Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HLI6_LEIBR

TriTrypDb:

LbrM.33.1520 , LBRM2903_330020500

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4
GO:0005576	extracellular region	2	2

Expansion

Sequence features

A4HLI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	503	507	PF00656	0.319
CLV_NRD_NRD_1	125	127	PF00675	0.504
CLV_NRD_NRD_1	180	182	PF00675	0.462
CLV_NRD_NRD_1	214	216	PF00675	0.469
CLV_NRD_NRD_1	239	241	PF00675	0.442
CLV_NRD_NRD_1	455	457	PF00675	0.660
CLV_NRD_NRD_1	638	640	PF00675	0.448
CLV_PCSK_FUR_1	237	241	PF00082	0.478
CLV_PCSK_KEX2_1	236	238	PF00082	0.464
CLV_PCSK_KEX2_1	239	241	PF00082	0.476
CLV_PCSK_KEX2_1	286	288	PF00082	0.456
CLV_PCSK_KEX2_1	455	457	PF00082	0.612
CLV_PCSK_KEX2_1	510	512	PF00082	0.604
CLV_PCSK_KEX2_1	619	621	PF00082	0.423
CLV_PCSK_KEX2_1	638	640	PF00082	0.432
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.474
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.456
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.604
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.404
CLV_PCSK_SKI1_1	111	115	PF00082	0.428
CLV_PCSK_SKI1_1	204	208	PF00082	0.451
CLV_PCSK_SKI1_1	239	243	PF00082	0.484
CLV_PCSK_SKI1_1	286	290	PF00082	0.442
CLV_PCSK_SKI1_1	448	452	PF00082	0.591
CLV_PCSK_SKI1_1	589	593	PF00082	0.477
CLV_PCSK_SKI1_1	75	79	PF00082	0.610
CLV_Separin_Metazoa	449	453	PF03568	0.441
DEG_APCC_DBOX_1	518	526	PF00400	0.375
DEG_APCC_DBOX_1	588	596	PF00400	0.222
DEG_SPOP_SBC_1	256	260	PF00917	0.151
DEG_SPOP_SBC_1	336	340	PF00917	0.350
DOC_CKS1_1	369	374	PF01111	0.248
DOC_CKS1_1	57	62	PF01111	0.376
DOC_CYCLIN_RxL_1	108	115	PF00134	0.306
DOC_CYCLIN_RxL_1	201	211	PF00134	0.318
DOC_CYCLIN_RxL_1	584	596	PF00134	0.310
DOC_MAPK_gen_1	239	250	PF00069	0.290
DOC_MAPK_gen_1	376	385	PF00069	0.208
DOC_MAPK_gen_1	40	48	PF00069	0.326
DOC_MAPK_gen_1	455	464	PF00069	0.384
DOC_MAPK_MEF2A_6	135	144	PF00069	0.273
DOC_MAPK_MEF2A_6	243	250	PF00069	0.320
DOC_MAPK_MEF2A_6	83	91	PF00069	0.290
DOC_PP1_RVXF_1	202	208	PF00149	0.245
DOC_PP1_RVXF_1	372	378	PF00149	0.311
DOC_PP1_RVXF_1	587	594	PF00149	0.204
DOC_PP2B_LxvP_1	162	165	PF13499	0.311
DOC_PP2B_LxvP_1	248	251	PF13499	0.256
DOC_PP4_FxxP_1	207	210	PF00568	0.208
DOC_PP4_FxxP_1	57	60	PF00568	0.386
DOC_USP7_MATH_1	148	152	PF00917	0.208
DOC_USP7_MATH_1	166	170	PF00917	0.288
DOC_USP7_MATH_1	256	260	PF00917	0.256
DOC_USP7_MATH_1	582	586	PF00917	0.256
DOC_USP7_UBL2_3	510	514	PF12436	0.409
DOC_WW_Pin1_4	144	149	PF00397	0.365
DOC_WW_Pin1_4	167	172	PF00397	0.194
DOC_WW_Pin1_4	338	343	PF00397	0.308
DOC_WW_Pin1_4	368	373	PF00397	0.350
DOC_WW_Pin1_4	477	482	PF00397	0.376
DOC_WW_Pin1_4	56	61	PF00397	0.316
LIG_14-3-3_CanoR_1	215	219	PF00244	0.298
LIG_14-3-3_CanoR_1	287	293	PF00244	0.256
LIG_14-3-3_CanoR_1	40	46	PF00244	0.288
LIG_14-3-3_CanoR_1	622	627	PF00244	0.711
LIG_Actin_RPEL_3	4	23	PF02755	0.454
LIG_Actin_WH2_2	381	399	PF00022	0.311
LIG_Actin_WH2_2	457	474	PF00022	0.327
LIG_Actin_WH2_2	606	624	PF00022	0.591
LIG_BIR_III_4	294	298	PF00653	0.250
LIG_BRCT_BRCA1_1	589	593	PF00533	0.355
LIG_Clathr_ClatBox_1	262	266	PF01394	0.213
LIG_CSL_BTD_1	160	163	PF09270	0.311
LIG_CtBP_PxDLS_1	63	67	PF00389	0.416
LIG_eIF4E_1	257	263	PF01652	0.274
LIG_eIF4E_1	379	385	PF01652	0.311
LIG_eIF4E_1	603	609	PF01652	0.300
LIG_FHA_1	105	111	PF00498	0.313
LIG_FHA_1	18	24	PF00498	0.253
LIG_FHA_1	185	191	PF00498	0.309
LIG_FHA_1	258	264	PF00498	0.193
LIG_FHA_1	37	43	PF00498	0.278
LIG_FHA_1	452	458	PF00498	0.399
LIG_FHA_2	131	137	PF00498	0.262
LIG_FHA_2	215	221	PF00498	0.238
LIG_FHA_2	289	295	PF00498	0.243
LIG_FHA_2	430	436	PF00498	0.329
LIG_FHA_2	56	62	PF00498	0.303
LIG_GBD_Chelix_1	571	579	PF00786	0.479
LIG_LIR_Gen_1	105	114	PF02991	0.179
LIG_LIR_Gen_1	138	149	PF02991	0.220
LIG_LIR_Gen_1	290	301	PF02991	0.241
LIG_LIR_Gen_1	359	367	PF02991	0.307
LIG_LIR_Gen_1	409	419	PF02991	0.277
LIG_LIR_Gen_1	427	436	PF02991	0.322
LIG_LIR_Gen_1	532	541	PF02991	0.386
LIG_LIR_Gen_1	602	613	PF02991	0.308
LIG_LIR_Gen_1	85	95	PF02991	0.256
LIG_LIR_Nem_3	105	109	PF02991	0.172
LIG_LIR_Nem_3	138	144	PF02991	0.245
LIG_LIR_Nem_3	189	194	PF02991	0.212
LIG_LIR_Nem_3	290	296	PF02991	0.241
LIG_LIR_Nem_3	359	363	PF02991	0.307
LIG_LIR_Nem_3	409	414	PF02991	0.282
LIG_LIR_Nem_3	427	431	PF02991	0.315
LIG_LIR_Nem_3	528	533	PF02991	0.451
LIG_LIR_Nem_3	602	608	PF02991	0.308
LIG_LIR_Nem_3	85	91	PF02991	0.276
LIG_MAD2	111	119	PF02301	0.311
LIG_NRBOX	109	115	PF00104	0.279
LIG_NRBOX	201	207	PF00104	0.311
LIG_NRBOX	570	576	PF00104	0.468
LIG_NRBOX	587	593	PF00104	0.300
LIG_PCNA_yPIPBox_3	261	272	PF02747	0.365
LIG_PCNA_yPIPBox_3	606	620	PF02747	0.576
LIG_Pex14_2	238	242	PF04695	0.311
LIG_Pex14_2	301	305	PF04695	0.218
LIG_Pex14_2	385	389	PF04695	0.274
LIG_Rb_pABgroove_1	201	209	PF01858	0.311
LIG_Rb_pABgroove_1	287	295	PF01858	0.274
LIG_SH2_CRK	196	200	PF00017	0.218
LIG_SH2_CRK	360	364	PF00017	0.311
LIG_SH2_CRK	381	385	PF00017	0.208
LIG_SH2_CRK	478	482	PF00017	0.268
LIG_SH2_CRK	605	609	PF00017	0.274
LIG_SH2_NCK_1	428	432	PF00017	0.359
LIG_SH2_NCK_1	502	506	PF00017	0.271
LIG_SH2_NCK_1	533	537	PF00017	0.374
LIG_SH2_PTP2	27	30	PF00017	0.272
LIG_SH2_PTP2	88	91	PF00017	0.275
LIG_SH2_SRC	379	382	PF00017	0.311
LIG_SH2_SRC	428	431	PF00017	0.359
LIG_SH2_SRC	502	505	PF00017	0.245
LIG_SH2_STAP1	106	110	PF00017	0.362
LIG_SH2_STAP1	196	200	PF00017	0.293
LIG_SH2_STAP1	381	385	PF00017	0.208
LIG_SH2_STAP1	533	537	PF00017	0.374
LIG_SH2_STAT5	106	109	PF00017	0.264
LIG_SH2_STAT5	249	252	PF00017	0.218
LIG_SH2_STAT5	257	260	PF00017	0.218
LIG_SH2_STAT5	27	30	PF00017	0.275
LIG_SH2_STAT5	508	511	PF00017	0.281
LIG_SH2_STAT5	603	606	PF00017	0.387
LIG_SH2_STAT5	88	91	PF00017	0.250
LIG_SH3_3	115	121	PF00018	0.218
LIG_SH3_3	177	183	PF00018	0.218
LIG_SH3_3	57	63	PF00018	0.375
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.180
LIG_SUMO_SIM_anti_2	258	266	PF11976	0.231
LIG_SUMO_SIM_anti_2	467	472	PF11976	0.263
LIG_SUMO_SIM_anti_2	64	71	PF11976	0.234
LIG_SUMO_SIM_par_1	361	366	PF11976	0.208
LIG_TRAF2_1	62	65	PF00917	0.318
LIG_UBA3_1	199	204	PF00899	0.285
LIG_UBA3_1	384	393	PF00899	0.323
LIG_WRC_WIRS_1	411	416	PF05994	0.276
MOD_CDK_SPxK_1	368	374	PF00069	0.248
MOD_CDK_SPxxK_3	477	484	PF00069	0.375
MOD_CK1_1	186	192	PF00069	0.311
MOD_CK1_1	214	220	PF00069	0.311
MOD_CK1_1	387	393	PF00069	0.274
MOD_CK1_1	41	47	PF00069	0.301
MOD_CK2_1	130	136	PF00069	0.254
MOD_CK2_1	166	172	PF00069	0.312
MOD_CK2_1	424	430	PF00069	0.350
MOD_CK2_1	488	494	PF00069	0.346
MOD_CK2_1	59	65	PF00069	0.317
MOD_GlcNHglycan	150	153	PF01048	0.408
MOD_GlcNHglycan	196	199	PF01048	0.460
MOD_GlcNHglycan	490	493	PF01048	0.516
MOD_GlcNHglycan	538	542	PF01048	0.612
MOD_GSK3_1	144	151	PF00069	0.348
MOD_GSK3_1	226	233	PF00069	0.256
MOD_GSK3_1	34	41	PF00069	0.291
MOD_GSK3_1	55	62	PF00069	0.308
MOD_GSK3_1	604	611	PF00069	0.450
MOD_GSK3_1	64	71	PF00069	0.295
MOD_NEK2_1	17	22	PF00069	0.284
MOD_NEK2_1	230	235	PF00069	0.351
MOD_NEK2_1	3	8	PF00069	0.608
MOD_NEK2_1	38	43	PF00069	0.305
MOD_NEK2_1	384	389	PF00069	0.236
MOD_NEK2_1	451	456	PF00069	0.431
MOD_NEK2_1	488	493	PF00069	0.354
MOD_NEK2_1	587	592	PF00069	0.400
MOD_NEK2_1	593	598	PF00069	0.326
MOD_NEK2_1	601	606	PF00069	0.247
MOD_NEK2_1	608	613	PF00069	0.264
MOD_NMyristoyl	1	7	PF02799	0.493
MOD_PIKK_1	184	190	PF00454	0.256
MOD_PIKK_1	257	263	PF00454	0.231
MOD_PIKK_1	565	571	PF00454	0.366
MOD_PKA_2	125	131	PF00069	0.228
MOD_PKA_2	214	220	PF00069	0.248
MOD_PKA_2	348	354	PF00069	0.318
MOD_PKA_2	451	457	PF00069	0.422
MOD_PKB_1	620	628	PF00069	0.506
MOD_Plk_1	226	232	PF00069	0.250
MOD_Plk_1	34	40	PF00069	0.314
MOD_Plk_1	630	636	PF00069	0.571
MOD_Plk_1	64	70	PF00069	0.398
MOD_Plk_2-3	31	37	PF00069	0.226
MOD_Plk_2-3	532	538	PF00069	0.381
MOD_Plk_4	186	192	PF00069	0.286
MOD_Plk_4	288	294	PF00069	0.214
MOD_Plk_4	384	390	PF00069	0.221
MOD_Plk_4	47	53	PF00069	0.333
MOD_Plk_4	532	538	PF00069	0.343
MOD_Plk_4	570	576	PF00069	0.410
MOD_Plk_4	604	610	PF00069	0.211
MOD_Plk_4	64	70	PF00069	0.288
MOD_ProDKin_1	144	150	PF00069	0.365
MOD_ProDKin_1	167	173	PF00069	0.194
MOD_ProDKin_1	338	344	PF00069	0.308
MOD_ProDKin_1	368	374	PF00069	0.350
MOD_ProDKin_1	477	483	PF00069	0.377
MOD_ProDKin_1	56	62	PF00069	0.315
MOD_SUMO_for_1	82	85	PF00179	0.289
MOD_SUMO_rev_2	278	288	PF00179	0.275
TRG_ENDOCYTIC_2	106	109	PF00928	0.264
TRG_ENDOCYTIC_2	196	199	PF00928	0.223
TRG_ENDOCYTIC_2	27	30	PF00928	0.272
TRG_ENDOCYTIC_2	360	363	PF00928	0.311
TRG_ENDOCYTIC_2	381	384	PF00928	0.208
TRG_ENDOCYTIC_2	428	431	PF00928	0.353
TRG_ENDOCYTIC_2	502	505	PF00928	0.306
TRG_ENDOCYTIC_2	533	536	PF00928	0.434
TRG_ENDOCYTIC_2	605	608	PF00928	0.268
TRG_ENDOCYTIC_2	88	91	PF00928	0.250
TRG_ER_diArg_1	238	240	PF00400	0.249
TRG_ER_diArg_1	374	377	PF00400	0.311
TRG_ER_diArg_1	455	457	PF00400	0.415
TRG_ER_diArg_1	620	623	PF00400	0.646
TRG_ER_diArg_1	638	640	PF00400	0.665
TRG_NLS_MonoExtC_3	235	240	PF00514	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML7	Leptomonas seymouri	27%	100%
A0A0N1PA82	Leptomonas seymouri	66%	100%
A0A0S4KEI7	Bodo saltans	27%	100%
A0A0S4KLC8	Bodo saltans	39%	100%
A0A179HKZ8	Purpureocillium lilacinum	29%	100%
A0A1X0P192	Trypanosomatidae	44%	100%
A0A3R7KBH2	Trypanosoma rangeli	43%	100%
A0A3R7KJM1	Trypanosoma rangeli	30%	100%
A0A3S5H636	Leishmania donovani	29%	100%
A0A3S5H7U4	Leishmania donovani	86%	100%
A4H590	Leishmania braziliensis	28%	100%
A4HTH4	Leishmania infantum	29%	100%
A4I8Z6	Leishmania infantum	85%	100%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AMA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B3W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q06567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q3MIX3	Homo sapiens	28%	100%
Q4Q459	Leishmania major	84%	99%
Q4QIE6	Leishmania major	30%	100%
Q54P00	Dictyostelium discoideum	28%	94%
Q6INL7	Xenopus laevis	29%	100%
Q80V03	Mus musculus	27%	100%
Q86TW2	Homo sapiens	29%	100%
Q9D0L4	Mus musculus	29%	100%
Q9W133	Drosophila melanogaster	27%	100%
V5AX60	Trypanosoma cruzi	28%	100%
V5BCS0	Trypanosoma cruzi	45%	100%