Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLH1_LEIBR

TriTrypDb:

LbrM.33.1370 , LBRM2903_330018700

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.587
CLV_PCSK_KEX2_1	4	6	PF00082	0.587
CLV_PCSK_KEX2_1	54	56	PF00082	0.646
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.670
CLV_PCSK_SKI1_1	5	9	PF00082	0.660
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DOC_USP7_MATH_1	40	44	PF00917	0.541
DOC_USP7_MATH_1	75	79	PF00917	0.487
DOC_WW_Pin1_4	82	87	PF00397	0.332
LIG_14-3-3_CanoR_1	4	8	PF00244	0.373
LIG_Clathr_ClatBox_1	137	141	PF01394	0.357
LIG_FHA_2	112	118	PF00498	0.600
LIG_LIR_Gen_1	141	147	PF02991	0.357
LIG_LIR_Nem_3	141	147	PF02991	0.357
LIG_LIR_Nem_3	81	87	PF02991	0.287
LIG_PDZ_Class_2	142	147	PF00595	0.519
LIG_SH2_CRK	130	134	PF00017	0.391
LIG_SH2_CRK	84	88	PF00017	0.357
LIG_SH2_CRK	97	101	PF00017	0.357
LIG_SH2_NCK_1	84	88	PF00017	0.438
LIG_SH2_STAP1	109	113	PF00017	0.578
LIG_SH2_STAT5	118	121	PF00017	0.614
LIG_SH2_STAT5	57	60	PF00017	0.482
LIG_SUMO_SIM_par_1	98	104	PF11976	0.357
LIG_SxIP_EBH_1	55	69	PF03271	0.490
LIG_TYR_ITIM	82	87	PF00017	0.357
LIG_TYR_ITIM	95	100	PF00017	0.357
MOD_CK1_1	3	9	PF00069	0.376
MOD_CK1_1	78	84	PF00069	0.419
MOD_GlcNHglycan	17	20	PF01048	0.604
MOD_GlcNHglycan	46	49	PF01048	0.769
MOD_GSK3_1	107	114	PF00069	0.581
MOD_GSK3_1	29	36	PF00069	0.494
MOD_GSK3_1	3	10	PF00069	0.505
MOD_GSK3_1	40	47	PF00069	0.514
MOD_GSK3_1	74	81	PF00069	0.427
MOD_GSK3_1	82	89	PF00069	0.360
MOD_N-GLC_1	107	112	PF02516	0.393
MOD_NEK2_1	111	116	PF00069	0.609
MOD_NEK2_1	29	34	PF00069	0.544
MOD_NEK2_1	50	55	PF00069	0.477
MOD_NEK2_1	58	63	PF00069	0.474
MOD_NEK2_1	7	12	PF00069	0.515
MOD_PIKK_1	68	74	PF00454	0.482
MOD_PIKK_1	7	13	PF00454	0.502
MOD_PKA_2	29	35	PF00069	0.502
MOD_PKA_2	3	9	PF00069	0.376
MOD_Plk_1	107	113	PF00069	0.596
MOD_Plk_4	123	129	PF00069	0.518
MOD_Plk_4	58	64	PF00069	0.475
MOD_Plk_4	78	84	PF00069	0.276
MOD_ProDKin_1	82	88	PF00069	0.332
TRG_ENDOCYTIC_2	130	133	PF00928	0.357
TRG_ENDOCYTIC_2	84	87	PF00928	0.357
TRG_ENDOCYTIC_2	97	100	PF00928	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG2	Leptomonas seymouri	73%	100%
A0A1X0P172	Trypanosomatidae	48%	100%
A0A3S5H7U3	Leishmania donovani	86%	100%
A0A422MW56	Trypanosoma rangeli	54%	100%
A4I8Y1	Leishmania infantum	86%	100%
E9B3V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q474	Leishmania major	83%	100%