AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania braziliensis

UniProt:

A4HLH5_LEIBR

TriTrypDb:

LbrM.33.1410 , LBRM2903_330019100

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HLH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0005524	ATP binding	5	19
GO:0016462	pyrophosphatase activity	5	19
GO:0016787	hydrolase activity	2	19
GO:0016817	hydrolase activity, acting on acid anhydrides	3	19
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	19
GO:0016887	ATP hydrolysis activity	7	19
GO:0017076	purine nucleotide binding	4	19
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	19
GO:0030554	adenyl nucleotide binding	5	19
GO:0032553	ribonucleotide binding	3	19
GO:0032555	purine ribonucleotide binding	4	19
GO:0032559	adenyl ribonucleotide binding	5	19
GO:0035639	purine ribonucleoside triphosphate binding	4	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0097159	organic cyclic compound binding	2	19
GO:0097367	carbohydrate derivative binding	2	19
GO:1901265	nucleoside phosphate binding	3	19
GO:1901363	heterocyclic compound binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.423
CLV_C14_Caspase3-7	454	458	PF00656	0.769
CLV_C14_Caspase3-7	581	585	PF00656	0.516
CLV_NRD_NRD_1	424	426	PF00675	0.536
CLV_NRD_NRD_1	431	433	PF00675	0.574
CLV_PCSK_KEX2_1	249	251	PF00082	0.442
CLV_PCSK_KEX2_1	341	343	PF00082	0.286
CLV_PCSK_KEX2_1	429	431	PF00082	0.569
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.384
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.323
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.474
CLV_PCSK_PC7_1	425	431	PF00082	0.511
CLV_PCSK_SKI1_1	293	297	PF00082	0.344
CLV_PCSK_SKI1_1	316	320	PF00082	0.292
CLV_PCSK_SKI1_1	342	346	PF00082	0.290
CLV_PCSK_SKI1_1	360	364	PF00082	0.342
CLV_PCSK_SKI1_1	473	477	PF00082	0.523
CLV_PCSK_SKI1_1	570	574	PF00082	0.410
CLV_PCSK_SKI1_1	83	87	PF00082	0.405
CLV_PCSK_SKI1_1	92	96	PF00082	0.446
CLV_Separin_Metazoa	624	628	PF03568	0.519
DEG_Nend_UBRbox_2	1	3	PF02207	0.393
DEG_SCF_FBW7_1	436	442	PF00400	0.668
DEG_SPOP_SBC_1	467	471	PF00917	0.603
DEG_SPOP_SBC_1	594	598	PF00917	0.569
DEG_SPOP_SBC_1	60	64	PF00917	0.548
DOC_ANK_TNKS_1	160	167	PF00023	0.603
DOC_CKS1_1	436	441	PF01111	0.668
DOC_CYCLIN_RxL_1	193	201	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	286	292	PF00134	0.491
DOC_MAPK_gen_1	278	288	PF00069	0.519
DOC_MAPK_gen_1	341	349	PF00069	0.473
DOC_MAPK_gen_1	486	496	PF00069	0.543
DOC_PP1_RVXF_1	262	268	PF00149	0.556
DOC_SPAK_OSR1_1	366	370	PF12202	0.439
DOC_SPAK_OSR1_1	97	101	PF12202	0.708
DOC_USP7_MATH_1	171	175	PF00917	0.772
DOC_USP7_MATH_1	177	181	PF00917	0.737
DOC_USP7_MATH_1	228	232	PF00917	0.701
DOC_USP7_MATH_1	276	280	PF00917	0.634
DOC_USP7_MATH_1	32	36	PF00917	0.381
DOC_USP7_MATH_1	440	444	PF00917	0.713
DOC_USP7_MATH_1	467	471	PF00917	0.688
DOC_USP7_MATH_1	576	580	PF00917	0.576
DOC_USP7_MATH_1	594	598	PF00917	0.762
DOC_USP7_UBL2_3	245	249	PF12436	0.589
DOC_USP7_UBL2_3	303	307	PF12436	0.623
DOC_USP7_UBL2_3	368	372	PF12436	0.545
DOC_USP7_UBL2_3	473	477	PF12436	0.790
DOC_USP7_UBL2_3	482	486	PF12436	0.758
DOC_WW_Pin1_4	435	440	PF00397	0.624
DOC_WW_Pin1_4	595	600	PF00397	0.667
DOC_WW_Pin1_4	602	607	PF00397	0.553
LIG_14-3-3_CanoR_1	140	147	PF00244	0.623
LIG_14-3-3_CanoR_1	52	57	PF00244	0.625
LIG_14-3-3_CanoR_1	83	93	PF00244	0.626
LIG_Actin_WH2_2	1	19	PF00022	0.460
LIG_Actin_WH2_2	134	150	PF00022	0.715
LIG_Actin_WH2_2	517	532	PF00022	0.631
LIG_Actin_WH2_2	99	116	PF00022	0.589
LIG_BIR_III_2	130	134	PF00653	0.654
LIG_BRCT_BRCA1_1	284	288	PF00533	0.500
LIG_BRCT_BRCA1_1	363	367	PF00533	0.512
LIG_BRCT_BRCA1_1	63	67	PF00533	0.657
LIG_CSL_BTD_1	44	47	PF09270	0.645
LIG_eIF4E_1	254	260	PF01652	0.603
LIG_eIF4E_1	339	345	PF01652	0.525
LIG_FHA_1	118	124	PF00498	0.700
LIG_FHA_1	140	146	PF00498	0.676
LIG_FHA_1	16	22	PF00498	0.399
LIG_FHA_1	404	410	PF00498	0.492
LIG_FHA_1	436	442	PF00498	0.661
LIG_FHA_1	498	504	PF00498	0.538
LIG_FHA_1	516	522	PF00498	0.476
LIG_FHA_1	533	539	PF00498	0.579
LIG_FHA_1	557	563	PF00498	0.593
LIG_FHA_1	578	584	PF00498	0.625
LIG_FHA_1	599	605	PF00498	0.660
LIG_FHA_1	79	85	PF00498	0.691
LIG_FHA_1	89	95	PF00498	0.704
LIG_FHA_2	141	147	PF00498	0.720
LIG_FHA_2	338	344	PF00498	0.573
LIG_FHA_2	467	473	PF00498	0.737
LIG_FHA_2	474	480	PF00498	0.736
LIG_FHA_2	587	593	PF00498	0.727
LIG_FHA_2	616	622	PF00498	0.516
LIG_LIR_Apic_2	305	311	PF02991	0.544
LIG_LIR_Gen_1	102	113	PF02991	0.633
LIG_LIR_Gen_1	125	134	PF02991	0.646
LIG_LIR_Gen_1	2	12	PF02991	0.361
LIG_LIR_Gen_1	280	290	PF02991	0.477
LIG_LIR_Gen_1	55	65	PF02991	0.670
LIG_LIR_Nem_3	102	108	PF02991	0.644
LIG_LIR_Nem_3	125	129	PF02991	0.577
LIG_LIR_Nem_3	190	194	PF02991	0.724
LIG_LIR_Nem_3	2	7	PF02991	0.360
LIG_LIR_Nem_3	280	286	PF02991	0.490
LIG_LIR_Nem_3	44	49	PF02991	0.549
LIG_LIR_Nem_3	55	60	PF02991	0.616
LIG_LIR_Nem_3	64	70	PF02991	0.686
LIG_MLH1_MIPbox_1	284	288	PF16413	0.499
LIG_NRBOX	316	322	PF00104	0.433
LIG_NRBOX	568	574	PF00104	0.516
LIG_Pex14_2	283	287	PF04695	0.459
LIG_Pex14_2	363	367	PF04695	0.512
LIG_PTB_Apo_2	6	13	PF02174	0.402
LIG_Rb_LxCxE_1	608	624	PF01857	0.429
LIG_SH2_CRK	256	260	PF00017	0.521
LIG_SH2_CRK	308	312	PF00017	0.586
LIG_SH2_CRK	322	326	PF00017	0.398
LIG_SH2_NCK_1	308	312	PF00017	0.621
LIG_SH2_PTP2	105	108	PF00017	0.586
LIG_SH2_PTP2	4	7	PF00017	0.284
LIG_SH2_SRC	308	311	PF00017	0.614
LIG_SH2_STAP1	119	123	PF00017	0.683
LIG_SH2_STAT3	240	243	PF00017	0.509
LIG_SH2_STAT3	254	257	PF00017	0.519
LIG_SH2_STAT5	105	108	PF00017	0.632
LIG_SH2_STAT5	119	122	PF00017	0.638
LIG_SH2_STAT5	126	129	PF00017	0.599
LIG_SH2_STAT5	254	257	PF00017	0.521
LIG_SH2_STAT5	339	342	PF00017	0.413
LIG_SH2_STAT5	398	401	PF00017	0.442
LIG_SH2_STAT5	4	7	PF00017	0.395
LIG_SH2_STAT5	40	43	PF00017	0.531
LIG_SH2_STAT5	555	558	PF00017	0.583
LIG_SH2_STAT5	56	59	PF00017	0.625
LIG_SH2_STAT5	89	92	PF00017	0.591
LIG_SH3_1	308	314	PF00018	0.618
LIG_SH3_2	311	316	PF14604	0.545
LIG_SH3_3	286	292	PF00018	0.601
LIG_SH3_3	308	314	PF00018	0.535
LIG_SH3_3	387	393	PF00018	0.358
LIG_SH3_3	433	439	PF00018	0.690
LIG_SH3_3	90	96	PF00018	0.684
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.462
LIG_SUMO_SIM_anti_2	620	627	PF11976	0.541
LIG_TRAF2_1	176	179	PF00917	0.618
LIG_TRAF2_1	618	621	PF00917	0.574
LIG_TYR_ITIM	103	108	PF00017	0.673
LIG_UBA3_1	181	188	PF00899	0.544
LIG_UBA3_1	294	303	PF00899	0.559
LIG_WRC_WIRS_1	191	196	PF05994	0.526
LIG_WRC_WIRS_1	587	592	PF05994	0.562
MOD_CDK_SPxxK_3	595	602	PF00069	0.577
MOD_CK1_1	15	21	PF00069	0.385
MOD_CK1_1	159	165	PF00069	0.743
MOD_CK1_1	180	186	PF00069	0.655
MOD_CK1_1	190	196	PF00069	0.689
MOD_CK1_1	209	215	PF00069	0.589
MOD_CK1_1	279	285	PF00069	0.500
MOD_CK1_1	384	390	PF00069	0.527
MOD_CK1_1	442	448	PF00069	0.750
MOD_CK1_1	468	474	PF00069	0.650
MOD_CK1_1	492	498	PF00069	0.593
MOD_CK1_1	557	563	PF00069	0.622
MOD_CK1_1	577	583	PF00069	0.527
MOD_CK1_1	585	591	PF00069	0.585
MOD_CK1_1	593	599	PF00069	0.792
MOD_CK2_1	115	121	PF00069	0.583
MOD_CK2_1	140	146	PF00069	0.668
MOD_CK2_1	159	165	PF00069	0.777
MOD_CK2_1	228	234	PF00069	0.709
MOD_CK2_1	466	472	PF00069	0.705
MOD_CK2_1	473	479	PF00069	0.706
MOD_CK2_1	568	574	PF00069	0.604
MOD_CK2_1	602	608	PF00069	0.523
MOD_CK2_1	615	621	PF00069	0.485
MOD_GlcNHglycan	158	161	PF01048	0.445
MOD_GlcNHglycan	35	38	PF01048	0.428
MOD_GlcNHglycan	363	366	PF01048	0.292
MOD_GlcNHglycan	463	466	PF01048	0.580
MOD_GlcNHglycan	491	494	PF01048	0.327
MOD_GlcNHglycan	591	595	PF01048	0.533
MOD_GlcNHglycan	63	66	PF01048	0.473
MOD_GlcNHglycan	71	75	PF01048	0.492
MOD_GSK3_1	198	205	PF00069	0.696
MOD_GSK3_1	324	331	PF00069	0.436
MOD_GSK3_1	435	442	PF00069	0.744
MOD_GSK3_1	445	452	PF00069	0.675
MOD_GSK3_1	461	468	PF00069	0.723
MOD_GSK3_1	48	55	PF00069	0.653
MOD_GSK3_1	574	581	PF00069	0.627
MOD_GSK3_1	582	589	PF00069	0.688
MOD_GSK3_1	59	66	PF00069	0.636
MOD_GSK3_1	590	597	PF00069	0.768
MOD_GSK3_1	598	605	PF00069	0.617
MOD_GSK3_1	84	91	PF00069	0.647
MOD_N-GLC_1	156	161	PF02516	0.392
MOD_N-GLC_1	203	208	PF02516	0.340
MOD_N-GLC_1	384	389	PF02516	0.158
MOD_N-GLC_1	594	599	PF02516	0.455
MOD_NEK2_1	12	17	PF00069	0.414
MOD_NEK2_1	139	144	PF00069	0.715
MOD_NEK2_1	147	152	PF00069	0.697
MOD_NEK2_1	182	187	PF00069	0.573
MOD_NEK2_1	198	203	PF00069	0.549
MOD_NEK2_1	33	38	PF00069	0.343
MOD_NEK2_1	345	350	PF00069	0.473
MOD_NEK2_1	41	46	PF00069	0.425
MOD_NEK2_1	556	561	PF00069	0.625
MOD_NEK2_1	583	588	PF00069	0.637
MOD_NEK2_1	590	595	PF00069	0.638
MOD_NEK2_1	70	75	PF00069	0.734
MOD_NEK2_2	177	182	PF00069	0.614
MOD_NEK2_2	532	537	PF00069	0.521
MOD_NEK2_2	78	83	PF00069	0.675
MOD_PIKK_1	182	188	PF00454	0.703
MOD_PIKK_1	258	264	PF00454	0.613
MOD_PK_1	104	110	PF00069	0.601
MOD_PKA_2	139	145	PF00069	0.723
MOD_PKA_2	381	387	PF00069	0.463
MOD_PKA_2	449	455	PF00069	0.596
MOD_Plk_1	233	239	PF00069	0.701
MOD_Plk_1	279	285	PF00069	0.452
MOD_Plk_1	384	390	PF00069	0.547
MOD_Plk_1	583	589	PF00069	0.535
MOD_Plk_2-3	115	121	PF00069	0.588
MOD_Plk_2-3	568	574	PF00069	0.582
MOD_Plk_2-3	615	621	PF00069	0.565
MOD_Plk_4	177	183	PF00069	0.636
MOD_Plk_4	190	196	PF00069	0.652
MOD_Plk_4	228	234	PF00069	0.719
MOD_Plk_4	282	288	PF00069	0.484
MOD_Plk_4	52	58	PF00069	0.652
MOD_Plk_4	524	530	PF00069	0.598
MOD_Plk_4	557	563	PF00069	0.538
MOD_Plk_4	85	91	PF00069	0.626
MOD_ProDKin_1	435	441	PF00069	0.626
MOD_ProDKin_1	595	601	PF00069	0.663
MOD_ProDKin_1	602	608	PF00069	0.550
MOD_SUMO_for_1	411	414	PF00179	0.592
MOD_SUMO_rev_2	299	305	PF00179	0.534
MOD_SUMO_rev_2	442	448	PF00179	0.731
MOD_SUMO_rev_2	99	106	PF00179	0.663
TRG_DiLeu_BaEn_1	568	573	PF01217	0.623
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.602
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.604
TRG_ENDOCYTIC_2	105	108	PF00928	0.605
TRG_ENDOCYTIC_2	126	129	PF00928	0.613
TRG_ENDOCYTIC_2	256	259	PF00928	0.518
TRG_ENDOCYTIC_2	4	7	PF00928	0.350
TRG_ER_diArg_1	430	432	PF00400	0.624
TRG_NES_CRM1_1	136	149	PF08389	0.611
TRG_NES_CRM1_1	357	371	PF08389	0.542
TRG_NLS_MonoCore_2	428	433	PF00514	0.744
TRG_NLS_MonoExtC_3	428	434	PF00514	0.750
TRG_NLS_MonoExtN_4	426	433	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V2	Leptomonas seymouri	60%	94%
A0A0S4JAD3	Bodo saltans	32%	100%
A0A0S4JHU3	Bodo saltans	33%	100%
A0A1X0NTT2	Trypanosomatidae	28%	94%
A0A1X0P9I4	Trypanosomatidae	28%	79%
A0A3S7X6K2	Leishmania donovani	73%	97%
A0A422NUH1	Trypanosoma rangeli	27%	94%
A0A422P3P3	Trypanosoma rangeli	31%	100%
A4I8Y5	Leishmania infantum	73%	97%
C9ZQW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	95%
D0A1W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	88%
E9B3V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	97%
Q4Q470	Leishmania major	71%	99%
V5DMJ8	Trypanosoma cruzi	25%	88%
V5DQN5	Trypanosoma cruzi	32%	100%