Genome assembly, chromosome: II

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLJ1_LEIBR

TriTrypDb:

LbrM.33.1570 , LBRM2903_330021500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.672
CLV_PCSK_KEX2_1	224	226	PF00082	0.543
CLV_PCSK_KEX2_1	86	88	PF00082	0.639
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.542
CLV_PCSK_SKI1_1	105	109	PF00082	0.656
CLV_PCSK_SKI1_1	196	200	PF00082	0.653
DEG_SPOP_SBC_1	149	153	PF00917	0.513
DOC_CKS1_1	110	115	PF01111	0.560
DOC_CYCLIN_RxL_1	193	201	PF00134	0.587
DOC_CYCLIN_yClb3_PxF_3	138	146	PF00134	0.734
DOC_PP1_RVXF_1	85	92	PF00149	0.640
DOC_PP2B_LxvP_1	245	248	PF13499	0.661
DOC_PP4_FxxP_1	110	113	PF00568	0.642
DOC_PP4_FxxP_1	241	244	PF00568	0.573
DOC_USP7_MATH_1	70	74	PF00917	0.768
DOC_WW_Pin1_4	109	114	PF00397	0.764
DOC_WW_Pin1_4	136	141	PF00397	0.594
DOC_WW_Pin1_4	176	181	PF00397	0.682
LIG_14-3-3_CanoR_1	132	140	PF00244	0.679
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BIR_III_4	120	124	PF00653	0.594
LIG_deltaCOP1_diTrp_1	168	171	PF00928	0.546
LIG_FHA_1	235	241	PF00498	0.493
LIG_FHA_1	32	38	PF00498	0.634
LIG_FHA_2	177	183	PF00498	0.675
LIG_LIR_Apic_2	108	113	PF02991	0.647
LIG_LIR_Nem_3	197	202	PF02991	0.639
LIG_Pex14_2	199	203	PF04695	0.658
LIG_SH2_NCK_1	119	123	PF00017	0.770
LIG_SH3_2	124	129	PF14604	0.644
LIG_SH3_3	111	117	PF00018	0.702
LIG_SH3_3	121	127	PF00018	0.672
LIG_SH3_3	135	141	PF00018	0.751
LIG_SH3_3	227	233	PF00018	0.736
LIG_SH3_3	72	78	PF00018	0.601
LIG_SUMO_SIM_par_1	10	16	PF11976	0.754
LIG_TRFH_1	181	185	PF08558	0.630
LIG_WW_3	112	116	PF00397	0.748
LIG_WW_3	83	87	PF00397	0.567
MOD_CDK_SPxK_1	109	115	PF00069	0.766
MOD_CK2_1	176	182	PF00069	0.676
MOD_GlcNHglycan	72	75	PF01048	0.633
MOD_GSK3_1	105	112	PF00069	0.731
MOD_NEK2_1	203	208	PF00069	0.701
MOD_NEK2_1	234	239	PF00069	0.558
MOD_NEK2_2	194	199	PF00069	0.696
MOD_PKA_2	128	134	PF00069	0.678
MOD_Plk_1	149	155	PF00069	0.532
MOD_ProDKin_1	109	115	PF00069	0.766
MOD_ProDKin_1	136	142	PF00069	0.592
MOD_ProDKin_1	176	182	PF00069	0.686
TRG_ER_diArg_1	85	88	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P385	Leptomonas seymouri	48%	90%
A0A1X0P111	Trypanosomatidae	30%	70%
A0A3S7X6L8	Leishmania donovani	68%	94%
A0A422NCP6	Trypanosoma rangeli	30%	83%
A4HLJ3	Leishmania braziliensis	100%	100%
A4I8Z9	Leishmania infantum	68%	94%
E9B3W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	94%
Q4Q456	Leishmania major	68%	100%