Putative expression-site associated gene (ESAG3)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3), putative

Species:

Leishmania braziliensis

UniProt:

A4HLJ0_LEIBR

TriTrypDb:

LbrM.33.1560 , LBRM2903_330020700

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HLJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.544
CLV_NRD_NRD_1	130	132	PF00675	0.504
CLV_NRD_NRD_1	133	135	PF00675	0.544
CLV_NRD_NRD_1	15	17	PF00675	0.442
CLV_NRD_NRD_1	177	179	PF00675	0.546
CLV_NRD_NRD_1	22	24	PF00675	0.404
CLV_NRD_NRD_1	400	402	PF00675	0.498
CLV_NRD_NRD_1	458	460	PF00675	0.594
CLV_NRD_NRD_1	479	481	PF00675	0.554
CLV_NRD_NRD_1	617	619	PF00675	0.590
CLV_PCSK_FUR_1	109	113	PF00082	0.561
CLV_PCSK_FUR_1	131	135	PF00082	0.554
CLV_PCSK_KEX2_1	111	113	PF00082	0.544
CLV_PCSK_KEX2_1	130	132	PF00082	0.504
CLV_PCSK_KEX2_1	133	135	PF00082	0.544
CLV_PCSK_KEX2_1	14	16	PF00082	0.459
CLV_PCSK_KEX2_1	177	179	PF00082	0.546
CLV_PCSK_KEX2_1	22	24	PF00082	0.451
CLV_PCSK_KEX2_1	264	266	PF00082	0.574
CLV_PCSK_KEX2_1	364	366	PF00082	0.616
CLV_PCSK_KEX2_1	400	402	PF00082	0.498
CLV_PCSK_KEX2_1	458	460	PF00082	0.562
CLV_PCSK_KEX2_1	479	481	PF00082	0.554
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.621
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.616
CLV_PCSK_SKI1_1	265	269	PF00082	0.594
CLV_PCSK_SKI1_1	336	340	PF00082	0.634
CLV_PCSK_SKI1_1	401	405	PF00082	0.557
CLV_PCSK_SKI1_1	552	556	PF00082	0.574
DEG_APCC_DBOX_1	439	447	PF00400	0.361
DEG_APCC_DBOX_1	617	625	PF00400	0.291
DEG_SPOP_SBC_1	95	99	PF00917	0.377
DOC_ANK_TNKS_1	467	474	PF00023	0.343
DOC_ANK_TNKS_1	87	94	PF00023	0.357
DOC_CKS1_1	50	55	PF01111	0.446
DOC_CKS1_1	544	549	PF01111	0.393
DOC_CYCLIN_RxL_1	175	189	PF00134	0.349
DOC_MAPK_gen_1	130	139	PF00069	0.325
DOC_MAPK_gen_1	177	185	PF00069	0.349
DOC_MAPK_gen_1	479	485	PF00069	0.345
DOC_MAPK_gen_1	618	626	PF00069	0.290
DOC_MAPK_MEF2A_6	380	387	PF00069	0.404
DOC_MAPK_MEF2A_6	618	626	PF00069	0.366
DOC_PP1_RVXF_1	134	140	PF00149	0.340
DOC_PP1_RVXF_1	179	186	PF00149	0.344
DOC_PP2B_LxvP_1	268	271	PF13499	0.357
DOC_PP2B_LxvP_1	645	648	PF13499	0.459
DOC_PP2B_LxvP_1	65	68	PF13499	0.410
DOC_PP4_FxxP_1	162	165	PF00568	0.304
DOC_PP4_FxxP_1	82	85	PF00568	0.355
DOC_SPAK_OSR1_1	138	142	PF12202	0.251
DOC_USP7_MATH_1	105	109	PF00917	0.317
DOC_USP7_MATH_1	153	157	PF00917	0.261
DOC_USP7_MATH_1	323	327	PF00917	0.383
DOC_USP7_MATH_1	34	38	PF00917	0.264
DOC_USP7_MATH_1	363	367	PF00917	0.410
DOC_USP7_MATH_1	609	613	PF00917	0.448
DOC_USP7_MATH_1	68	72	PF00917	0.397
DOC_USP7_MATH_1	95	99	PF00917	0.448
DOC_WW_Pin1_4	219	224	PF00397	0.344
DOC_WW_Pin1_4	354	359	PF00397	0.403
DOC_WW_Pin1_4	379	384	PF00397	0.384
DOC_WW_Pin1_4	411	416	PF00397	0.373
DOC_WW_Pin1_4	457	462	PF00397	0.412
DOC_WW_Pin1_4	49	54	PF00397	0.445
DOC_WW_Pin1_4	543	548	PF00397	0.398
LIG_14-3-3_CanoR_1	16	22	PF00244	0.630
LIG_14-3-3_CanoR_1	308	316	PF00244	0.401
LIG_14-3-3_CanoR_1	479	486	PF00244	0.347
LIG_14-3-3_CanoR_1	512	517	PF00244	0.369
LIG_14-3-3_CanoR_1	594	600	PF00244	0.354
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.342
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	286	290	PF00533	0.332
LIG_BRCT_BRCA1_1	559	563	PF00533	0.471
LIG_Clathr_ClatBox_1	474	478	PF01394	0.361
LIG_deltaCOP1_diTrp_1	203	211	PF00928	0.314
LIG_deltaCOP1_diTrp_1	623	632	PF00928	0.368
LIG_EH1_1	38	46	PF00400	0.234
LIG_eIF4E_1	469	475	PF01652	0.379
LIG_FHA_1	258	264	PF00498	0.416
LIG_FHA_1	382	388	PF00498	0.328
LIG_FHA_1	44	50	PF00498	0.339
LIG_FHA_1	458	464	PF00498	0.453
LIG_FHA_1	544	550	PF00498	0.398
LIG_FHA_1	612	618	PF00498	0.393
LIG_FHA_1	97	103	PF00498	0.445
LIG_FHA_2	205	211	PF00498	0.351
LIG_FHA_2	408	414	PF00498	0.309
LIG_FHA_2	553	559	PF00498	0.394
LIG_FHA_2	95	101	PF00498	0.469
LIG_Integrin_isoDGR_2	29	31	PF01839	0.356
LIG_LIR_Apic_2	466	472	PF02991	0.387
LIG_LIR_Gen_1	172	179	PF02991	0.359
LIG_LIR_Gen_1	180	186	PF02991	0.349
LIG_LIR_Gen_1	629	638	PF02991	0.337
LIG_LIR_Nem_3	172	176	PF02991	0.367
LIG_LIR_Nem_3	180	185	PF02991	0.353
LIG_LIR_Nem_3	210	214	PF02991	0.320
LIG_LIR_Nem_3	321	325	PF02991	0.439
LIG_LIR_Nem_3	369	375	PF02991	0.308
LIG_LIR_Nem_3	629	635	PF02991	0.357
LIG_PCNA_yPIPBox_3	336	350	PF02747	0.334
LIG_Pex14_2	214	218	PF04695	0.454
LIG_Pex14_2	82	86	PF04695	0.277
LIG_RPA_C_Fungi	390	402	PF08784	0.307
LIG_SH2_CRK	322	326	PF00017	0.475
LIG_SH2_CRK	469	473	PF00017	0.460
LIG_SH2_GRB2like	182	185	PF00017	0.261
LIG_SH2_STAP1	359	363	PF00017	0.431
LIG_SH2_STAP1	465	469	PF00017	0.502
LIG_SH2_STAP1	56	60	PF00017	0.440
LIG_SH2_STAP1	597	601	PF00017	0.378
LIG_SH2_STAT3	359	362	PF00017	0.531
LIG_SH2_STAT5	123	126	PF00017	0.433
LIG_SH2_STAT5	182	185	PF00017	0.405
LIG_SH2_STAT5	359	362	PF00017	0.440
LIG_SH2_STAT5	409	412	PF00017	0.434
LIG_SH2_STAT5	438	441	PF00017	0.356
LIG_SH2_STAT5	502	505	PF00017	0.485
LIG_SH3_1	458	464	PF00018	0.435
LIG_SH3_3	260	266	PF00018	0.555
LIG_SH3_3	288	294	PF00018	0.370
LIG_SH3_3	458	464	PF00018	0.462
LIG_SH3_3	482	488	PF00018	0.396
LIG_SH3_3	542	548	PF00018	0.439
LIG_SH3_3	571	577	PF00018	0.441
LIG_Sin3_3	40	47	PF02671	0.209
LIG_TRAF2_1	223	226	PF00917	0.340
LIG_TRAF2_2	223	228	PF00917	0.354
LIG_TYR_ITIM	295	300	PF00017	0.286
MOD_CDK_SPK_2	49	54	PF00069	0.436
MOD_CK1_1	326	332	PF00069	0.496
MOD_CK1_1	357	363	PF00069	0.409
MOD_CK1_1	379	385	PF00069	0.444
MOD_CK1_1	457	463	PF00069	0.492
MOD_CK1_1	507	513	PF00069	0.548
MOD_CK1_1	98	104	PF00069	0.432
MOD_CK2_1	407	413	PF00069	0.349
MOD_CK2_1	514	520	PF00069	0.410
MOD_CK2_1	94	100	PF00069	0.584
MOD_CMANNOS	513	516	PF00535	0.545
MOD_GlcNHglycan	155	158	PF01048	0.405
MOD_GlcNHglycan	275	278	PF01048	0.299
MOD_GlcNHglycan	325	328	PF01048	0.416
MOD_GlcNHglycan	36	39	PF01048	0.281
MOD_GlcNHglycan	552	555	PF01048	0.448
MOD_GSK3_1	149	156	PF00069	0.416
MOD_GSK3_1	160	167	PF00069	0.313
MOD_GSK3_1	354	361	PF00069	0.484
MOD_GSK3_1	405	412	PF00069	0.468
MOD_GSK3_1	94	101	PF00069	0.581
MOD_LATS_1	13	19	PF00433	0.546
MOD_N-GLC_1	169	174	PF02516	0.390
MOD_N-GLC_1	257	262	PF02516	0.520
MOD_N-GLC_1	373	378	PF02516	0.483
MOD_N-GLC_1	633	638	PF02516	0.540
MOD_N-GLC_1	95	100	PF02516	0.446
MOD_N-GLC_2	279	281	PF02516	0.335
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	169	174	PF00069	0.332
MOD_NEK2_1	17	22	PF00069	0.499
MOD_NEK2_1	334	339	PF00069	0.421
MOD_NEK2_1	391	396	PF00069	0.360
MOD_NEK2_1	43	48	PF00069	0.325
MOD_NEK2_1	536	541	PF00069	0.502
MOD_NEK2_1	550	555	PF00069	0.499
MOD_PIKK_1	329	335	PF00454	0.376
MOD_PIKK_1	358	364	PF00454	0.533
MOD_PKA_1	15	21	PF00069	0.536
MOD_PKA_2	132	138	PF00069	0.418
MOD_PKA_2	15	21	PF00069	0.757
MOD_PKA_2	422	428	PF00069	0.427
MOD_PKA_2	478	484	PF00069	0.410
MOD_PKA_2	609	615	PF00069	0.459
MOD_Plk_1	169	175	PF00069	0.429
MOD_Plk_1	373	379	PF00069	0.486
MOD_Plk_1	504	510	PF00069	0.534
MOD_Plk_1	633	639	PF00069	0.412
MOD_Plk_2-3	224	230	PF00069	0.466
MOD_Plk_4	286	292	PF00069	0.307
MOD_Plk_4	373	379	PF00069	0.476
MOD_Plk_4	381	387	PF00069	0.399
MOD_Plk_4	492	498	PF00069	0.411
MOD_Plk_4	595	601	PF00069	0.488
MOD_Plk_4	640	646	PF00069	0.449
MOD_ProDKin_1	219	225	PF00069	0.412
MOD_ProDKin_1	354	360	PF00069	0.492
MOD_ProDKin_1	379	385	PF00069	0.455
MOD_ProDKin_1	411	417	PF00069	0.455
MOD_ProDKin_1	457	463	PF00069	0.492
MOD_ProDKin_1	49	55	PF00069	0.449
MOD_ProDKin_1	543	549	PF00069	0.479
MOD_SUMO_rev_2	238	246	PF00179	0.386
TRG_DiLeu_BaEn_2	627	633	PF01217	0.447
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.505
TRG_DiLeu_BaLyEn_6	545	550	PF01217	0.435
TRG_ENDOCYTIC_2	173	176	PF00928	0.431
TRG_ENDOCYTIC_2	182	185	PF00928	0.405
TRG_ENDOCYTIC_2	297	300	PF00928	0.318
TRG_ENDOCYTIC_2	322	325	PF00928	0.503
TRG_ENDOCYTIC_2	56	59	PF00928	0.565
TRG_ENDOCYTIC_2	597	600	PF00928	0.388
TRG_ER_diArg_1	109	112	PF00400	0.434
TRG_ER_diArg_1	129	131	PF00400	0.329
TRG_ER_diArg_1	133	136	PF00400	0.366
TRG_ER_diArg_1	14	16	PF00400	0.606
TRG_ER_diArg_1	176	178	PF00400	0.414
TRG_ER_diArg_1	21	23	PF00400	0.529
TRG_ER_diArg_1	399	401	PF00400	0.337
TRG_ER_diArg_1	439	442	PF00400	0.359
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	54%	100%
A0A3Q8ID98	Leishmania donovani	32%	100%
A0A3Q8IM92	Leishmania donovani	75%	97%
A4H7X2	Leishmania braziliensis	32%	100%
A4HLI8	Leishmania braziliensis	90%	100%
A4HLJ2	Leishmania braziliensis	92%	100%
A4HW99	Leishmania infantum	32%	100%
A4I8Z8	Leishmania infantum	75%	97%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%
Q4Q457	Leishmania major	76%	100%
Q4QFI2	Leishmania major	31%	100%