IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLG9_LEIBR

TriTrypDb:

LbrM.33.1350 , LBRM2903_330018500

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 4
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HLG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.362
CLV_C14_Caspase3-7	244	248	PF00656	0.310
CLV_C14_Caspase3-7	334	338	PF00656	0.359
CLV_NRD_NRD_1	437	439	PF00675	0.482
CLV_PCSK_FUR_1	435	439	PF00082	0.436
CLV_PCSK_KEX2_1	437	439	PF00082	0.436
CLV_PCSK_SKI1_1	298	302	PF00082	0.503
DOC_MAPK_gen_1	311	319	PF00069	0.308
DOC_SPAK_OSR1_1	238	242	PF12202	0.442
DOC_USP7_MATH_1	114	118	PF00917	0.478
DOC_USP7_MATH_1	188	192	PF00917	0.303
DOC_USP7_MATH_1	276	280	PF00917	0.372
DOC_USP7_MATH_1	312	316	PF00917	0.480
DOC_USP7_MATH_1	340	344	PF00917	0.363
DOC_USP7_MATH_1	382	386	PF00917	0.445
DOC_USP7_MATH_1	433	437	PF00917	0.558
DOC_WW_Pin1_4	156	161	PF00397	0.364
DOC_WW_Pin1_4	18	23	PF00397	0.491
DOC_WW_Pin1_4	206	211	PF00397	0.322
DOC_WW_Pin1_4	336	341	PF00397	0.475
DOC_WW_Pin1_4	356	361	PF00397	0.241
DOC_WW_Pin1_4	7	12	PF00397	0.574
LIG_14-3-3_CanoR_1	23	32	PF00244	0.524
LIG_Actin_WH2_2	347	364	PF00022	0.294
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_2	202	206	PF00653	0.382
LIG_BRCT_BRCA1_1	182	186	PF00533	0.353
LIG_BRCT_BRCA1_1	192	196	PF00533	0.343
LIG_deltaCOP1_diTrp_1	178	186	PF00928	0.371
LIG_FHA_1	125	131	PF00498	0.455
LIG_FHA_1	177	183	PF00498	0.306
LIG_FHA_1	27	33	PF00498	0.450
LIG_FHA_1	285	291	PF00498	0.310
LIG_FHA_1	328	334	PF00498	0.464
LIG_FHA_1	55	61	PF00498	0.472
LIG_FHA_2	132	138	PF00498	0.348
LIG_FHA_2	197	203	PF00498	0.340
LIG_FHA_2	242	248	PF00498	0.331
LIG_FHA_2	332	338	PF00498	0.378
LIG_FHA_2	87	93	PF00498	0.490
LIG_FHA_2	95	101	PF00498	0.407
LIG_GBD_Chelix_1	32	40	PF00786	0.573
LIG_LIR_Gen_1	191	197	PF02991	0.280
LIG_LIR_Gen_1	28	38	PF02991	0.453
LIG_LIR_Gen_1	299	309	PF02991	0.353
LIG_LIR_Nem_3	191	195	PF02991	0.351
LIG_LIR_Nem_3	28	33	PF02991	0.457
LIG_LIR_Nem_3	299	305	PF02991	0.356
LIG_LIR_Nem_3	343	347	PF02991	0.339
LIG_LIR_Nem_3	412	417	PF02991	0.270
LIG_PCNA_APIM_2	236	242	PF02747	0.446
LIG_PCNA_yPIPBox_3	351	362	PF02747	0.456
LIG_Pex14_2	414	418	PF04695	0.511
LIG_SH2_CRK	192	196	PF00017	0.343
LIG_SH2_CRK	237	241	PF00017	0.325
LIG_SH2_CRK	460	464	PF00017	0.617
LIG_SH2_CRK	48	52	PF00017	0.445
LIG_SH2_NCK_1	192	196	PF00017	0.272
LIG_SH2_NCK_1	48	52	PF00017	0.445
LIG_SH2_STAP1	192	196	PF00017	0.343
LIG_SH2_STAP1	30	34	PF00017	0.451
LIG_SH2_STAT5	363	366	PF00017	0.331
LIG_SH2_STAT5	404	407	PF00017	0.511
LIG_SH3_2	160	165	PF14604	0.373
LIG_SH3_3	157	163	PF00018	0.378
LIG_SH3_3	202	208	PF00018	0.361
LIG_SH3_3	258	264	PF00018	0.351
LIG_SH3_3	39	45	PF00018	0.595
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.485
LIG_SUMO_SIM_anti_2	423	429	PF11976	0.330
LIG_SUMO_SIM_par_1	126	132	PF11976	0.462
LIG_SUMO_SIM_par_1	330	337	PF11976	0.310
LIG_TYR_ITSM	26	33	PF00017	0.464
LIG_WW_2	263	266	PF00397	0.363
MOD_CDC14_SPxK_1	162	165	PF00782	0.369
MOD_CDC14_SPxK_1	359	362	PF00782	0.470
MOD_CDK_SPK_2	18	23	PF00069	0.491
MOD_CDK_SPK_2	7	12	PF00069	0.574
MOD_CDK_SPxK_1	159	165	PF00069	0.378
MOD_CDK_SPxK_1	356	362	PF00069	0.475
MOD_CDK_SPxxK_3	7	14	PF00069	0.575
MOD_CK1_1	172	178	PF00069	0.327
MOD_CK1_1	209	215	PF00069	0.498
MOD_CK1_1	255	261	PF00069	0.442
MOD_CK1_1	26	32	PF00069	0.467
MOD_CK1_1	284	290	PF00069	0.311
MOD_CK1_1	398	404	PF00069	0.429
MOD_CK1_1	448	454	PF00069	0.693
MOD_CK2_1	131	137	PF00069	0.355
MOD_CK2_1	172	178	PF00069	0.330
MOD_CK2_1	382	388	PF00069	0.452
MOD_CK2_1	86	92	PF00069	0.488
MOD_Cter_Amidation	12	15	PF01082	0.668
MOD_GlcNHglycan	1	4	PF01048	0.676
MOD_GlcNHglycan	117	120	PF01048	0.682
MOD_GlcNHglycan	15	18	PF01048	0.615
MOD_GlcNHglycan	182	185	PF01048	0.585
MOD_GlcNHglycan	271	274	PF01048	0.554
MOD_GlcNHglycan	278	281	PF01048	0.569
MOD_GlcNHglycan	283	286	PF01048	0.597
MOD_GlcNHglycan	314	317	PF01048	0.573
MOD_GlcNHglycan	370	373	PF01048	0.596
MOD_GlcNHglycan	401	404	PF01048	0.658
MOD_GlcNHglycan	68	71	PF01048	0.563
MOD_GSK3_1	105	112	PF00069	0.362
MOD_GSK3_1	151	158	PF00069	0.407
MOD_GSK3_1	164	171	PF00069	0.376
MOD_GSK3_1	172	179	PF00069	0.481
MOD_GSK3_1	214	221	PF00069	0.391
MOD_GSK3_1	250	257	PF00069	0.374
MOD_GSK3_1	286	293	PF00069	0.420
MOD_GSK3_1	303	310	PF00069	0.413
MOD_GSK3_1	327	334	PF00069	0.473
MOD_GSK3_1	336	343	PF00069	0.409
MOD_GSK3_1	395	402	PF00069	0.451
MOD_GSK3_1	73	80	PF00069	0.397
MOD_N-GLC_1	433	438	PF02516	0.362
MOD_NEK2_1	102	107	PF00069	0.407
MOD_NEK2_1	115	120	PF00069	0.374
MOD_NEK2_1	146	151	PF00069	0.334
MOD_NEK2_1	223	228	PF00069	0.309
MOD_NEK2_1	250	255	PF00069	0.353
MOD_NEK2_1	36	41	PF00069	0.475
MOD_NEK2_1	445	450	PF00069	0.687
MOD_NEK2_2	286	291	PF00069	0.286
MOD_PIKK_1	131	137	PF00454	0.425
MOD_PIKK_1	146	152	PF00454	0.313
MOD_PK_1	190	196	PF00069	0.289
MOD_Plk_1	168	174	PF00069	0.348
MOD_Plk_4	124	130	PF00069	0.333
MOD_Plk_4	137	143	PF00069	0.343
MOD_Plk_4	190	196	PF00069	0.347
MOD_Plk_4	223	229	PF00069	0.441
MOD_Plk_4	409	415	PF00069	0.311
MOD_Plk_4	423	429	PF00069	0.388
MOD_ProDKin_1	156	162	PF00069	0.369
MOD_ProDKin_1	18	24	PF00069	0.486
MOD_ProDKin_1	206	212	PF00069	0.322
MOD_ProDKin_1	336	342	PF00069	0.471
MOD_ProDKin_1	356	362	PF00069	0.241
MOD_ProDKin_1	7	13	PF00069	0.575
MOD_SUMO_for_1	71	74	PF00179	0.442
TRG_ENDOCYTIC_2	192	195	PF00928	0.343
TRG_ENDOCYTIC_2	237	240	PF00928	0.326
TRG_ENDOCYTIC_2	30	33	PF00928	0.450
TRG_ENDOCYTIC_2	302	305	PF00928	0.348
TRG_ENDOCYTIC_2	344	347	PF00928	0.332
TRG_ENDOCYTIC_2	460	463	PF00928	0.620
TRG_ER_diArg_1	435	438	PF00400	0.634
TRG_NES_CRM1_1	77	90	PF08389	0.313
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J7	Leptomonas seymouri	55%	96%
A0A3S7X6Q5	Leishmania donovani	71%	100%
A4I8X9	Leishmania infantum	71%	100%
E9B3U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q476	Leishmania major	72%	100%