Putative expression-site associated gene (ESAG3)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3), putative

Species:

Leishmania braziliensis

UniProt:

A4HLJ2_LEIBR

TriTrypDb:

LbrM.33.1580 , LBRM2903_330021400

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HLJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.436
CLV_NRD_NRD_1	201	203	PF00675	0.385
CLV_NRD_NRD_1	259	261	PF00675	0.743
CLV_NRD_NRD_1	280	282	PF00675	0.570
CLV_NRD_NRD_1	418	420	PF00675	0.547
CLV_PCSK_KEX2_1	165	167	PF00082	0.551
CLV_PCSK_KEX2_1	201	203	PF00082	0.385
CLV_PCSK_KEX2_1	259	261	PF00082	0.522
CLV_PCSK_KEX2_1	280	282	PF00082	0.570
CLV_PCSK_KEX2_1	65	67	PF00082	0.575
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.551
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.581
CLV_PCSK_SKI1_1	137	141	PF00082	0.523
CLV_PCSK_SKI1_1	202	206	PF00082	0.470
CLV_PCSK_SKI1_1	295	299	PF00082	0.674
CLV_PCSK_SKI1_1	353	357	PF00082	0.563
CLV_PCSK_SKI1_1	66	70	PF00082	0.662
DEG_APCC_DBOX_1	240	248	PF00400	0.463
DEG_APCC_DBOX_1	418	426	PF00400	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.421
DOC_ANK_TNKS_1	268	275	PF00023	0.526
DOC_CKS1_1	345	350	PF01111	0.660
DOC_CYCLIN_RxL_1	292	301	PF00134	0.442
DOC_MAPK_gen_1	180	188	PF00069	0.404
DOC_MAPK_gen_1	419	427	PF00069	0.458
DOC_MAPK_MEF2A_6	180	188	PF00069	0.550
DOC_MAPK_MEF2A_6	419	427	PF00069	0.564
DOC_PP2B_LxvP_1	446	449	PF13499	0.615
DOC_PP2B_LxvP_1	69	72	PF13499	0.553
DOC_USP7_MATH_1	164	168	PF00917	0.581
DOC_USP7_MATH_1	285	289	PF00917	0.434
DOC_USP7_MATH_1	383	387	PF00917	0.586
DOC_USP7_MATH_1	410	414	PF00917	0.626
DOC_USP7_UBL2_3	125	129	PF12436	0.355
DOC_WW_Pin1_4	155	160	PF00397	0.515
DOC_WW_Pin1_4	20	25	PF00397	0.623
DOC_WW_Pin1_4	212	217	PF00397	0.517
DOC_WW_Pin1_4	258	263	PF00397	0.611
DOC_WW_Pin1_4	344	349	PF00397	0.664
LIG_14-3-3_CanoR_1	109	117	PF00244	0.553
LIG_14-3-3_CanoR_1	280	287	PF00244	0.576
LIG_14-3-3_CanoR_1	395	401	PF00244	0.601
LIG_BRCT_BRCA1_1	360	364	PF00533	0.663
LIG_BRCT_BRCA1_1	87	91	PF00533	0.477
LIG_Clathr_ClatBox_1	275	279	PF01394	0.592
LIG_deltaCOP1_diTrp_1	4	12	PF00928	0.587
LIG_deltaCOP1_diTrp_1	424	433	PF00928	0.580
LIG_eIF4E_1	270	276	PF01652	0.525
LIG_FHA_1	183	189	PF00498	0.507
LIG_FHA_1	259	265	PF00498	0.741
LIG_FHA_1	284	290	PF00498	0.570
LIG_FHA_1	345	351	PF00498	0.659
LIG_FHA_1	413	419	PF00498	0.553
LIG_FHA_1	59	65	PF00498	0.527
LIG_FHA_2	354	360	PF00498	0.637
LIG_FHA_2	6	12	PF00498	0.642
LIG_GBD_Chelix_1	203	211	PF00786	0.321
LIG_LIR_Apic_2	267	273	PF02991	0.579
LIG_LIR_Gen_1	122	131	PF02991	0.486
LIG_LIR_Gen_1	430	439	PF02991	0.578
LIG_LIR_Nem_3	11	15	PF02991	0.559
LIG_LIR_Nem_3	122	126	PF02991	0.597
LIG_LIR_Nem_3	170	176	PF02991	0.452
LIG_LIR_Nem_3	430	436	PF02991	0.559
LIG_PCNA_yPIPBox_3	137	151	PF02747	0.400
LIG_Pex14_2	15	19	PF04695	0.711
LIG_RPA_C_Fungi	191	203	PF08784	0.405
LIG_SH2_CRK	123	127	PF00017	0.476
LIG_SH2_CRK	270	274	PF00017	0.523
LIG_SH2_CRK	382	386	PF00017	0.537
LIG_SH2_NCK_1	123	127	PF00017	0.390
LIG_SH2_STAP1	160	164	PF00017	0.457
LIG_SH2_STAP1	266	270	PF00017	0.554
LIG_SH2_STAP1	293	297	PF00017	0.433
LIG_SH2_STAP1	398	402	PF00017	0.564
LIG_SH2_STAT3	160	163	PF00017	0.557
LIG_SH2_STAT5	160	163	PF00017	0.519
LIG_SH2_STAT5	193	196	PF00017	0.547
LIG_SH2_STAT5	239	242	PF00017	0.452
LIG_SH2_STAT5	303	306	PF00017	0.568
LIG_SH3_1	259	265	PF00018	0.532
LIG_SH3_3	259	265	PF00018	0.568
LIG_SH3_3	343	349	PF00018	0.611
LIG_SH3_3	372	378	PF00018	0.614
LIG_SH3_3	61	67	PF00018	0.603
LIG_SH3_3	89	95	PF00018	0.465
LIG_TRAF2_1	24	27	PF00917	0.471
LIG_TRAF2_2	24	29	PF00917	0.471
LIG_TYR_ITIM	96	101	PF00017	0.321
MOD_CK1_1	127	133	PF00069	0.554
MOD_CK1_1	158	164	PF00069	0.436
MOD_CK1_1	182	188	PF00069	0.541
MOD_CK1_1	258	264	PF00069	0.605
MOD_CK1_1	308	314	PF00069	0.573
MOD_CMANNOS	314	317	PF00535	0.567
MOD_GlcNHglycan	126	129	PF01048	0.582
MOD_GlcNHglycan	353	356	PF01048	0.575
MOD_GlcNHglycan	76	79	PF01048	0.512
MOD_GSK3_1	155	162	PF00069	0.512
MOD_GSK3_1	206	213	PF00069	0.582
MOD_GSK3_1	279	286	PF00069	0.441
MOD_N-GLC_1	174	179	PF02516	0.551
MOD_N-GLC_1	434	439	PF02516	0.643
MOD_N-GLC_1	58	63	PF02516	0.534
MOD_N-GLC_2	80	82	PF02516	0.416
MOD_NEK2_1	135	140	PF00069	0.401
MOD_NEK2_1	192	197	PF00069	0.547
MOD_NEK2_1	291	296	PF00069	0.530
MOD_NEK2_1	337	342	PF00069	0.631
MOD_NEK2_1	351	356	PF00069	0.573
MOD_NEK2_1	390	395	PF00069	0.381
MOD_NEK2_2	293	298	PF00069	0.433
MOD_PIKK_1	130	136	PF00454	0.375
MOD_PIKK_1	159	165	PF00454	0.559
MOD_PKA_2	179	185	PF00069	0.444
MOD_PKA_2	279	285	PF00069	0.582
MOD_PKA_2	410	416	PF00069	0.591
MOD_Plk_1	174	180	PF00069	0.557
MOD_Plk_1	305	311	PF00069	0.648
MOD_Plk_1	434	440	PF00069	0.576
MOD_Plk_2-3	25	31	PF00069	0.564
MOD_Plk_4	174	180	PF00069	0.604
MOD_Plk_4	182	188	PF00069	0.520
MOD_Plk_4	206	212	PF00069	0.441
MOD_Plk_4	293	299	PF00069	0.529
MOD_Plk_4	396	402	PF00069	0.657
MOD_Plk_4	441	447	PF00069	0.566
MOD_ProDKin_1	155	161	PF00069	0.520
MOD_ProDKin_1	20	26	PF00069	0.623
MOD_ProDKin_1	212	218	PF00069	0.524
MOD_ProDKin_1	258	264	PF00069	0.605
MOD_ProDKin_1	344	350	PF00069	0.667
MOD_SUMO_rev_2	39	47	PF00179	0.526
TRG_DiLeu_BaEn_2	428	434	PF01217	0.578
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.630
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.593
TRG_ENDOCYTIC_2	123	126	PF00928	0.504
TRG_ENDOCYTIC_2	398	401	PF00928	0.580
TRG_ENDOCYTIC_2	98	101	PF00928	0.380
TRG_ER_diArg_1	200	202	PF00400	0.401
TRG_ER_diArg_1	240	243	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	58%	70%
A0A3Q8ID98	Leishmania donovani	30%	72%
A0A3Q8IM92	Leishmania donovani	79%	67%
A4H7X2	Leishmania braziliensis	31%	100%
A4HLI8	Leishmania braziliensis	90%	100%
A4HLJ0	Leishmania braziliensis	92%	100%
A4HW99	Leishmania infantum	30%	72%
A4I8Z8	Leishmania infantum	79%	67%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	72%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	67%
Q4Q457	Leishmania major	79%	100%
Q4QFI2	Leishmania major	30%	100%