2_PTP2	144	147	PF00017	0.380
LIG_SH2_SRC	132	135	PF00017	0.465
LIG_SH2_STAP1	128	132	PF00017	0.352
LIG_SH2_STAP1	304	308	PF00017	0.394
LIG_SH2_STAP1	384	388	PF00017	0.348
LIG_SH2_STAP1	84	88	PF00017	0.348
LIG_SH2_STAT5	144	147	PF00017	0.418
LIG_SH2_STAT5	215	218	PF00017	0.417
LIG_SH2_STAT5	387	390	PF00017	0.355
LIG_SH2_STAT5	67	70	PF00017	0.378
LIG_SH3_3	319	325	PF00018	0.324
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.423
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.324
LIG_SUMO_SIM_anti_2	224	229	PF11976	0.212
LIG_SUMO_SIM_par_1	119	125	PF11976	0.423
LIG_SUMO_SIM_par_1	204	211	PF11976	0.302
LIG_SUMO_SIM_par_1	233	240	PF11976	0.380
LIG_TYR_ITAM	129	147	PF00017	0.423
LIG_UBA3_1	76	82	PF00899	0.212
LIG_WRC_WIRS_1	271	276	PF05994	0.348
LIG_WW_3	42	46	PF00397	0.465
MOD_CDK_SPK_2	66	71	PF00069	0.212
MOD_CK1_1	14	20	PF00069	0.491
MOD_CK1_1	150	156	PF00069	0.423
MOD_CK1_1	270	276	PF00069	0.434
MOD_CK1_1	347	353	PF00069	0.465
MOD_CK1_1	377	383	PF00069	0.319
MOD_CK1_1	400	406	PF00069	0.212
MOD_CK2_1	14	20	PF00069	0.538
MOD_CK2_1	398	404	PF00069	0.389
MOD_GlcNHglycan	152	155	PF01048	0.474
MOD_GlcNHglycan	239	242	PF01048	0.333
MOD_GlcNHglycan	317	320	PF01048	0.411
MOD_GSK3_1	135	142	PF00069	0.380
MOD_GSK3_1	143	150	PF00069	0.304
MOD_GSK3_1	153	160	PF00069	0.134
MOD_GSK3_1	237	244	PF00069	0.339
MOD_GSK3_1	270	277	PF00069	0.388
MOD_GSK3_1	309	316	PF00069	0.343
MOD_GSK3_1	370	377	PF00069	0.420
MOD_GSK3_1	82	89	PF00069	0.368
MOD_GSK3_1	97	104	PF00069	0.214
MOD_N-GLC_1	347	352	PF02516	0.411
MOD_NEK2_1	11	16	PF00069	0.592
MOD_NEK2_1	214	219	PF00069	0.382
MOD_NEK2_1	245	250	PF00069	0.348
MOD_NEK2_1	274	279	PF00069	0.388
MOD_NEK2_1	315	320	PF00069	0.436
MOD_NEK2_1	359	364	PF00069	0.342
MOD_NEK2_1	383	388	PF00069	0.212
MOD_NEK2_1	80	85	PF00069	0.382
MOD_PIKK_1	101	107	PF00454	0.224
MOD_PIKK_1	347	353	PF00454	0.465
MOD_PIKK_1	75	81	PF00454	0.439
MOD_PIKK_1	86	92	PF00454	0.405
MOD_PKA_2	259	265	PF00069	0.333
MOD_Plk_1	232	238	PF00069	0.348
MOD_Plk_4	14	20	PF00069	0.448
MOD_Plk_4	383	389	PF00069	0.212
MOD_ProDKin_1	176	182	PF00069	0.348
MOD_ProDKin_1	20	26	PF00069	0.377
MOD_ProDKin_1	275	281	PF00069	0.324
MOD_ProDKin_1	66	72	PF00069	0.283
MOD_SUMO_for_1	289	292	PF00179	0.212
MOD_SUMO_rev_2	49	54	PF00179	0.212
TRG_DiLeu_BaEn_3	49	55	PF01217	0.319
TRG_DiLeu_BaEn_4	20	26	PF01217	0.496
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.429
TRG_ENDOCYTIC_2	132	135	PF00928	0.375
TRG_ENDOCYTIC_2	144	147	PF00928	0.327
TRG_ENDOCYTIC_2	213	216	PF00928	0.324
TRG_ENDOCYTIC_2	271	274	PF00928	0.348
TRG_ENDOCYTIC_2	29	32	PF00928	0.429
TRG_ENDOCYTIC_2	297	300	PF00928	0.351
TRG_ENDOCYTIC_2	387	390	PF00928	0.352
TRG_ENDOCYTIC_2	84	87	PF00928	0.481
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I393	Leptomonas seymouri	22%	96%
A0A0N1II57	Leptomonas seymouri	24%	93%
A0A0N1PA03	Leptomonas seymouri	23%	100%
A0A0N1PB68	Leptomonas seymouri	74%	100%
A0A0P0VI36	Oryza sativa subsp. japonica	24%	84%
A0A0S4J4K7	Bodo saltans	26%	95%
A0A0S4KNT6	Bodo saltans	47%	98%
A0A1X0NDS5	Trypanosomatidae	22%	98%
A0A1X0P1M2	Trypanosomatidae	56%	98%
A0A1X0P7X4	Trypanosomatidae	25%	100%
A0A3Q8IGK8	Leishmania donovani	84%	100%
A0A3S5IQG1	Trypanosoma rangeli	23%	100%
A0LEA5	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	26%	100%
A1VDD3	Desulfovibrio vulgaris subsp. vulgaris (strain DP4)	24%	100%
A2AIG8	Mus musculus	25%	82%
A3PMF8	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	26%	100%
A4FWW1	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	23%	100%
A4HPA3	Leishmania braziliensis	24%	100%
A4I904	Leishmania infantum	84%	100%
A5FRC5	Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)	23%	100%
A5UKY0	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	23%	100%
A6UPL6	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	22%	100%
A6UTL8	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	22%	100%
A8FEJ6	Bacillus pumilus (strain SAFR-032)	23%	100%
A9AA96	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	22%	100%
B1I544	Desulforudis audaxviator (strain MP104C)	23%	100%
B2A250	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	22%	100%
B8CX89	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	23%	100%
B8DJJ6	Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F)	24%	100%
C6BUK3	Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763)	25%	100%
C6C2Z3	Musicola paradisiaca (strain Ech703)	26%	100%
D0A500	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9B3W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9L7A5	Petunia hybrida	25%	86%
H3ZPL1	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	24%	99%
H3ZPU1	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	29%	100%
O07587	Bacillus subtilis (strain 168)	21%	100%
O14209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	98%
O31665	Bacillus subtilis (strain 168)	23%	100%
O33822	Thermus aquaticus	29%	100%
O58489	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O66630	Aquifex aeolicus (strain VF5)	27%	100%
O67781	Aquifex aeolicus (strain VF5)	28%	100%
O86459	Rhizobium leguminosarum bv. phaseoli	25%	100%
O87320	Rhizobium meliloti (strain 1021)	24%	100%
P04694	Rattus norvegicus	22%	91%
P09053	Escherichia coli (strain K12)	24%	99%
P0A959	Escherichia coli (strain K12)	24%	100%
P0A960	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
P0A961	Shigella flexneri	24%	100%
P14909	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
P16524	Bacillus subtilis (strain 168)	28%	100%
P17735	Homo sapiens	21%	91%
P18485	Solanum lycopersicum	25%	85%
P23034	Bacillus sp. (strain YM-2)	26%	100%
P23279	Cucurbita pepo	22%	84%
P23599	Cucurbita maxima	22%	84%
P27486	Dianthus caryophyllus	24%	80%
P31531	Glycine max	23%	86%
P39643	Bacillus subtilis (strain 168)	23%	100%
P47039	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	93%
P53001	Bacillus subtilis (strain 168)	27%	100%
P58350	Rhizobium meliloti (strain 1021)	25%	100%
P61003	Methanococcus maripaludis (strain S2 / LL)	22%	100%
P63499	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	22%	97%
P71348	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	100%
P77434	Escherichia coli (strain K12)	24%	100%
P77806	Escherichia coli (strain K12)	33%	100%
P96847	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
P9WPZ4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	100%
P9WPZ5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	35%	100%
P9WQ90	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	97%
P9WQ91	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	97%
Q00379	Cucurbita pepo	22%	84%
Q01912	Vigna radiata var. radiata	24%	100%
Q02635	Rhizobium meliloti (strain 1021)	28%	100%
Q06191	Rhizobium meliloti	25%	100%
Q06429	Arabidopsis thaliana	24%	85%
Q07262	Nicotiana tabacum	23%	84%
Q08415	Rattus norvegicus	33%	98%
Q0P5G4	Bos taurus	36%	91%
Q16773	Homo sapiens	35%	98%
Q17CS8	Aedes aegypti	38%	87%
Q1RGV0	Rickettsia bellii (strain RML369-C)	24%	100%
Q2RK33	Moorella thermoacetica (strain ATCC 39073 / JCM 9320)	24%	100%
Q30ZX9	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	25%	100%
Q31GD4	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	26%	100%
Q3AC10	Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)	26%	100%
Q3S8P9	Streptomyces rimosus	24%	100%
Q3Z8H5	Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)	23%	100%
Q3ZXC8	Dehalococcoides mccartyi (strain CBDB1)	23%	100%
Q4J8X2	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	100%
Q4Q455	Leishmania major	85%	100%
Q4UND3	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	26%	100%
Q4WMJ9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	95%
Q54K95	Dictyostelium discoideum	25%	99%
Q54KM6	Dictyostelium discoideum	38%	95%
Q55128	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	100%
Q56232	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	29%	100%
Q58097	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	25%	100%
Q58365	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q58786	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	99%
Q58874	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	21%	96%
Q58CZ9	Bos taurus	21%	93%
Q58FK9	Rattus norvegicus	35%	91%
Q59228	Geobacillus stearothermophilus	26%	100%
Q5E9H2	Bos taurus	24%	82%
Q5E9N4	Bos taurus	22%	97%
Q5F4K8	Pinus pinaster	27%	84%
Q60013	Streptomyces virginiae	24%	100%
Q60317	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q68XV9	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	25%	100%
Q6LX26	Methanococcus maripaludis (strain S2 / LL)	24%	100%
Q6YP21	Homo sapiens	37%	91%
Q71RI9	Mus musculus	36%	91%
Q72BI1	Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)	24%	100%
Q795M6	Bacillus subtilis (strain 168)	30%	100%
Q7T3E5	Danio rerio	34%	92%
Q7XQ85	Oryza sativa subsp. japonica	23%	86%
Q82DR2	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	25%	100%
Q82WA8	Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)	23%	100%
Q84CG1	Streptomyces vinaceus	24%	100%
Q8BTY1	Mus musculus	34%	98%
Q8DTM1	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
Q8KDS8	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	24%	100%
Q8QZR1	Mus musculus	22%	91%
Q92JE7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	25%	100%
Q93703	Caenorhabditis elegans	24%	89%
Q96QU6	Homo sapiens	24%	83%
Q972A2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	100%
Q9C969	Arabidopsis thaliana	24%	100%
Q9HUI9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	100%
Q9SIE1	Arabidopsis thaliana	23%	87%
Q9SIV0	Arabidopsis thaliana	22%	90%
Q9SNN8	Oryza sativa subsp. japonica	24%	76%
Q9ST02	Hordeum vulgare	24%	90%
Q9SUR6	Arabidopsis thaliana	21%	98%
Q9V0L2	Pyrococcus abyssi (strain GE5 / Orsay)	29%	100%
Q9W698	Takifugu rubripes	21%	67%
Q9WVM8	Mus musculus	22%	97%
Q9X0Y2	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	29%	100%
Q9ZE56	Rickettsia prowazekii (strain Madrid E)	24%	100%
V5BGG8	Trypanosoma cruzi	21%	100%