Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLG7_LEIBR

TriTrypDb:

LbrM.33.1330 , LBRM2903_330018300

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HLG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.544
CLV_NRD_NRD_1	402	404	PF00675	0.478
CLV_NRD_NRD_1	544	546	PF00675	0.452
CLV_NRD_NRD_1	553	555	PF00675	0.431
CLV_NRD_NRD_1	557	559	PF00675	0.408
CLV_PCSK_FUR_1	551	555	PF00082	0.527
CLV_PCSK_KEX2_1	544	546	PF00082	0.436
CLV_PCSK_KEX2_1	553	555	PF00082	0.464
CLV_PCSK_SKI1_1	157	161	PF00082	0.631
CLV_PCSK_SKI1_1	326	330	PF00082	0.507
CLV_PCSK_SKI1_1	8	12	PF00082	0.602
CLV_PCSK_SKI1_1	88	92	PF00082	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DEG_SCF_TRCP1_1	509	515	PF00400	0.393
DOC_CKS1_1	203	208	PF01111	0.332
DOC_CKS1_1	573	578	PF01111	0.791
DOC_CKS1_1	608	613	PF01111	0.617
DOC_CYCLIN_RxL_1	453	461	PF00134	0.393
DOC_MAPK_gen_1	5	13	PF00069	0.406
DOC_MAPK_HePTP_8	468	480	PF00069	0.254
DOC_MAPK_MEF2A_6	471	480	PF00069	0.250
DOC_PP1_RVXF_1	454	461	PF00149	0.398
DOC_USP7_MATH_1	223	227	PF00917	0.472
DOC_USP7_MATH_1	484	488	PF00917	0.336
DOC_USP7_MATH_1	574	578	PF00917	0.650
DOC_USP7_MATH_1	603	607	PF00917	0.744
DOC_USP7_MATH_1	637	641	PF00917	0.776
DOC_USP7_MATH_2	42	48	PF00917	0.314
DOC_USP7_MATH_2	505	511	PF00917	0.363
DOC_WW_Pin1_4	199	204	PF00397	0.402
DOC_WW_Pin1_4	268	273	PF00397	0.455
DOC_WW_Pin1_4	379	384	PF00397	0.369
DOC_WW_Pin1_4	572	577	PF00397	0.780
DOC_WW_Pin1_4	588	593	PF00397	0.699
DOC_WW_Pin1_4	607	612	PF00397	0.793
DOC_WW_Pin1_4	628	633	PF00397	0.786
LIG_14-3-3_CanoR_1	151	156	PF00244	0.297
LIG_14-3-3_CanoR_1	2	8	PF00244	0.679
LIG_14-3-3_CanoR_1	352	358	PF00244	0.443
LIG_14-3-3_CanoR_1	403	407	PF00244	0.321
LIG_14-3-3_CanoR_1	437	442	PF00244	0.412
LIG_APCC_ABBA_1	158	163	PF00400	0.287
LIG_APCC_ABBA_1	478	483	PF00400	0.389
LIG_APCC_ABBAyCdc20_2	157	163	PF00400	0.358
LIG_APCC_ABBAyCdc20_2	477	483	PF00400	0.260
LIG_BIR_III_4	604	608	PF00653	0.617
LIG_BRCT_BRCA1_1	184	188	PF00533	0.355
LIG_BRCT_BRCA1_1	456	460	PF00533	0.388
LIG_eIF4E_1	171	177	PF01652	0.310
LIG_eIF4E_1	608	614	PF01652	0.618
LIG_FHA_1	108	114	PF00498	0.375
LIG_FHA_1	123	129	PF00498	0.537
LIG_FHA_1	131	137	PF00498	0.425
LIG_FHA_1	178	184	PF00498	0.457
LIG_FHA_1	230	236	PF00498	0.503
LIG_FHA_1	246	252	PF00498	0.423
LIG_FHA_1	259	265	PF00498	0.345
LIG_FHA_1	31	37	PF00498	0.567
LIG_FHA_1	315	321	PF00498	0.398
LIG_FHA_1	386	392	PF00498	0.439
LIG_FHA_1	517	523	PF00498	0.532
LIG_FHA_1	589	595	PF00498	0.782
LIG_FHA_1	608	614	PF00498	0.705
LIG_FHA_1	96	102	PF00498	0.312
LIG_FHA_2	106	112	PF00498	0.444
LIG_FHA_2	263	269	PF00498	0.392
LIG_FHA_2	300	306	PF00498	0.365
LIG_FHA_2	480	486	PF00498	0.387
LIG_LIR_Apic_2	461	465	PF02991	0.340
LIG_LIR_Apic_2	606	611	PF02991	0.615
LIG_LIR_Gen_1	413	423	PF02991	0.340
LIG_LIR_Gen_1	473	481	PF02991	0.356
LIG_LIR_LC3C_4	14	19	PF02991	0.366
LIG_LIR_Nem_3	130	134	PF02991	0.460
LIG_LIR_Nem_3	413	419	PF02991	0.317
LIG_LIR_Nem_3	426	432	PF02991	0.327
LIG_LIR_Nem_3	445	449	PF02991	0.388
LIG_LIR_Nem_3	457	462	PF02991	0.324
LIG_LIR_Nem_3	473	478	PF02991	0.355
LIG_LIR_Nem_3	71	76	PF02991	0.449
LIG_MYND_1	236	240	PF01753	0.381
LIG_NRBOX	12	18	PF00104	0.589
LIG_PCNA_yPIPBox_3	157	171	PF02747	0.301
LIG_Pex3_1	13	24	PF04882	0.629
LIG_PTB_Apo_2	440	447	PF02174	0.362
LIG_PTB_Phospho_1	440	446	PF10480	0.364
LIG_RPA_C_Fungi	542	554	PF08784	0.615
LIG_SH2_CRK	332	336	PF00017	0.311
LIG_SH2_CRK	39	43	PF00017	0.598
LIG_SH2_CRK	462	466	PF00017	0.449
LIG_SH2_CRK	531	535	PF00017	0.447
LIG_SH2_CRK	608	612	PF00017	0.787
LIG_SH2_NCK_1	27	31	PF00017	0.572
LIG_SH2_NCK_1	481	485	PF00017	0.620
LIG_SH2_NCK_1	608	612	PF00017	0.776
LIG_SH2_PTP2	475	478	PF00017	0.467
LIG_SH2_STAP1	27	31	PF00017	0.509
LIG_SH2_STAP1	347	351	PF00017	0.550
LIG_SH2_STAT5	117	120	PF00017	0.557
LIG_SH2_STAT5	39	42	PF00017	0.614
LIG_SH2_STAT5	430	433	PF00017	0.343
LIG_SH2_STAT5	446	449	PF00017	0.458
LIG_SH2_STAT5	475	478	PF00017	0.455
LIG_SH2_STAT5	481	484	PF00017	0.545
LIG_SH3_1	629	635	PF00018	0.533
LIG_SH3_3	123	129	PF00018	0.426
LIG_SH3_3	132	138	PF00018	0.360
LIG_SH3_3	200	206	PF00018	0.607
LIG_SH3_3	230	236	PF00018	0.604
LIG_SH3_3	386	392	PF00018	0.569
LIG_SH3_3	570	576	PF00018	0.782
LIG_SH3_3	629	635	PF00018	0.753
LIG_SH3_3	639	645	PF00018	0.532
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.591
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.353
LIG_SUMO_SIM_par_1	124	130	PF11976	0.604
LIG_SUMO_SIM_par_1	317	323	PF11976	0.452
LIG_SUMO_SIM_par_1	464	470	PF11976	0.356
LIG_TRAF2_1	563	566	PF00917	0.599
LIG_TYR_ITIM	529	534	PF00017	0.480
LIG_UBA3_1	211	215	PF00899	0.398
LIG_WRC_WIRS_1	183	188	PF05994	0.474
MOD_CDK_SPK_2	199	204	PF00069	0.372
MOD_CDK_SPxxK_3	588	595	PF00069	0.529
MOD_CK1_1	105	111	PF00069	0.441
MOD_CK1_1	122	128	PF00069	0.603
MOD_CK1_1	130	136	PF00069	0.603
MOD_CK1_1	178	184	PF00069	0.513
MOD_CK1_1	202	208	PF00069	0.531
MOD_CK1_1	287	293	PF00069	0.633
MOD_CK1_1	299	305	PF00069	0.629
MOD_CK1_1	369	375	PF00069	0.643
MOD_CK1_1	424	430	PF00069	0.499
MOD_CK1_1	439	445	PF00069	0.235
MOD_CK1_1	479	485	PF00069	0.570
MOD_CK1_1	546	552	PF00069	0.423
MOD_CK1_1	586	592	PF00069	0.722
MOD_CK1_1	623	629	PF00069	0.697
MOD_CK1_1	95	101	PF00069	0.457
MOD_CK2_1	479	485	PF00069	0.478
MOD_CK2_1	628	634	PF00069	0.532
MOD_GlcNHglycan	120	124	PF01048	0.617
MOD_GlcNHglycan	13	16	PF01048	0.547
MOD_GlcNHglycan	141	144	PF01048	0.385
MOD_GlcNHglycan	171	174	PF01048	0.620
MOD_GlcNHglycan	189	192	PF01048	0.345
MOD_GlcNHglycan	225	228	PF01048	0.655
MOD_GlcNHglycan	27	30	PF01048	0.596
MOD_GlcNHglycan	272	275	PF01048	0.581
MOD_GlcNHglycan	298	301	PF01048	0.648
MOD_GlcNHglycan	326	329	PF01048	0.515
MOD_GlcNHglycan	368	371	PF01048	0.648
MOD_GlcNHglycan	423	426	PF01048	0.468
MOD_GlcNHglycan	485	489	PF01048	0.578
MOD_GlcNHglycan	509	512	PF01048	0.701
MOD_GlcNHglycan	513	517	PF01048	0.704
MOD_GlcNHglycan	548	551	PF01048	0.522
MOD_GlcNHglycan	576	579	PF01048	0.645
MOD_GlcNHglycan	585	588	PF01048	0.653
MOD_GlcNHglycan	604	608	PF01048	0.785
MOD_GlcNHglycan	88	91	PF01048	0.537
MOD_GSK3_1	100	107	PF00069	0.405
MOD_GSK3_1	118	125	PF00069	0.436
MOD_GSK3_1	159	166	PF00069	0.546
MOD_GSK3_1	178	185	PF00069	0.438
MOD_GSK3_1	258	265	PF00069	0.577
MOD_GSK3_1	266	273	PF00069	0.546
MOD_GSK3_1	296	303	PF00069	0.629
MOD_GSK3_1	314	321	PF00069	0.459
MOD_GSK3_1	432	439	PF00069	0.443
MOD_GSK3_1	454	461	PF00069	0.393
MOD_GSK3_1	507	514	PF00069	0.652
MOD_GSK3_1	603	610	PF00069	0.708
MOD_GSK3_1	620	627	PF00069	0.699
MOD_GSK3_1	82	89	PF00069	0.508
MOD_GSK3_1	92	99	PF00069	0.442
MOD_N-GLC_1	163	168	PF02516	0.386
MOD_N-GLC_1	223	228	PF02516	0.654
MOD_N-GLC_1	275	280	PF02516	0.600
MOD_N-GLC_1	303	308	PF02516	0.718
MOD_N-GLC_1	410	415	PF02516	0.398
MOD_N-GLC_1	442	447	PF02516	0.469
MOD_N-GLC_1	583	588	PF02516	0.524
MOD_NEK2_1	102	107	PF00069	0.408
MOD_NEK2_1	11	16	PF00069	0.490
MOD_NEK2_1	118	123	PF00069	0.523
MOD_NEK2_1	150	155	PF00069	0.384
MOD_NEK2_1	177	182	PF00069	0.566
MOD_NEK2_1	186	191	PF00069	0.515
MOD_NEK2_1	197	202	PF00069	0.415
MOD_NEK2_1	245	250	PF00069	0.610
MOD_NEK2_1	431	436	PF00069	0.348
MOD_NEK2_1	454	459	PF00069	0.475
MOD_NEK2_1	76	81	PF00069	0.587
MOD_PIKK_1	217	223	PF00454	0.423
MOD_PIKK_1	266	272	PF00454	0.546
MOD_PIKK_1	432	438	PF00454	0.519
MOD_PK_1	437	443	PF00069	0.577
MOD_PKA_2	150	156	PF00069	0.396
MOD_PKA_2	197	203	PF00069	0.594
MOD_PKA_2	258	264	PF00069	0.493
MOD_PKA_2	402	408	PF00069	0.460
MOD_PKA_2	436	442	PF00069	0.573
MOD_PKA_2	543	549	PF00069	0.564
MOD_PKA_2	77	83	PF00069	0.624
MOD_PKA_2	92	98	PF00069	0.573
MOD_PKB_1	350	358	PF00069	0.334
MOD_Plk_1	163	169	PF00069	0.541
MOD_Plk_1	178	184	PF00069	0.504
MOD_Plk_1	275	281	PF00069	0.580
MOD_Plk_1	284	290	PF00069	0.521
MOD_Plk_1	410	416	PF00069	0.468
MOD_Plk_1	442	448	PF00069	0.441
MOD_Plk_1	583	589	PF00069	0.700
MOD_Plk_4	166	172	PF00069	0.532
MOD_Plk_4	178	184	PF00069	0.453
MOD_Plk_4	207	213	PF00069	0.500
MOD_Plk_4	320	326	PF00069	0.520
MOD_Plk_4	334	340	PF00069	0.486
MOD_Plk_4	402	408	PF00069	0.468
MOD_Plk_4	442	448	PF00069	0.518
MOD_Plk_4	476	482	PF00069	0.561
MOD_ProDKin_1	199	205	PF00069	0.505
MOD_ProDKin_1	268	274	PF00069	0.573
MOD_ProDKin_1	379	385	PF00069	0.459
MOD_ProDKin_1	572	578	PF00069	0.753
MOD_ProDKin_1	588	594	PF00069	0.640
MOD_ProDKin_1	607	613	PF00069	0.770
MOD_ProDKin_1	628	634	PF00069	0.755
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.367
TRG_ENDOCYTIC_2	332	335	PF00928	0.568
TRG_ENDOCYTIC_2	475	478	PF00928	0.507
TRG_ENDOCYTIC_2	531	534	PF00928	0.447
TRG_ER_diArg_1	280	283	PF00400	0.553
TRG_ER_diArg_1	350	353	PF00400	0.526
TRG_ER_diArg_1	543	545	PF00400	0.559
TRG_ER_diArg_1	551	554	PF00400	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM2	Leptomonas seymouri	45%	97%
A0A0S4J6Q6	Bodo saltans	27%	100%
A0A1X0P168	Trypanosomatidae	33%	100%
A0A3Q8IHQ4	Leishmania donovani	64%	96%
A0A3R7N2S1	Trypanosoma rangeli	30%	100%
A4I8X8	Leishmania infantum	65%	96%
E9B3U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	96%
Q4Q477	Leishmania major	64%	100%
V5BJT9	Trypanosoma cruzi	30%	100%