Putative pumilio protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HLH0_LEIBR

TriTrypDb:

LbrM.33.1360 , LBRM2903_330018600

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLH0

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.287
CLV_C14_Caspase3-7	509	513	PF00656	0.491
CLV_C14_Caspase3-7	707	711	PF00656	0.398
CLV_NRD_NRD_1	154	156	PF00675	0.731
CLV_NRD_NRD_1	336	338	PF00675	0.712
CLV_NRD_NRD_1	346	348	PF00675	0.588
CLV_NRD_NRD_1	784	786	PF00675	0.513
CLV_NRD_NRD_1	94	96	PF00675	0.448
CLV_PCSK_KEX2_1	336	338	PF00082	0.712
CLV_PCSK_KEX2_1	346	348	PF00082	0.588
CLV_PCSK_KEX2_1	670	672	PF00082	0.502
CLV_PCSK_KEX2_1	784	786	PF00082	0.513
CLV_PCSK_KEX2_1	94	96	PF00082	0.448
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.502
CLV_PCSK_PC7_1	332	338	PF00082	0.750
CLV_PCSK_SKI1_1	699	703	PF00082	0.628
CLV_PCSK_SKI1_1	706	710	PF00082	0.482
CLV_PCSK_SKI1_1	764	768	PF00082	0.460
CLV_PCSK_SKI1_1	786	790	PF00082	0.569
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DEG_SCF_FBW7_2	129	135	PF00400	0.565
DEG_SCF_TRCP1_1	322	327	PF00400	0.590
DEG_SPOP_SBC_1	68	72	PF00917	0.719
DOC_ANK_TNKS_1	20	27	PF00023	0.740
DOC_ANK_TNKS_1	690	697	PF00023	0.693
DOC_CKS1_1	129	134	PF01111	0.731
DOC_CKS1_1	209	214	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.509
DOC_MAPK_DCC_7	112	122	PF00069	0.609
DOC_MAPK_gen_1	706	715	PF00069	0.608
DOC_MAPK_gen_1	781	789	PF00069	0.555
DOC_MAPK_MEF2A_6	461	469	PF00069	0.425
DOC_PP2B_LxvP_1	111	114	PF13499	0.437
DOC_PP2B_LxvP_1	223	226	PF13499	0.722
DOC_PP4_FxxP_1	439	442	PF00568	0.398
DOC_PP4_FxxP_1	66	69	PF00568	0.737
DOC_USP7_MATH_1	116	120	PF00917	0.653
DOC_USP7_MATH_1	210	214	PF00917	0.736
DOC_USP7_MATH_1	224	228	PF00917	0.592
DOC_USP7_MATH_1	295	299	PF00917	0.628
DOC_USP7_MATH_1	422	426	PF00917	0.317
DOC_USP7_MATH_1	678	682	PF00917	0.736
DOC_USP7_MATH_1	69	73	PF00917	0.775
DOC_USP7_MATH_2	132	138	PF00917	0.712
DOC_USP7_UBL2_3	156	160	PF12436	0.728
DOC_USP7_UBL2_3	457	461	PF12436	0.425
DOC_USP7_UBL2_3	605	609	PF12436	0.340
DOC_WW_Pin1_4	128	133	PF00397	0.725
DOC_WW_Pin1_4	190	195	PF00397	0.595
DOC_WW_Pin1_4	202	207	PF00397	0.594
DOC_WW_Pin1_4	208	213	PF00397	0.581
DOC_WW_Pin1_4	424	429	PF00397	0.469
DOC_WW_Pin1_4	461	466	PF00397	0.430
DOC_WW_Pin1_4	57	62	PF00397	0.729
DOC_WW_Pin1_4	639	644	PF00397	0.433
DOC_WW_Pin1_4	72	77	PF00397	0.660
LIG_14-3-3_CanoR_1	354	362	PF00244	0.692
LIG_14-3-3_CanoR_1	671	679	PF00244	0.569
LIG_14-3-3_CanoR_1	770	775	PF00244	0.524
LIG_14-3-3_CanoR_1	94	102	PF00244	0.472
LIG_BRCT_BRCA1_1	194	198	PF00533	0.664
LIG_BRCT_BRCA1_1	372	376	PF00533	0.709
LIG_BRCT_BRCA1_1	70	74	PF00533	0.463
LIG_CSL_BTD_1	686	689	PF09270	0.674
LIG_CtBP_PxDLS_1	442	446	PF00389	0.365
LIG_eIF4E_1	453	459	PF01652	0.340
LIG_FHA_1	170	176	PF00498	0.653
LIG_FHA_1	265	271	PF00498	0.796
LIG_FHA_1	462	468	PF00498	0.425
LIG_FHA_1	674	680	PF00498	0.751
LIG_FHA_2	125	131	PF00498	0.705
LIG_FHA_2	271	277	PF00498	0.719
LIG_FHA_2	695	701	PF00498	0.690
LIG_FHA_2	73	79	PF00498	0.478
LIG_IBAR_NPY_1	179	181	PF08397	0.629
LIG_LIR_Apic_2	437	442	PF02991	0.391
LIG_LIR_Apic_2	64	69	PF02991	0.740
LIG_LIR_Apic_2	763	768	PF02991	0.441
LIG_LIR_Apic_2	771	777	PF02991	0.408
LIG_LIR_Gen_1	130	140	PF02991	0.681
LIG_LIR_Gen_1	298	307	PF02991	0.812
LIG_LIR_Gen_1	432	443	PF02991	0.365
LIG_LIR_Gen_1	574	584	PF02991	0.341
LIG_LIR_Gen_1	611	622	PF02991	0.415
LIG_LIR_Gen_1	753	762	PF02991	0.340
LIG_LIR_Gen_1	78	83	PF02991	0.484
LIG_LIR_Nem_3	130	136	PF02991	0.765
LIG_LIR_Nem_3	196	202	PF02991	0.590
LIG_LIR_Nem_3	266	271	PF02991	0.748
LIG_LIR_Nem_3	432	438	PF02991	0.372
LIG_LIR_Nem_3	447	453	PF02991	0.363
LIG_LIR_Nem_3	574	580	PF02991	0.341
LIG_LIR_Nem_3	590	595	PF02991	0.340
LIG_LIR_Nem_3	611	617	PF02991	0.416
LIG_LIR_Nem_3	735	741	PF02991	0.507
LIG_LIR_Nem_3	753	758	PF02991	0.226
LIG_LIR_Nem_3	78	82	PF02991	0.449
LIG_LIR_Nem_3	98	103	PF02991	0.317
LIG_NRBOX	454	460	PF00104	0.340
LIG_NRP_CendR_1	817	818	PF00754	0.600
LIG_PCNA_yPIPBox_3	452	461	PF02747	0.346
LIG_PCNA_yPIPBox_3	589	601	PF02747	0.345
LIG_Pex14_2	435	439	PF04695	0.340
LIG_SH2_CRK	316	320	PF00017	0.787
LIG_SH2_CRK	50	54	PF00017	0.730
LIG_SH2_CRK	614	618	PF00017	0.468
LIG_SH2_CRK	774	778	PF00017	0.433
LIG_SH2_GRB2like	738	741	PF00017	0.455
LIG_SH2_NCK_1	316	320	PF00017	0.736
LIG_SH2_NCK_1	39	43	PF00017	0.577
LIG_SH2_NCK_1	50	54	PF00017	0.689
LIG_SH2_PTP2	765	768	PF00017	0.552
LIG_SH2_SRC	218	221	PF00017	0.622
LIG_SH2_STAP1	234	238	PF00017	0.566
LIG_SH2_STAP1	405	409	PF00017	0.400
LIG_SH2_STAP1	738	742	PF00017	0.455
LIG_SH2_STAT3	2	5	PF00017	0.705
LIG_SH2_STAT3	259	262	PF00017	0.637
LIG_SH2_STAT3	453	456	PF00017	0.340
LIG_SH2_STAT3	595	598	PF00017	0.340
LIG_SH2_STAT3	741	744	PF00017	0.340
LIG_SH2_STAT5	260	263	PF00017	0.631
LIG_SH2_STAT5	316	319	PF00017	0.568
LIG_SH2_STAT5	453	456	PF00017	0.367
LIG_SH2_STAT5	595	598	PF00017	0.340
LIG_SH2_STAT5	623	626	PF00017	0.425
LIG_SH2_STAT5	741	744	PF00017	0.340
LIG_SH2_STAT5	765	768	PF00017	0.416
LIG_SH2_STAT5	772	775	PF00017	0.437
LIG_SH3_3	494	500	PF00018	0.250
LIG_SH3_3	785	791	PF00018	0.492
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.409
LIG_SUMO_SIM_anti_2	662	668	PF11976	0.498
LIG_SUMO_SIM_par_1	440	448	PF11976	0.365
LIG_SUMO_SIM_par_1	477	482	PF11976	0.367
LIG_TRAF2_1	132	135	PF00917	0.571
LIG_TRAF2_1	570	573	PF00917	0.340
LIG_TRAF2_1	681	684	PF00917	0.532
LIG_UBA3_1	506	511	PF00899	0.400
LIG_UBA3_1	576	582	PF00899	0.400
LIG_WRC_WIRS_1	265	270	PF05994	0.700
MOD_CDK_SPxxK_3	639	646	PF00069	0.455
MOD_CK1_1	184	190	PF00069	0.688
MOD_CK1_1	193	199	PF00069	0.545
MOD_CK1_1	253	259	PF00069	0.725
MOD_CK1_1	427	433	PF00069	0.425
MOD_CK1_1	543	549	PF00069	0.431
MOD_CK1_1	72	78	PF00069	0.533
MOD_CK2_1	124	130	PF00069	0.699
MOD_CK2_1	270	276	PF00069	0.552
MOD_CK2_1	638	644	PF00069	0.437
MOD_CK2_1	678	684	PF00069	0.789
MOD_CK2_1	694	700	PF00069	0.702
MOD_Cter_Amidation	153	156	PF01082	0.733
MOD_Cter_Amidation	344	347	PF01082	0.602
MOD_GlcNHglycan	140	143	PF01048	0.690
MOD_GlcNHglycan	322	325	PF01048	0.667
MOD_GlcNHglycan	340	343	PF01048	0.740
MOD_GlcNHglycan	357	360	PF01048	0.737
MOD_GlcNHglycan	42	45	PF01048	0.776
MOD_GlcNHglycan	420	423	PF01048	0.384
MOD_GlcNHglycan	424	427	PF01048	0.345
MOD_GlcNHglycan	542	545	PF01048	0.445
MOD_GlcNHglycan	680	683	PF01048	0.630
MOD_GSK3_1	124	131	PF00069	0.785
MOD_GSK3_1	134	141	PF00069	0.715
MOD_GSK3_1	186	193	PF00069	0.762
MOD_GSK3_1	282	289	PF00069	0.730
MOD_GSK3_1	314	321	PF00069	0.791
MOD_GSK3_1	324	331	PF00069	0.841
MOD_GSK3_1	418	425	PF00069	0.480
MOD_GSK3_1	461	468	PF00069	0.516
MOD_GSK3_1	57	64	PF00069	0.692
MOD_GSK3_1	669	676	PF00069	0.588
MOD_GSK3_1	68	75	PF00069	0.426
MOD_GSK3_1	683	690	PF00069	0.740
MOD_N-GLC_1	338	343	PF02516	0.736
MOD_N-GLC_1	799	804	PF02516	0.671
MOD_N-GLC_2	229	231	PF02516	0.568
MOD_NEK2_1	270	275	PF00069	0.655
MOD_NEK2_1	314	319	PF00069	0.781
MOD_NEK2_1	418	423	PF00069	0.425
MOD_NEK2_1	540	545	PF00069	0.406
MOD_NEK2_1	622	627	PF00069	0.459
MOD_NEK2_1	669	674	PF00069	0.561
MOD_NEK2_1	82	87	PF00069	0.587
MOD_NEK2_2	694	699	PF00069	0.676
MOD_PIKK_1	169	175	PF00454	0.717
MOD_PIKK_1	193	199	PF00454	0.595
MOD_PIKK_1	253	259	PF00454	0.672
MOD_PIKK_1	282	288	PF00454	0.799
MOD_PIKK_1	314	320	PF00454	0.734
MOD_PIKK_1	392	398	PF00454	0.560
MOD_PK_1	609	615	PF00069	0.479
MOD_PKA_1	670	676	PF00069	0.503
MOD_PKA_2	17	23	PF00069	0.672
MOD_PKA_2	670	676	PF00069	0.522
MOD_PKA_2	780	786	PF00069	0.556
MOD_PKA_2	93	99	PF00069	0.465
MOD_Plk_1	134	140	PF00069	0.762
MOD_Plk_1	479	485	PF00069	0.455
MOD_Plk_1	572	578	PF00069	0.455
MOD_Plk_1	799	805	PF00069	0.693
MOD_Plk_4	181	187	PF00069	0.819
MOD_Plk_4	572	578	PF00069	0.457
MOD_Plk_4	609	615	PF00069	0.479
MOD_Plk_4	725	731	PF00069	0.391
MOD_ProDKin_1	128	134	PF00069	0.727
MOD_ProDKin_1	190	196	PF00069	0.592
MOD_ProDKin_1	202	208	PF00069	0.591
MOD_ProDKin_1	424	430	PF00069	0.469
MOD_ProDKin_1	461	467	PF00069	0.430
MOD_ProDKin_1	57	63	PF00069	0.728
MOD_ProDKin_1	639	645	PF00069	0.433
MOD_ProDKin_1	72	78	PF00069	0.657
MOD_SUMO_for_1	604	607	PF00179	0.365
MOD_SUMO_rev_2	388	395	PF00179	0.556
MOD_SUMO_rev_2	606	610	PF00179	0.346
MOD_SUMO_rev_2	703	711	PF00179	0.660
TRG_DiLeu_BaEn_2	413	419	PF01217	0.340
TRG_DiLeu_BaEn_2	750	756	PF01217	0.425
TRG_ENDOCYTIC_2	301	304	PF00928	0.689
TRG_ENDOCYTIC_2	39	42	PF00928	0.580
TRG_ENDOCYTIC_2	50	53	PF00928	0.689
TRG_ENDOCYTIC_2	614	617	PF00928	0.467
TRG_ER_diArg_1	336	338	PF00400	0.716
TRG_ER_diArg_1	346	348	PF00400	0.621
TRG_ER_diArg_1	93	95	PF00400	0.444
TRG_NES_CRM1_1	472	484	PF08389	0.425
TRG_NES_CRM1_1	574	590	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	776	780	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2G5	Trypanosomatidae	48%	89%
A0A3Q8IET5	Leishmania donovani	87%	98%
A0A3R7N6T6	Trypanosoma rangeli	49%	99%
A4I8Y0	Leishmania infantum	87%	98%
D0A4X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9B3U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4Q475	Leishmania major	88%	100%
V5BZN6	Trypanosoma cruzi	50%	99%