LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLG6_LEIBR
TriTrypDb:
LbrM.33.1320 , LBRM2903_330018200 *
Length:
310

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 129 133 PF00656 0.630
CLV_NRD_NRD_1 139 141 PF00675 0.449
CLV_NRD_NRD_1 194 196 PF00675 0.701
CLV_NRD_NRD_1 271 273 PF00675 0.660
CLV_NRD_NRD_1 95 97 PF00675 0.569
CLV_PCSK_KEX2_1 139 141 PF00082 0.577
CLV_PCSK_KEX2_1 194 196 PF00082 0.701
CLV_PCSK_KEX2_1 271 273 PF00082 0.660
CLV_PCSK_SKI1_1 173 177 PF00082 0.657
CLV_PCSK_SKI1_1 224 228 PF00082 0.721
CLV_PCSK_SKI1_1 68 72 PF00082 0.550
CLV_PCSK_SKI1_1 80 84 PF00082 0.424
CLV_PCSK_SKI1_1 97 101 PF00082 0.477
DEG_APCC_DBOX_1 95 103 PF00400 0.523
DEG_SCF_FBW7_1 47 52 PF00400 0.536
DEG_SPOP_SBC_1 164 168 PF00917 0.516
DEG_SPOP_SBC_1 174 178 PF00917 0.739
DEG_SPOP_SBC_1 202 206 PF00917 0.629
DOC_MAPK_gen_1 96 102 PF00069 0.579
DOC_USP7_MATH_1 174 178 PF00917 0.756
DOC_USP7_MATH_1 18 22 PF00917 0.749
DOC_USP7_UBL2_3 286 290 PF12436 0.392
DOC_WW_Pin1_4 180 185 PF00397 0.789
DOC_WW_Pin1_4 241 246 PF00397 0.671
DOC_WW_Pin1_4 35 40 PF00397 0.756
DOC_WW_Pin1_4 43 48 PF00397 0.722
DOC_WW_Pin1_4 49 54 PF00397 0.640
LIG_14-3-3_CanoR_1 271 275 PF00244 0.639
LIG_14-3-3_CanoR_1 42 47 PF00244 0.729
LIG_14-3-3_CanoR_1 85 93 PF00244 0.515
LIG_BIR_II_1 1 5 PF00653 0.747
LIG_BRCT_BRCA1_1 218 222 PF00533 0.540
LIG_BRCT_BRCA1_1 66 70 PF00533 0.602
LIG_BRCT_BRCA1_2 218 224 PF00533 0.664
LIG_CaM_IQ_9 134 149 PF13499 0.607
LIG_FHA_1 29 35 PF00498 0.521
LIG_FHA_2 274 280 PF00498 0.512
LIG_FHA_2 286 292 PF00498 0.409
LIG_LIR_Gen_1 292 302 PF02991 0.440
LIG_LIR_Nem_3 292 298 PF02991 0.422
LIG_SH2_CRK 230 234 PF00017 0.687
LIG_SH2_CRK 295 299 PF00017 0.533
LIG_SH2_STAP1 152 156 PF00017 0.390
LIG_SH2_STAT5 242 245 PF00017 0.704
LIG_SH3_3 41 47 PF00018 0.734
LIG_SH3_3 50 56 PF00018 0.607
LIG_SUMO_SIM_par_1 111 118 PF11976 0.574
LIG_SUMO_SIM_par_1 30 36 PF11976 0.519
LIG_TRAF2_1 133 136 PF00917 0.639
LIG_TRAF2_1 254 257 PF00917 0.563
LIG_TYR_ITIM 228 233 PF00017 0.690
LIG_UBA3_1 99 105 PF00899 0.574
MOD_CDK_SPxxK_3 35 42 PF00069 0.519
MOD_CK1_1 11 17 PF00069 0.750
MOD_CK1_1 215 221 PF00069 0.568
MOD_CK1_1 23 29 PF00069 0.755
MOD_CK1_1 30 36 PF00069 0.701
MOD_CK1_1 45 51 PF00069 0.601
MOD_CK2_1 105 111 PF00069 0.498
MOD_CK2_1 273 279 PF00069 0.545
MOD_CK2_1 285 291 PF00069 0.412
MOD_GlcNHglycan 10 13 PF01048 0.760
MOD_GlcNHglycan 128 131 PF01048 0.488
MOD_GlcNHglycan 16 19 PF01048 0.745
MOD_GlcNHglycan 178 181 PF01048 0.666
MOD_GlcNHglycan 185 188 PF01048 0.683
MOD_GlcNHglycan 205 208 PF01048 0.625
MOD_GlcNHglycan 251 254 PF01048 0.658
MOD_GlcNHglycan 35 38 PF01048 0.705
MOD_GlcNHglycan 6 9 PF01048 0.623
MOD_GSK3_1 14 21 PF00069 0.794
MOD_GSK3_1 164 171 PF00069 0.713
MOD_GSK3_1 176 183 PF00069 0.708
MOD_GSK3_1 197 204 PF00069 0.563
MOD_GSK3_1 211 218 PF00069 0.480
MOD_GSK3_1 23 30 PF00069 0.714
MOD_GSK3_1 4 11 PF00069 0.687
MOD_GSK3_1 45 52 PF00069 0.718
MOD_N-GLC_1 169 174 PF02516 0.676
MOD_N-GLC_1 180 185 PF02516 0.654
MOD_N-GLC_1 202 207 PF02516 0.635
MOD_N-GLC_1 23 28 PF02516 0.571
MOD_N-GLC_2 249 251 PF02516 0.515
MOD_PIKK_1 105 111 PF00454 0.477
MOD_PIKK_1 23 29 PF00454 0.524
MOD_PKA_2 18 24 PF00069 0.532
MOD_PKA_2 270 276 PF00069 0.639
MOD_PKA_2 84 90 PF00069 0.576
MOD_Plk_1 215 221 PF00069 0.608
MOD_Plk_1 27 33 PF00069 0.523
MOD_Plk_4 197 203 PF00069 0.677
MOD_ProDKin_1 180 186 PF00069 0.789
MOD_ProDKin_1 241 247 PF00069 0.673
MOD_ProDKin_1 35 41 PF00069 0.758
MOD_ProDKin_1 43 49 PF00069 0.724
MOD_ProDKin_1 52 58 PF00069 0.752
MOD_SUMO_rev_2 279 288 PF00179 0.551
MOD_SUMO_rev_2 94 99 PF00179 0.552
TRG_DiLeu_BaEn_1 294 299 PF01217 0.559
TRG_DiLeu_BaEn_1 95 100 PF01217 0.616
TRG_DiLeu_BaLyEn_6 88 93 PF01217 0.573
TRG_ENDOCYTIC_2 230 233 PF00928 0.664
TRG_ENDOCYTIC_2 295 298 PF00928 0.448
TRG_ER_diArg_1 139 142 PF00400 0.474
TRG_ER_diArg_1 193 195 PF00400 0.624
TRG_ER_diArg_1 270 272 PF00400 0.665
TRG_NES_CRM1_1 111 126 PF08389 0.573
TRG_Pf-PMV_PEXEL_1 76 81 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 91 95 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE12 Leptomonas seymouri 58% 100%
A0A0S4IXZ1 Bodo saltans 26% 100%
A0A1X0P0W7 Trypanosomatidae 38% 100%
A0A3R7NUE3 Trypanosoma rangeli 34% 100%
A0A3S7X6M7 Leishmania donovani 76% 93%
A4I8X7 Leishmania infantum 75% 93%
D0A4X5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9B3U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 96%
Q4Q478 Leishmania major 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS