Putative expression-site associated gene (ESAG3)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression-site associated gene (ESAG3), putative

Species:

Leishmania braziliensis

UniProt:

A4HLI8_LEIBR

TriTrypDb:

LbrM.33.1540 , LBRM2903_330020700

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HLI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.525
CLV_NRD_NRD_1	133	135	PF00675	0.565
CLV_NRD_NRD_1	15	17	PF00675	0.440
CLV_NRD_NRD_1	177	179	PF00675	0.514
CLV_NRD_NRD_1	215	217	PF00675	0.478
CLV_NRD_NRD_1	22	24	PF00675	0.418
CLV_NRD_NRD_1	30	32	PF00675	0.236
CLV_NRD_NRD_1	400	402	PF00675	0.482
CLV_NRD_NRD_1	458	460	PF00675	0.620
CLV_NRD_NRD_1	479	481	PF00675	0.553
CLV_NRD_NRD_1	54	56	PF00675	0.636
CLV_NRD_NRD_1	617	619	PF00675	0.566
CLV_PCSK_FUR_1	131	135	PF00082	0.575
CLV_PCSK_KEX2_1	130	132	PF00082	0.525
CLV_PCSK_KEX2_1	133	135	PF00082	0.565
CLV_PCSK_KEX2_1	14	16	PF00082	0.467
CLV_PCSK_KEX2_1	177	179	PF00082	0.514
CLV_PCSK_KEX2_1	22	24	PF00082	0.436
CLV_PCSK_KEX2_1	264	266	PF00082	0.561
CLV_PCSK_KEX2_1	30	32	PF00082	0.285
CLV_PCSK_KEX2_1	364	366	PF00082	0.586
CLV_PCSK_KEX2_1	400	402	PF00082	0.482
CLV_PCSK_KEX2_1	458	460	PF00082	0.596
CLV_PCSK_KEX2_1	479	481	PF00082	0.553
CLV_PCSK_KEX2_1	54	56	PF00082	0.636
CLV_PCSK_KEX2_1	588	590	PF00082	0.681
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.593
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.586
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.686
CLV_PCSK_SKI1_1	265	269	PF00082	0.564
CLV_PCSK_SKI1_1	336	340	PF00082	0.605
CLV_PCSK_SKI1_1	401	405	PF00082	0.527
CLV_PCSK_SKI1_1	552	556	PF00082	0.626
CLV_PCSK_SKI1_1	588	592	PF00082	0.554
DEG_APCC_DBOX_1	13	21	PF00400	0.609
DEG_APCC_DBOX_1	439	447	PF00400	0.337
DEG_APCC_DBOX_1	617	625	PF00400	0.281
DEG_ODPH_VHL_1	486	498	PF01847	0.307
DEG_SCF_FBW7_2	412	418	PF00400	0.301
DOC_ANK_TNKS_1	467	474	PF00023	0.335
DOC_ANK_TNKS_1	87	94	PF00023	0.347
DOC_CKS1_1	412	417	PF01111	0.298
DOC_CKS1_1	50	55	PF01111	0.448
DOC_CKS1_1	544	549	PF01111	0.405
DOC_CYCLIN_RxL_1	175	189	PF00134	0.323
DOC_MAPK_gen_1	130	139	PF00069	0.313
DOC_MAPK_gen_1	177	185	PF00069	0.322
DOC_MAPK_gen_1	479	485	PF00069	0.340
DOC_MAPK_gen_1	516	523	PF00069	0.450
DOC_MAPK_gen_1	618	626	PF00069	0.280
DOC_MAPK_MEF2A_6	380	387	PF00069	0.397
DOC_MAPK_MEF2A_6	618	626	PF00069	0.340
DOC_MAPK_RevD_3	39	55	PF00069	0.299
DOC_PP1_RVXF_1	134	140	PF00149	0.327
DOC_PP1_RVXF_1	179	186	PF00149	0.319
DOC_PP2B_LxvP_1	268	271	PF13499	0.326
DOC_PP2B_LxvP_1	496	499	PF13499	0.336
DOC_PP2B_LxvP_1	645	648	PF13499	0.446
DOC_PP2B_LxvP_1	65	68	PF13499	0.357
DOC_PP4_FxxP_1	162	165	PF00568	0.287
DOC_PP4_FxxP_1	82	85	PF00568	0.334
DOC_SPAK_OSR1_1	138	142	PF12202	0.245
DOC_USP7_MATH_1	105	109	PF00917	0.309
DOC_USP7_MATH_1	34	38	PF00917	0.279
DOC_USP7_MATH_1	582	586	PF00917	0.391
DOC_USP7_MATH_1	60	64	PF00917	0.372
DOC_USP7_MATH_1	609	613	PF00917	0.416
DOC_USP7_MATH_1	68	72	PF00917	0.374
DOC_WW_Pin1_4	219	224	PF00397	0.330
DOC_WW_Pin1_4	354	359	PF00397	0.396
DOC_WW_Pin1_4	411	416	PF00397	0.352
DOC_WW_Pin1_4	457	462	PF00397	0.438
DOC_WW_Pin1_4	49	54	PF00397	0.438
DOC_WW_Pin1_4	543	548	PF00397	0.402
DOC_WW_Pin1_4	573	578	PF00397	0.310
LIG_14-3-3_CanoR_1	308	316	PF00244	0.389
LIG_14-3-3_CanoR_1	479	486	PF00244	0.341
LIG_14-3-3_CanoR_1	516	523	PF00244	0.378
LIG_14-3-3_CanoR_1	589	597	PF00244	0.334
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.322
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	286	290	PF00533	0.339
LIG_BRCT_BRCA1_1	559	563	PF00533	0.490
LIG_Clathr_ClatBox_1	474	478	PF01394	0.352
LIG_deltaCOP1_diTrp_1	203	211	PF00928	0.305
LIG_deltaCOP1_diTrp_1	623	632	PF00928	0.340
LIG_EH1_1	38	46	PF00400	0.225
LIG_eIF4E_1	469	475	PF01652	0.357
LIG_FHA_1	258	264	PF00498	0.414
LIG_FHA_1	358	364	PF00498	0.359
LIG_FHA_1	382	388	PF00498	0.338
LIG_FHA_1	44	50	PF00498	0.336
LIG_FHA_1	458	464	PF00498	0.462
LIG_FHA_1	493	499	PF00498	0.388
LIG_FHA_1	517	523	PF00498	0.410
LIG_FHA_1	544	550	PF00498	0.411
LIG_FHA_1	574	580	PF00498	0.291
LIG_FHA_1	612	618	PF00498	0.367
LIG_FHA_1	97	103	PF00498	0.430
LIG_FHA_2	205	211	PF00498	0.342
LIG_FHA_2	408	414	PF00498	0.291
LIG_FHA_2	553	559	PF00498	0.434
LIG_FHA_2	95	101	PF00498	0.449
LIG_LIR_Apic_2	466	472	PF02991	0.377
LIG_LIR_Gen_1	180	186	PF02991	0.332
LIG_LIR_Gen_1	37	47	PF02991	0.298
LIG_LIR_Gen_1	408	417	PF02991	0.284
LIG_LIR_Gen_1	629	638	PF02991	0.324
LIG_LIR_Nem_3	180	185	PF02991	0.336
LIG_LIR_Nem_3	210	214	PF02991	0.309
LIG_LIR_Nem_3	321	325	PF02991	0.413
LIG_LIR_Nem_3	369	375	PF02991	0.299
LIG_LIR_Nem_3	37	42	PF02991	0.298
LIG_LIR_Nem_3	408	412	PF02991	0.271
LIG_LIR_Nem_3	576	581	PF02991	0.349
LIG_LIR_Nem_3	629	635	PF02991	0.330
LIG_PCNA_yPIPBox_3	336	350	PF02747	0.323
LIG_Pex14_2	214	218	PF04695	0.408
LIG_Pex14_2	82	86	PF04695	0.271
LIG_RPA_C_Fungi	390	402	PF08784	0.292
LIG_SH2_CRK	469	473	PF00017	0.428
LIG_SH2_CRK	56	60	PF00017	0.484
LIG_SH2_CRK	581	585	PF00017	0.417
LIG_SH2_NCK_1	409	413	PF00017	0.305
LIG_SH2_NCK_1	56	60	PF00017	0.402
LIG_SH2_NCK_1	581	585	PF00017	0.409
LIG_SH2_PTP2	322	325	PF00017	0.355
LIG_SH2_STAP1	359	363	PF00017	0.420
LIG_SH2_STAP1	465	469	PF00017	0.467
LIG_SH2_STAP1	597	601	PF00017	0.379
LIG_SH2_STAT3	359	362	PF00017	0.497
LIG_SH2_STAT5	123	126	PF00017	0.411
LIG_SH2_STAT5	182	185	PF00017	0.386
LIG_SH2_STAT5	322	325	PF00017	0.375
LIG_SH2_STAT5	359	362	PF00017	0.431
LIG_SH2_STAT5	409	412	PF00017	0.396
LIG_SH2_STAT5	438	441	PF00017	0.341
LIG_SH2_STAT5	502	505	PF00017	0.509
LIG_SH3_1	458	464	PF00018	0.475
LIG_SH3_3	288	294	PF00018	0.375
LIG_SH3_3	409	415	PF00018	0.312
LIG_SH3_3	458	464	PF00018	0.499
LIG_SH3_3	482	488	PF00018	0.379
LIG_SH3_3	542	548	PF00018	0.444
LIG_SUMO_SIM_par_1	40	46	PF11976	0.327
LIG_TRAF2_1	223	226	PF00917	0.329
LIG_TRAF2_2	223	228	PF00917	0.344
MOD_CDK_SPK_2	49	54	PF00069	0.431
MOD_CDK_SPxK_1	49	55	PF00069	0.425
MOD_CK1_1	326	332	PF00069	0.471
MOD_CK1_1	357	363	PF00069	0.404
MOD_CK1_1	381	387	PF00069	0.432
MOD_CK1_1	457	463	PF00069	0.530
MOD_CK1_1	507	513	PF00069	0.512
MOD_CK1_1	96	102	PF00069	0.492
MOD_CK2_1	107	113	PF00069	0.402
MOD_CK2_1	407	413	PF00069	0.325
MOD_CK2_1	94	100	PF00069	0.564
MOD_GlcNHglycan	155	158	PF01048	0.400
MOD_GlcNHglycan	325	328	PF01048	0.397
MOD_GlcNHglycan	36	39	PF01048	0.262
MOD_GlcNHglycan	552	555	PF01048	0.528
MOD_GSK3_1	149	156	PF00069	0.424
MOD_GSK3_1	160	167	PF00069	0.294
MOD_GSK3_1	354	361	PF00069	0.473
MOD_GSK3_1	407	414	PF00069	0.426
MOD_GSK3_1	94	101	PF00069	0.586
MOD_LATS_1	13	19	PF00433	0.494
MOD_N-GLC_1	257	262	PF02516	0.521
MOD_N-GLC_1	373	378	PF02516	0.453
MOD_N-GLC_1	516	521	PF02516	0.511
MOD_N-GLC_1	633	638	PF02516	0.482
MOD_NEK2_1	150	155	PF00069	0.314
MOD_NEK2_1	334	339	PF00069	0.399
MOD_NEK2_1	391	396	PF00069	0.343
MOD_NEK2_1	43	48	PF00069	0.306
MOD_NEK2_1	536	541	PF00069	0.480
MOD_NEK2_1	550	555	PF00069	0.565
MOD_PIKK_1	358	364	PF00454	0.499
MOD_PIKK_1	422	428	PF00454	0.440
MOD_PKA_1	15	21	PF00069	0.488
MOD_PKA_1	588	594	PF00069	0.394
MOD_PKA_2	132	138	PF00069	0.386
MOD_PKA_2	15	21	PF00069	0.714
MOD_PKA_2	478	484	PF00069	0.405
MOD_PKA_2	588	594	PF00069	0.383
MOD_PKA_2	609	615	PF00069	0.444
MOD_Plk_1	373	379	PF00069	0.456
MOD_Plk_1	504	510	PF00069	0.540
MOD_Plk_1	633	639	PF00069	0.393
MOD_Plk_2-3	224	230	PF00069	0.432
MOD_Plk_4	318	324	PF00069	0.395
MOD_Plk_4	373	379	PF00069	0.464
MOD_Plk_4	381	387	PF00069	0.415
MOD_Plk_4	492	498	PF00069	0.424
MOD_Plk_4	595	601	PF00069	0.489
MOD_Plk_4	640	646	PF00069	0.431
MOD_ProDKin_1	219	225	PF00069	0.393
MOD_ProDKin_1	354	360	PF00069	0.481
MOD_ProDKin_1	411	417	PF00069	0.425
MOD_ProDKin_1	457	463	PF00069	0.530
MOD_ProDKin_1	49	55	PF00069	0.446
MOD_ProDKin_1	543	549	PF00069	0.490
MOD_ProDKin_1	573	579	PF00069	0.348
MOD_SUMO_rev_2	143	150	PF00179	0.273
MOD_SUMO_rev_2	238	246	PF00179	0.386
MOD_SUMO_rev_2	332	337	PF00179	0.334
TRG_DiLeu_BaEn_2	627	633	PF01217	0.405
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.474
TRG_DiLeu_BaLyEn_6	545	550	PF01217	0.463
TRG_ENDOCYTIC_2	173	176	PF00928	0.392
TRG_ENDOCYTIC_2	182	185	PF00928	0.386
TRG_ENDOCYTIC_2	322	325	PF00928	0.477
TRG_ENDOCYTIC_2	409	412	PF00928	0.306
TRG_ENDOCYTIC_2	56	59	PF00928	0.524
TRG_ENDOCYTIC_2	597	600	PF00928	0.388
TRG_ER_diArg_1	129	131	PF00400	0.371
TRG_ER_diArg_1	133	136	PF00400	0.383
TRG_ER_diArg_1	14	16	PF00400	0.593
TRG_ER_diArg_1	176	178	PF00400	0.401
TRG_ER_diArg_1	21	23	PF00400	0.517
TRG_ER_diArg_1	399	401	PF00400	0.316
TRG_ER_diArg_1	439	442	PF00400	0.343
TRG_ER_diArg_1	53	55	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGZ4	Leptomonas seymouri	57%	100%
A0A3Q8ID98	Leishmania donovani	33%	100%
A0A3Q8IM92	Leishmania donovani	80%	97%
A4H7X2	Leishmania braziliensis	34%	100%
A4HLJ0	Leishmania braziliensis	90%	100%
A4HLJ2	Leishmania braziliensis	90%	100%
A4HW99	Leishmania infantum	33%	100%
A4I8Z8	Leishmania infantum	79%	97%
E9APZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B3W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4Q457	Leishmania major	79%	100%
Q4QFI2	Leishmania major	32%	100%