Retrotransposon protein, putative, unclassified

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLJ3_LEIBR

TriTrypDb:

LbrM.33.1590 , LBRM2903_330021500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.627
CLV_PCSK_KEX2_1	224	226	PF00082	0.552
CLV_PCSK_KEX2_1	86	88	PF00082	0.592
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.551
CLV_PCSK_SKI1_1	105	109	PF00082	0.638
CLV_PCSK_SKI1_1	196	200	PF00082	0.661
DEG_SPOP_SBC_1	149	153	PF00917	0.460
DOC_CKS1_1	110	115	PF01111	0.555
DOC_CYCLIN_RxL_1	193	201	PF00134	0.592
DOC_CYCLIN_yClb3_PxF_3	138	146	PF00134	0.692
DOC_PP1_RVXF_1	85	92	PF00149	0.599
DOC_PP2B_LxvP_1	245	248	PF13499	0.649
DOC_PP4_FxxP_1	110	113	PF00568	0.637
DOC_PP4_FxxP_1	241	244	PF00568	0.557
DOC_USP7_MATH_1	70	74	PF00917	0.772
DOC_WW_Pin1_4	109	114	PF00397	0.757
DOC_WW_Pin1_4	136	141	PF00397	0.581
DOC_WW_Pin1_4	176	181	PF00397	0.672
LIG_14-3-3_CanoR_1	132	140	PF00244	0.678
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_BIR_III_4	120	124	PF00653	0.594
LIG_deltaCOP1_diTrp_1	168	171	PF00928	0.540
LIG_FHA_1	235	241	PF00498	0.501
LIG_FHA_1	32	38	PF00498	0.610
LIG_FHA_2	177	183	PF00498	0.666
LIG_LIR_Apic_2	108	113	PF02991	0.636
LIG_LIR_Nem_3	197	202	PF02991	0.649
LIG_Pex14_2	199	203	PF04695	0.671
LIG_SH2_NCK_1	119	123	PF00017	0.771
LIG_SH3_2	124	129	PF14604	0.646
LIG_SH3_3	111	117	PF00018	0.697
LIG_SH3_3	121	127	PF00018	0.679
LIG_SH3_3	135	141	PF00018	0.739
LIG_SH3_3	227	233	PF00018	0.741
LIG_SH3_3	72	78	PF00018	0.595
LIG_SUMO_SIM_par_1	10	16	PF11976	0.747
LIG_TRFH_1	181	185	PF08558	0.637
LIG_WW_3	112	116	PF00397	0.746
LIG_WW_3	83	87	PF00397	0.529
MOD_CDK_SPxK_1	109	115	PF00069	0.758
MOD_CK2_1	176	182	PF00069	0.667
MOD_GlcNHglycan	72	75	PF01048	0.628
MOD_GSK3_1	105	112	PF00069	0.716
MOD_NEK2_1	203	208	PF00069	0.721
MOD_NEK2_1	234	239	PF00069	0.573
MOD_NEK2_2	194	199	PF00069	0.697
MOD_PKA_2	128	134	PF00069	0.678
MOD_Plk_1	149	155	PF00069	0.479
MOD_ProDKin_1	109	115	PF00069	0.758
MOD_ProDKin_1	136	142	PF00069	0.577
MOD_ProDKin_1	176	182	PF00069	0.677
TRG_ER_diArg_1	85	88	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P385	Leptomonas seymouri	48%	90%
A0A1X0P111	Trypanosomatidae	30%	70%
A0A3S7X6L8	Leishmania donovani	69%	94%
A0A422NCP6	Trypanosoma rangeli	30%	83%
A4HLJ1	Leishmania braziliensis	100%	100%
A4I8Z9	Leishmania infantum	69%	94%
E9B3W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	94%
Q4Q456	Leishmania major	68%	100%