Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLH4_LEIBR

TriTrypDb:

LbrM.33.1400 , LBRM2903_330019000

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.462
CLV_C14_Caspase3-7	677	681	PF00656	0.489
CLV_C14_Caspase3-7	811	815	PF00656	0.734
CLV_NRD_NRD_1	257	259	PF00675	0.633
CLV_NRD_NRD_1	331	333	PF00675	0.677
CLV_NRD_NRD_1	39	41	PF00675	0.692
CLV_NRD_NRD_1	474	476	PF00675	0.654
CLV_NRD_NRD_1	480	482	PF00675	0.683
CLV_NRD_NRD_1	626	628	PF00675	0.790
CLV_NRD_NRD_1	63	65	PF00675	0.597
CLV_PCSK_KEX2_1	257	259	PF00082	0.633
CLV_PCSK_KEX2_1	333	335	PF00082	0.645
CLV_PCSK_KEX2_1	39	41	PF00082	0.692
CLV_PCSK_KEX2_1	474	476	PF00082	0.654
CLV_PCSK_KEX2_1	479	481	PF00082	0.695
CLV_PCSK_KEX2_1	508	510	PF00082	0.520
CLV_PCSK_KEX2_1	626	628	PF00082	0.790
CLV_PCSK_KEX2_1	63	65	PF00082	0.597
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.527
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.520
CLV_PCSK_PC7_1	475	481	PF00082	0.570
CLV_PCSK_SKI1_1	109	113	PF00082	0.645
CLV_PCSK_SKI1_1	171	175	PF00082	0.608
CLV_PCSK_SKI1_1	220	224	PF00082	0.696
CLV_PCSK_SKI1_1	39	43	PF00082	0.696
CLV_PCSK_SKI1_1	475	479	PF00082	0.752
CLV_PCSK_SKI1_1	527	531	PF00082	0.562
CLV_PCSK_SKI1_1	63	67	PF00082	0.601
CLV_PCSK_SKI1_1	82	86	PF00082	0.478
CLV_Separin_Metazoa	654	658	PF03568	0.546
CLV_Separin_Metazoa	685	689	PF03568	0.452
DEG_APCC_DBOX_1	38	46	PF00400	0.687
DEG_APCC_DBOX_1	62	70	PF00400	0.683
DEG_SPOP_SBC_1	826	830	PF00917	0.511
DOC_CYCLIN_RxL_1	60	71	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	709	715	PF00134	0.534
DOC_MAPK_gen_1	14	23	PF00069	0.716
DOC_MAPK_gen_1	193	201	PF00069	0.677
DOC_MAPK_gen_1	39	50	PF00069	0.696
DOC_MAPK_gen_1	52	61	PF00069	0.459
DOC_MAPK_gen_1	562	569	PF00069	0.473
DOC_MAPK_gen_1	63	69	PF00069	0.438
DOC_MAPK_MEF2A_6	195	203	PF00069	0.668
DOC_MAPK_RevD_3	25	40	PF00069	0.705
DOC_PP1_RVXF_1	560	566	PF00149	0.595
DOC_PP1_RVXF_1	725	731	PF00149	0.647
DOC_PP2B_LxvP_1	207	210	PF13499	0.562
DOC_PP2B_LxvP_1	30	33	PF13499	0.712
DOC_PP2B_LxvP_1	309	312	PF13499	0.569
DOC_PP2B_LxvP_1	545	548	PF13499	0.793
DOC_PP2B_LxvP_1	65	68	PF13499	0.426
DOC_PP2B_LxvP_1	709	712	PF13499	0.612
DOC_USP7_MATH_1	154	158	PF00917	0.713
DOC_USP7_MATH_1	160	164	PF00917	0.638
DOC_USP7_MATH_1	222	226	PF00917	0.432
DOC_USP7_MATH_1	265	269	PF00917	0.690
DOC_USP7_MATH_1	518	522	PF00917	0.777
DOC_USP7_MATH_1	671	675	PF00917	0.627
DOC_USP7_MATH_1	740	744	PF00917	0.790
DOC_USP7_MATH_1	749	753	PF00917	0.642
DOC_USP7_MATH_1	75	79	PF00917	0.653
DOC_USP7_MATH_1	785	789	PF00917	0.757
DOC_USP7_MATH_1	790	794	PF00917	0.692
DOC_USP7_MATH_1	852	856	PF00917	0.615
DOC_USP7_UBL2_3	108	112	PF12436	0.441
DOC_USP7_UBL2_3	416	420	PF12436	0.477
DOC_WW_Pin1_4	176	181	PF00397	0.497
DOC_WW_Pin1_4	501	506	PF00397	0.775
DOC_WW_Pin1_4	568	573	PF00397	0.643
DOC_WW_Pin1_4	645	650	PF00397	0.626
DOC_WW_Pin1_4	711	716	PF00397	0.652
DOC_WW_Pin1_4	831	836	PF00397	0.731
LIG_14-3-3_CanoR_1	16	22	PF00244	0.455
LIG_14-3-3_CanoR_1	193	203	PF00244	0.662
LIG_14-3-3_CanoR_1	257	266	PF00244	0.690
LIG_14-3-3_CanoR_1	285	290	PF00244	0.468
LIG_14-3-3_CanoR_1	403	409	PF00244	0.559
LIG_14-3-3_CanoR_1	43	48	PF00244	0.455
LIG_14-3-3_CanoR_1	499	506	PF00244	0.658
LIG_14-3-3_CanoR_1	509	513	PF00244	0.708
LIG_14-3-3_CanoR_1	562	568	PF00244	0.596
LIG_14-3-3_CanoR_1	626	635	PF00244	0.749
LIG_14-3-3_CanoR_1	650	656	PF00244	0.525
LIG_14-3-3_CanoR_1	703	711	PF00244	0.638
LIG_Actin_WH2_2	23	41	PF00022	0.618
LIG_BIR_III_4	585	589	PF00653	0.498
LIG_BIR_III_4	680	684	PF00653	0.486
LIG_BRCT_BRCA1_1	117	121	PF00533	0.719
LIG_BRCT_BRCA1_1	171	175	PF00533	0.717
LIG_BRCT_BRCA1_1	570	574	PF00533	0.657
LIG_BRCT_BRCA1_1	77	81	PF00533	0.498
LIG_BRCT_BRCA1_1	97	101	PF00533	0.444
LIG_CaM_IQ_9	519	535	PF13499	0.552
LIG_deltaCOP1_diTrp_1	558	565	PF00928	0.477
LIG_FHA_1	144	150	PF00498	0.640
LIG_FHA_1	176	182	PF00498	0.647
LIG_FHA_1	18	24	PF00498	0.572
LIG_FHA_1	210	216	PF00498	0.623
LIG_FHA_1	226	232	PF00498	0.670
LIG_FHA_1	274	280	PF00498	0.451
LIG_FHA_1	311	317	PF00498	0.642
LIG_FHA_1	338	344	PF00498	0.770
LIG_FHA_1	403	409	PF00498	0.559
LIG_FHA_1	457	463	PF00498	0.542
LIG_FHA_1	508	514	PF00498	0.682
LIG_FHA_1	517	523	PF00498	0.700
LIG_FHA_1	54	60	PF00498	0.543
LIG_FHA_1	635	641	PF00498	0.557
LIG_FHA_1	650	656	PF00498	0.530
LIG_FHA_2	348	354	PF00498	0.600
LIG_FHA_2	484	490	PF00498	0.770
LIG_FHA_2	502	508	PF00498	0.522
LIG_FHA_2	544	550	PF00498	0.696
LIG_FHA_2	675	681	PF00498	0.584
LIG_FHA_2	814	820	PF00498	0.465
LIG_FHA_2	90	96	PF00498	0.455
LIG_Integrin_RGD_1	115	117	PF01839	0.469
LIG_LIR_Gen_1	598	608	PF02991	0.524
LIG_LIR_Nem_3	400	404	PF02991	0.532
LIG_LIR_Nem_3	590	596	PF02991	0.615
LIG_LIR_Nem_3	598	603	PF02991	0.502
LIG_LIR_Nem_3	707	713	PF02991	0.529
LIG_LIR_Nem_3	768	773	PF02991	0.637
LIG_LIR_Nem_3	98	104	PF02991	0.484
LIG_LYPXL_yS_3	401	404	PF13949	0.532
LIG_PCNA_yPIPBox_3	464	477	PF02747	0.728
LIG_PDZ_Class_1	852	857	PF00595	0.657
LIG_SH2_NCK_1	468	472	PF00017	0.453
LIG_SH2_SRC	189	192	PF00017	0.460
LIG_SH2_STAP1	233	237	PF00017	0.601
LIG_SH2_STAP1	242	246	PF00017	0.597
LIG_SH2_STAT3	773	776	PF00017	0.651
LIG_SH2_STAT5	186	189	PF00017	0.524
LIG_SH2_STAT5	512	515	PF00017	0.800
LIG_SH2_STAT5	596	599	PF00017	0.537
LIG_SH2_STAT5	710	713	PF00017	0.528
LIG_SH2_STAT5	773	776	PF00017	0.651
LIG_SH3_3	153	159	PF00018	0.634
LIG_SH3_3	309	315	PF00018	0.608
LIG_SH3_3	418	424	PF00018	0.714
LIG_SH3_3	460	466	PF00018	0.745
LIG_SH3_3	5	11	PF00018	0.565
LIG_SH3_3	640	646	PF00018	0.550
LIG_SH3_3	690	696	PF00018	0.581
LIG_SH3_3	709	715	PF00018	0.417
LIG_SH3_3	829	835	PF00018	0.623
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.405
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.396
LIG_SUMO_SIM_anti_2	528	537	PF11976	0.548
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.462
LIG_SUMO_SIM_anti_2	682	688	PF11976	0.465
LIG_SUMO_SIM_par_1	276	283	PF11976	0.548
LIG_SUMO_SIM_par_1	361	370	PF11976	0.551
LIG_SUMO_SIM_par_1	43	49	PF11976	0.439
LIG_SUMO_SIM_par_1	609	614	PF11976	0.668
LIG_SxIP_EBH_1	843	856	PF03271	0.626
LIG_TRAF2_1	130	133	PF00917	0.592
LIG_TRAF2_1	433	436	PF00917	0.560
LIG_TRAF2_1	547	550	PF00917	0.791
LIG_TYR_ITIM	708	713	PF00017	0.526
LIG_UBA3_1	372	377	PF00899	0.663
LIG_WRC_WIRS_1	599	604	PF05994	0.534
LIG_WW_3	166	170	PF00397	0.516
MOD_CDK_SPK_2	645	650	PF00069	0.643
MOD_CDK_SPxxK_3	501	508	PF00069	0.525
MOD_CK1_1	150	156	PF00069	0.719
MOD_CK1_1	161	167	PF00069	0.646
MOD_CK1_1	176	182	PF00069	0.651
MOD_CK1_1	225	231	PF00069	0.419
MOD_CK1_1	267	273	PF00069	0.567
MOD_CK1_1	367	373	PF00069	0.451
MOD_CK1_1	46	52	PF00069	0.455
MOD_CK1_1	501	507	PF00069	0.696
MOD_CK1_1	534	540	PF00069	0.742
MOD_CK1_1	575	581	PF00069	0.571
MOD_CK1_1	598	604	PF00069	0.533
MOD_CK1_1	674	680	PF00069	0.643
MOD_CK1_1	743	749	PF00069	0.803
MOD_CK1_1	788	794	PF00069	0.765
MOD_CK1_1	827	833	PF00069	0.694
MOD_CK1_1	834	840	PF00069	0.578
MOD_CK1_1	89	95	PF00069	0.622
MOD_CK2_1	127	133	PF00069	0.596
MOD_CK2_1	501	507	PF00069	0.776
MOD_CK2_1	543	549	PF00069	0.695
MOD_CK2_1	679	685	PF00069	0.687
MOD_CK2_1	813	819	PF00069	0.574
MOD_CK2_1	89	95	PF00069	0.510
MOD_CMANNOS	422	425	PF00535	0.593
MOD_Cter_Amidation	524	527	PF01082	0.554
MOD_GlcNHglycan	152	155	PF01048	0.711
MOD_GlcNHglycan	171	174	PF01048	0.477
MOD_GlcNHglycan	267	270	PF01048	0.720
MOD_GlcNHglycan	3	6	PF01048	0.780
MOD_GlcNHglycan	368	372	PF01048	0.568
MOD_GlcNHglycan	492	495	PF01048	0.776
MOD_GlcNHglycan	500	503	PF01048	0.643
MOD_GlcNHglycan	535	539	PF01048	0.532
MOD_GlcNHglycan	577	580	PF01048	0.628
MOD_GlcNHglycan	613	616	PF01048	0.625
MOD_GlcNHglycan	680	684	PF01048	0.577
MOD_GlcNHglycan	758	761	PF01048	0.737
MOD_GlcNHglycan	77	80	PF01048	0.605
MOD_GlcNHglycan	788	791	PF01048	0.747
MOD_GlcNHglycan	797	800	PF01048	0.629
MOD_GlcNHglycan	810	813	PF01048	0.527
MOD_GlcNHglycan	836	839	PF01048	0.761
MOD_GlcNHglycan	89	92	PF01048	0.664
MOD_GSK3_1	115	122	PF00069	0.622
MOD_GSK3_1	143	150	PF00069	0.669
MOD_GSK3_1	154	161	PF00069	0.605
MOD_GSK3_1	169	176	PF00069	0.581
MOD_GSK3_1	205	212	PF00069	0.566
MOD_GSK3_1	222	229	PF00069	0.662
MOD_GSK3_1	264	271	PF00069	0.697
MOD_GSK3_1	393	400	PF00069	0.690
MOD_GSK3_1	490	497	PF00069	0.783
MOD_GSK3_1	507	514	PF00069	0.572
MOD_GSK3_1	527	534	PF00069	0.783
MOD_GSK3_1	568	575	PF00069	0.636
MOD_GSK3_1	645	652	PF00069	0.398
MOD_GSK3_1	786	793	PF00069	0.774
MOD_GSK3_1	824	831	PF00069	0.731
MOD_GSK3_1	841	848	PF00069	0.493
MOD_GSK3_1	85	92	PF00069	0.642
MOD_GSK3_1	95	102	PF00069	0.574
MOD_N-GLC_1	553	558	PF02516	0.488
MOD_N-GLC_1	86	91	PF02516	0.734
MOD_NEK2_1	119	124	PF00069	0.717
MOD_NEK2_1	149	154	PF00069	0.628
MOD_NEK2_1	174	179	PF00069	0.556
MOD_NEK2_1	563	568	PF00069	0.600
MOD_NEK2_1	86	91	PF00069	0.734
MOD_NEK2_2	740	745	PF00069	0.793
MOD_PIKK_1	222	228	PF00454	0.423
MOD_PIKK_1	375	381	PF00454	0.572
MOD_PIKK_1	456	462	PF00454	0.549
MOD_PK_1	285	291	PF00069	0.472
MOD_PK_1	43	49	PF00069	0.439
MOD_PKA_1	257	263	PF00069	0.631
MOD_PKA_1	508	514	PF00069	0.531
MOD_PKA_1	626	632	PF00069	0.762
MOD_PKA_2	194	200	PF00069	0.662
MOD_PKA_2	256	262	PF00069	0.663
MOD_PKA_2	347	353	PF00069	0.570
MOD_PKA_2	402	408	PF00069	0.587
MOD_PKA_2	498	504	PF00069	0.705
MOD_PKA_2	508	514	PF00069	0.672
MOD_PKA_2	563	569	PF00069	0.597
MOD_PKA_2	580	586	PF00069	0.688
MOD_PKA_2	625	631	PF00069	0.776
MOD_PKA_2	649	655	PF00069	0.380
MOD_PKA_2	702	708	PF00069	0.639
MOD_PKB_1	479	487	PF00069	0.547
MOD_Plk_1	367	373	PF00069	0.577
MOD_Plk_1	553	559	PF00069	0.486
MOD_Plk_1	813	819	PF00069	0.467
MOD_Plk_2-3	364	370	PF00069	0.515
MOD_Plk_4	115	121	PF00069	0.465
MOD_Plk_4	17	23	PF00069	0.487
MOD_Plk_4	226	232	PF00069	0.588
MOD_Plk_4	508	514	PF00069	0.682
MOD_Plk_4	527	533	PF00069	0.593
MOD_Plk_4	595	601	PF00069	0.545
MOD_Plk_4	765	771	PF00069	0.708
MOD_Plk_4	845	851	PF00069	0.696
MOD_Plk_4	89	95	PF00069	0.674
MOD_ProDKin_1	176	182	PF00069	0.489
MOD_ProDKin_1	501	507	PF00069	0.776
MOD_ProDKin_1	568	574	PF00069	0.642
MOD_ProDKin_1	645	651	PF00069	0.625
MOD_ProDKin_1	711	717	PF00069	0.650
MOD_ProDKin_1	831	837	PF00069	0.727
MOD_SUMO_for_1	532	535	PF00179	0.547
TRG_DiLeu_BaEn_1	294	299	PF01217	0.413
TRG_DiLeu_BaEn_4	706	712	PF01217	0.638
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.622
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.563
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.382
TRG_ENDOCYTIC_2	401	404	PF00928	0.532
TRG_ENDOCYTIC_2	596	599	PF00928	0.537
TRG_ENDOCYTIC_2	710	713	PF00928	0.528
TRG_ER_diArg_1	13	16	PF00400	0.671
TRG_ER_diArg_1	168	171	PF00400	0.504
TRG_ER_diArg_1	256	258	PF00400	0.559
TRG_ER_diArg_1	284	287	PF00400	0.576
TRG_ER_diArg_1	331	334	PF00400	0.718
TRG_ER_diArg_1	38	40	PF00400	0.697
TRG_ER_diArg_1	473	475	PF00400	0.602
TRG_ER_diArg_1	478	481	PF00400	0.711
TRG_ER_diArg_1	561	564	PF00400	0.596
TRG_ER_diArg_1	63	65	PF00400	0.595
TRG_ER_diArg_1	667	670	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	727	731	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS9	Leptomonas seymouri	34%	92%
A0A3S7X6J9	Leishmania donovani	70%	97%
A4I8Y4	Leishmania infantum	70%	97%
E9B3V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q471	Leishmania major	68%	100%