Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLH9_LEIBR

TriTrypDb:

LbrM.33.1450 , LBRM2903_330019500

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A4HLH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.531
CLV_NRD_NRD_1	165	167	PF00675	0.572
CLV_NRD_NRD_1	57	59	PF00675	0.548
CLV_NRD_NRD_1	696	698	PF00675	0.649
CLV_NRD_NRD_1	716	718	PF00675	0.477
CLV_PCSK_KEX2_1	466	468	PF00082	0.598
CLV_PCSK_KEX2_1	57	59	PF00082	0.548
CLV_PCSK_KEX2_1	671	673	PF00082	0.573
CLV_PCSK_KEX2_1	696	698	PF00082	0.649
CLV_PCSK_KEX2_1	715	717	PF00082	0.649
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.531
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.573
CLV_PCSK_PC7_1	462	468	PF00082	0.509
CLV_PCSK_SKI1_1	189	193	PF00082	0.318
CLV_PCSK_SKI1_1	742	746	PF00082	0.610
CLV_PCSK_SKI1_1	754	758	PF00082	0.633
CLV_Separin_Metazoa	54	58	PF03568	0.531
DEG_APCC_DBOX_1	445	453	PF00400	0.387
DEG_APCC_DBOX_1	716	724	PF00400	0.660
DEG_Kelch_Keap1_1	142	147	PF01344	0.494
DEG_SPOP_SBC_1	534	538	PF00917	0.678
DEG_SPOP_SBC_1	549	553	PF00917	0.573
DEG_SPOP_SBC_1	580	584	PF00917	0.670
DEG_SPOP_SBC_1	626	630	PF00917	0.635
DEG_SPOP_SBC_1	756	760	PF00917	0.713
DEG_SPOP_SBC_1	761	765	PF00917	0.786
DOC_CDC14_PxL_1	503	511	PF14671	0.475
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	554	560	PF00134	0.658
DOC_MAPK_DCC_7	715	725	PF00069	0.660
DOC_MAPK_gen_1	715	725	PF00069	0.636
DOC_MAPK_MEF2A_6	282	291	PF00069	0.324
DOC_MAPK_MEF2A_6	488	495	PF00069	0.537
DOC_MAPK_MEF2A_6	716	725	PF00069	0.635
DOC_MAPK_NFAT4_5	488	496	PF00069	0.543
DOC_PP1_RVXF_1	347	354	PF00149	0.491
DOC_PP2B_LxvP_1	113	116	PF13499	0.448
DOC_PP2B_LxvP_1	20	23	PF13499	0.498
DOC_PP2B_LxvP_1	493	496	PF13499	0.582
DOC_PP2B_LxvP_1	558	561	PF13499	0.705
DOC_SPAK_OSR1_1	349	353	PF12202	0.466
DOC_USP7_MATH_1	171	175	PF00917	0.450
DOC_USP7_MATH_1	220	224	PF00917	0.502
DOC_USP7_MATH_1	386	390	PF00917	0.445
DOC_USP7_MATH_1	550	554	PF00917	0.649
DOC_USP7_MATH_1	570	574	PF00917	0.649
DOC_USP7_MATH_1	627	631	PF00917	0.620
DOC_USP7_MATH_1	634	638	PF00917	0.664
DOC_USP7_MATH_1	701	705	PF00917	0.641
DOC_WW_Pin1_4	154	159	PF00397	0.483
DOC_WW_Pin1_4	387	392	PF00397	0.552
DOC_WW_Pin1_4	515	520	PF00397	0.799
DOC_WW_Pin1_4	572	577	PF00397	0.552
DOC_WW_Pin1_4	699	704	PF00397	0.644
LIG_14-3-3_CanoR_1	166	175	PF00244	0.431
LIG_14-3-3_CanoR_1	203	210	PF00244	0.293
LIG_14-3-3_CanoR_1	296	301	PF00244	0.417
LIG_14-3-3_CanoR_1	425	431	PF00244	0.537
LIG_14-3-3_CanoR_1	467	471	PF00244	0.600
LIG_14-3-3_CanoR_1	501	507	PF00244	0.579
LIG_14-3-3_CanoR_1	747	755	PF00244	0.723
LIG_BIR_III_4	271	275	PF00653	0.412
LIG_BRCT_BRCA1_1	427	431	PF00533	0.544
LIG_deltaCOP1_diTrp_1	34	40	PF00928	0.433
LIG_EVH1_1	623	627	PF00568	0.545
LIG_FHA_1	167	173	PF00498	0.390
LIG_FHA_1	231	237	PF00498	0.511
LIG_FHA_1	241	247	PF00498	0.448
LIG_FHA_1	313	319	PF00498	0.429
LIG_FHA_1	329	335	PF00498	0.494
LIG_FHA_1	401	407	PF00498	0.532
LIG_FHA_1	478	484	PF00498	0.451
LIG_FHA_1	50	56	PF00498	0.548
LIG_FHA_1	509	515	PF00498	0.608
LIG_FHA_1	518	524	PF00498	0.640
LIG_FHA_1	560	566	PF00498	0.590
LIG_FHA_1	581	587	PF00498	0.665
LIG_FHA_1	66	72	PF00498	0.626
LIG_FHA_1	705	711	PF00498	0.575
LIG_FHA_1	761	767	PF00498	0.799
LIG_FHA_1	81	87	PF00498	0.477
LIG_FHA_2	29	35	PF00498	0.463
LIG_FHA_2	371	377	PF00498	0.475
LIG_FHA_2	448	454	PF00498	0.443
LIG_FHA_2	508	514	PF00498	0.656
LIG_FHA_2	738	744	PF00498	0.684
LIG_LIR_Apic_2	684	688	PF02991	0.560
LIG_LIR_Gen_1	34	45	PF02991	0.510
LIG_LIR_Gen_1	367	377	PF02991	0.540
LIG_LIR_LC3C_4	17	22	PF02991	0.507
LIG_LIR_Nem_3	122	128	PF02991	0.416
LIG_LIR_Nem_3	177	181	PF02991	0.448
LIG_LIR_Nem_3	34	40	PF02991	0.438
LIG_LIR_Nem_3	389	395	PF02991	0.561
LIG_MYND_1	597	601	PF01753	0.518
LIG_NRBOX	160	166	PF00104	0.473
LIG_PCNA_yPIPBox_3	687	697	PF02747	0.528
LIG_SH2_SRC	181	184	PF00017	0.349
LIG_SH2_SRC	219	222	PF00017	0.554
LIG_SH2_STAT5	181	184	PF00017	0.407
LIG_SH2_STAT5	249	252	PF00017	0.458
LIG_SH2_STAT5	517	520	PF00017	0.632
LIG_SH2_STAT5	693	696	PF00017	0.632
LIG_SH3_3	19	25	PF00018	0.434
LIG_SH3_3	338	344	PF00018	0.442
LIG_SH3_3	544	550	PF00018	0.656
LIG_SH3_3	560	566	PF00018	0.667
LIG_SH3_3	585	591	PF00018	0.653
LIG_SH3_3	594	600	PF00018	0.655
LIG_SH3_3	621	627	PF00018	0.710
LIG_SH3_3	729	735	PF00018	0.561
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.510
LIG_SUMO_SIM_anti_2	479	485	PF11976	0.452
LIG_SUMO_SIM_anti_2	602	607	PF11976	0.546
LIG_SUMO_SIM_par_1	111	117	PF11976	0.530
LIG_SUMO_SIM_par_1	25	31	PF11976	0.427
LIG_SUMO_SIM_par_1	337	342	PF11976	0.309
LIG_UBA3_1	161	167	PF00899	0.471
LIG_UBA3_1	85	90	PF00899	0.492
MOD_CDK_SPxK_1	387	393	PF00069	0.557
MOD_CDK_SPxxK_3	699	706	PF00069	0.643
MOD_CK1_1	139	145	PF00069	0.600
MOD_CK1_1	28	34	PF00069	0.505
MOD_CK1_1	309	315	PF00069	0.435
MOD_CK1_1	387	393	PF00069	0.557
MOD_CK1_1	540	546	PF00069	0.751
MOD_CK1_1	629	635	PF00069	0.768
MOD_CK1_1	69	75	PF00069	0.800
MOD_CK1_1	704	710	PF00069	0.575
MOD_CK1_1	8	14	PF00069	0.664
MOD_CK1_1	93	99	PF00069	0.547
MOD_CK2_1	141	147	PF00069	0.497
MOD_CK2_1	171	177	PF00069	0.478
MOD_CK2_1	181	187	PF00069	0.345
MOD_CK2_1	370	376	PF00069	0.569
MOD_CK2_1	447	453	PF00069	0.440
MOD_CK2_1	737	743	PF00069	0.732
MOD_GlcNHglycan	104	107	PF01048	0.477
MOD_GlcNHglycan	144	147	PF01048	0.706
MOD_GlcNHglycan	183	186	PF01048	0.352
MOD_GlcNHglycan	226	229	PF01048	0.320
MOD_GlcNHglycan	253	256	PF01048	0.459
MOD_GlcNHglycan	268	271	PF01048	0.384
MOD_GlcNHglycan	272	275	PF01048	0.415
MOD_GlcNHglycan	293	296	PF01048	0.508
MOD_GlcNHglycan	308	311	PF01048	0.357
MOD_GlcNHglycan	322	325	PF01048	0.486
MOD_GlcNHglycan	353	356	PF01048	0.404
MOD_GlcNHglycan	386	389	PF01048	0.493
MOD_GlcNHglycan	529	532	PF01048	0.689
MOD_GlcNHglycan	539	542	PF01048	0.723
MOD_GlcNHglycan	567	570	PF01048	0.792
MOD_GlcNHglycan	572	575	PF01048	0.645
MOD_GlcNHglycan	610	613	PF01048	0.703
MOD_GlcNHglycan	63	66	PF01048	0.579
MOD_GlcNHglycan	636	639	PF01048	0.597
MOD_GlcNHglycan	68	71	PF01048	0.645
MOD_GlcNHglycan	73	76	PF01048	0.652
MOD_GlcNHglycan	747	750	PF01048	0.721
MOD_GlcNHglycan	95	98	PF01048	0.562
MOD_GSK3_1	136	143	PF00069	0.554
MOD_GSK3_1	150	157	PF00069	0.649
MOD_GSK3_1	166	173	PF00069	0.575
MOD_GSK3_1	220	227	PF00069	0.503
MOD_GSK3_1	240	247	PF00069	0.501
MOD_GSK3_1	266	273	PF00069	0.419
MOD_GSK3_1	308	315	PF00069	0.378
MOD_GSK3_1	380	387	PF00069	0.523
MOD_GSK3_1	437	444	PF00069	0.526
MOD_GSK3_1	533	540	PF00069	0.762
MOD_GSK3_1	561	568	PF00069	0.669
MOD_GSK3_1	595	602	PF00069	0.564
MOD_GSK3_1	61	68	PF00069	0.505
MOD_GSK3_1	625	632	PF00069	0.656
MOD_GSK3_1	634	641	PF00069	0.637
MOD_GSK3_1	701	708	PF00069	0.641
MOD_GSK3_1	743	750	PF00069	0.712
MOD_GSK3_1	755	762	PF00069	0.660
MOD_GSK3_1	93	100	PF00069	0.616
MOD_N-GLC_1	150	155	PF02516	0.607
MOD_N-GLC_2	130	132	PF02516	0.433
MOD_NEK2_1	126	131	PF00069	0.463
MOD_NEK2_1	141	146	PF00069	0.597
MOD_NEK2_1	204	209	PF00069	0.404
MOD_NEK2_1	244	249	PF00069	0.448
MOD_NEK2_1	525	530	PF00069	0.661
MOD_NEK2_1	579	584	PF00069	0.571
MOD_NEK2_1	71	76	PF00069	0.513
MOD_NEK2_2	240	245	PF00069	0.417
MOD_PIKK_1	249	255	PF00454	0.429
MOD_PIKK_1	400	406	PF00454	0.588
MOD_PIKK_1	437	443	PF00454	0.432
MOD_PKA_1	166	172	PF00069	0.441
MOD_PKA_1	466	472	PF00069	0.386
MOD_PKA_2	244	250	PF00069	0.478
MOD_PKA_2	466	472	PF00069	0.593
MOD_PKA_2	47	53	PF00069	0.630
MOD_PKA_2	705	711	PF00069	0.637
MOD_Plk_1	230	236	PF00069	0.510
MOD_Plk_4	104	110	PF00069	0.486
MOD_Plk_4	15	21	PF00069	0.434
MOD_Plk_4	221	227	PF00069	0.420
MOD_Plk_4	380	386	PF00069	0.580
MOD_Plk_4	426	432	PF00069	0.600
MOD_Plk_4	550	556	PF00069	0.603
MOD_Plk_4	601	607	PF00069	0.562
MOD_Plk_4	762	768	PF00069	0.646
MOD_ProDKin_1	154	160	PF00069	0.467
MOD_ProDKin_1	387	393	PF00069	0.557
MOD_ProDKin_1	515	521	PF00069	0.800
MOD_ProDKin_1	572	578	PF00069	0.552
MOD_ProDKin_1	699	705	PF00069	0.642
MOD_SUMO_for_1	711	714	PF00179	0.631
MOD_SUMO_for_1	723	726	PF00179	0.684
MOD_SUMO_rev_2	41	45	PF00179	0.365
MOD_SUMO_rev_2	746	756	PF00179	0.609
TRG_DiLeu_BaEn_1	221	226	PF01217	0.626
TRG_DiLeu_BaEn_1	490	495	PF01217	0.540
TRG_ENDOCYTIC_2	369	372	PF00928	0.574
TRG_ENDOCYTIC_2	392	395	PF00928	0.524
TRG_ER_diArg_1	455	458	PF00400	0.537
TRG_ER_diArg_1	56	58	PF00400	0.566
TRG_ER_diArg_1	696	698	PF00400	0.649
TRG_ER_diArg_1	715	717	PF00400	0.649
TRG_ER_diArg_1	734	737	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4G0	Leptomonas seymouri	61%	98%
A0A3Q8IGU1	Leishmania donovani	31%	100%
A0A3S7X6R5	Leishmania donovani	75%	100%
A4HLH8	Leishmania braziliensis	31%	100%
A4I8Y8	Leishmania infantum	30%	100%
A4I8Y9	Leishmania infantum	75%	100%
E9B3V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	89%
Q4Q466	Leishmania major	74%	100%
Q4Q467	Leishmania major	32%	100%