LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLI5_LEIBR
TriTrypDb:
LbrM.33.1510 , LBRM2903_330020200 *
Length:
589

Annotations

LeishMANIAdb annotations

Appears to be a transporter, related to vertebrate MFSD6 proteins (whose function is likewise unexplored).. Only expanded in Leptomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A4HLI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 4
GO:0022857 transmembrane transporter activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.706
CLV_C14_Caspase3-7 337 341 PF00656 0.430
CLV_C14_Caspase3-7 40 44 PF00656 0.577
CLV_NRD_NRD_1 208 210 PF00675 0.401
CLV_NRD_NRD_1 474 476 PF00675 0.548
CLV_NRD_NRD_1 501 503 PF00675 0.372
CLV_NRD_NRD_1 534 536 PF00675 0.592
CLV_NRD_NRD_1 553 555 PF00675 0.607
CLV_PCSK_KEX2_1 208 210 PF00082 0.401
CLV_PCSK_KEX2_1 320 322 PF00082 0.264
CLV_PCSK_KEX2_1 501 503 PF00082 0.329
CLV_PCSK_KEX2_1 552 554 PF00082 0.616
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.320
CLV_PCSK_SKI1_1 321 325 PF00082 0.307
CLV_PCSK_SKI1_1 475 479 PF00082 0.442
CLV_PCSK_SKI1_1 554 558 PF00082 0.424
DEG_APCC_DBOX_1 222 230 PF00400 0.197
DEG_APCC_DBOX_1 500 508 PF00400 0.482
DEG_COP1_1 204 213 PF00400 0.181
DOC_CKS1_1 560 565 PF01111 0.618
DOC_CYCLIN_RxL_1 314 328 PF00134 0.416
DOC_MAPK_gen_1 181 190 PF00069 0.545
DOC_MAPK_gen_1 301 309 PF00069 0.527
DOC_MAPK_gen_1 314 324 PF00069 0.382
DOC_MAPK_MEF2A_6 301 309 PF00069 0.530
DOC_MAPK_MEF2A_6 317 326 PF00069 0.341
DOC_MAPK_MEF2A_6 385 392 PF00069 0.477
DOC_MAPK_RevD_3 193 209 PF00069 0.225
DOC_PP4_MxPP_1 1 4 PF00568 0.547
DOC_USP7_MATH_1 101 105 PF00917 0.710
DOC_USP7_MATH_1 196 200 PF00917 0.278
DOC_USP7_MATH_1 54 58 PF00917 0.744
DOC_WW_Pin1_4 150 155 PF00397 0.196
DOC_WW_Pin1_4 224 229 PF00397 0.228
DOC_WW_Pin1_4 50 55 PF00397 0.650
DOC_WW_Pin1_4 559 564 PF00397 0.730
LIG_14-3-3_CanoR_1 183 191 PF00244 0.509
LIG_14-3-3_CanoR_1 223 227 PF00244 0.257
LIG_14-3-3_CanoR_1 377 383 PF00244 0.478
LIG_14-3-3_CanoR_1 558 563 PF00244 0.681
LIG_14-3-3_CanoR_1 96 103 PF00244 0.654
LIG_AP2alpha_1 338 342 PF02296 0.430
LIG_BRCT_BRCA1_1 131 135 PF00533 0.382
LIG_BRCT_BRCA1_1 143 147 PF00533 0.311
LIG_BRCT_BRCA1_1 265 269 PF00533 0.467
LIG_BRCT_BRCA1_1 30 34 PF00533 0.698
LIG_BRCT_BRCA1_1 433 437 PF00533 0.384
LIG_BRCT_BRCA1_1 64 68 PF00533 0.674
LIG_CSL_BTD_1 425 428 PF09270 0.388
LIG_EH1_1 154 162 PF00400 0.333
LIG_eIF4E_1 155 161 PF01652 0.348
LIG_FHA_1 115 121 PF00498 0.672
LIG_FHA_1 184 190 PF00498 0.520
LIG_FHA_1 300 306 PF00498 0.423
LIG_FHA_1 358 364 PF00498 0.332
LIG_FHA_1 444 450 PF00498 0.525
LIG_FHA_1 451 457 PF00498 0.412
LIG_FHA_1 485 491 PF00498 0.373
LIG_FHA_1 555 561 PF00498 0.676
LIG_FHA_2 202 208 PF00498 0.464
LIG_FHA_2 379 385 PF00498 0.459
LIG_FHA_2 38 44 PF00498 0.698
LIG_LIR_Gen_1 214 224 PF02991 0.245
LIG_LIR_Gen_1 244 255 PF02991 0.525
LIG_LIR_Gen_1 272 283 PF02991 0.348
LIG_LIR_Gen_1 31 41 PF02991 0.653
LIG_LIR_Gen_1 340 350 PF02991 0.252
LIG_LIR_Gen_1 406 417 PF02991 0.286
LIG_LIR_Gen_1 421 432 PF02991 0.241
LIG_LIR_Gen_1 467 477 PF02991 0.288
LIG_LIR_Nem_3 212 218 PF02991 0.302
LIG_LIR_Nem_3 244 250 PF02991 0.492
LIG_LIR_Nem_3 252 256 PF02991 0.284
LIG_LIR_Nem_3 272 278 PF02991 0.141
LIG_LIR_Nem_3 31 37 PF02991 0.699
LIG_LIR_Nem_3 340 345 PF02991 0.253
LIG_LIR_Nem_3 396 400 PF02991 0.297
LIG_LIR_Nem_3 406 412 PF02991 0.284
LIG_LIR_Nem_3 421 427 PF02991 0.241
LIG_LIR_Nem_3 467 472 PF02991 0.288
LIG_PCNA_PIPBox_1 124 133 PF02747 0.381
LIG_Pex14_2 131 135 PF04695 0.312
LIG_Pex14_2 338 342 PF04695 0.327
LIG_Pex14_2 422 426 PF04695 0.283
LIG_PTB_Apo_2 338 345 PF02174 0.388
LIG_SH2_CRK 143 147 PF00017 0.263
LIG_SH2_CRK 291 295 PF00017 0.388
LIG_SH2_CRK 402 406 PF00017 0.283
LIG_SH2_CRK 469 473 PF00017 0.294
LIG_SH2_NCK_1 143 147 PF00017 0.311
LIG_SH2_NCK_1 469 473 PF00017 0.348
LIG_SH2_SRC 155 158 PF00017 0.356
LIG_SH2_STAP1 143 147 PF00017 0.359
LIG_SH2_STAP1 291 295 PF00017 0.197
LIG_SH2_STAT5 130 133 PF00017 0.266
LIG_SH2_STAT5 177 180 PF00017 0.463
LIG_SH2_STAT5 203 206 PF00017 0.446
LIG_SH2_STAT5 249 252 PF00017 0.534
LIG_SH2_STAT5 271 274 PF00017 0.288
LIG_SH2_STAT5 282 285 PF00017 0.246
LIG_SH2_STAT5 402 405 PF00017 0.424
LIG_SH2_STAT5 469 472 PF00017 0.351
LIG_SH3_2 51 56 PF14604 0.571
LIG_SH3_3 292 298 PF00018 0.379
LIG_SH3_3 48 54 PF00018 0.694
LIG_SUMO_SIM_anti_2 518 524 PF11976 0.552
LIG_SUMO_SIM_par_1 359 364 PF11976 0.343
LIG_SUMO_SIM_par_1 409 415 PF11976 0.296
LIG_SUMO_SIM_par_1 42 49 PF11976 0.752
LIG_TRAF2_1 239 242 PF00917 0.381
LIG_TYR_ITIM 289 294 PF00017 0.388
LIG_TYR_ITIM 400 405 PF00017 0.236
LIG_TYR_ITIM 490 495 PF00017 0.197
LIG_TYR_ITSM 465 472 PF00017 0.430
LIG_UBA3_1 234 240 PF00899 0.461
LIG_WRC_WIRS_1 394 399 PF05994 0.283
MOD_CDC14_SPxK_1 53 56 PF00782 0.568
MOD_CDK_SPK_2 559 564 PF00069 0.730
MOD_CDK_SPxK_1 50 56 PF00069 0.573
MOD_CK1_1 104 110 PF00069 0.687
MOD_CK1_1 134 140 PF00069 0.350
MOD_CK1_1 22 28 PF00069 0.765
MOD_CK1_1 222 228 PF00069 0.335
MOD_CK1_1 393 399 PF00069 0.357
MOD_CK1_1 443 449 PF00069 0.489
MOD_CK1_1 69 75 PF00069 0.649
MOD_CK2_1 150 156 PF00069 0.311
MOD_CK2_1 378 384 PF00069 0.434
MOD_CK2_1 494 500 PF00069 0.263
MOD_CK2_1 539 545 PF00069 0.701
MOD_GlcNHglycan 102 106 PF01048 0.478
MOD_GlcNHglycan 107 110 PF01048 0.497
MOD_GlcNHglycan 136 139 PF01048 0.278
MOD_GlcNHglycan 15 18 PF01048 0.529
MOD_GlcNHglycan 161 164 PF01048 0.325
MOD_GlcNHglycan 374 377 PF01048 0.314
MOD_GlcNHglycan 443 446 PF01048 0.305
MOD_GlcNHglycan 453 456 PF01048 0.308
MOD_GlcNHglycan 479 482 PF01048 0.326
MOD_GlcNHglycan 48 51 PF01048 0.506
MOD_GlcNHglycan 539 542 PF01048 0.531
MOD_GlcNHglycan 64 67 PF01048 0.529
MOD_GlcNHglycan 83 86 PF01048 0.356
MOD_GlcNHglycan 90 93 PF01048 0.457
MOD_GSK3_1 101 108 PF00069 0.706
MOD_GSK3_1 11 18 PF00069 0.741
MOD_GSK3_1 110 117 PF00069 0.678
MOD_GSK3_1 130 137 PF00069 0.431
MOD_GSK3_1 241 248 PF00069 0.557
MOD_GSK3_1 357 364 PF00069 0.272
MOD_GSK3_1 439 446 PF00069 0.465
MOD_GSK3_1 46 53 PF00069 0.754
MOD_GSK3_1 464 471 PF00069 0.197
MOD_GSK3_1 535 542 PF00069 0.827
MOD_GSK3_1 554 561 PF00069 0.733
MOD_GSK3_1 62 69 PF00069 0.568
MOD_GSK3_1 81 88 PF00069 0.588
MOD_N-GLC_1 167 172 PF02516 0.326
MOD_N-GLC_1 70 75 PF02516 0.483
MOD_NEK2_1 131 136 PF00069 0.372
MOD_NEK2_1 167 172 PF00069 0.403
MOD_NEK2_1 201 206 PF00069 0.311
MOD_NEK2_1 217 222 PF00069 0.338
MOD_NEK2_1 263 268 PF00069 0.323
MOD_NEK2_1 269 274 PF00069 0.302
MOD_NEK2_1 289 294 PF00069 0.141
MOD_NEK2_1 325 330 PF00069 0.327
MOD_NEK2_1 357 362 PF00069 0.298
MOD_NEK2_1 372 377 PF00069 0.508
MOD_NEK2_1 378 383 PF00069 0.499
MOD_NEK2_1 441 446 PF00069 0.504
MOD_NEK2_1 448 453 PF00069 0.292
MOD_NEK2_1 468 473 PF00069 0.337
MOD_NEK2_1 477 482 PF00069 0.251
MOD_NEK2_1 485 490 PF00069 0.153
MOD_NEK2_2 196 201 PF00069 0.440
MOD_PIKK_1 528 534 PF00454 0.727
MOD_PKA_1 535 541 PF00069 0.631
MOD_PKA_2 222 228 PF00069 0.476
MOD_PKA_2 95 101 PF00069 0.722
MOD_PKB_1 552 560 PF00069 0.622
MOD_Plk_1 167 173 PF00069 0.357
MOD_Plk_1 70 76 PF00069 0.750
MOD_Plk_2-3 19 25 PF00069 0.580
MOD_Plk_4 115 121 PF00069 0.652
MOD_Plk_4 173 179 PF00069 0.321
MOD_Plk_4 196 202 PF00069 0.363
MOD_Plk_4 2 8 PF00069 0.563
MOD_Plk_4 263 269 PF00069 0.338
MOD_Plk_4 271 277 PF00069 0.245
MOD_Plk_4 289 295 PF00069 0.158
MOD_Plk_4 327 333 PF00069 0.388
MOD_Plk_4 334 340 PF00069 0.327
MOD_Plk_4 390 396 PF00069 0.297
MOD_Plk_4 400 406 PF00069 0.247
MOD_Plk_4 464 470 PF00069 0.332
MOD_Plk_4 485 491 PF00069 0.404
MOD_Plk_4 494 500 PF00069 0.372
MOD_ProDKin_1 150 156 PF00069 0.196
MOD_ProDKin_1 224 230 PF00069 0.228
MOD_ProDKin_1 50 56 PF00069 0.648
MOD_ProDKin_1 559 565 PF00069 0.728
MOD_SUMO_for_1 239 242 PF00179 0.381
TRG_DiLeu_BaEn_1 156 161 PF01217 0.322
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.430
TRG_DiLeu_BaLyEn_6 225 230 PF01217 0.388
TRG_ENDOCYTIC_2 143 146 PF00928 0.359
TRG_ENDOCYTIC_2 291 294 PF00928 0.352
TRG_ENDOCYTIC_2 336 339 PF00928 0.312
TRG_ENDOCYTIC_2 402 405 PF00928 0.283
TRG_ENDOCYTIC_2 469 472 PF00928 0.252
TRG_ENDOCYTIC_2 492 495 PF00928 0.326
TRG_ER_diArg_1 208 210 PF00400 0.201
TRG_ER_diArg_1 552 554 PF00400 0.686
TRG_ER_FFAT_2 57 69 PF00635 0.556
TRG_NES_CRM1_1 354 368 PF08389 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U9 Leptomonas seymouri 56% 100%
A0A0S4J6V2 Bodo saltans 37% 100%
A0A0S4JFI6 Bodo saltans 35% 100%
A0A1X0P0Y1 Trypanosomatidae 35% 100%
A0A3R7NAF7 Trypanosoma rangeli 35% 100%
A0A3S7X6L2 Leishmania donovani 70% 100%
A4I8Z5 Leishmania infantum 70% 100%
D0A4Z3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9B3W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
Q4Q460 Leishmania major 69% 100%
V5BHD1 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS