Mitochondrial RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLI1_LEIBR

TriTrypDb:

LbrM.33.1470 , LBRM2903_330019700

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HLI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.564
CLV_PCSK_SKI1_1	154	158	PF00082	0.422
CLV_PCSK_SKI1_1	34	38	PF00082	0.326
DEG_Nend_UBRbox_1	1	4	PF02207	0.655
DOC_CYCLIN_RxL_1	150	161	PF00134	0.447
DOC_MAPK_DCC_7	295	303	PF00069	0.360
DOC_MAPK_gen_1	180	189	PF00069	0.396
DOC_MAPK_MEF2A_6	231	238	PF00069	0.305
DOC_MAPK_MEF2A_6	295	303	PF00069	0.335
DOC_MAPK_NFAT4_5	231	239	PF00069	0.294
DOC_PP2B_LxvP_1	83	86	PF13499	0.368
DOC_USP7_MATH_1	178	182	PF00917	0.437
DOC_WW_Pin1_4	174	179	PF00397	0.703
DOC_WW_Pin1_4	253	258	PF00397	0.418
DOC_WW_Pin1_4	303	308	PF00397	0.458
LIG_14-3-3_CanoR_1	2	10	PF00244	0.514
LIG_14-3-3_CanoR_1	295	299	PF00244	0.288
LIG_14-3-3_CanoR_1	93	101	PF00244	0.353
LIG_BIR_III_2	194	198	PF00653	0.340
LIG_BRCT_BRCA1_1	180	184	PF00533	0.394
LIG_BRCT_BRCA1_1	93	97	PF00533	0.499
LIG_Clathr_ClatBox_1	219	223	PF01394	0.373
LIG_eIF4E_1	255	261	PF01652	0.336
LIG_FHA_1	254	260	PF00498	0.416
LIG_FHA_1	308	314	PF00498	0.647
LIG_FHA_2	180	186	PF00498	0.436
LIG_FHA_2	50	56	PF00498	0.484
LIG_FHA_2	86	92	PF00498	0.442
LIG_LIR_Gen_1	181	189	PF02991	0.446
LIG_LIR_Gen_1	281	292	PF02991	0.377
LIG_LIR_Nem_3	181	187	PF02991	0.465
LIG_LIR_Nem_3	200	204	PF02991	0.458
LIG_LIR_Nem_3	249	253	PF02991	0.436
LIG_LIR_Nem_3	43	48	PF02991	0.298
LIG_SH2_CRK	45	49	PF00017	0.345
LIG_SH2_SRC	240	243	PF00017	0.336
LIG_SH2_STAT5	103	106	PF00017	0.361
LIG_SH2_STAT5	116	119	PF00017	0.367
LIG_SH2_STAT5	201	204	PF00017	0.324
LIG_SH2_STAT5	240	243	PF00017	0.363
LIG_SH2_STAT5	255	258	PF00017	0.475
LIG_SH3_3	11	17	PF00018	0.370
LIG_SH3_3	128	134	PF00018	0.359
LIG_SH3_3	172	178	PF00018	0.718
LIG_SH3_3	21	27	PF00018	0.422
LIG_SH3_5	197	201	PF00018	0.342
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.213
LIG_SUMO_SIM_par_1	185	190	PF11976	0.413
LIG_SUMO_SIM_par_1	218	223	PF11976	0.331
LIG_WRC_WIRS_1	247	252	PF05994	0.334
MOD_CDC14_SPxK_1	177	180	PF00782	0.494
MOD_CDK_SPxK_1	174	180	PF00069	0.491
MOD_CK1_1	268	274	PF00069	0.411
MOD_CK1_1	293	299	PF00069	0.353
MOD_CK1_1	306	312	PF00069	0.551
MOD_CK2_1	179	185	PF00069	0.497
MOD_CK2_1	85	91	PF00069	0.430
MOD_GlcNHglycan	113	116	PF01048	0.446
MOD_GlcNHglycan	126	129	PF01048	0.356
MOD_GlcNHglycan	158	161	PF01048	0.556
MOD_GlcNHglycan	27	30	PF01048	0.473
MOD_GlcNHglycan	5	8	PF01048	0.499
MOD_GSK3_1	174	181	PF00069	0.623
MOD_GSK3_1	18	25	PF00069	0.510
MOD_GSK3_1	278	285	PF00069	0.458
MOD_GSK3_1	290	297	PF00069	0.469
MOD_GSK3_1	303	310	PF00069	0.582
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	290	295	PF00069	0.293
MOD_NEK2_1	314	319	PF00069	0.627
MOD_NEK2_1	44	49	PF00069	0.343
MOD_NEK2_1	97	102	PF00069	0.383
MOD_NEK2_2	65	70	PF00069	0.472
MOD_PIKK_1	324	330	PF00454	0.644
MOD_PKA_2	1	7	PF00069	0.607
MOD_PKA_2	179	185	PF00069	0.453
MOD_PKA_2	294	300	PF00069	0.376
MOD_PKA_2	92	98	PF00069	0.369
MOD_Plk_1	265	271	PF00069	0.389
MOD_Plk_2-3	185	191	PF00069	0.482
MOD_Plk_4	246	252	PF00069	0.345
MOD_Plk_4	294	300	PF00069	0.214
MOD_Plk_4	49	55	PF00069	0.380
MOD_ProDKin_1	174	180	PF00069	0.704
MOD_ProDKin_1	253	259	PF00069	0.406
MOD_ProDKin_1	303	309	PF00069	0.465
MOD_SUMO_for_1	230	233	PF00179	0.547
TRG_ENDOCYTIC_2	201	204	PF00928	0.342
TRG_ENDOCYTIC_2	45	48	PF00928	0.351
TRG_ER_diArg_1	318	321	PF00400	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y0	Leptomonas seymouri	34%	78%
A0A0N1PDA3	Leptomonas seymouri	75%	100%
A0A0S4INL4	Bodo saltans	35%	77%
A0A0S4JAJ5	Bodo saltans	60%	100%
A0A1X0NQR5	Trypanosomatidae	34%	83%
A0A1X0P2H5	Trypanosomatidae	66%	100%
A0A3Q8IH71	Leishmania donovani	32%	77%
A0A3R7M1X1	Trypanosoma rangeli	33%	90%
A0A3R7MCA7	Trypanosoma rangeli	66%	100%
A0A3S7X6N8	Leishmania donovani	92%	100%
A4H647	Leishmania braziliensis	31%	100%
A4HUG7	Leishmania infantum	32%	77%
A4I8Z1	Leishmania infantum	92%	100%
D0A4Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AN65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	77%
E9B3W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q464	Leishmania major	92%	100%
Q4QHG0	Leishmania major	33%	100%
V5B205	Trypanosoma cruzi	35%	79%
V5BLV5	Trypanosoma cruzi	65%	100%