Pre-mRNA-splicing factor CWC15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLI7_LEIBR

TriTrypDb:

LbrM.33.1530 , LBRM2903_330020600

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HLI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.586
CLV_NRD_NRD_1	19	21	PF00675	0.632
CLV_PCSK_KEX2_1	17	19	PF00082	0.625
CLV_PCSK_KEX2_1	186	188	PF00082	0.642
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.625
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.662
CLV_PCSK_SKI1_1	105	109	PF00082	0.559
CLV_PCSK_SKI1_1	209	213	PF00082	0.560
CLV_PCSK_SKI1_1	48	52	PF00082	0.682
DEG_SPOP_SBC_1	80	84	PF00917	0.784
DOC_USP7_MATH_1	11	15	PF00917	0.665
DOC_USP7_MATH_1	128	132	PF00917	0.685
DOC_USP7_MATH_1	136	140	PF00917	0.686
DOC_USP7_MATH_1	148	152	PF00917	0.639
DOC_USP7_MATH_1	70	74	PF00917	0.706
DOC_USP7_MATH_1	80	84	PF00917	0.606
DOC_USP7_UBL2_3	186	190	PF12436	0.621
DOC_USP7_UBL2_3	209	213	PF12436	0.478
DOC_USP7_UBL2_3	72	76	PF12436	0.779
DOC_WW_Pin1_4	144	149	PF00397	0.781
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	200	204	PF00533	0.566
LIG_BRCT_BRCA1_1	63	67	PF00533	0.537
LIG_eIF4E_1	163	169	PF01652	0.569
LIG_FHA_2	179	185	PF00498	0.658
LIG_LIR_Nem_3	201	207	PF02991	0.513
LIG_Pex14_2	207	211	PF04695	0.521
LIG_REV1ctd_RIR_1	209	213	PF16727	0.560
LIG_SH2_STAP1	163	167	PF00017	0.614
LIG_TRAF2_1	182	185	PF00917	0.456
LIG_ULM_U2AF65_1	186	192	PF00076	0.557
MOD_CK1_1	146	152	PF00069	0.724
MOD_CK1_1	178	184	PF00069	0.657
MOD_CK1_1	66	72	PF00069	0.753
MOD_CK1_1	82	88	PF00069	0.683
MOD_CK2_1	178	184	PF00069	0.736
MOD_CK2_1	86	92	PF00069	0.629
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	134	137	PF01048	0.674
MOD_GlcNHglycan	138	141	PF01048	0.703
MOD_GlcNHglycan	148	151	PF01048	0.602
MOD_GlcNHglycan	48	51	PF01048	0.582
MOD_GlcNHglycan	63	66	PF01048	0.737
MOD_GlcNHglycan	68	71	PF01048	0.725
MOD_GlcNHglycan	73	76	PF01048	0.675
MOD_GSK3_1	128	135	PF00069	0.686
MOD_GSK3_1	144	151	PF00069	0.553
MOD_GSK3_1	175	182	PF00069	0.631
MOD_GSK3_1	20	27	PF00069	0.680
MOD_GSK3_1	44	51	PF00069	0.734
MOD_GSK3_1	57	64	PF00069	0.719
MOD_GSK3_1	66	73	PF00069	0.664
MOD_GSK3_1	79	86	PF00069	0.611
MOD_N-GLC_1	136	141	PF02516	0.543
MOD_N-GLC_1	195	200	PF02516	0.518
MOD_N-GLC_1	57	62	PF02516	0.621
MOD_PIKK_1	195	201	PF00454	0.591
MOD_PIKK_1	20	26	PF00454	0.768
MOD_PK_1	190	196	PF00069	0.703
MOD_PKA_2	80	86	PF00069	0.737
MOD_PKB_1	18	26	PF00069	0.761
MOD_Plk_4	11	17	PF00069	0.738
MOD_Plk_4	190	196	PF00069	0.703
MOD_ProDKin_1	144	150	PF00069	0.779
TRG_ER_diArg_1	18	20	PF00400	0.633
TRG_NLS_MonoCore_2	16	21	PF00514	0.631
TRG_NLS_MonoExtC_3	16	22	PF00514	0.683
TRG_NLS_MonoExtC_3	186	192	PF00514	0.501
TRG_NLS_MonoExtN_4	186	191	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U6	Leptomonas seymouri	47%	100%
A0A3S7X6R7	Leishmania donovani	76%	99%
A4I8Z7	Leishmania infantum	72%	100%
D0A4Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q458	Leishmania major	75%	100%
V5BLV0	Trypanosoma cruzi	31%	100%