IPT/TIG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLG8_LEIBR

TriTrypDb:

LbrM.33.1340 , LBRM2903_330018400

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	3
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HLG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.375
CLV_C14_Caspase3-7	221	225	PF00656	0.441
CLV_C14_Caspase3-7	86	90	PF00656	0.443
CLV_PCSK_KEX2_1	57	59	PF00082	0.467
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.467
CLV_PCSK_SKI1_1	185	189	PF00082	0.369
CLV_PCSK_SKI1_1	266	270	PF00082	0.504
CLV_PCSK_SKI1_1	31	35	PF00082	0.506
DEG_ODPH_VHL_1	54	67	PF01847	0.422
DOC_MAPK_gen_1	13	21	PF00069	0.498
DOC_MAPK_gen_1	198	206	PF00069	0.361
DOC_MAPK_gen_1	57	65	PF00069	0.414
DOC_MAPK_MEF2A_6	15	23	PF00069	0.489
DOC_SPAK_OSR1_1	125	129	PF12202	0.583
DOC_USP7_MATH_1	163	167	PF00917	0.437
DOC_USP7_MATH_1	199	203	PF00917	0.618
DOC_USP7_MATH_1	227	231	PF00917	0.617
DOC_USP7_MATH_1	286	290	PF00917	0.566
DOC_USP7_MATH_1	75	79	PF00917	0.508
DOC_USP7_UBL2_3	11	15	PF12436	0.514
DOC_WW_Pin1_4	223	228	PF00397	0.403
DOC_WW_Pin1_4	243	248	PF00397	0.303
DOC_WW_Pin1_4	65	70	PF00397	0.401
DOC_WW_Pin1_4	93	98	PF00397	0.436
LIG_14-3-3_CanoR_1	58	63	PF00244	0.414
LIG_Actin_WH2_2	234	251	PF00022	0.359
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BIR_III_2	89	93	PF00653	0.504
LIG_BRCT_BRCA1_1	79	83	PF00533	0.393
LIG_FHA_1	109	115	PF00498	0.407
LIG_FHA_1	172	178	PF00498	0.362
LIG_FHA_1	215	221	PF00498	0.600
LIG_FHA_1	269	275	PF00498	0.555
LIG_FHA_2	1	7	PF00498	0.558
LIG_FHA_2	129	135	PF00498	0.407
LIG_FHA_2	219	225	PF00498	0.429
LIG_FHA_2	84	90	PF00498	0.423
LIG_LIR_Gen_1	186	196	PF02991	0.443
LIG_LIR_Gen_1	61	69	PF02991	0.394
LIG_LIR_Gen_1	78	84	PF02991	0.336
LIG_LIR_Nem_3	186	192	PF02991	0.451
LIG_LIR_Nem_3	230	234	PF02991	0.453
LIG_LIR_Nem_3	61	65	PF02991	0.603
LIG_LIR_Nem_3	78	82	PF02991	0.428
LIG_PCNA_APIM_2	123	129	PF02747	0.586
LIG_PCNA_yPIPBox_3	238	249	PF02747	0.604
LIG_PDZ_Class_3	285	290	PF00595	0.559
LIG_SH2_CRK	124	128	PF00017	0.579
LIG_SH2_CRK	79	83	PF00017	0.593
LIG_SH2_NCK_1	79	83	PF00017	0.337
LIG_SH2_STAP1	79	83	PF00017	0.435
LIG_SH2_STAT5	250	253	PF00017	0.504
LIG_SH3_3	145	151	PF00018	0.633
LIG_SH3_3	272	278	PF00018	0.561
LIG_SH3_3	50	56	PF00018	0.449
LIG_SH3_3	89	95	PF00018	0.499
LIG_SUMO_SIM_par_1	217	224	PF11976	0.368
LIG_SUMO_SIM_par_1	22	27	PF11976	0.508
LIG_UBA3_1	23	31	PF00899	0.489
LIG_WRC_WIRS_1	59	64	PF05994	0.399
LIG_WW_2	150	153	PF00397	0.632
MOD_CDC14_SPxK_1	246	249	PF00782	0.607
MOD_CDK_SPxK_1	243	249	PF00069	0.618
MOD_CK1_1	142	148	PF00069	0.371
MOD_CK1_1	171	177	PF00069	0.331
MOD_CK1_1	42	48	PF00069	0.575
MOD_CK1_1	96	102	PF00069	0.484
MOD_CK2_1	281	287	PF00069	0.647
MOD_GlcNHglycan	158	161	PF01048	0.446
MOD_GlcNHglycan	165	168	PF01048	0.483
MOD_GlcNHglycan	170	173	PF01048	0.536
MOD_GlcNHglycan	201	204	PF01048	0.608
MOD_GlcNHglycan	257	260	PF01048	0.526
MOD_GlcNHglycan	261	264	PF01048	0.447
MOD_GlcNHglycan	283	286	PF01048	0.755
MOD_GSK3_1	101	108	PF00069	0.629
MOD_GSK3_1	137	144	PF00069	0.495
MOD_GSK3_1	173	180	PF00069	0.455
MOD_GSK3_1	190	197	PF00069	0.350
MOD_GSK3_1	214	221	PF00069	0.543
MOD_GSK3_1	223	230	PF00069	0.526
MOD_GSK3_1	255	262	PF00069	0.409
MOD_N-GLC_1	269	274	PF02516	0.640
MOD_N-GLC_1	281	286	PF02516	0.561
MOD_N-GLC_1	42	47	PF02516	0.481
MOD_NEK2_1	110	115	PF00069	0.444
MOD_NEK2_1	137	142	PF00069	0.608
MOD_NEK2_1	44	49	PF00069	0.467
MOD_NEK2_2	173	178	PF00069	0.356
MOD_OFUCOSY	40	46	PF10250	0.484
MOD_PK_1	77	83	PF00069	0.347
MOD_Plk_4	110	116	PF00069	0.540
MOD_Plk_4	44	50	PF00069	0.441
MOD_Plk_4	58	64	PF00069	0.421
MOD_Plk_4	77	83	PF00069	0.497
MOD_ProDKin_1	223	229	PF00069	0.397
MOD_ProDKin_1	243	249	PF00069	0.302
MOD_ProDKin_1	65	71	PF00069	0.397
MOD_ProDKin_1	93	99	PF00069	0.429
TRG_ENDOCYTIC_2	124	127	PF00928	0.457
TRG_ENDOCYTIC_2	189	192	PF00928	0.461
TRG_ENDOCYTIC_2	231	234	PF00928	0.469
TRG_ENDOCYTIC_2	79	82	PF00928	0.483
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6Q5	Leishmania donovani	71%	67%
A4I8X9	Leishmania infantum	71%	67%
E9B3U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	67%
Q4Q476	Leishmania major	75%	67%