Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLI2_LEIBR

TriTrypDb:

LbrM.33.1480 , LBRM2903_330019800

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.303
CLV_C14_Caspase3-7	611	615	PF00656	0.639
CLV_NRD_NRD_1	104	106	PF00675	0.528
CLV_NRD_NRD_1	11	13	PF00675	0.513
CLV_NRD_NRD_1	228	230	PF00675	0.670
CLV_NRD_NRD_1	367	369	PF00675	0.668
CLV_NRD_NRD_1	39	41	PF00675	0.592
CLV_NRD_NRD_1	428	430	PF00675	0.692
CLV_NRD_NRD_1	463	465	PF00675	0.564
CLV_NRD_NRD_1	513	515	PF00675	0.563
CLV_NRD_NRD_1	702	704	PF00675	0.712
CLV_PCSK_KEX2_1	104	106	PF00082	0.528
CLV_PCSK_KEX2_1	13	15	PF00082	0.515
CLV_PCSK_KEX2_1	228	230	PF00082	0.670
CLV_PCSK_KEX2_1	367	369	PF00082	0.635
CLV_PCSK_KEX2_1	39	41	PF00082	0.592
CLV_PCSK_KEX2_1	421	423	PF00082	0.697
CLV_PCSK_KEX2_1	428	430	PF00082	0.627
CLV_PCSK_KEX2_1	513	515	PF00082	0.572
CLV_PCSK_KEX2_1	701	703	PF00082	0.718
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.482
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.697
CLV_PCSK_SKI1_1	127	131	PF00082	0.443
CLV_PCSK_SKI1_1	183	187	PF00082	0.389
CLV_PCSK_SKI1_1	295	299	PF00082	0.570
CLV_PCSK_SKI1_1	496	500	PF00082	0.589
CLV_PCSK_SKI1_1	60	64	PF00082	0.540
CLV_Separin_Metazoa	42	46	PF03568	0.334
DEG_APCC_DBOX_1	11	19	PF00400	0.471
DEG_APCC_DBOX_1	46	54	PF00400	0.300
DEG_APCC_DBOX_1	702	710	PF00400	0.703
DEG_Nend_UBRbox_2	1	3	PF02207	0.648
DEG_SCF_FBW7_1	574	579	PF00400	0.566
DEG_SPOP_SBC_1	254	258	PF00917	0.528
DEG_SPOP_SBC_1	340	344	PF00917	0.603
DEG_SPOP_SBC_1	4	8	PF00917	0.408
DOC_CKS1_1	300	305	PF01111	0.658
DOC_CKS1_1	659	664	PF01111	0.690
DOC_MAPK_DCC_7	101	111	PF00069	0.579
DOC_MAPK_gen_1	101	111	PF00069	0.458
DOC_MAPK_RevD_3	416	429	PF00069	0.553
DOC_PP2B_LxvP_1	41	44	PF13499	0.337
DOC_PP2B_LxvP_1	574	577	PF13499	0.552
DOC_PP4_FxxP_1	185	188	PF00568	0.470
DOC_PP4_FxxP_1	275	278	PF00568	0.550
DOC_USP7_MATH_1	138	142	PF00917	0.524
DOC_USP7_MATH_1	192	196	PF00917	0.508
DOC_USP7_MATH_1	254	258	PF00917	0.663
DOC_USP7_MATH_1	293	297	PF00917	0.707
DOC_USP7_MATH_1	340	344	PF00917	0.654
DOC_USP7_MATH_1	398	402	PF00917	0.615
DOC_USP7_MATH_1	5	9	PF00917	0.580
DOC_USP7_MATH_1	553	557	PF00917	0.622
DOC_WW_Pin1_4	144	149	PF00397	0.616
DOC_WW_Pin1_4	235	240	PF00397	0.555
DOC_WW_Pin1_4	299	304	PF00397	0.656
DOC_WW_Pin1_4	312	317	PF00397	0.613
DOC_WW_Pin1_4	320	325	PF00397	0.633
DOC_WW_Pin1_4	431	436	PF00397	0.700
DOC_WW_Pin1_4	467	472	PF00397	0.592
DOC_WW_Pin1_4	524	529	PF00397	0.693
DOC_WW_Pin1_4	572	577	PF00397	0.570
DOC_WW_Pin1_4	648	653	PF00397	0.719
DOC_WW_Pin1_4	655	660	PF00397	0.711
DOC_WW_Pin1_4	734	739	PF00397	0.599
DOC_WW_Pin1_4	748	753	PF00397	0.671
LIG_14-3-3_CanoR_1	113	117	PF00244	0.497
LIG_14-3-3_CanoR_1	228	234	PF00244	0.553
LIG_14-3-3_CanoR_1	339	348	PF00244	0.628
LIG_14-3-3_CanoR_1	45	53	PF00244	0.404
LIG_14-3-3_CanoR_1	486	495	PF00244	0.581
LIG_14-3-3_CanoR_1	55	60	PF00244	0.497
LIG_14-3-3_CanoR_1	590	600	PF00244	0.535
LIG_14-3-3_CanoR_1	618	625	PF00244	0.694
LIG_14-3-3_CanoR_1	629	634	PF00244	0.579
LIG_14-3-3_CanoR_1	73	83	PF00244	0.567
LIG_BIR_III_4	614	618	PF00653	0.567
LIG_DLG_GKlike_1	55	62	PF00625	0.521
LIG_EVH1_2	662	666	PF00568	0.611
LIG_FHA_1	203	209	PF00498	0.543
LIG_FHA_1	256	262	PF00498	0.526
LIG_FHA_1	325	331	PF00498	0.546
LIG_FHA_1	525	531	PF00498	0.713
LIG_FHA_1	678	684	PF00498	0.571
LIG_FHA_1	710	716	PF00498	0.553
LIG_FHA_1	730	736	PF00498	0.569
LIG_FHA_2	145	151	PF00498	0.643
LIG_FHA_2	364	370	PF00498	0.677
LIG_FHA_2	382	388	PF00498	0.518
LIG_FHA_2	421	427	PF00498	0.547
LIG_FHA_2	714	720	PF00498	0.693
LIG_Integrin_isoDGR_2	637	639	PF01839	0.552
LIG_LIR_Apic_2	184	188	PF02991	0.468
LIG_LIR_Apic_2	260	266	PF02991	0.527
LIG_LIR_Apic_2	273	278	PF02991	0.518
LIG_LIR_Gen_1	161	172	PF02991	0.484
LIG_LIR_Gen_1	209	220	PF02991	0.519
LIG_LIR_Nem_3	161	167	PF02991	0.495
LIG_LIR_Nem_3	209	215	PF02991	0.523
LIG_LIR_Nem_3	57	62	PF02991	0.528
LIG_LYPXL_S_1	396	400	PF13949	0.537
LIG_LYPXL_yS_3	397	400	PF13949	0.538
LIG_PDZ_Class_1	758	763	PF00595	0.579
LIG_Pex14_1	164	168	PF04695	0.302
LIG_Pex14_2	181	185	PF04695	0.545
LIG_Pex14_2	59	63	PF04695	0.517
LIG_PTB_Apo_2	262	269	PF02174	0.527
LIG_Rb_LxCxE_1	369	387	PF01857	0.548
LIG_Rb_pABgroove_1	170	178	PF01858	0.450
LIG_SH2_CRK	168	172	PF00017	0.302
LIG_SH2_CRK	22	26	PF00017	0.392
LIG_SH2_CRK	301	305	PF00017	0.715
LIG_SH2_GRB2like	263	266	PF00017	0.528
LIG_SH2_NCK_1	135	139	PF00017	0.513
LIG_SH2_PTP2	212	215	PF00017	0.522
LIG_SH2_PTP2	263	266	PF00017	0.528
LIG_SH2_SRC	263	266	PF00017	0.528
LIG_SH2_STAP1	135	139	PF00017	0.489
LIG_SH2_STAP1	168	172	PF00017	0.288
LIG_SH2_STAP1	22	26	PF00017	0.512
LIG_SH2_STAP1	233	237	PF00017	0.618
LIG_SH2_STAP1	570	574	PF00017	0.647
LIG_SH2_STAT5	174	177	PF00017	0.597
LIG_SH2_STAT5	212	215	PF00017	0.522
LIG_SH2_STAT5	263	266	PF00017	0.528
LIG_SH2_STAT5	301	304	PF00017	0.711
LIG_SH3_1	301	307	PF00018	0.712
LIG_SH3_1	465	471	PF00018	0.701
LIG_SH3_2	303	308	PF14604	0.654
LIG_SH3_2	357	362	PF14604	0.553
LIG_SH3_3	297	303	PF00018	0.700
LIG_SH3_3	313	319	PF00018	0.577
LIG_SH3_3	354	360	PF00018	0.548
LIG_SH3_3	392	398	PF00018	0.523
LIG_SH3_3	407	413	PF00018	0.500
LIG_SH3_3	465	471	PF00018	0.701
LIG_SH3_3	547	553	PF00018	0.656
LIG_SH3_3	649	655	PF00018	0.788
LIG_SH3_3	656	662	PF00018	0.687
LIG_SH3_3	717	723	PF00018	0.705
LIG_SH3_3	732	738	PF00018	0.564
LIG_SH3_CIN85_PxpxPR_1	357	362	PF14604	0.553
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.436
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.688
LIG_TYR_ITIM	395	400	PF00017	0.532
LIG_WRC_WIRS_1	56	61	PF05994	0.527
LIG_WW_3	302	306	PF00397	0.668
LIG_WW_3	359	363	PF00397	0.676
MOD_CDC14_SPxK_1	651	654	PF00782	0.646
MOD_CDK_SPK_2	433	438	PF00069	0.690
MOD_CDK_SPK_2	524	529	PF00069	0.572
MOD_CDK_SPxK_1	299	305	PF00069	0.586
MOD_CDK_SPxK_1	648	654	PF00069	0.648
MOD_CDK_SPxxK_3	431	438	PF00069	0.695
MOD_CK1_1	235	241	PF00069	0.541
MOD_CK1_1	257	263	PF00069	0.546
MOD_CK1_1	267	273	PF00069	0.519
MOD_CK1_1	320	326	PF00069	0.675
MOD_CK1_1	405	411	PF00069	0.656
MOD_CK1_1	548	554	PF00069	0.513
MOD_CK1_1	568	574	PF00069	0.503
MOD_CK1_1	609	615	PF00069	0.590
MOD_CK1_1	658	664	PF00069	0.693
MOD_CK1_1	673	679	PF00069	0.550
MOD_CK2_1	144	150	PF00069	0.718
MOD_CK2_1	363	369	PF00069	0.680
MOD_CK2_1	371	377	PF00069	0.605
MOD_CK2_1	381	387	PF00069	0.519
MOD_CK2_1	420	426	PF00069	0.547
MOD_CK2_1	713	719	PF00069	0.700
MOD_CK2_1	752	758	PF00069	0.703
MOD_DYRK1A_RPxSP_1	467	471	PF00069	0.646
MOD_GlcNHglycan	136	139	PF01048	0.552
MOD_GlcNHglycan	194	197	PF01048	0.589
MOD_GlcNHglycan	22	25	PF01048	0.355
MOD_GlcNHglycan	335	339	PF01048	0.563
MOD_GlcNHglycan	352	356	PF01048	0.562
MOD_GlcNHglycan	534	537	PF01048	0.562
MOD_GlcNHglycan	607	611	PF01048	0.620
MOD_GlcNHglycan	676	679	PF01048	0.673
MOD_GSK3_1	134	141	PF00069	0.620
MOD_GSK3_1	228	235	PF00069	0.641
MOD_GSK3_1	252	259	PF00069	0.664
MOD_GSK3_1	266	273	PF00069	0.544
MOD_GSK3_1	320	327	PF00069	0.669
MOD_GSK3_1	398	405	PF00069	0.614
MOD_GSK3_1	487	494	PF00069	0.575
MOD_GSK3_1	524	531	PF00069	0.673
MOD_GSK3_1	532	539	PF00069	0.597
MOD_GSK3_1	568	575	PF00069	0.576
MOD_GSK3_1	602	609	PF00069	0.717
MOD_GSK3_1	629	636	PF00069	0.632
MOD_GSK3_1	666	673	PF00069	0.787
MOD_GSK3_1	709	716	PF00069	0.554
MOD_GSK3_1	74	81	PF00069	0.506
MOD_GSK3_1	748	755	PF00069	0.704
MOD_N-GLC_1	524	529	PF02516	0.572
MOD_NEK2_1	134	139	PF00069	0.490
MOD_NEK2_1	181	186	PF00069	0.592
MOD_NEK2_1	403	408	PF00069	0.554
MOD_NEK2_1	509	514	PF00069	0.706
MOD_NEK2_1	666	671	PF00069	0.609
MOD_NEK2_2	293	298	PF00069	0.566
MOD_NEK2_2	371	376	PF00069	0.552
MOD_OFUCOSY	547	552	PF10250	0.519
MOD_PIKK_1	240	246	PF00454	0.550
MOD_PIKK_1	267	273	PF00454	0.527
MOD_PIKK_1	324	330	PF00454	0.544
MOD_PIKK_1	469	475	PF00454	0.707
MOD_PIKK_1	529	535	PF00454	0.570
MOD_PIKK_1	694	700	PF00454	0.653
MOD_PIKK_1	74	80	PF00454	0.556
MOD_PK_1	629	635	PF00069	0.539
MOD_PKA_1	228	234	PF00069	0.597
MOD_PKA_2	112	118	PF00069	0.501
MOD_PKA_2	228	234	PF00069	0.657
MOD_PKA_2	487	493	PF00069	0.700
MOD_PKA_2	54	60	PF00069	0.540
MOD_PKA_2	617	623	PF00069	0.670
MOD_PKA_2	647	653	PF00069	0.657
MOD_Plk_4	166	172	PF00069	0.511
MOD_Plk_4	257	263	PF00069	0.570
MOD_Plk_4	398	404	PF00069	0.540
MOD_Plk_4	666	672	PF00069	0.734
MOD_Plk_4	84	90	PF00069	0.304
MOD_ProDKin_1	144	150	PF00069	0.616
MOD_ProDKin_1	235	241	PF00069	0.555
MOD_ProDKin_1	299	305	PF00069	0.659
MOD_ProDKin_1	312	318	PF00069	0.612
MOD_ProDKin_1	320	326	PF00069	0.625
MOD_ProDKin_1	431	437	PF00069	0.695
MOD_ProDKin_1	467	473	PF00069	0.594
MOD_ProDKin_1	524	530	PF00069	0.693
MOD_ProDKin_1	572	578	PF00069	0.570
MOD_ProDKin_1	648	654	PF00069	0.720
MOD_ProDKin_1	655	661	PF00069	0.707
MOD_ProDKin_1	734	740	PF00069	0.600
MOD_ProDKin_1	748	754	PF00069	0.672
MOD_SUMO_rev_2	151	161	PF00179	0.494
MOD_SUMO_rev_2	195	203	PF00179	0.503
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.339
TRG_ENDOCYTIC_2	168	171	PF00928	0.302
TRG_ENDOCYTIC_2	212	215	PF00928	0.522
TRG_ENDOCYTIC_2	22	25	PF00928	0.377
TRG_ENDOCYTIC_2	397	400	PF00928	0.538
TRG_ER_diArg_1	104	106	PF00400	0.521
TRG_ER_diArg_1	11	14	PF00400	0.487
TRG_ER_diArg_1	227	229	PF00400	0.665
TRG_ER_diArg_1	39	41	PF00400	0.619
TRG_ER_diArg_1	461	464	PF00400	0.636
TRG_ER_diArg_1	513	515	PF00400	0.563
TRG_ER_diArg_1	557	560	PF00400	0.517
TRG_ER_diArg_1	701	703	PF00400	0.718
TRG_NLS_MonoExtC_3	463	468	PF00514	0.562
TRG_NLS_MonoExtN_4	462	468	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDQ6	Leishmania donovani	58%	78%
A4I8Z2	Leishmania infantum	58%	78%
E9B3W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	81%
Q4Q463	Leishmania major	58%	100%