Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HLH8_LEIBR

TriTrypDb:

LbrM.33.1440 , LBRM2903_330019400

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A4HLH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.406
CLV_NRD_NRD_1	420	422	PF00675	0.513
CLV_NRD_NRD_1	430	432	PF00675	0.436
CLV_NRD_NRD_1	630	632	PF00675	0.722
CLV_NRD_NRD_1	77	79	PF00675	0.469
CLV_PCSK_FUR_1	75	79	PF00082	0.483
CLV_PCSK_KEX2_1	403	405	PF00082	0.526
CLV_PCSK_KEX2_1	430	432	PF00082	0.566
CLV_PCSK_KEX2_1	630	632	PF00082	0.729
CLV_PCSK_KEX2_1	77	79	PF00082	0.495
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.561
CLV_PCSK_SKI1_1	158	162	PF00082	0.338
CLV_PCSK_SKI1_1	374	378	PF00082	0.519
CLV_PCSK_SKI1_1	542	546	PF00082	0.646
CLV_PCSK_SKI1_1	622	626	PF00082	0.510
CLV_Separin_Metazoa	427	431	PF03568	0.570
DEG_APCC_DBOX_1	373	381	PF00400	0.440
DEG_APCC_DBOX_1	429	437	PF00400	0.597
DEG_SIAH_1	590	598	PF03145	0.499
DOC_CDC14_PxL_1	1	9	PF14671	0.465
DOC_MAPK_DCC_7	467	477	PF00069	0.497
DOC_MAPK_gen_1	421	428	PF00069	0.495
DOC_MAPK_gen_1	6	14	PF00069	0.475
DOC_MAPK_gen_1	77	87	PF00069	0.511
DOC_MAPK_MEF2A_6	357	364	PF00069	0.348
DOC_MAPK_NFAT4_5	357	365	PF00069	0.343
DOC_PP2B_LxvP_1	445	448	PF13499	0.600
DOC_PP2B_LxvP_1	470	473	PF13499	0.740
DOC_PP2B_LxvP_1	511	514	PF13499	0.602
DOC_PP2B_LxvP_1	525	528	PF13499	0.749
DOC_PP2B_LxvP_1	562	565	PF13499	0.613
DOC_USP7_MATH_1	139	143	PF00917	0.461
DOC_USP7_MATH_1	176	180	PF00917	0.492
DOC_USP7_MATH_1	372	376	PF00917	0.619
DOC_USP7_MATH_1	439	443	PF00917	0.464
DOC_USP7_MATH_1	466	470	PF00917	0.619
DOC_USP7_MATH_1	485	489	PF00917	0.690
DOC_USP7_MATH_1	506	510	PF00917	0.682
DOC_USP7_MATH_1	521	525	PF00917	0.736
DOC_USP7_MATH_1	526	530	PF00917	0.770
DOC_USP7_MATH_1	534	538	PF00917	0.725
DOC_USP7_UBL2_3	399	403	PF12436	0.574
DOC_WW_Pin1_4	468	473	PF00397	0.607
DOC_WW_Pin1_4	486	491	PF00397	0.660
DOC_WW_Pin1_4	536	541	PF00397	0.678
LIG_14-3-3_CanoR_1	249	254	PF00244	0.438
LIG_14-3-3_CanoR_1	421	427	PF00244	0.599
LIG_14-3-3_CanoR_1	467	471	PF00244	0.499
LIG_14-3-3_CanoR_1	499	504	PF00244	0.637
LIG_14-3-3_CanoR_1	536	540	PF00244	0.754
LIG_14-3-3_CanoR_1	6	14	PF00244	0.498
LIG_14-3-3_CterR_2	630	634	PF00244	0.719
LIG_Actin_WH2_2	239	256	PF00022	0.521
LIG_APCC_ABBA_1	106	111	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	140	144	PF00533	0.344
LIG_Clathr_ClatBox_1	578	582	PF01394	0.533
LIG_EVH1_1	511	515	PF00568	0.541
LIG_EVH1_1	562	566	PF00568	0.631
LIG_EVH1_2	563	567	PF00568	0.510
LIG_FHA_1	183	189	PF00498	0.493
LIG_FHA_1	338	344	PF00498	0.649
LIG_FHA_1	423	429	PF00498	0.467
LIG_FHA_1	43	49	PF00498	0.458
LIG_FHA_1	435	441	PF00498	0.463
LIG_FHA_1	481	487	PF00498	0.645
LIG_FHA_1	60	66	PF00498	0.542
LIG_FHA_1	608	614	PF00498	0.667
LIG_FHA_1	623	629	PF00498	0.654
LIG_FHA_1	7	13	PF00498	0.620
LIG_FHA_2	14	20	PF00498	0.609
LIG_GBD_Chelix_1	279	287	PF00786	0.429
LIG_Integrin_RGD_1	133	135	PF01839	0.404
LIG_LIR_Gen_1	44	55	PF02991	0.536
LIG_LIR_Gen_1	79	88	PF02991	0.413
LIG_LIR_LC3C_4	361	364	PF02991	0.462
LIG_LIR_Nem_3	552	558	PF02991	0.733
LIG_LIR_Nem_3	79	85	PF02991	0.413
LIG_LIR_Nem_3	86	91	PF02991	0.479
LIG_LYPXL_SIV_4	344	352	PF13949	0.586
LIG_SH2_CRK	88	92	PF00017	0.524
LIG_SH2_SRC	171	174	PF00017	0.493
LIG_SH2_SRC	555	558	PF00017	0.627
LIG_SH2_STAP1	109	113	PF00017	0.505
LIG_SH2_STAP1	339	343	PF00017	0.682
LIG_SH2_STAT3	339	342	PF00017	0.616
LIG_SH2_STAT5	109	112	PF00017	0.506
LIG_SH2_STAT5	127	130	PF00017	0.338
LIG_SH2_STAT5	166	169	PF00017	0.450
LIG_SH2_STAT5	303	306	PF00017	0.455
LIG_SH2_STAT5	339	342	PF00017	0.548
LIG_SH2_STAT5	345	348	PF00017	0.539
LIG_SH3_1	444	450	PF00018	0.593
LIG_SH3_3	444	450	PF00018	0.666
LIG_SH3_3	472	478	PF00018	0.693
LIG_SH3_3	484	490	PF00018	0.678
LIG_SH3_3	494	500	PF00018	0.665
LIG_SH3_3	507	513	PF00018	0.649
LIG_SH3_3	515	521	PF00018	0.678
LIG_SH3_3	560	566	PF00018	0.664
LIG_SH3_3	585	591	PF00018	0.597
LIG_SH3_3	593	599	PF00018	0.524
LIG_SH3_3	602	608	PF00018	0.668
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.577
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.548
LIG_SUMO_SIM_par_1	361	367	PF11976	0.458
LIG_TRAF2_1	407	410	PF00917	0.520
LIG_WRC_WIRS_1	373	378	PF05994	0.520
LIG_WW_2	447	450	PF00397	0.478
LIG_WW_3	496	500	PF00397	0.583
LIG_WW_3	539	543	PF00397	0.520
MOD_CDC14_SPxK_1	539	542	PF00782	0.517
MOD_CDK_SPxK_1	536	542	PF00069	0.525
MOD_CK1_1	13	19	PF00069	0.704
MOD_CK1_1	142	148	PF00069	0.351
MOD_CK1_1	192	198	PF00069	0.572
MOD_CK1_1	275	281	PF00069	0.503
MOD_CK1_1	289	295	PF00069	0.449
MOD_CK1_1	366	372	PF00069	0.509
MOD_CK1_1	41	47	PF00069	0.544
MOD_CK1_1	458	464	PF00069	0.711
MOD_CK1_1	481	487	PF00069	0.729
MOD_CK1_1	489	495	PF00069	0.738
MOD_CK1_1	571	577	PF00069	0.597
MOD_DYRK1A_RPxSP_1	536	540	PF00069	0.524
MOD_GlcNHglycan	102	105	PF01048	0.505
MOD_GlcNHglycan	123	126	PF01048	0.460
MOD_GlcNHglycan	178	181	PF01048	0.301
MOD_GlcNHglycan	192	195	PF01048	0.509
MOD_GlcNHglycan	206	209	PF01048	0.504
MOD_GlcNHglycan	210	213	PF01048	0.433
MOD_GlcNHglycan	221	224	PF01048	0.367
MOD_GlcNHglycan	225	228	PF01048	0.409
MOD_GlcNHglycan	263	266	PF01048	0.413
MOD_GlcNHglycan	291	294	PF01048	0.511
MOD_GlcNHglycan	306	309	PF01048	0.418
MOD_GlcNHglycan	366	369	PF01048	0.532
MOD_GlcNHglycan	441	444	PF01048	0.624
MOD_GlcNHglycan	482	486	PF01048	0.692
MOD_GlcNHglycan	491	494	PF01048	0.622
MOD_GlcNHglycan	504	507	PF01048	0.695
MOD_GlcNHglycan	582	586	PF01048	0.644
MOD_GSK3_1	117	124	PF00069	0.459
MOD_GSK3_1	138	145	PF00069	0.392
MOD_GSK3_1	178	185	PF00069	0.504
MOD_GSK3_1	188	195	PF00069	0.586
MOD_GSK3_1	204	211	PF00069	0.486
MOD_GSK3_1	215	222	PF00069	0.477
MOD_GSK3_1	306	313	PF00069	0.489
MOD_GSK3_1	34	41	PF00069	0.426
MOD_GSK3_1	481	488	PF00069	0.797
MOD_GSK3_1	498	505	PF00069	0.684
MOD_GSK3_1	547	554	PF00069	0.728
MOD_GSK3_1	6	13	PF00069	0.575
MOD_GSK3_1	622	629	PF00069	0.669
MOD_GSK3_1	83	90	PF00069	0.355
MOD_N-GLC_1	272	277	PF02516	0.287
MOD_N-GLC_1	289	294	PF02516	0.272
MOD_N-GLC_1	42	47	PF02516	0.518
MOD_NEK2_1	144	149	PF00069	0.452
MOD_NEK2_1	304	309	PF00069	0.430
MOD_NEK2_1	38	43	PF00069	0.430
MOD_NEK2_1	581	586	PF00069	0.763
MOD_NEK2_1	99	104	PF00069	0.425
MOD_NEK2_2	83	88	PF00069	0.380
MOD_PIKK_1	144	150	PF00454	0.474
MOD_PIKK_1	338	344	PF00454	0.633
MOD_PIKK_1	398	404	PF00454	0.541
MOD_PIKK_1	544	550	PF00454	0.723
MOD_PKA_2	204	210	PF00069	0.563
MOD_PKA_2	248	254	PF00069	0.311
MOD_PKA_2	383	389	PF00069	0.554
MOD_PKA_2	434	440	PF00069	0.545
MOD_PKA_2	466	472	PF00069	0.493
MOD_PKA_2	498	504	PF00069	0.636
MOD_PKA_2	535	541	PF00069	0.825
MOD_PKA_2	571	577	PF00069	0.527
MOD_PKA_2	76	82	PF00069	0.354
MOD_Plk_1	142	148	PF00069	0.421
MOD_Plk_1	182	188	PF00069	0.492
MOD_Plk_1	275	281	PF00069	0.486
MOD_Plk_1	289	295	PF00069	0.409
MOD_Plk_1	310	316	PF00069	0.452
MOD_Plk_1	42	48	PF00069	0.479
MOD_Plk_1	481	487	PF00069	0.648
MOD_Plk_4	275	281	PF00069	0.491
MOD_Plk_4	42	48	PF00069	0.513
MOD_Plk_4	506	512	PF00069	0.628
MOD_Plk_4	83	89	PF00069	0.424
MOD_ProDKin_1	468	474	PF00069	0.611
MOD_ProDKin_1	486	492	PF00069	0.661
MOD_ProDKin_1	536	542	PF00069	0.681
MOD_SUMO_rev_2	19	29	PF00179	0.495
MOD_SUMO_rev_2	416	423	PF00179	0.622
TRG_DiLeu_BaEn_1	173	178	PF01217	0.579
TRG_DiLeu_BaEn_1	358	363	PF01217	0.525
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.306
TRG_ENDOCYTIC_2	200	203	PF00928	0.542
TRG_ENDOCYTIC_2	391	394	PF00928	0.640
TRG_ENDOCYTIC_2	555	558	PF00928	0.627
TRG_ENDOCYTIC_2	88	91	PF00928	0.520
TRG_ER_diArg_1	429	431	PF00400	0.583
TRG_ER_diArg_1	5	8	PF00400	0.466
TRG_ER_diArg_1	630	632	PF00400	0.722
TRG_ER_diArg_1	74	77	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	70%	93%
A0A0S4JA89	Bodo saltans	35%	72%
A0A1X0P0X2	Trypanosomatidae	39%	96%
A0A1X0P178	Trypanosomatidae	36%	100%
A0A3Q8IGU1	Leishmania donovani	74%	100%
A0A3R7M637	Trypanosoma rangeli	33%	100%
A0A3S7X6R5	Leishmania donovani	29%	73%
A4HLH9	Leishmania braziliensis	31%	82%
A4I8Y8	Leishmania infantum	74%	100%
A4I8Y9	Leishmania infantum	28%	74%
D0A4Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	86%
E9B3V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	72%
Q4Q466	Leishmania major	28%	74%
Q4Q467	Leishmania major	74%	96%