Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLH6_LEIBR

TriTrypDb:

LbrM.33.1420 , LBRM2903_330019200

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.468
CLV_PCSK_KEX2_1	327	329	PF00082	0.464
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.464
CLV_PCSK_SKI1_1	132	136	PF00082	0.492
CLV_PCSK_SKI1_1	179	183	PF00082	0.517
CLV_PCSK_SKI1_1	276	280	PF00082	0.536
CLV_PCSK_SKI1_1	282	286	PF00082	0.577
CLV_PCSK_SKI1_1	95	99	PF00082	0.361
DEG_APCC_DBOX_1	94	102	PF00400	0.342
DOC_PP2B_LxvP_1	261	264	PF13499	0.516
DOC_USP7_MATH_1	242	246	PF00917	0.490
DOC_USP7_MATH_1	322	326	PF00917	0.547
DOC_WW_Pin1_4	333	338	PF00397	0.421
LIG_14-3-3_CanoR_1	23	27	PF00244	0.442
LIG_14-3-3_CanoR_1	276	285	PF00244	0.560
LIG_14-3-3_CanoR_1	286	294	PF00244	0.470
LIG_14-3-3_CanoR_1	321	327	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_FHA_1	120	126	PF00498	0.353
LIG_FHA_1	287	293	PF00498	0.518
LIG_FHA_1	321	327	PF00498	0.440
LIG_HCF-1_HBM_1	75	78	PF13415	0.446
LIG_Integrin_RGD_1	256	258	PF01839	0.472
LIG_LIR_Gen_1	27	34	PF02991	0.318
LIG_LIR_Nem_3	27	32	PF02991	0.347
LIG_LIR_Nem_3	63	68	PF02991	0.338
LIG_SH2_CRK	29	33	PF00017	0.303
LIG_SH2_GRB2like	184	187	PF00017	0.319
LIG_SH2_SRC	184	187	PF00017	0.441
LIG_SH2_STAP1	184	188	PF00017	0.417
LIG_SH2_STAP1	34	38	PF00017	0.351
LIG_SH2_STAP1	80	84	PF00017	0.396
LIG_SH2_STAT5	294	297	PF00017	0.447
LIG_SH2_STAT5	66	69	PF00017	0.315
LIG_SH3_3	297	303	PF00018	0.364
LIG_TRAF2_1	269	272	PF00917	0.605
LIG_TYR_ITSM	61	68	PF00017	0.336
MOD_CK1_1	111	117	PF00069	0.364
MOD_CK1_1	2	8	PF00069	0.397
MOD_CK1_1	223	229	PF00069	0.687
MOD_CMANNOS	310	313	PF00535	0.375
MOD_GlcNHglycan	212	215	PF01048	0.596
MOD_GlcNHglycan	223	226	PF01048	0.647
MOD_GlcNHglycan	240	243	PF01048	0.556
MOD_GlcNHglycan	244	247	PF01048	0.610
MOD_GlcNHglycan	267	270	PF01048	0.493
MOD_GSK3_1	111	118	PF00069	0.328
MOD_GSK3_1	221	228	PF00069	0.691
MOD_GSK3_1	234	241	PF00069	0.582
MOD_GSK3_1	242	249	PF00069	0.575
MOD_GSK3_1	28	35	PF00069	0.307
MOD_GSK3_1	292	299	PF00069	0.367
MOD_N-GLC_1	2	7	PF02516	0.509
MOD_N-GLC_1	276	281	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.441
MOD_NEK2_1	115	120	PF00069	0.315
MOD_NEK2_1	202	207	PF00069	0.566
MOD_NEK2_1	227	232	PF00069	0.692
MOD_NEK2_2	322	327	PF00069	0.503
MOD_PIKK_1	32	38	PF00454	0.299
MOD_PKA_2	22	28	PF00069	0.351
MOD_PKA_2	238	244	PF00069	0.486
MOD_PKA_2	320	326	PF00069	0.388
MOD_PKB_1	165	173	PF00069	0.354
MOD_Plk_1	2	8	PF00069	0.509
MOD_Plk_1	202	208	PF00069	0.466
MOD_Plk_1	257	263	PF00069	0.476
MOD_Plk_4	115	121	PF00069	0.493
MOD_Plk_4	246	252	PF00069	0.501
MOD_Plk_4	28	34	PF00069	0.317
MOD_Plk_4	296	302	PF00069	0.338
MOD_Plk_4	60	66	PF00069	0.329
MOD_ProDKin_1	333	339	PF00069	0.423
MOD_SUMO_for_1	232	235	PF00179	0.430
TRG_DiLeu_BaEn_1	168	173	PF01217	0.337
TRG_ENDOCYTIC_2	29	32	PF00928	0.308
TRG_ENDOCYTIC_2	294	297	PF00928	0.482
TRG_ENDOCYTIC_2	64	67	PF00928	0.318
TRG_ER_diArg_1	164	167	PF00400	0.411
TRG_ER_diArg_1	301	304	PF00400	0.325
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F8	Leptomonas seymouri	81%	95%
A0A0S4J7D5	Bodo saltans	51%	97%
A0A1X0P104	Trypanosomatidae	64%	100%
A0A3Q8IGJ8	Leishmania donovani	92%	100%
A0A3R7N235	Trypanosoma rangeli	64%	100%
A4I8Y6	Leishmania infantum	92%	100%
D0A4Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B3V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q469	Leishmania major	91%	100%
V5BZN0	Trypanosoma cruzi	64%	100%