F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLH7_LEIBR

TriTrypDb:

LbrM.33.1430 , LBRM2903_330019300

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.555
CLV_MEL_PAP_1	250	256	PF00089	0.657
CLV_NRD_NRD_1	104	106	PF00675	0.807
CLV_NRD_NRD_1	123	125	PF00675	0.432
CLV_NRD_NRD_1	438	440	PF00675	0.679
CLV_NRD_NRD_1	543	545	PF00675	0.520
CLV_NRD_NRD_1	701	703	PF00675	0.657
CLV_PCSK_KEX2_1	123	125	PF00082	0.630
CLV_PCSK_KEX2_1	438	440	PF00082	0.679
CLV_PCSK_KEX2_1	543	545	PF00082	0.520
CLV_PCSK_KEX2_1	701	703	PF00082	0.662
CLV_PCSK_SKI1_1	433	437	PF00082	0.639
CLV_PCSK_SKI1_1	562	566	PF00082	0.576
CLV_PCSK_SKI1_1	574	578	PF00082	0.570
CLV_PCSK_SKI1_1	625	629	PF00082	0.571
CLV_Separin_Metazoa	274	278	PF03568	0.519
DEG_APCC_DBOX_1	90	98	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DEG_ODPH_VHL_1	628	640	PF01847	0.553
DEG_SPOP_SBC_1	176	180	PF00917	0.564
DOC_CDC14_PxL_1	626	634	PF14671	0.564
DOC_CKS1_1	245	250	PF01111	0.782
DOC_CKS1_1	558	563	PF01111	0.581
DOC_CYCLIN_RxL_1	613	624	PF00134	0.609
DOC_MAPK_DCC_7	613	622	PF00069	0.588
DOC_MAPK_gen_1	433	442	PF00069	0.661
DOC_PP2B_LxvP_1	10	13	PF13499	0.603
DOC_PP2B_LxvP_1	521	524	PF13499	0.733
DOC_PP4_FxxP_1	627	630	PF00568	0.557
DOC_USP7_MATH_1	278	282	PF00917	0.643
DOC_USP7_MATH_1	291	295	PF00917	0.793
DOC_USP7_MATH_1	35	39	PF00917	0.600
DOC_USP7_MATH_1	384	388	PF00917	0.762
DOC_USP7_MATH_1	460	464	PF00917	0.791
DOC_USP7_MATH_1	469	473	PF00917	0.632
DOC_USP7_MATH_1	591	595	PF00917	0.838
DOC_WW_Pin1_4	164	169	PF00397	0.797
DOC_WW_Pin1_4	172	177	PF00397	0.735
DOC_WW_Pin1_4	183	188	PF00397	0.530
DOC_WW_Pin1_4	198	203	PF00397	0.739
DOC_WW_Pin1_4	210	215	PF00397	0.748
DOC_WW_Pin1_4	233	238	PF00397	0.811
DOC_WW_Pin1_4	244	249	PF00397	0.689
DOC_WW_Pin1_4	303	308	PF00397	0.618
DOC_WW_Pin1_4	340	345	PF00397	0.825
DOC_WW_Pin1_4	348	353	PF00397	0.742
DOC_WW_Pin1_4	483	488	PF00397	0.846
DOC_WW_Pin1_4	557	562	PF00397	0.835
DOC_WW_Pin1_4	565	570	PF00397	0.669
DOC_WW_Pin1_4	579	584	PF00397	0.702
DOC_WW_Pin1_4	600	605	PF00397	0.775
DOC_WW_Pin1_4	611	616	PF00397	0.760
DOC_WW_Pin1_4	663	668	PF00397	0.678
LIG_14-3-3_CanoR_1	109	116	PF00244	0.538
LIG_14-3-3_CanoR_1	222	231	PF00244	0.783
LIG_14-3-3_CanoR_1	329	333	PF00244	0.680
LIG_14-3-3_CanoR_1	459	468	PF00244	0.574
LIG_14-3-3_CanoR_1	52	57	PF00244	0.703
LIG_14-3-3_CanoR_1	574	584	PF00244	0.662
LIG_BRCT_BRCA1_1	185	189	PF00533	0.717
LIG_Clathr_ClatBox_1	640	644	PF01394	0.547
LIG_Clathr_ClatBox_1	649	653	PF01394	0.528
LIG_deltaCOP1_diTrp_1	133	136	PF00928	0.650
LIG_deltaCOP1_diTrp_1	47	57	PF00928	0.616
LIG_EVH1_2	206	210	PF00568	0.571
LIG_FHA_1	149	155	PF00498	0.707
LIG_FHA_1	183	189	PF00498	0.590
LIG_FHA_1	19	25	PF00498	0.505
LIG_FHA_1	245	251	PF00498	0.780
LIG_FHA_1	566	572	PF00498	0.540
LIG_FHA_1	595	601	PF00498	0.570
LIG_FHA_1	612	618	PF00498	0.670
LIG_FHA_1	70	76	PF00498	0.660
LIG_FHA_2	415	421	PF00498	0.600
LIG_FHA_2	507	513	PF00498	0.630
LIG_FHA_2	548	554	PF00498	0.810
LIG_FHA_2	558	564	PF00498	0.633
LIG_FHA_2	97	103	PF00498	0.555
LIG_LIR_Apic_2	198	202	PF02991	0.557
LIG_LIR_Apic_2	624	630	PF02991	0.566
LIG_LIR_Apic_2	663	667	PF02991	0.678
LIG_LIR_Gen_1	114	120	PF02991	0.629
LIG_LIR_Gen_1	133	143	PF02991	0.654
LIG_LIR_Gen_1	25	32	PF02991	0.596
LIG_LIR_Gen_1	38	46	PF02991	0.466
LIG_LIR_Gen_1	529	538	PF02991	0.626
LIG_LIR_Gen_1	55	64	PF02991	0.681
LIG_LIR_Gen_1	635	645	PF02991	0.516
LIG_LIR_Gen_1	690	699	PF02991	0.685
LIG_LIR_Nem_3	114	119	PF02991	0.632
LIG_LIR_Nem_3	133	139	PF02991	0.651
LIG_LIR_Nem_3	20	26	PF02991	0.602
LIG_LIR_Nem_3	38	43	PF02991	0.456
LIG_LIR_Nem_3	529	533	PF02991	0.635
LIG_LIR_Nem_3	55	61	PF02991	0.524
LIG_LIR_Nem_3	635	640	PF02991	0.505
LIG_LIR_Nem_3	690	695	PF02991	0.676
LIG_MYND_1	170	174	PF01753	0.554
LIG_MYND_1	237	241	PF01753	0.718
LIG_MYND_1	248	252	PF01753	0.674
LIG_MYND_1	615	619	PF01753	0.735
LIG_Pex14_2	622	626	PF04695	0.610
LIG_REV1ctd_RIR_1	117	128	PF16727	0.627
LIG_REV1ctd_RIR_1	620	629	PF16727	0.598
LIG_SH2_CRK	542	546	PF00017	0.744
LIG_SH2_CRK	692	696	PF00017	0.685
LIG_SH2_PTP2	637	640	PF00017	0.494
LIG_SH2_PTP2	694	697	PF00017	0.690
LIG_SH2_SRC	536	539	PF00017	0.710
LIG_SH2_STAP1	116	120	PF00017	0.625
LIG_SH2_STAT3	2	5	PF00017	0.742
LIG_SH2_STAT3	682	685	PF00017	0.640
LIG_SH2_STAT5	126	129	PF00017	0.634
LIG_SH2_STAT5	23	26	PF00017	0.577
LIG_SH2_STAT5	271	274	PF00017	0.540
LIG_SH2_STAT5	326	329	PF00017	0.610
LIG_SH2_STAT5	56	59	PF00017	0.618
LIG_SH2_STAT5	637	640	PF00017	0.494
LIG_SH2_STAT5	687	690	PF00017	0.667
LIG_SH2_STAT5	694	697	PF00017	0.690
LIG_SH3_1	613	619	PF00018	0.592
LIG_SH3_2	696	701	PF14604	0.705
LIG_SH3_3	163	169	PF00018	0.749
LIG_SH3_3	201	207	PF00018	0.704
LIG_SH3_3	213	219	PF00018	0.746
LIG_SH3_3	239	245	PF00018	0.721
LIG_SH3_3	246	252	PF00018	0.670
LIG_SH3_3	341	347	PF00018	0.733
LIG_SH3_3	485	491	PF00018	0.746
LIG_SH3_3	613	619	PF00018	0.631
LIG_SH3_3	693	699	PF00018	0.673
LIG_SH3_3	71	77	PF00018	0.661
LIG_SUMO_SIM_anti_2	391	398	PF11976	0.585
LIG_SUMO_SIM_par_1	150	156	PF11976	0.707
LIG_SUMO_SIM_par_1	391	398	PF11976	0.585
LIG_SUMO_SIM_par_1	504	510	PF11976	0.634
LIG_SUMO_SIM_par_1	648	653	PF11976	0.548
LIG_TRAF2_1	331	334	PF00917	0.519
LIG_TRAF2_1	417	420	PF00917	0.457
LIG_TRAF2_1	99	102	PF00917	0.558
LIG_TRFH_1	626	630	PF08558	0.561
LIG_TYR_ITIM	24	29	PF00017	0.588
LIG_TYR_ITIM	408	413	PF00017	0.712
LIG_TYR_ITIM	540	545	PF00017	0.732
MOD_CDK_SPK_2	557	562	PF00069	0.835
MOD_CDK_SPxxK_3	565	572	PF00069	0.545
MOD_CDK_SPxxK_3	579	586	PF00069	0.664
MOD_CDK_SPxxK_3	611	618	PF00069	0.763
MOD_CK1_1	108	114	PF00069	0.609
MOD_CK1_1	175	181	PF00069	0.728
MOD_CK1_1	182	188	PF00069	0.562
MOD_CK1_1	232	238	PF00069	0.745
MOD_CK1_1	303	309	PF00069	0.826
MOD_CK1_1	472	478	PF00069	0.718
MOD_CK1_1	594	600	PF00069	0.825
MOD_CK1_1	90	96	PF00069	0.688
MOD_CK2_1	111	117	PF00069	0.626
MOD_CK2_1	127	133	PF00069	0.633
MOD_CK2_1	293	299	PF00069	0.594
MOD_CK2_1	328	334	PF00069	0.693
MOD_CK2_1	414	420	PF00069	0.599
MOD_CK2_1	506	512	PF00069	0.636
MOD_CK2_1	557	563	PF00069	0.764
MOD_CK2_1	96	102	PF00069	0.797
MOD_GlcNHglycan	113	116	PF01048	0.664
MOD_GlcNHglycan	179	182	PF01048	0.667
MOD_GlcNHglycan	231	234	PF01048	0.683
MOD_GlcNHglycan	302	305	PF01048	0.753
MOD_GlcNHglycan	433	436	PF01048	0.643
MOD_GlcNHglycan	462	465	PF01048	0.811
MOD_GlcNHglycan	476	479	PF01048	0.735
MOD_GlcNHglycan	593	596	PF01048	0.776
MOD_GSK3_1	101	108	PF00069	0.629
MOD_GSK3_1	144	151	PF00069	0.691
MOD_GSK3_1	172	179	PF00069	0.774
MOD_GSK3_1	18	25	PF00069	0.669
MOD_GSK3_1	206	213	PF00069	0.808
MOD_GSK3_1	229	236	PF00069	0.745
MOD_GSK3_1	328	335	PF00069	0.682
MOD_GSK3_1	384	391	PF00069	0.656
MOD_GSK3_1	460	467	PF00069	0.704
MOD_GSK3_1	470	477	PF00069	0.772
MOD_GSK3_1	575	582	PF00069	0.801
MOD_GSK3_1	586	593	PF00069	0.551
MOD_GSK3_1	594	601	PF00069	0.577
MOD_GSK3_1	92	99	PF00069	0.714
MOD_LATS_1	220	226	PF00433	0.857
MOD_N-GLC_2	6	8	PF02516	0.549
MOD_NEK2_1	189	194	PF00069	0.551
MOD_NEK2_1	332	337	PF00069	0.656
MOD_NEK2_1	428	433	PF00069	0.609
MOD_NEK2_1	476	481	PF00069	0.811
MOD_NEK2_1	69	74	PF00069	0.660
MOD_PIKK_1	223	229	PF00454	0.718
MOD_PIKK_1	332	338	PF00454	0.633
MOD_PIKK_1	554	560	PF00454	0.585
MOD_PK_1	45	51	PF00069	0.469
MOD_PKA_1	105	111	PF00069	0.568
MOD_PKA_2	108	114	PF00069	0.553
MOD_PKA_2	221	227	PF00069	0.850
MOD_PKA_2	328	334	PF00069	0.687
MOD_PKA_2	426	432	PF00069	0.619
MOD_PKA_2	585	591	PF00069	0.776
MOD_PKA_2	703	709	PF00069	0.771
MOD_PKA_2	90	96	PF00069	0.685
MOD_PKB_1	267	275	PF00069	0.544
MOD_PKB_1	412	420	PF00069	0.448
MOD_Plk_1	189	195	PF00069	0.610
MOD_Plk_4	22	28	PF00069	0.624
MOD_Plk_4	45	51	PF00069	0.576
MOD_Plk_4	516	522	PF00069	0.634
MOD_Plk_4	52	58	PF00069	0.579
MOD_ProDKin_1	164	170	PF00069	0.791
MOD_ProDKin_1	172	178	PF00069	0.735
MOD_ProDKin_1	183	189	PF00069	0.530
MOD_ProDKin_1	198	204	PF00069	0.739
MOD_ProDKin_1	210	216	PF00069	0.744
MOD_ProDKin_1	233	239	PF00069	0.837
MOD_ProDKin_1	244	250	PF00069	0.787
MOD_ProDKin_1	303	309	PF00069	0.612
MOD_ProDKin_1	340	346	PF00069	0.826
MOD_ProDKin_1	348	354	PF00069	0.744
MOD_ProDKin_1	483	489	PF00069	0.849
MOD_ProDKin_1	557	563	PF00069	0.834
MOD_ProDKin_1	565	571	PF00069	0.667
MOD_ProDKin_1	579	585	PF00069	0.702
MOD_ProDKin_1	600	606	PF00069	0.776
MOD_ProDKin_1	611	617	PF00069	0.751
MOD_ProDKin_1	663	669	PF00069	0.678
TRG_DiLeu_BaEn_3	419	425	PF01217	0.472
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.551
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.774
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.470
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.677
TRG_ENDOCYTIC_2	116	119	PF00928	0.629
TRG_ENDOCYTIC_2	26	29	PF00928	0.567
TRG_ENDOCYTIC_2	410	413	PF00928	0.590
TRG_ENDOCYTIC_2	542	545	PF00928	0.742
TRG_ENDOCYTIC_2	58	61	PF00928	0.719
TRG_ENDOCYTIC_2	637	640	PF00928	0.494
TRG_ENDOCYTIC_2	692	695	PF00928	0.638
TRG_ER_diArg_1	123	125	PF00400	0.630
TRG_ER_diArg_1	266	269	PF00400	0.694
TRG_ER_diArg_1	411	414	PF00400	0.455
TRG_ER_diArg_1	438	440	PF00400	0.679
TRG_ER_diArg_1	542	544	PF00400	0.475
TRG_ER_diArg_1	701	704	PF00400	0.728
TRG_NES_CRM1_1	322	334	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH7	Leptomonas seymouri	49%	86%
A0A3Q8IK34	Leishmania donovani	75%	88%
A4I8Y7	Leishmania infantum	75%	88%
E9B3V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	89%
Q4Q468	Leishmania major	76%	100%